Articles tagged "Kidney transplantation"

2017 American Transplant Congress
Similar Elevation of Gene Expression Associated with Antibody-Mediated Rejection (ABMR) of Renal Allografts Can Be Detected in Both Plasma Exosomes (pExo) and Biopsies (Bx) by Assessing mRNA Transcript Profiles.
H. Zhang,¹ C. Nast,² J. Doldron,² M. Cheung,² J. Mirocha,³ J. Kahwaji,¹ A. Vo,¹ S. Jordan,¹ M. Toyoda.¹
¹Transplant Immunology Laboratory, Cedars-Sinai Medical Center, Los Angeles; ²Pathology, Cedars-Sinai Medical Center, Los Angeles; ³Biostatistics Center, Cedars-Sinai Medical Center, Los Angeles
Background: ABMR is a major obstacle for successful transplant in HLA-sensitized patients (Pts). Prediction of ABMR by non-invasive diagnostic tools is desirable. Previously we showed…
2017 American Transplant Congress
Transplant Readiness Assessment Clinic: A New Approach to Kidney Waitlist Management in the KAS Era.
X. Cheng,¹ J. Lee,² Z. Tulu,² J. Tan.²
¹Div Nephrology, Stanford University, Palo Alto; ²Kidney Transplant Program, Stanford University, Palo Alto, CA
Kidney waitlist management has become increasingly complex in regions with long wait times. Increasing transplant options and the new Kidney Allocation System has added to…
2017 American Transplant Congress
How to Improve Pre-Kidney Transplant Education for Hispanics: Preferences and Perceptions of Northwestern Memorial Hospital's Hispanic Transplant Program.
H. Gomez, E. Malagon-Blackwell, J. Caicedo.
The Comprehensive Transplantation Center, Northwestern University Feinberg School of Medicine, Chicago, IL
Context: Pre-Transplant educational sessions improve access to transplantation. Currently, however, there is lack of culturally competent approaches to improve living kidney donation for Hispanics Americans.…
2017 American Transplant Congress
Belatacept Conversion for Calcineurin Inhibitor (CNI) Toxicity: Our First 100 Patients.
R. Crew, S. Patel, A. Pai, I. Batal, H. Fernandez.
Columbia University, New York
Intro: CNIs improve kidney transplant (KT) survival, but have significant toxicities, including graft dysfunction (GD), neurotoxicity (NT), or thrombotic microangiopathy (TMA). Belatacept is an alternative…
2017 American Transplant Congress
Activated Th1 and Th17 cT_FH Phenotype Correlates with DSA Production in Kidney Transplant Recipients.
C. Macedo, P. Fadakar, K. Hadi, B. Ellinof, A. Zeevi, S. Hariharan, D. Metes.
University of Pittsburgh, Starzl Transplantation Institute, Pittsburgh
Donor-specific anti-HLA antibodies (DSA) represent an important biomarker for acute rejection and are a major cause of long-term graft failure after kidney transplantation (KTx). The…
2017 American Transplant Congress
Update of a Placebo-Controlled Trial of C1 Esterase Inhibitor for Prevention of Antibody Mediated Rejection (ABMR) in Highly-HLA Sensitized Patients.
A. Vo, J. Choi, A. Peng, K. Lim, L. Varanasi, R. Najjar, E. Huang, D. Puliyanda, S. Jordan.
Kidney Transplant, Cedars-Sinai Medical Center, LA, CA
INTRODUCTION: Desensitization (DES) strategies focus primarily on antibody reduction using IVIG, rituximab ± PLEX to prevent DSA-induced ABMR and rebound B-cell activity. Pathologic features of…
2017 American Transplant Congress
Donor/Recipient Matching Using the Creatinine Clearance Match Ratio (CCMR) Is Superior to the Kidney Donor Profile Index (KDPI) Predicting Early but Not Late Outcomes for Deceased Donor Kidney Transplantation.
J. Halldorson, N. Karimi.
Transplant Surgery, University of California, San Diego, CA; Surgery, Royal College of Surgeons, Dublin, Ireland
A Creatinine Clearance based Donor/Recipient matching strategy (CCMR) was developed to better optimize metabolic demand of the recipient with donor kidney function. Prior work in…
2017 American Transplant Congress
mRNA Biomarkers in Renal Allograft Protocol Biopsies Detected by the Nanostring Platform Predict Tolerance in Non-Human Primates.
M. Matsunami,¹ T. Oura,¹ I. Rosales,² R.-N. Smith,² B. Adam,³ M. Mengel,³ A. Cosimi,¹ R. Colvin,² T. Kawai.¹
¹Department of Surgery, Center for Transplantation Sciences, Massachusetts General Hospital, Harvard Medical School, Boston, MA; ²Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, MA; ³Department of Laboratory Medicine and Pathology, University of Alberta, Edmonton, AB, Canada
Background. Renal allograft tolerance has been achieved in some but not all MHC mismatched kidneys in non-human primates (NHPs) and humans after induction of transient…
2017 American Transplant Congress
On the Pathogenesis of Post-Transplant Diarrhea in Kidney Transplant Recipients.
J. Lee,¹ M. Mcgruder,¹ L. Zhang,¹ M. Thangamani,¹ D. Dadhania,¹ L. Westblade,¹ M. Satlin,¹ A. Robertson,² L. Ling,² Y. Taur,² E. Pamer,² M. Suthanthiran.¹
¹Medicine, Weill Cornell, NY, NY; ²Medicine, Memorial Sloan Kettering Cancer Center, NY, NY
Introduction. Post-transplant diarrhea is a frequent complication after kidney transplantation but its etiology is unknown in the majority of cases; herein, we investigated whether post-transplant…
2017 American Transplant Congress
Highly Sensitized Patients and the Association of Early Cardiovascular Disease: Analysis of Korean Organ Transplantation Registry(KOTRY) Data.
J. Jeong,¹ J. Yang,² M. Kim,³ S. Shin,⁴ B. Chung,⁵ S. Han,⁶ C. Ahn.⁷
¹Department of Nephrology, Ajou University School of Medicine, Suwon, Korea; ²Transplantation Center, Department of Surgery, Seoul National University Hospital, Seoul, Korea; ³Department of Transplant Surgery, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea; ⁴Department of Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea; ⁵Division of Nephrology, Department of Internal Medicine, Seoul St. Mary's Hospital, College of Medicine, the Catholic University of Korea, Seoul, Korea; ⁶Department of Internal Medicine, Keimyung University School of Medicine, Daegu, Korea; ⁷Department of Internal Medicine, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Korea
Introduction : In recent studies, immune sensitization was associated with increased mortality in wait-listed kidney transplant candidates. We investigated whether the risk of immune sensitization…