Articles tagged "Kidney transplantation"

2017 American Transplant Congress
Pre-Kidney Transplant Lower Extremity Impairment and Post-Transplant Mortality.
A. Nastasi,^1,2 M. McAdams-DeMarco,^1,2 J. Schrack,¹ H. Ying,² C. Haugen,² M. González Fernández,³ D. Segev.^1,2
¹Epidemiology, Johns Hopkins University, Baltimore, MD; ²Surgery, Johns Hopkins University, Baltimore, MD; ³Physical Medicine and Rehabilitation, Johns Hopkins University, Baltimore, MD
INTRODUCTION. Few objective tests can be easily performed prior to kidney transplantation (KT) to effectively stratify patients by risk of post-KT mortality. The short physical…
2017 American Transplant Congress
Dual Targeting with Carfilzomib and Tocilizumab Abrogates Antibody-Mediated Rejection and Prolongs Survival in a Highly Sensitized Rhesus Model of Kidney Transplantation.
B. Ezekian, J. Kwun, M. Manook, K. Freischlag, V. Curfman, E. Branum, J. Park, J. Yi, S. Jordan, S. Knechtle.
Duke University Medical Center, Durham, NC; Cedars-Sinai Medical Center, Los Angeles, CA
Purpose:Sensitized recipients have poor access to kidney transplantation (KT) and worse outcomes when transplanted. We have shown that bortezomib inhibits plasma cells (PCs), but does…
2017 American Transplant Congress
Advanced Donation within a Paired Exchange Program.
M. Charlton,¹ F. Desrosiers,¹ G. Bretzlaff,¹ D. Serur.²
¹Kidney and Pancreas Transplant Program, New York Presbyterian Weill Cornell, New York, NY; ²Division of Nephrology and the Rogosin Institute, New York Presbyterian Weill Cornell, New York, NY
BACKGROUND:Advanced Donation (ADP) within Kidney Paired Donation (KDP) occurs when a donor is time-limited and chooses to donate a kidney before their intended recipient with…
2017 American Transplant Congress
A Possible Unintended Consequence of the Kidney Allocation System: The Effect of Duration of Dialysis on Mental Health Outcomes.
S. Radomski,^1,2 I. Feurer,² R. Forbes,² B. Concepcion,² H. Schaefer.²
¹Georgetown University School of Medicine, Washington, DC; ²Vanderbilt University Medical Center, Nashville, TN
Purpose: Long-term dialysis has been shown to adversely affect physical health-related quality of life (HRQOL) but its effect on mental HRQOL and symptoms of depression…
2017 American Transplant Congress
Tacrolimus Trough Concentration Variability and Disparities in African American Kidney Transplantation.
D. Taber, Z. Su, A. Posadas, M. Gebregziabher, L. Egede, D. Dubay, J. McGillicuddy, C. Bratton, S. Nadig, K. Chavin, P. Baliga.
MUSC, Charleston, SC
Low tacrolimus (FK) trough concentrations have been associated with higher risk of acute rejection, particularly within African-American (AA) kidney transplant recipients; less is known about…
2017 American Transplant Congress
Hepatitis B Virus Infection Is Associated with Recurrent Nephropathy After Kidney Transplantation.
G. Chen, C. Wang, Z. Wu, C. Wang, J. Qiu, L. Chen.
Organ Transplant Center, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China
Background Hepatitis B virus(HBV) infection can cause HBV associated nephropathy, and is one of the major reasons for secondary nephropathy. We carried out a retrospective…
2017 American Transplant Congress
A Non-Invasive Urinary Common Rejection Module (uCRM) Gene Expression Score Quantifies and Differentiates Kidney Transplant Injury.
T. Sigdel,¹ J. Yang,¹ O. Bestard,² S.-C. Hsieh,¹ S. Roedder,² I. Damm,¹ J. Liberto,¹ S. Nandoe,¹ M. Sarwal.¹
¹University of California San Francisco, San Francisco; ²Immucor Inc, Atlanta
We sought to investigate the use of the common rejection module (CRM) genes in the discrimination of AR, BKVN, and stable transplant phenotypes in urine…
2017 American Transplant Congress
Lower Incidence of DSA-Induced Chronic Antibody-Mediated Rejection in Abo-Incompatible Renal Transplantation.
M. Okada,¹ Y. Watarai,¹ K. Iwasaki,² K. Futamura,¹ T. Hiramitsu,¹ M. Tsujita,¹ N. Goto,¹ S. Narumi,¹ T. Kobayashi.²
¹Transplant and Endocrine Surgery, Nagoya Daini Red Cross Hospital, Nagoya, Japan; ²Transplant Surgery, Aichi Medical University, Nagakute, Japan
<INTRODUCTION>Current progress in immunosuppressive therapy has successfully controlled ABO-incompatibility in renal transplantation, although donor specific HLA antibody (DSA) is still insurmountable. Our in vitro experiments…
2017 American Transplant Congress
Assessment and Transplantation of Declined Human Kidneys Using Ex-Vivo Normothermic Kidney Perfusion.
S. Hosgood,¹ M. Hamed,¹ A. Sawpaul,² R. Figueiredo,² K. Saeb-Parsy,¹ C. Wilson,² M. Nicholson.¹
¹Department of Surgery, University of Cambridge, Cambridge, United Kingdom; ²Transplantation, Transplant Institute, The Newcastle upon Tyne Hospitals NHS Foundation Trust, Newcastle, United Kingdom
PurposeThe aim of this study was to make more kidneys available for transplantation by using ex-vivo normothermic kidney perfusion (EVKP) technology to assess the quality…
2017 American Transplant Congress
The Associations Between Body Mass Index and Kidney Transplant Outcomes Are Mediated by Weight-Adjusted Immunosuppression Dosing.
K. Flabouris,^1,2 S. Chadban,^1,3,4 M. Ladhani,^1,3,5 M. Cervelli,⁶ P. Clayton.^1,2,6
¹Australia and New Zealand Dialysis and Transplant (ANZDATA) Registry, Adelaide, Australia; ²School of Medicine, University of Adelaide, Adelaide, Australia; ³Sydney Medical School, University of Sydney, Sydney, Australia; ⁴Department of Renal Medicine, Royal Prince Alfred Hospital, Sydney, Australia; ⁵Department of Renal Medicine, Lyell McEwin Hospital, Adelaide, Australia; ⁶Central Northern Adelaide Renal and Transplantation Service, Royal Adelaide Hospital, Adelaide, Australia
Purpose: High body mass index (BMI) is associated with acute rejection after kidney transplantation. We hypothesised that weight-adjusted immunosuppression dosing is a contributing factor. We…