Articles tagged "Kidney transplantation"

2018 American Transplant Congress
Effects of IdeS on HLA-SAB, C1q-SAB and CDC-XM
S. Järnum,¹ A. Runström,¹ L. Winstedt,¹ T. Lorant,² C. Kjellman.¹
¹Hansa Medical AB, Lund, Sweden; ²Department of Surgical Sciences, Section of Transplantation Surgery, Uppsala, Sweden.
IgG degrading enzyme of Streptococcus pyogenes (IdeS) cleaves human IgG in two steps, first cleaving one of the heavy chains resulting in a single-cleaved IgG…
2018 American Transplant Congress
Use of Surgically Placed Transversus Abdominis Plane (TAP) Block Catheter with Local Anesthetic Infusion in Renal Transplantation
M. Dib,¹ S. Borden,² T. Schell,¹ P. Stahler,¹ T. Al-Qaoud,¹ E. Martinez,¹ E. Grodstein,¹ A. D'Alessandro,¹ J. Odorico,¹ L. Fernandez,¹ J. Mezrich,¹ R. Redfield,¹ D. Foley,¹ D. Al-Adra,¹ D. Kaufman.¹
¹Surgery, University of Wisconsin-Madison, Madison, WI; ²Anesthesia, University of Wisconsin-Madison, Madison, WI.
BackgroundRenal transplant recipients have limitations in pain management, given the nephrotoxicity of NSAIDS and contraindications to regional neuroaxial techniques. Although opioids are widely used post-transplant,…
2018 American Transplant Congress
Parsing the 100% CPRA Kidney Transplant Candidates, Who Gets Transplanted?
D. Keith.
Medicine, Sacred Heart Hospital, Pensacola, FL.
Currently the United States kidney allocation system gives priority to candidates with a CPRA of 100% by giving them additional allocation points and providing national…
2018 American Transplant Congress
The First 9 Years of KPD through the National Kidney Registry: Characteristics of Donors and Recipients Compared to National Transplant Registries
S. Flechner,¹ A. Thomas,² M. Ronin,³ J. Veale,⁴ D. Leeser,⁵ S. Kapur,⁶ J. Piepert,⁴ D. Segev,² G. Hil,³ A. Waterman.⁴
¹Cleveland Clinic, Cleveland, OH; ²Johns Hopkins, Baltimore, MD; ³National Kidney Registry, Babylon, NY; ⁴UCLA, Los Angeles, CA; ⁵East Carolina, Greenville, NC; ⁶Cornell, New York, NY.
Purpose: The NKR is a voluntary network of 75 transplant centers in 28 States in the USA focused on the facilitation of live donor kidney…
2018 American Transplant Congress
Origin and Pattern of Human Polyomaviruses Replication after Kidney Transplantation: A Prospective Study
E. Favi,¹ S. Delbue,² C. Colico,¹ P. Ferrante,² S. Villani,² I. Perna,² N. Mondoni,² A. Giussani,¹ L. Clementoni,¹ P. Messa,³ M. Ferraresso.¹
¹Kidney Transplantation, Fondazione IRCCS Ca' Granda, Milan, Italy; ²Biomedical, Surgical and Dental Sciences, University of Milan, Milan, Italy; ³Nephrology, Fondazione IRCCS Ca' Granda, Milan, Italy.
Background. Human Polyomaviruses (HPyVs) are able to establish latent infection in the kidney of the host. Immunosuppression is recognized risk factor for HPyVs reactivation. Besides…
2018 American Transplant Congress
A Phase-I Clinical Trial of Donor-Derived MIC Cell Infusion for the Induction of Donor-Specific Hyporesponsiveness after Living Donor Kidney Transplantation (TOL-1 Study)
C. Morath,¹ A. Schmitt,² C. Kleist,³ V. Daniel,³ G. Opelz,³ C. Süsal,³ F. Fälble,¹ C. Sommerer,¹ L. Wang,² M. Zeier,¹ M. Schmitt,² M. Schaier,¹ P. Terness.³
¹Nephrology, University of Heidelberg, Heidelberg, Germany; ²Hematology, University of Heidelberg, Heidelberg, Germany; ³Transplant Immunology, University of Heidelberg, Heidelberg, Germany.
MIC cells are donor-derived monocytes that gain immunosuppressive properties after incubation with the proliferation inhibitor mitomycin C.PBMCs were harvested from living donors by leukapheresis and…
2018 American Transplant Congress
Long-Term Follow-Up of a Phase 2 Clinical Trial to Induce Tolerance in Living Donor Renal Transplant Recipients
J. Leventhal,¹ J. Galvin,¹ J. Mathew,¹ L. Gallon,¹ D. Stare,¹ K. Kurtenbach,¹ K. Ravindra,³ M. Horwitz,³ J. Miller,¹ M. Abecassis,¹ S. Ildstad.²
¹Surgery, Northwestern U, Chicago; ²U of Louisville, Louisville; ³Duke U, Durham.
37 pts have been transplanted in a phase 2 protocol to induce tolerance in recipients of living donor renal allografts (KTx). The protocol is based…
2018 American Transplant Congress
The Inhibitory Effect of Plasma on Activation of Lymphocytes from Kidney Transplants is Significantly More Severe in Tacrolimus Based Regimen: What Implications for Plasma Exchange Role in Anti-Rejection Therapy?
A. Assounga,^1,2 S. Omarjee.¹
¹Dept of Nephrology, University of KwaZulu-Natal, Durban, South Africa; ²Inkosi Albert Luthuli Central Hospital, Durban, South Africa.
Background:Reduction of lymphocyte proliferation by human plasma has been previously reported. Reduced activation of lymphocytes of patients on immunosuppressive drugs is well documented. However, trial…
2018 American Transplant Congress
Diagnosis of Antibody-Mediated Rejection after Kidney Transplantation by Blood Expression of Genes Involved in IFN Signaling
M. Matz,¹ Q. Zhang,¹ F. Heinrich,² C. Lorkowski,¹ K. Wu,³ P. Durek,² N. Lachmann,⁴ M-.F. Mashreghi,² K. Budde.¹
¹Nephrology, University Medicine Charité Berlin, Berlin, Germany; ²Drfz, Berlin, Germany; ³Pathology, University Medicine Charité Berlin, Berlin, Germany; ⁴Center For Tumor Medicine, H&I Laboratory, University Medicine Charité Berlin, Berlin, Germany.
Purpose: Antibody-mediated rejection (ABMR) has been recognized as a major cause of graft loss. Early diagnosis and effective treatment are crucial for salvaging grafts undergoing…
2018 American Transplant Congress
An Increase in Spot Urine Protein Excretion during the First Year after Kidney Transplantation Associates with Subclinical De-Novo Donor-Specific Antibodies and Microvascular Inflammation at 1-Year Surveillance Biopsies
M. Arnol,¹ G. Mlin[scaron]ek,¹ M. Oblak,¹ A. Kandus,¹ N. Kojc,² J. Buturović-Ponikvar.¹
¹Department of Nephrology, University Medical Centre Ljubljana, Ljubljana, Slovenia; ²Institute of Pathology, University of Ljubljana, Ljubljana, Slovenia.
Introduction. We investigated whether an increase in spot urine protein excretion during the first year after kidney transplantation associates with subclinical de-novo donor-specific antibodies (DSA)…