Articles tagged "Kidney transplantation"

2018 American Transplant Congress
Impact of Ambulatory Transplant Pharmacy Services on Outcomes and Readmissions in Adult Abdominal Transplant Recipients
K. Joyal,¹ C. Rogers,² M. Cote,² M. Pavlakis,² A. Evenson,² V. Patwardhan,² K. Richards.²
¹Northeastern University, Boston, MA; ²Beth Israel Deaconess Medical Center, Boston, MA.
Over the past two decades, the role of transplant pharmacists (Txp Rx) has expanded following revised guidance from UNOS and CMS. There is little data…
2018 American Transplant Congress
Intragraft MicroRNAs Foretell Fibrosis in Kidney Transplant Recipients
H. Yang,¹ L. Amrouche,² K. Akat,³ C. Li,¹ Z. Khan,¹ C. Tinel,² T. Tuschl,³ D. Anglicheau,² T. Muthukumar.¹
¹Weill Cornell Medicine, New York; ²Hôpital Necker, Paris, France; ³Rockefeller University, New York.
BackgroundIdentifying biomarkers that anticipate tubulointerstitial fibrosis (IFTA) of the kidney allograft will be a transformative advance.Aim/HypothesisIntragraft microRNA profile of 3-month surveillance biopsies reported as normal…
2018 American Transplant Congress
Changes in Phenotype, Immune Suppressive, Function, and Gene Expression of Myeloid Derived Suppressor Cells in Patients Given Combined Kidney and Hematopoietic Cell Transplants in a Tolerance Protocol
K. Jensen,¹ P. Zheng,² J. Xuhuai,² A. Saraswathula,¹ J. Scandling,³ S. Busque,⁴ J. Shizuru,⁵ R. Lowsky,⁵ A. Shori,⁴ H. Maecker,² E. Engleman,¹ E. Meyer,⁵ S. Strober.¹
¹Immunology, Stanford School of Medicine, Stanford, CA; ²Human Immune Monitoring Center, Stanford School of Medicine, Stanford, CA; ³Nephrology, Stanford School of Medicine, Stanford, CA; ⁴Surgery, Stanford School of Medicine, Stanford, CA; ⁵Blood & Marrow Transplantation, Stanford School of Medicine, Stanford, CA.
Tolerance induction after combined organ and hematopoietic cell transplantation can be achieved using conditioning with total lymphoid irradiation (TLI) and anti-thymocyte globulin (ATG), in both…
2018 American Transplant Congress
NK Cells in Allograft Kidney Biopsies during Rejection: Detection, Quantification, and Precise Localization Using Multiplex Immunofluorescence
M. Terada,¹ J. Duong Van Huyen,² F. Drieux,⁴ C. Legendre,³ P. Bruneval,¹ M. Rabant.²
¹Pathology Department, Georges Pompidou European Hospital, Paris, France; ²Pathology Department, Necker-Enfants Malades Hospital, Paris, France; ³Kidney Transplantation Department, Necker-Enfants Malades Hospital, Paris, France; ⁴Pathology Department, Centre Henri Becquerel, Rouen, France.
Introduction: Among the complex cellular interplay engaged in renal rejection, recent transcriptomic analysis of renal biopsies has detected NK cell transcripts in the setting of…
2018 American Transplant Congress
Do Protocol Biopsies in the Highly Sensitized Improve Renal Allograft Survival? A Single Center Evaluation of 2 Year Graft Function
S. Kuppachi, R. Kalil, M. Fraer, M. Sanders, M. Swee, Z. Stewart, C. Thomas.
Organ Transplant Center, University of Iowa, Iowa City, IA.
Highly sensitized kidney transplant recipients (hsKTR) are at an increased risk of antibody mediated rejection (AMR). Following implementation of the new kidney allocation system (KAS)…
2018 American Transplant Congress
Contemporary Desensitization with Low Dose Rituximab Ensures Kidney Transplant Outcome beyond ABO Blood Type Incompatibility:A Comparison between past Regimens in Single Institute
H. Harada, Y. Wada, A. Mitsuke, T. Hirose, N. Fukuzawa, T. Seki.
Kidney Transplant Surgery and Urology, Sapporo City General Hospital, Sapporo, Japan.
INTRODUCTION: An ABO incompatible kidney transplant (ABOiKT) requires desensitization (DS). The ways of DS have been changed chronologically and the outcome could have been subsequently…
2018 American Transplant Congress
Outpatient Prophylactic Valganciclovir Dose Optimization Post-Renal Transplant
M. Spinner,¹ V. Athans,¹ C. Koval.²
¹Dept. of Pharmacy, Cleveland Clinic, Cleveland, OH; ²Dept. of Infectious Diseases, Cleveland Clinic, Cleveland, OH.
Purpose: Renal function rapidly changes post-transplant requiring dose adjustment of CMV prophylaxis. We describe valganciclovir (VGCV) dosing accuracy in the outpatient setting and its associated…
2018 American Transplant Congress
Lower Uric Acid Level after Kidney Transplantation Impact on Better Long-Term Allograft Outcomes
D. Kim,¹ H. Choi,² Y. Jung,¹ J. Lee,¹ J. Lee,¹ J. Lee,¹ K. Huh,¹ M. Kim,¹ B. Kim,² Y. Kim.¹
¹Transplantation Surgery, Yonsei University Health System, Seoul, Korea; ²Nephrology, Yonsei University Health System, Seoul, Korea.
BackgroundIt has been on debate that hyperuricemia was an independent risk factor for poor prognosis in kidney transplantation. Considering the link of UA with diabetes,…
2018 American Transplant Congress
Direct Oral Anticoagulation Use in Kidney Transplant Recipients
S. Shaikh,¹ M. Samaniego,² J. Park.²
¹MedStar Georgetown University Hospital, Washington DC; ²Michigan Medicine, Ann Arbor, MI.
Objective: There is a lack of high-level evidence identifying meaningful outcomes with direct oral anticoagulants (DOACs) in kidney transplant recipients. The primary objective of this…
2018 American Transplant Congress
The Opioid Strikes Back: Pre-Transplant Opioid Exposure is Associated with Increased Readmissions after Renal Transplant
B. O'Brien, N. Patel, L. Wilson, P. Mauldin, S. Ball, R. Gilbert, Z. Elmaasarani, P. Baliga, N. Pilch, D. Taber, J. Fleming.
Medical University of South Carolina, Charleston, SC.
Recent analyses suggest that opioid use in renal transplant recipients is associated with increased complications, graft loss and mortality. The aim of this study was…