Articles tagged "Kidney transplantation"

2018 American Transplant Congress
Large Volume Intraoperative Fluid Use in Small (<20kg) Renal Recipients is Safe
N. Liow,¹ N. Mudalige,² N. Melhem,¹ S. Boyle,¹ N. Kessaris,¹ H. Hume-Smith,¹ S. Marks,¹ N. Mamode,¹ J. Stojanovic.¹
¹Paediatric Nephrology Unit, Great Ormond Street Hospital for Children NHS Foundation Trust, London, United Kingdom; ²University College London, London, United Kingdom.
INTRODUCTION: With advances in surgical and medical transplantation, progressively younger children are being transplanted. There is no consensus and little evidence on the optimal intraoperative…
2018 American Transplant Congress
Comparative Cost Analysis of ABO-Incompatible Living Kidney Transplantation
Y. Kakuta,¹ M. Okumi,¹ K. Unagami,² M. Furusawa,¹ H. Ishida,¹ K. Tanabe.¹
¹Urology, Tokyo Women's Medical School, Tokyo, Japan; ²Nephrology, Tokyo Women's Medical School, Tokyo, Japan.
BackgroundABO-incompatible living kidney transplantation (ABO-I) has been accepted as a valid alternative therapy for patients with end-stage kidney disease. The number of ABO-I has been…
2018 American Transplant Congress
Functional Fc Gamma Receptor Gene Polymorphisms and Donor-Specific Antibody-Triggered Transplant Injury
M-.L. Arnold,¹ A. Kainz,² F. Eskandary,² N. Kozakowski,³ M. Wahrmann,² H. Haslacher,⁴ R. Oberbauer,² A. Heilos,⁵ B. Spriewald,⁶ L. Hidalgo,⁷ P. Halloran,⁸ G. Bohmig.²
¹Department of Internal Medicine 3, Friedrich-Alexander University, Erlangen-Nuremberg, Germany; ²Department of Medicine III, Medical University of Vienna, Vienna, Austria; ³Department of Pathology, Medical University of Vienna, Vienna, Austria; ⁴Department of Laboratory Medicine, Medical University of Vienna, Vienna, Austria; ⁵Department of Paediatrics and Adolescent Medicine, Medical University of Vienna, Vienna, Austria; ⁶Department of Internal Medicine 5, Friedrich-Alexander University, Erlangen-Nuremberg, Germany; ⁷Department of Laboratory Medicine and Pathology, University of Alberta, Edmonton, AB, Canada; ⁸Alberta Transplant Applied Genomics Centre, ATAGC, University of Alberta, Edmonton, AB, Canada.
Fc-dependent effector mechanisms may play an important role in antibody-mediated rejection (ABMR). Distinct gene polymorphisms may determine the function of Fc gamma receptors (FcγR), potentially…
2018 American Transplant Congress
Immunogenic HLA Mismatches and Evidence That Belatacept May Be the First Therapy Able to Prevent DQ De Novo DSA: An Analysis of the BENEFIT and BENEFIT-EXT Trial Cohorts
M. Everly,¹ V. Jucaud,¹ M. Roberts,² H. Gebel,³ R. Bray.³
¹Terasaki Research Institute, Los Angeles, CA; ²Immunology Biomarker Group, Bristol-Myers Squibb, Princeton, NJ; ³Pathology & Laboratory Medicine, Emory University School of Medicine, Atlanta, GA.
The use of belatacept over cyclosporine is associated with lower rates of DSA development in adult kidney transplantation. However, the effect of belatacept on the…
2018 American Transplant Congress
Outcomes after Kidney Transplantation in Patients with AL Amyloid Following Autologous Stem Cell Transplantation
V. Gutgarts,^1,2 I. Jaffer Sathick,² C. Rosenbaum,³ T. Muthukumar,¹ H. Hassoun,⁴ C. Flombaum,² H. Landau.⁴
¹Nephrology, Weill Cornell, NY; ²Renal Medicine, Memorial Sloan Kettering, NY; ³Hematology, Weill Cornell, NY; ⁴Hematology, Memorial Sloan Kettering, NY.
BackgroundAL amyloidosis results in kidney failure in about 15-30% of patients and is considered a relative contraindication for kidney transplantation. There is limited data on…
2018 American Transplant Congress
Impact of Steroid Maintenance on the Outcomes of HLA-DR Mismatch Kidney Transplantation
B. Chopra, K. Sureshkumar.
Allegheny General Hospital, Pittsburgh, PA.
In kidney transplantation, donor-recipient HLA-DR mismatch poses high immunologic risk and is associated with inferior outcomes. We aimed to explore the impact of enhanced immunosuppression…
2018 American Transplant Congress
Calcineurin Inhibitors, Macrolides, and the Risk of Adverse Drug Events in Kidney Transplant Recipients
R. Jeong,¹ R. Quinn,² P. Ravani,² K. Lentine,³ A. Lloyd,¹ B. Hemmelgarn,² K. Wen,¹ B. Braam,¹ S. Gourishankar,¹ A. Wong,¹ N. Lam.¹
¹Univ of Alberta, Edmonton, Canada; ²Univ of Calgary, Calgary, Canada; ³Saint Louis Univ, St. Louis.
Background: After kidney transplantation, calcineurin inhibitors (CNIs, cyclosporine, tacrolimus) are key components of immunosuppression but have multiple potential drug interactions. Macrolide antibiotics are often used…
2018 American Transplant Congress
South Asian and Muslim Canadian Patients Are Less Likely to Receive Living Donor Kidney Transplant Offers Compared to Caucasian, Non-Muslim Patients
A. Ali,¹ A. Ayub,¹ C. Richardson,¹ N. Edwards,¹ T. Ahmed,¹ M. Novak,^2,3 I. Mucsi.¹
¹Multi-Organ Transplant Program, Toronto General Hospital, Toronto, ON, Canada; ²Centre for Mental Health, University Health Network, Toronto, ON, Canada; ³Department of Psychiatry, University of Toronto, Toronto, ON, Canada.
Background:No studies have assessed whether Muslim Canadians face barriers to accessing LDKT. We explored how frequently Muslim or South Asian patients with and stage kidney…
2018 American Transplant Congress
Urological Complications of Prophylactic Ureteral Stent vs. No Stent in Kidney Transplant Recipients at Erie County Medical Center (ECMC)
M. Hamid,¹ J. Kumar,¹ S. Anjum,¹ S. Patel,² G. Gudleski,⁴ S. Mietz,³ M. Ott,³ S. Chang.¹
¹Nephrology, SUNY Buffalo, Buffalo, NY; ²Surgery, SUNY Buffalo, Buffalo, NY; ³Pharmacy, Erie County Medical Center, Buffalo, NY; ⁴Medicine, SUNY Buffalo, Buffalo, NY.
Introduction:Complications after kidney transplant (tx) commonly originate from ureterovesical anastomosis, it accounts for 3-9% of urinary complications. Due to the difference in the surgical preference,…
2018 American Transplant Congress
mTOR Inhibitor Based Immunosuppression Regimens Are Not Associated with Lower Risk for BK Infection
R. Daloul,¹ R. Pelletier,² A. Rajab,² G. Bumgardner,² M. Alebrahim,² C. Akateh,³ K. Washburn,² A. El-Hinnawi.²
¹Nephrology, The Ohio State University Wexner Medical Center, Columbus, OH; ²Transplant Surgery, The Ohio State University Wexner Medical Center, Columbus, OH; ³Surgery, The Ohio State University Wexner Medical Center, Columbus, OH.
Introduction: BK virus continues to be a significant post-transplant complication with increasing incidence in the current era of potent immunosuppression. Mammalian target of rapamycin inhibitors…