Articles tagged "Kidney transplantation"

2018 American Transplant Congress
mRNA Transcript Profiles of 14 Genes in Plasma Exosome Predict Risk for Antibody-Mediated Rejection (ABMR) of Renal Allografts
H. Zhang,¹ E. Huang,² C. Nast,³ J. Kahwaji,² A. Vo,² S. Jordan,² M. Toyoda.¹
¹Transplant Immunology Laboratory, Cedars-Sinai Medical Center, Los Angeles, CA; ²Comprehensive Transplant Center, Cedars-Sinai Medical Center, Los Angeles, CA; ³Pathology, Cedars-Sinai Medical Center, Los Angeles, CA.
Background: Previously we reported that mRNA transcript profiles of 4 genes (gp130, SH2D1B, TNFα and CCL4) in plasma exosome could predict the risk of ABMR,…
2018 American Transplant Congress
Investigation of Lower Treatment Failure Rate Seen among Black Kidney Recipients on LCP-Tacrolimus vs. IR-Tacrolimus: Subgroup Analyses of Two Phase 3 Trials
T. Sparkes,¹ B. Masters,¹ C. Staino,² S. Patel,² M. Cooper.³
¹University of Maryland, Baltimore, MD; ²Veloxis, Cary, NC; ³Medstar Georgetown Transplant Institute, Washington, DC.
Black kidney transplant recipients are recognized as high risk for inferior allograft survival due to immunologic and non-immunologic factors. Pooled data from 2 Phase 3…
2018 American Transplant Congress
Multicentre Epidemiological Study on Prevalence of Recurrent Glomerular Disease Post-Transplantation in the United Kingdom
R. Aguiar.
On Behalf of NIHR Health Informatics Collaborative (HIC)- Transplantation Theme, London, United Kingdom.
Introduction: Primary glomerulonephritidies (GN) can recur in the renal allograft and are possibly associated with poorer allograft outcome. The prevalence of recurrence varies widely and…
2018 American Transplant Congress
Cannabis Dependence or Abuse before and after Kidney Transplantation: Implications for Post-Transplant Outcomes
K. Lentine,¹ T. Alhamad,² N. Lam,³ A. Naik,⁴ F. Koraishy,¹ H. Randall,¹ D. Segev,⁵ V. Dharnidharka,² D. Brennan,⁵ B. Kasiske,⁶ R. Ouseph,¹ M. Schnitzler.¹
¹Saint Louis Univ, St. Louis; ²Washington Univ, St. Louis; ³Univ Alberta, Edmonton, Canada; ⁴Univ Michigan, Ann Arbor; ⁵Johns Hopkins, Baltimore; ⁶Hennepin County Med Ctr, Minneapolis.
Currently, transplant centers vary in screening practices for marijuana use and requirements for abstinence before kidney transplantationWe examined billing claims and linked SRTR data for…
2018 American Transplant Congress
Secular Trends in the Medical Complexity and Outcomes of Medicare-Insured Patients Undergoing Kidney Transplant
C. Lenihan,¹ S. Liu,¹ M. Montez-Rath,¹ W. Winkelmayer.²
¹Stanford University, Palo Alto, CA; ²Baylor College of Medicine, Houston, TX.
Graft and patient survival following kidney transplant (KT) are improving. The reasons for this trend are unclear. We set out to examine concurrent changes in…
2018 American Transplant Congress
Extra-Renal Effects of Estrogen Receptor-Alpha Mediate Protection from Renal Ischemia-Reperfusion Injury
D. Aufhauser, D. Murken,¹ S. Concors,¹ Z. Wang,¹ G. Ge,¹ T. Bhatti,² W. Hancock,^2,3 M. Levine.¹
¹Surgery, University of Pennsylvania, Philadelphia, PA; ²Pathology, Children's Hospital of Philadelphia, Philadelphia, PA; ³Pathology, University of Pennsylvania, Philadelphia, PA.
Introduction: Females exhibit protection from renal ischemia-reperfusion injury (IRI) compared to males in animal models and in human kidneys transplants. Previous experiments have shown that…
2018 American Transplant Congress
Donor Hypothermia Outcomes in Living Kidney Transplantation
J. Buggs,¹ J. Wei,² E. Rogers,³ R. Liu,² V. Bowers.¹
¹Transplant Surgery, Tampa General Medical Group, Tampa General Hospital, Tampa, FL; ²Molecular Pharmacology and Physiology, University of South Florida Morsani College of Medicine, Tampa, FL; ³Transplant Research, Tampa General Hospital, Tampa, FL.
Background: The effect of donor hypothermia is known to significantly reduce the rate of delayed graft function (DGF) in cadaveric donor kidney transplantation. The effect…
2018 American Transplant Congress
A Protocol for the Management of Alemtuzumab Induced Leukopenia in Kidney Transplant Recipients
S. Hammad, B. Ravichandran, M. Crist, B. Masters.
University of Maryland Medical Center, Baltimore.
Purpose: Leukopenia is a common complication following alemtuzumab induction in kidney transplant recipients (KTR), often limiting its use. Our institution developed a protocol to manage…
2018 American Transplant Congress
p16^INK4a Deletion in Vascular Endothelium Improves Kidney Regeneration Post Ischemia Reperfusion Injury
A. Melk,¹ A. Baisantry,^1,2 S. Wang,¹ F. Kubaink,¹ R. Bhayadia,¹ R. Schmitt.²
¹Department of Kidney, Liver & Metabolic Diseases, MHH, Hannover, Germany; ²Department of Nephrology, MHH, Hannover, Germany.
Background: Ischemia Reperfusion injury (IRI) mediated cellular senescence in kidney allografts has been linked to a loss in regenerative potential and delayed graft function. Injured…
2018 American Transplant Congress
Pilot Study of Plasma Cell Niche-Targeted Therapy for Enhancement of Proteasome Inhibitor Effectiveness
S. Tremblay,¹ C. Castro-Rojas,² J. Driscoll,¹ S. Knechtle,³ A. Shields,¹ R. Alloway,¹ H. Singh,² D. Hildeman,² E. Woodle.¹
¹UCincinnati, Cincinnati; ²Cincinnati Children's, Cincinnati; ³Duke, Durham.
HLA antibody (Ab)-secreting bone marrow (BM) plasma cell (PC) survival depends on niche occupancy via a CXCR4 (PC)-CXCL12 (BM stromal cell) interaction. Plerixafor inhibits CXCR4-CXCL12…