2018 American Transplant Congress
Early Considerations for Deceased Donor Chains
Background: The potential use of deceased kidney donors (DDs) to initiate kidney paired donation (KPD) chains (DD chains) has been of interest to the transplant…2018 American Transplant Congress
A Novel Peripheral Blood mRNA Biomarker Predicts Subclinical Rejection and Kidney Transplant Outcomes
BACKGROUNDSub-clinical acute rejection (subAR) in kidney transplant recipients (KTR), defined as histological rejection on surveillance biopsy (Bx) in a patient with stable renal function, signals…2018 American Transplant Congress
Dialysis Modality, Inflammation, and Frailty in Kidney Transplant Candidates
Inflammation is associated with poor physical performance, frailty, disability and death in community-dwelling older adults. Given the elevated inflammation levels among ESRD patients, it is…2018 American Transplant Congress
Everolimus with Reduced Calcineurin Inhibitor Exposure in De Novo Kidney Transplant Recipients: Efficacy and Safety Outcomes from the TRANSFORM Study
1TRANSFORM Study Group, Livingston; 2Novartis Pharma AG, Basel, Switzerland.
Purpose: Everolimus (EVR)-facilitated calcineurin inhibitor (CNI) reduction regimens help prevent long-term CNI nephrotoxicity in kidney transplant recipients (KTxRs). TRANSFORM (NCT01950819) is the largest study in…2018 American Transplant Congress
Validation Study of Operational Tolerance Signatures in Korean Kidney Transplantation Recipients
Background:A peripheral B cell population was significantly higher in drug-free operationally tolerant patients than those with stable graft function or acute rejection under standard immunosuppression.…2018 American Transplant Congress
Donor-Derived Cell-Free DNA Outperforms Serum Creatinine Changes for Identifying Kidney Transplant Rejection
Purpose: In the DART study, donor-derived cell-free DNA (dd-cfDNA) discriminated biopsy-based diagnosis of active rejection in kidney transplant patients but serum creatinine (sCr) level did…2018 American Transplant Congress
Biopsy Correlates of DSA in Antibody-Mediated Rejection: C4d vs Microvascular Inflammation Scores
Icahn School of Medicine at Mount Sinai, New York, NY.
Background: The diagnosis of antibody-mediated rejection (AMR) requires the presence of both the histologic features of AMR as well as donor-specific antibodies (DSA). Whether anti-HLA…2018 American Transplant Congress
A Substantial Fraction of Surveillance Transplant Biopsies Have Clinically Actionable Findings
1Pathology, Michigan Medicine, Ann Arbor; 2Nephrology, Michigan Medicine, Ann Arbor.
Background: Surveillance biopsies in renal transplant recipients may detect subclinical disease that affects graft longevity. At our transplant center, most patients with stable allograft function…2018 American Transplant Congress
Gains from Joining Kidney Paired Donation with Several Incompatible Donors
University of Michigan, Ann Arbor, MI.
In kidney paired donation (KPD), a transplant candidate with an incompatible donor joins a pool of similar pairs in an effort to find new transplant…2018 American Transplant Congress
Do We Need to Worry about EBV DNAemia in the Late Post-Transplant Period?
Background: Despite detectable Epstein-Barr virus (EBV) in blood, kidney transplant patients (KTR) may have no apparent clinical consequence. This study aims to explore the clinical…
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