Articles tagged "Kidney transplantation"

2019 American Transplant Congress
Development and Validation of a Capillary Blood Mitra-Based Assay for the Quantitative Determination of Advagraf® Concentrations in Transplant Patients
N. Undre¹, I. Dawson², V. Aluvihare³, N. Kamar⁴, F. Saliba⁵, N. Torpey⁶, S. Anaokar⁷, G. Kazeem¹
¹Astellas Pharma Europe Ltd, Chertsey, United Kingdom, ²Covance Laboratories, Harrogate, United Kingdom, ³Kings College Hospital, London, United Kingdom, ⁴CHU Rangueil, Toulouse, France, ⁵Hôpital Paul-Brousse, Villejuif, France, ⁶Addenbrookes Hospital, Cambridge, United Kingdom, ⁷Astellas Pharma Europe Ltd, Surrey, United Kingdom
*Purpose: Therapeutic drug monitoring of tacrolimus (TAC) requires venepuncture blood samples taken by specialists, requiring patients to attend an outpatient clinic; this can be inconvenient…
2019 American Transplant Congress
Significant Increase in Moderate to High KDPI Kidney Transplants Using a Multi-Operational Approach: Results from the COIIN (Collaborative Innovation and Improvement Network) Initiative
T. Pesavento¹, J. Foutz², K. Sisaithong², D. Klassen², L. Stillion¹, A. Rajab¹, R. Pelletier³, K. Washburn¹, H. Tosoc-Haskell²
¹Ohio State University, Columbus, OH, ²UNOS, Richmond, VA, ³Robert Wood Johnson, New Brunswick, NJ
*Purpose: Kidney transplant (KTx) utilization of moderate to high KDPI (MH-KDPI) deceased donor kidneys remains an opportunity to reduce organ discards. We participated in COIIN,…
2019 American Transplant Congress
Circulating T Follicular Helper Proliferation And Memory B Cell Activation Correlate With Donor Specific Allo-antibody Occurrence And Antibody-mediated Rejection After Kidney Transplantation
K. Louis¹, C. Macedo¹, M. Marrari¹, B. Ramaswami¹, M. Lucas¹, B. Elinoff¹, M. Yamada¹, X. Gu¹, G. Chalasani¹, A. Zeevi¹, P. Randhawa¹, C. Lefaucheur², D. Metes¹
¹Surgery, University of Pittsburgh, Pittsburgh, PA, ²Inserm Unité mixte de recherche 1160, Paris, France
*Purpose: Crosstalk between T follicular helper (Tfh) cells and B cells is necessary for class-switched antibody generation. The contribution of memory Tfh and B cells…
2019 American Transplant Congress
De Novo Donor Specific Antibody and Panel Reactivity Antibody Are Critical Risk Factors for Antibody Mediated Rejection of Kidney Allograft after Simultaneous Liver-Kidney Transplantation (a Single Center Study Using Surveillance Renal Biopsies)
Y. Sun¹, A. Zhang², Z. Zaky²
¹Avalon Medical University, Willemstad, Netherlands Antilles, ²Cleveland Clinic, Cleveland, OH
*Purpose: Even though the liver may provide immunologic protection to the kidney from hyperacute rejection, previous publications suggest this protective effect is not sufficient to…
2019 American Transplant Congress
Effect of Everolimus with Reduced-Exposure Tacrolimus and Early Steroid Elimination in Pediatric Kidney Transplant Recipients: 36-Month Outcomes from the CRADLE Study
H. Tedesco Silva¹, R. Ettenger¹, A. Bjerre¹, M. Christian¹, L. Dello Strologo¹, S. D. Marks¹, L. Pape¹, P. Lopez², M. Cousin², P. Pandey², B. Rauer², M. Meier², B. Tönshoff¹
¹A2314 Study Group, Basel, Switzerland, ²Novartis Pharma AG, Basel, Switzerland
*Purpose: To compare 36-month (M) efficacy and safety outcomes of an everolimus+reduced-exposure tacrolimus (EVR+rTAC)+steroids (CS) withdrawal regimen vs mycophenolate mofetil+standard-exposure TAC (MMF+sTAC)+CS in pediatric kidney…
2019 American Transplant Congress
Hard-to-Place Kidney Offers: Through the Lens of the United Network for Organ Sharing Organ Center
S. M. Noreen, R. S. Brown, M. Lane, B. Wolford, C. A. Humphries
United Network for Organ Sharing, Richmond, VA
*Purpose: In 2016, the rate of deceased donor kidney discard continued to increase to 20%. It is well documented that multiple factors contribute to lower…
2019 American Transplant Congress
Kidney Xenotransplantation from Genetically Engineered Pigs to Baboons with FDA-Approved Immunosuppressive Therapy
T. Yamamoto¹, H. Hara¹, J. Foote¹, E. C. Klein², H. J. Schuurman³, L. Wang¹, Q. Li¹, H. Zhou¹, J. Li¹, J. A. Tector¹, Z. Zhang², M. Ezzelarab², R. Lovingood¹, D. Ayares⁴, D. E. Eckhoff¹, D. K. Cooper¹, H. Iwase¹
¹University of Alabama at Birmingham, Birmingham, AL, ²University of Pittsburgh, Pittsburgh, PA, ³Schubiomed Consultancy, Utrecht, Netherlands, ⁴Revivicor, Blacksburg, VA
*Purpose: Genetically-engineered pigs might present a solution to the critical shortage of organs for clinical transplantation. The aims of this study were to evaluate the…
2019 American Transplant Congress
Impact of Belatacept Conversion on Renal Function, Histology and Gene Expression in Kidney Transplant Patients with Interstitial Fibrosis and Tubular Atrophy
G. Gupta¹, D. Kumar¹, M. Raynaud², A. Loupy², J. Chang³, J. Reeve³, P. Sanghi¹, I. Yakubu¹, L. Kamal¹, M. Levy¹, C. Bhati¹, P. Kimball¹, A. King¹, H. Massey¹, P. Halloran³
¹Virginia Commonwealth University, Richmond, VA, ²Paris Transplant Group, Paris, France, ³Alberta Transplant Genomics Applied Centre, Edmonton, AB, Canada
*Purpose: Prior studies on the conversion of tacrolimus (Calcineurin Inhibitor; CNI) to belatacept have been limited in scope due to either the absence of, post-conversion…
2019 American Transplant Congress
Successful Use of Hizentra to Address BK Viremia in Pediatric Transplant Population
K. Gruenkemeyer, E. Wood, A. Beck, C. Belsha
Pediatric Nephrology, Saint Louis University, Saint Louis, MO
*Purpose: BK viremia is an important problem in the pediatric renal transplant population leading to increased risk for viral associated nephropathy in the transplant. Early…
2019 American Transplant Congress
Prophylactic Use of Eculizumab in Patients at High Risk of Post-Transplant aHUS Recurrence Improves Graft Outcomes
J. Zuber, S. Caillard, M. Frimat, N. Kamar, P. Gatault, F. Petitprez, M. Louis, V. Chatelet, A. Thierry, D. Bertrand, R. Gaisne, L. Couzi, L. Albano, N. Jourde-Chiche, M. Matignon, J. Bamoulid, C. Pouteil-Noble, M. Peraldi, C. Legendre, E. Rondeau, M. Le Quintrec, V. Frémeaux-Bacchi
On behalf of the French aHUS Group, France, France
*Purpose: Eculizumab has revolutionized the management of atypical Hemolytic Uremic Syndrome (aHUS). In 2012, the French aHUS Study Group issued recommendations to advocate the prophylactic…