Articles tagged "Kidney transplantation"

2019 American Transplant Congress
Risk Stratification of Cytomegalovirus Seropositive Kidney Transplant Recipients for CMV Infection
M. M. Azar¹, A. Baghban¹, K. Belfield¹, R. Assi², M. Malinis¹
¹Yale University, New Haven, CT, ²University of Pennsylvania, Philadelphia, PA
*Purpose: Current consensus guidelines for CMV prevention recommend valganciclovir (VGCV) prophylaxis for 3 months after transplantation for CMV R+ kidney transplant recipients (KTR). This standard…
2019 American Transplant Congress
Treg And Bone Marrow Infusion Promotes Survival Of Donor Kidney Grafted Months After Disappearance Of Mixed Chimerism
K. Bruestle, P. Alonso-Guallart, E. Lopes, G. Pierre, N. Llore, H. Sakai, S. Kofman, D. Ekanayake-Alper, M. Sykes, A. Griesemer
Columbia Center for Translational Immunology, Columbia University, New York City, NY
*Purpose: Transient mixed chimerism induced with non-myeloablative conditioning in monkeys and humans induces tolerance to about 70% of donor kidney grafts transplanted at the time…
2019 American Transplant Congress
Urinary Injury Biomarkers in Deceased Donors and Acute Rejection Post Kidney Transplant
P. Reese¹, I. Hall², S. Mohan³, H. Theissen-Philbrook⁴, Y. Jia⁴, M. Doshi⁵, J. Bromberg⁶, S. Mansour⁷, M. Harhay⁸, F. Weng⁹, E. Akalin¹⁰, C. Parikh⁴
¹UPENN, Philadelphia, PA, ²Univ of Utah, Salt Lake City, UT, ³Columbia, NY, NY, ⁴Johns Hopkins, Baltimore, MD, ⁵Univ of Michigan, Ann Arbor, MI, ⁶Univ of Maryland, Baltimore, MD, ⁷Yale, New Haven, CT, ⁸Drexel, Philadelphia, PA, ⁹St. Barnabas, Philadelphia, PA, ¹⁰Montefiore, NY, NY
*Purpose: Acute kidney injury (AKI) is common among deceased kidney donors. We hypothesized that inflammation from kidney injury could lead to enhanced expression of HLA…
2019 American Transplant Congress
Urinary Cell mRNA Sequencing Profiles of Kidney Allograft Recipients Mirror Intragraft Events and Demonstrate Enrichment for Immune Cells
M. Lubetzky¹, A. Verma², H. Yang¹, T. Muthukumar¹, S. Salvatore¹, J. Lee¹, D. Dadhania¹, S. Seshan¹, F. Mueller¹, O. Elemento², M. Suthanthiran¹
¹Division of Nephrology, Weill Cornell, New York, NY, ²Institute for Computational Biomedicine, Weill Cornell, New York, NY
*Purpose: Urinary cell mRNA profiling to interrogate kidney allograft status is based on the premise that the allograft can function as an in-vivo flow cytometer…
2019 American Transplant Congress
Tacrolimus Concentrations Can Be Reliably Measured in Capillary Microsamples
M. T. Gustavsen, N. Vethe, M. Lauritsen, A. Andersen, A. Åsberg, S. Bergan, K. Midtvedt
Oslo University Hospital, Rikshospitalet, Oslo, Norway
*Purpose: Routine therapeutic drug monitoring (TDM) of tacrolimus (Tac) is currently performed in venous bloods samples drawn at the hospital. The novel volumetric absorptive microsampling…
2019 American Transplant Congress
Association Of Lymphocyte-depleting Antibody And Steroids Induction With The Risk And Outcomes Of Post-transplant Diabetes: Analysis Of Deceased-donor Kidney Transplants
A. Santos¹, J. Gregg², U. L. Akanit³, K. Alquadan¹, H. Bejjanki¹, K. L. Womer¹
¹Div. of Nephrology, Hypertension & Renal Transplantation, University of Florida, Gainesville, FL, ²University of Florida, Gainesville, FL, ³Ubon Ratchathani University, Ubonratchathani, Thailand
*Purpose: We aimed to determine the risk and outcomes of post-transplant diabetes(PTDM) associated with combined lymphocyte-depleting antibody (LDA) [anti-thymocyte globulin (ATG) or alemtuzumab (ALM)] and…
2019 American Transplant Congress
Using an Electronic Medical Record Tool to Document Transplant Option Discussions among Patients with EGFR ≤ 20 mL/min/1.73m²
A. Yishak¹, R. R. Brentari², R. M. Love La Londe³, E. Clark⁴, E. Clark⁴, J. Sun⁵, S. Vupputuri⁶
¹Nephrology, MAPMG, Mc Lean, VA, ²KP National Transplant Service, Oakland, CA, ³KP National Transplant Services, Oakland, CA, ⁴KP National Transplant Services, silver spring, MD, ⁵KP, Rockville, MD, ⁶MAPRI, MAPMG, Rockville, MD
*Purpose: The purpose of this study, in a large integrated health system, was to improve: 1) the documentation of transplant option discussions by providers among…
2019 American Transplant Congress
Expression of Prostaglandin E2 Receptors Track with Rejection in Porcine Kidney Transplants
A. Harner¹, Y. Wang², X. Fang², R. Lassiter¹, T. D. Merchen¹, S. Ho³, S. Nahman Jr²
¹Surgery, Augusta University, Augusta, GA, ²Nephrology, Augusta University, Augusta, GA, ³Gift of Life Michigan, Ann Arbor, MI
*Purpose: Prostaglandin E2 (PGE2) is generated from arachidonic acid via cyclooxygenase-2 (COX2) and is known to modulate the immune response via its receptors: EP1, EP2,…
2019 American Transplant Congress
Pharmacological Mobilization of Host Stem Cells Prevents Delayed Graft Function Following Kidney Transplantation in Rats
W. Wang, L. Qi, J. Huang, A. Ahmadi, A. Krishnan, R. Wesson, A. Cameron, Z. Sun
Johns Hopkins University School of Medicine, Baltimore, MD
*Purpose: Delayed graft function (DGF) caused by ischemia-reperfusion injury (IRI) is an early complication that occurs in nearly a quarter of all deceased-donor kidneys and…
2019 American Transplant Congress
Liquid Biopsy for Chronic Rejection after Kidney Transplantation. A Novel Non-Invasive Biomarker Involved in Inflammatory Amplifier
Y. Takada¹, D. Kamimura², H. Higuchi¹, D. Iwami¹, K. Hotta¹, N. Iwahara¹, N. Shinohara¹, M. Murakami²
¹Renal and Genitourinary Surgery, Hokkaido University Hospital, Sapporo, Japan, ²Molecular Psychoimmunology, Institute for Genetic Medicine, Graduate School of Medicine, Hokkaido University, Sapporo, Japan
*Purpose: In kidney transplantation (KTx), despite recent advances of medical technology, chronic rejection accounts for 25% of the graft loss. Chronic active antibody-mediated rejection (CAAMR)…