Articles tagged "Kidney transplantation"

2019 American Transplant Congress
B Cell-Specific IRE1a Deficiency Protects Renal Allografts from Rejection via Inhibition of Donor-Specific Antibodies and Induction of B Regulatory Cells
L. Qiu¹, J. Wang¹, X. Yeap¹, D. Fang², Z. J. Zhang¹
¹Comprehensive Transplant Center, Department of Surgery, Northwestern University, Chicago, IL, ²Department of Pathology, Northwestern University, Chicago, IL
*Purpose: Despite the progress in immunosuppressive regimens, antibody-mediated rejection remains a major contributor to renal allograft loss in recipients with donor-specific antibodies (DSA). IRE1a, an…
2019 American Transplant Congress
An International Comparison of Kidney Utilization in the United States and United Kingdom: What Can Be Learned?
D. Stewart¹, G. Vece¹, M. Ibrahim², C. Callaghan²
¹UNOS, Richmond, VA, ²NHS, London, United Kingdom
*Purpose: International discussions in 2017 about kidney “discard rates” between transplant (TX) professionals in the US and UK led to the realization that the two…
2019 American Transplant Congress
OPO Aggressiveness Index: A Novel OPO Performance Metric That Incentivizes Pursuit of Marginal Deceased Donor Candidates
L. Liyanage, Y. Yu, K. Jackson, J. Garonzik-Wang, D. Segev, A. Massie
Johns Hopkins, Baltimore, MD
*Purpose: Of 2.5M deaths in the US every year, only 10,000 are recovered for transplantation; recovery of organs from older donors is rare although similar…
2019 American Transplant Congress
Long Term Outcomes Using Tocilizumab For The Treatment Of Chronic Antibody Mediated Rejection
J. Choi¹, E. Huang¹, O. Aubert², A. Vo¹, A. Peng¹, R. Najjar¹, S. Sethi¹, N. Ammerman¹, K. Lim¹, D. Puliyanda¹, A. Loupy², S. Jordan¹
¹Comprehensive Transplant Center, Cedars-Sinai Medical Center, Los Angeles, CA, ²Paris Translational Center for Organ Transplantation, Paris, France
*Purpose: Limited options exist for the treatment of kidney allograft rejection and preservation of allograft function. We reported our experience with anti-IL-6R (tocilizumab, TCZ) as…
2019 American Transplant Congress
Biomarker Candidate Discovery for Kidney Allograft Monitoring via Urinary Exosome Proteome Analysis
J. Kim¹, Y. Wee¹, M. Choi¹, H. Jung¹, J. Choi¹, H. Kwon¹, J. Jung¹, Y. Ko¹, D. Kim¹, K. Kim², Y. Cho³, H. Go³, Y. Kim¹, D. Han¹, S. Shin¹
¹Department of Surgery, Asan Medical Center, Seoul, Korea, Republic of, ²Department of Convergence Medicine, Asan Institute for Life Sciences, Asan Medical Center, Seoul, Korea, Republic of, ³Department of Pathology, Asan Medical Center, Seoul, Korea, Republic of
*Purpose: There is a need for the development of noninvasive molecular biomarkers with high reliability and predictive power for early diagnosis and monitoring of any…
2019 American Transplant Congress
Quantifying Donor Effects on Transplant Outcomes Using Kidney Pairs from Deceased Donors
K. F. Kerr¹, E. R. Morenz¹, H. Thiessen Philbrook², S. G. Coca³, F. P. Wilson⁴, P. P. Reese⁵, C. R. Parikh²
¹University of Washington, Seattle, WA, ²Johns Hopkins University, Baltimore, MD, ³Icahn School of Medicine at Mount Sinai, New York, NY, ⁴Yale University, New Haven, CT, ⁵University of Pennsylvania, Philadelphia, PA
*Purpose: In kidney transplantation, the relative contribution of donor versus other factors on clinical outcomes is unknown.*Methods: For paired donations from deceased donors resulting in…
2019 American Transplant Congress
Correlation of Donor-Derived Cell-Free DNA with Histology and Molecular Diagnoses of Kidney Transplant Biopsies
I. Moinuddin¹, D. Kumar¹, P. Halloran², L. Kamal¹, A. King¹, P. Kimball¹, M. Levy¹, C. Bhati¹, D. Massey¹, G. Gupta¹
¹VCU Medical Center, Richmond, VA, ²Alberta Transplant Genomics Applied Centre, Edmonton, AB, Canada
*Purpose: Circulating donor-derived cell free DNA (cfDNA; Allosure, CareDx, USA), a non-invasive test that could detect rejection in kidney allografts was validated using histologic diagnoses(HDx).…
2019 American Transplant Congress
Are We Underestimating The Number Of Paired Kidney Exchange Transplants In The United States? Relationship Insights From The National Kidney Registry
A. Thomas¹, A. Shaffer², D. Segev²
¹Epidemiology, UNC Chapel Hill, Chapel Hill, NC, ²Johns Hopkins University, Baltimore, MD
*Purpose: Despite an overall decline in the number of living donor kidney transplants (LDKTs) since 2005, Kidney Paired Donation (KPD) rates have increased over the…
2019 American Transplant Congress
Opening the Doors of Hope: HIV-Positive Living Kidney Donation
S. Rusch, L. Fieldman, M. Hemmersbach-Miller, C. R. Wolfe
Duke University Medical Center, Durham, NC
*Purpose: Living donation (LD) has been allowed under the HOPE Act since 2013, yet to date there have been no HIV+ LD organ transplants performed…
2019 American Transplant Congress
Ex Vivo Normothermic Perfusion Of Discarded Human Kidneys Reveals Cold-storage-induced Renal Fibrinogen And Provides A Platform For Therapeutic Repair
J. DiRito¹, S. A. Hosgood², M. Reschke³, M. L. Nicholson², G. T. Tietjen⁴
¹Surgery, Yale University & University of Cambridge, New Haven, CT, ²Surgery, University of Cambridge, Cambridge, United Kingdom, ³Biomedical Engineering, Yale University, New Haven, CT, ⁴Surgery - Transplantation, Yale University, New Haven, CT
*Purpose: The purpose of this study was to: 1) determine the cause of microvascular obstructions that arise during ex vivo normothermic perfusion (NMP) of human…