Articles tagged "Kidney transplantation"

2018 American Transplant Congress
Targeting Calcium Release-Activated Calcium (CRAC) Channel in Non-Human Primate Kidney Transplantation
J. Kwun,¹ B. Ezekian,¹ M. Manook,¹ J. Park,¹ J. Yoon,¹ J. Sloan-Lancaster,² C. Fortier,³ P. Rao,⁴ S. Knechtle.¹
¹Surgery, Duke University, Durham, NC; ²Eli Lilly and Company, Indianapolis, IN, Canada; ³PRCL Research Inc, Montreal, QC, Canada; ⁴Synta Pharmaceuticals Inc., Lexington, MA.
[Background] Long-term administration of calcineurin inhibitors (CNIs) successfully controls rejection of transplanted organs. However, the chronic use of these drugs causes organ damage often resulting…
2018 American Transplant Congress
Timeline and Histopathological Characteristics of Graft Failure after Kidney Transplantation: What is Preventable and What is Not?
S. Parajuli, F. Aziz, N. Garg, B. Muth, M. Mohamed, W. Zhong, B. Astor, D. Mandelbrot, A. Djamali.
University of Wisconsin, Madison.
Background: There is limited information on the histopathological characteristics of kidney transplant recipients (KTRs) with graft failure at different post-transplant time intervals. Methods:We addressed this…
2018 American Transplant Congress
Characteristics and Outcomes of Kidney Transplant Recipients with More Than 25 Years of a Functioning Graft
S. Parajuli, D. Mandelbrot, F. Aziz, N. Garg, M. Mohamed, B. Muth, B. Astor, A. Djamali.
University of Wisconsin, Madison.
Background: There is limited information on clinical characteristics and outcomes of kidney transplant recipients (KTRs) with more than 25 years of graft survival.Methods: We addressed…
2018 American Transplant Congress
Reducing Discards for Deceased Kidney Donors over Age 50 by Restricting Biopsy Criteria
C. Hostetler, J. Rogge, B. Nicely, S. Rudich.
Clinical Division, Gift of Life Michigan, Ann Arbor, MI.
The placement of kidneys from deceased organ donors of advanced age is an ongoing challenge. An Organ Procurement Organization (OPO) evaluated its discard rate for…
2018 American Transplant Congress
Elbasvir-Grazoprevir (Zepatier) is Effective and Safe for the Treatment of Chronic Hepatitis C (HCV) Genotype 1 Virus in the Post Kidney Transplant Patient
P. Brown, D. Venkat.
Henry Ford Hospital, Detroit.
Objective: Limited real world data exists regarding the use of direct acting antivirals (DAA) for HCV viremia in renal transplant patients, particularly those with marked…
2018 American Transplant Congress
Impact of Cigarette Smoking on Living Kidney Donor
Y. Yoon,¹ H. Lee,² J. Na,³ K. Huh,⁴ M. Kim,⁴ S. Kim,⁴ Y. Kim,⁴ W. Han.³
¹Urology, Hanyang University College of Medicine, Seoul, Korea; ²Urology, National Health Insurance Service Ilsan Hospital, Goyang, Korea; ³Urology, Urological Science Institute, Yonsei University College of Medicine, Seoul, Korea; ⁴Transplantation Surgery, Research Institute for Transplantation, Yonsei University College of Medicine, Seoul, Korea.
Introduction: Smoking is known to result in the decline of renal allograft function and survival of recipients. However, effect of smoking on living kidney donor…
2018 American Transplant Congress
Laparoscopic Donor Nephrectomy Safety: Experience of 500 Cases in Hispanic Population at a Single Institution
Y. Baez Suarez, F. Giron Luque, J. Amaya Nieto.
Transplantation Surgery, Colombiana de Trasplantes, Bogota, Colombia.
Background: Laparoscopic live donor nephrectomy (LDN) has become the best option in living donation because its safety and low rate of complications. This report aims…
2018 American Transplant Congress
Donor-Derived Cell-Free DNA Identifies Antibody-Mediated Rejection with Graft Injury in DSA-Positive Kidney Transplant Recipients
S. Jordan,¹ S. Bunnapradist,² J. Bromberg,³ A. Langone,⁴ D. Hiller,⁵ J. Yee,⁵ J. Sninsky,⁵ R. Woodward,⁵ A. Matas.⁶
¹Cedars-Sinai Medical Center, Los Angeles, CA; ²UCLA, Los Angeles, CA; ³University of Maryland School of Medicine, Baltimore, MD; ⁴Vanerbilt University Medical Center, Nashville, TN; ⁵CareDx, Brisbane, CA; ⁶University of Minnesota School of Medicine, Minneapolis, MN.
Purpose: Donor-derived cell-free DNA (dd-cfDNA) discriminates active rejection in kidney transplant patients. Donor-specific antibodies (DSA) to HLA antigens are associated with risk of antibody-mediated rejection…
2018 American Transplant Congress
Mortality and Kidney Transplantation Outcomes among Chronic Dialysis Patients Who Are Seropositive for Hepatitis C Virus
D. Sawinski,¹ F. Kimberly,¹ L. Vincent,¹ S. Justine,¹ B. Colleen,¹ C. Jordana,¹ G. David,¹ L. Jayme,² W. Joe,³ R. Peter.¹
¹Univ of Pennsylvania, Philadelphia, PA; ²Univ of Alabama, Birmingham, AL; ³DaVita, Minneapolis, MN.
Hepatitis C virus (HCV) infection is common among patients receiving chronic dialysis. However, few studies have examined both survival on dialysis as well as transplantation…
2018 American Transplant Congress
Recurrence of Immunoglobulin A Nephropathy in Related Donor Kidney Transplant Recipients
M. Okumi,¹ D. Okada,¹ K. Unagami,² Y. Kakuta,¹ H. Shirakawa,³ T. Shimizu,⁴ K. Omoto,⁴ H. Ishida,¹ K. Tanabe.¹
¹Urology, Toyko Women's Medical University, Tokyo, Japan; ²Nephrology, Toyko Women's Medical University, Tokyo, Japan; ³Urology, Ohkubo Hospital, Tokyo, Japan; ⁴Urology, Toda Chuo General Hospital, Saitama, Japan.
BackgroundSecondary to an increase in the graft survival rates in patients undergoing successful kidney transplantation, an increase in the occurrence of recurrent glomerulonephritis has been…