Articles tagged "Kidney transplantation"

2018 American Transplant Congress
High Calcineurin Inhibitor Intra Patient Variability is Associated with Early Renal Allograft Inflammation, Chronicity and Loss
A. Sharma,¹ A. Cherukuri,² R. Mehta,¹ P. Sood,¹ S. Hariharan.¹
¹Thomas E. Starzl Transplantation Institute, University of Pittsburgh Medical Center, Pittsburgh, PA; ²Thomas E. Starzl Transplantation Institute, University of Pittsburgh, Pittsburgh, PA.
High CNI IPV has been associated with poor kidney allograft outcomes, albeit in small limited studies. We evaluated effect of CNI IPV (the degree of…
2018 American Transplant Congress
Long-Term Outcomes of Primary Kidney Transplant from Expanded Criteria Maastricht Category 3 DCD Donors: A Single-Centre Observational Study
E. Favi,¹ C. Puliatti,² S. Iesari,³ M. Ferraresso,¹ R. Cacciola.²
¹Kidney Transplantation, Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico, Milan, Italy; ²Kidney Transplantation, The Royal London Hospital, London, United Kingdom; ³Kidney Transplantation, University of L'Aquila, L'Aquila, Italy.
Background. Kidney transplants (KTx) from standard (STD) DCD donors have higher rates of primary non function (PNF) and delayed graft function (DGF) than DBD but…
2018 American Transplant Congress
Pump Resistive Index Values and Not Preimplantation Kidney Biopsy Predict Kidney Allograft Survival
J. Liu,¹ A. Blumfield,¹ M. Trivedi,¹ N. Mishra,¹ O. Mohammed,^1,2 J. Lin,³ M. Ajaimy,^1,2 J. Graham,^1,2 J. Rocca,^1,2 E. Akalin,^1,2 S. Greenstein.^1,2
¹Albert Einstein College of Medicine, Bronx, NY; ²Department of Surgery, Montefiore Medical Center, Bronx, NY; ³Department of Epidemiology and Population Health, Albert Einstein College of Medicine, Bronx, NY.
AimTo investigate the relationship between histological findings of preimplantation kidney biopsies and pump resistive index (RI) values during machine preservation and subsequent allograft survival.MethodsWe retrospectively…
2018 American Transplant Congress
Willingness to Consider Increased Risk Donors: A Single Center Experience
V. Richards,¹ C. Johnson,¹ J. Perkins,² A. Limaye,³ L. Sibulesky.²
¹Nephrology, University of Washington, Seattle, WA; ²Surgery, University of Washington, Seattle, WA; ³Allergy and Infectious Diseases, University of Washington, Seattle, WA.
Background: The number of Public Health Service increased risk organ donors (PHS IRD) is growing, largely due to the opioid epidemic.Methods: We conducted a retrospective…
2018 American Transplant Congress
Latent Tuberculosis Diagnosis Prior to Kidney Transplantation in a High Burden Country: Improvement with Serological Tests
V. Garcia, G. Meinerz, C. da Silva, E. Keitel.
Nephrology and Kidney Transplant Department, ISCMPA, Porto Alegre, Brazil.
Introduction: Diagnosing and treating tuberculosis after kidney transplantation is challenging, and mortality is high. In an epidemiological study performed at our Center, there was an…
2018 American Transplant Congress
Clinically Relevant Variation of Donor-Derived Cell-Free DNA during Longitudinal Surveillance of Renal Allografts
M. Narayanan,¹ T. Alhamad,² D. Hiller,³ J. Yee,³ R. Woodward,³ J. Bromberg.⁴
¹Texas A&M Health Science Center, Temple, TX; ²Washington University School of Medicine, St. Louis, MO; ³CareDx, Brisbane, CA; ⁴University of Maryland School of Medicine, Baltimore, MD.
Purpose: Donor-derived cell-free DNA (dd-cfDNA) levels >1% are associated with active rejection in renal transplant recipients. This report defines the clinically relevant variation of dd-cfDNA…
2018 American Transplant Congress
Living-Donor Preemptive Kidney Transplant Timing Calculator: An Online Decision Support Tool
M. Barah,¹ M. Kurt,² A. Khojandi,¹ B. Tanriover.³
¹Industrial and Systems Engineering, Univeristy of Tennessee, Knoxville, TN; ²Economic and Data Sciences, Merck Research Labs, North Wales, PA; ³Division of Nephrology, UT Southwestern Medical Center, Dallas, TX.
Purpose: Optimal glomerular filtration rate (GFR) and timing for living preemptive kidney transplantation (PKT) is not well studied.Method: We developed an online engine to calculate…
2018 American Transplant Congress
Carfilzomib and Belatacept Reduces DSA and Prolongs Survival in a Highly Sensitized Rhesus Model of Kidney Transplantation
B. Ezekian, J. Kwun, P. Schroder, M. Manook, J. Yoon, M. Mulvihill, K. Freischlag, J. Cochran, K. Kroning, J. Yi, S. Knechtle.
Duke Transplant Center, Duke University Medical Center, Durham, NC.
Purpose:Sensitized kidney transplant (KT) recipients have poor access to transplantation and inferior outcomes when transplanted. Conventional methods of desensitization remove donor specific antibody (DSA) temporarily,…
2018 American Transplant Congress
The TRANSFORM Study: Infection Outcomes with Everolimus Plus Reduced Calcineurin Inhibitor and Mycophenolate Plus Standard Calcineurin Inhibitor Regimens in De Novo Kidney Transplant Recipients
F. Vincenti, J. Cruzado, S. Mulgaonkar, V. Garcia, D. Kuypers, M. Buchler, F. Citterio, U. Huynh-Do, W-.L. Luo, P. Bernhardt, C. Sommerer.
TRANSFORM Study Group, Novartis Pharma AG, Basel, Switzerland.
Purpose: Post-transplant (Tx) bacterial and viral infections are known to affect graft and patient survival. Accumulating evidence supports the protective effect of everolimus (EVR) against…
2018 American Transplant Congress
Endothelin-1 Type A Receptor Antibodies Are Associated with Elevated Il-8, Arteritis and Decline in Renal Function in Pediatric Renal Transplant Recipients
M. Pearl,¹ J. Grotts,¹ M. Rossetti,¹ Q. Zhang,¹ P. Weng,¹ E. Reed,¹ E. Tsai Chambers.²
¹University of California, Los Angeles, Los Angeles, CA; ²Duke University, Durham, NC.
Background: We have recently shown that the non-HLA antibody, AT1R-Ab, is prevalent and associated with poor outcomes in pediatric kidney transplant recipients (KTRs). The prevalence…