Articles tagged "Kidney transplantation"

2018 American Transplant Congress
Temporal Changes in the Characteristics and Sensitization of Kidney Paired Donation Registrants
C. Holscher,¹ K. Jackson,¹ A. Thomas,¹ C. Haugen,¹ S. DiBrito,¹ M. Ronin,² A. Waterman,^3,4 A. Massie,^1,5 J. Garonzik Wang,¹ D. Segev.^1,5
¹Johns Hopkins School of Medicine, Baltimore; ²National Kidney Registry, New York; ³David Geffen School of Medicine at UCLA, Los Angeles; ⁴Terasaki Research Institute, Los Angeles; ⁵Johns Hopkins School of Public Health, Baltimore.
In order to utilize a willing but incompatible living donor, candidates must either proceed with incompatible transplantation or find a more compatible match using kidney…
2018 American Transplant Congress
Cost Effectiveness of Lifelong Medicare Immunosuppressant Drug Coverage for Kidney Transplant Recipients in the Current Era
M. Kadatz,¹ J. Gill,² J. Gill,² K. Scott.³
¹Clinician Investigator Program, University of British Columbia, Vancouver, BC, Canada; ²Division of Nephrology, Department of Medicine, University of British Columbia, Vancouver, BC, Canada; ³Division of Nephrology, Department of Medicine, University of Alberta, Edmonton, AB, Canada.
While there is no Medicare time limit for dialysis patients, kidney transplant recipients lose their Medicare coverage 36 months after they receive their transplant. The…
2018 American Transplant Congress
RNA Expression Profiling of Renal Allografts in the Cynomolgus Monkey Identifies Tolerance
R. Smith,¹ M. Matsunami,³ B. Adam,² A. Rosales,¹ T. Oura,³ A. Cosimi,³ T. Kawai,³ M. Mengel,² R. Colvin.¹
¹Pathology, Massachusetts General Hospital, Boston, MA; ²Laboratory Medicine and Pathology, University of Alberta, Edmonton, AB, Canada; ³Department of Surgery, Massachusetts General Hospital, Boston, MA.
IntroductionTolerance induction is a long standing clinical goal. However, identification remains elusive. Here we profile intra-renal allograft RNA expression in a mixed chimerism renal allograft…
2018 American Transplant Congress
PD-L1 May Serve as a Biomarker for Chimerism-Induced Tolerance in Kidney Transplant Recipients
A. Merchak,¹ A. Khalil,¹ A. Chhabra,¹ J. Leventhal,² S. Ildstad.¹
¹University of Louisville, Louisville, KY; ²Northwestern Memorial Hospital, Chicago, IL.
Durable chimerism is currently the most reliable biomarker of donor specific tolerance. Identifying and validating other predictive biomarkers is therefore a high priority. Since 2009…
2018 American Transplant Congress
Bioinformatics Approach to the Development of a Novel Molecular Biomarker for Sub-Clinical Acute Rejection (subAR) in the Peripheral Blood Following Kidney Transplant (KT)
T. Whisenant,¹ S. Kurian,¹ M. Kandpal,² L. Zhao,² D. Ikle,³ B. Armstrong,³ J. Friedewald,² R. Heilman,⁴ E. Poggio,⁵ C. Marsh,¹ P. Baliga,⁶ N. Bridges,⁷ J. Odim,⁷ M. Brown,⁷ J. Charette,² S. Brietigam,² N. Sustento-Reodica,² D. Salomon,¹ M. Abecassis.²
¹Scripps, La Jolla; ²Northwestern, Chicago; ³Rho, Chapel Hill; ⁴Mayo AZ, Scottsdale; ⁵Cleveland Clinic, Cleveland; ⁶MUSC, Charleston; ⁷NIAID, Bethesda.
Sub-clinical acute rejection (subAR) following KT is associated with poor long-term graft outcomes and can only be detected using invasive surveillance biopsies (SBx). Non-invasive biomarker…
2018 American Transplant Congress
A Pre-Transplant Blood-Based Lipid Signature for Prediction of Antibody-Mediated Rejection in Kidney Transplant Patients
G. Gupta, S. Bobba, D. Contaifer, P. Kimball, A. King, D. Kumar, M. Levy, J. Stern, D. Wijesinghe.
Virginia Commonwealth University, Richmond.
BACKGROUNDThere is a lack of biomarkers for pre-kidney transplant immune risk stratification to avoid over- or under-immunosuppression. Since the circulating lipidome is integrally involved in…
2018 American Transplant Congress
Waning Enthusiasm for a Once Promising Test: C1q Testing Does Not Provide Prognostic Information for DSA Screening Protocols
A. Gilbert, D. Li, M. Awwad, S. Rosen-Bronson, P. Abrams, J. Verbesey, G. Vranic, M. Cooper.
Medstar Georgetown Transplant Institute, Medstar Georgetown University Hospital, Washington, DC.
Introduction: Testing of donor specific antibodies (DSA) for binding of complement component C1q has been used to better elucidate pathologic antibodies from more benign reactions.…
2018 American Transplant Congress
Glucocorticoid Receptor Polymorphism Affects Susceptibility of Dyslipidemia in Recipients One Year after Kidney Transplantation
K. Numakura,¹ H. Kagaya,² N. Komine,¹ R. Yamamoto,¹ N. Fujiyama,³ H. Tsuruta,¹ A. Maeno,¹ M. Saito,¹ S. Narita,⁴ T. Inoue,¹ T. Niioka,² M. Miura,² T. Habuchi,¹ S. Satoh.³
¹Urology, Akita University Graduate School of Medicine, Akita, Japan; ²Pharmacy, Akita University Hospital, Akita, Japan; ³Center for Kidney Disease and Transplantation, Akita University Hospital, Akita, Japan; ⁴Blood Purification, Akita University Hospital, Akita, Japan.
Purpose. Dyslipidemia (DL) is a critical comorbidity after renal transplantation and can arise cardiovascular diseases. The relationship between developing of DL and glucocorticoid receptor (NR3C1)…
2018 American Transplant Congress
Evaluation of KPD: Does It Improve Overall Transplant Center Performance?
M. Rees,³ E. Michelin,¹ N. Koizumi,² J. Ortiz.³
¹West Virginia School of Osteopathic Medicine, Lewisburg, WV; ²George Mason University, Fairfax, VA; ³University of Toledo College of Medicine, Toledo, OH.
Introduction: The medical community is facing a constant shortage of kidneys for transplant patients. The most effective way to combat the deficit is to increase…
2018 American Transplant Congress
Tuberculosis among Kidney Transplant Patients Compared to Dialysis and Non-Dialysis CKD Patients over a Decade Period
A. Metry, I. Al Salmi, F. Al Ismaili, A. Hola, F. Shaheen, I. Al Salmi.
The Renal Medicine, The Royal Hospital, Muscat, Oman; The Renal Medicine, The Royal Hospital, Muscat, Oman; The Renal Medicine, The Royal Hospital, Muscat, Oman; The Renal Medicine, The Royal Hospital, Muscat, Oman; SCOT, SCOT, Riyadh, Saudi Arabia; The Renal Medicine, The Royal Hospital, Muscat, Oman.
USRDS showed that 1.2% & 1.6% incidences of tuberculosis-TB in patients on peritoneal dialysis and hemodialysis-HD, respectively. Kidney transplant-KTX patients have higher rates.We studied the…