Articles tagged "Kidney transplantation"

2019 American Transplant Congress
Epidemiology and Outcomes of BKV Nephropathy Management by Screening Policy in a Real-Life Setting
V. D. GARCIA¹, F. V. Raupp¹, G. MEINERZ¹, K. Piegas², E. KEITEL¹
¹Nephrology and Kidney and Pancreas Transplant Department, ISCMPA, Porto Alegre, Brazil, ²Pathology Department, ISCMPA, Porto Alegre, Brazil
*Purpose: To verify the frequency of BKVAN in a single center's clinical setting and evaluate the response to immunosuppressive adjustments through graft survival analysis.*Methods: Retrospective…
2019 American Transplant Congress
Monitoring Circulating T Follicular Helper Cells Polarization, Activation and Function Distinguishes Asymptomatic Donor-Specific Anti-HLA Antibody Positive Kidney Transplant Recipients from Those Undergoing Antibody-Mediated Rejection
C. Macedo¹, K. Louis¹, P. Fadakar², M. Yamada², B. Elinoff¹, K. Hadi¹, P. Randhawa¹, D. Metes¹
¹Starzl Transplantation Institute, Pittsburgh, PA, ²Children's Hospital of Pittsburgh, Pittsburgh, PA
*Purpose: Donor-specific anti-HLA antibodies (DSA) represent an important biomarker for acute rejection and are a major cause of long-term graft failure after kidney transplantation (KTx).…
2019 American Transplant Congress
Association between a Chronic Kidney Disease Treatment Education Class and Receipt of a Kidney Transplantation in the Southeastern U.S. Population
J. C. Gander¹, L. Cromwell¹, A. S. Wilk², R. E. Patzer², M. Sesay¹, D. Walker-Williams¹, T. Davis¹, J. P. Austin¹, N. Mukerji¹
¹Kaiser Permanente, Atlanta, GA, ²Emory University, Atlanta, GA
*Purpose: Predialysis education is associated with improved patient survival and improved access to kidney transplantation (KT), however many of the findings are based on a…
2019 American Transplant Congress
Gut Microbiome And Acute Rejection After Kidney Transplantation
H. Cho¹, Y. Yang¹, J. Kim², J. Moon², J. Jeong², J. Park³, M. Kwak⁴, B. Kim⁴, D. Kim², J. Lee⁵, B. Kim⁶, Y. Kim², H. Lee²
¹Internal Medicine, Chungbuk National University Hospital, Cheongju, Korea, Republic of, ²Internal Medicine, Seoul National University Hospital, Seoul, Korea, Republic of, ³Internal Medicine, Kangwon National University Hospital, Chuncheon, Korea, Republic of, ⁴ChunLab Inc., Seoul, Korea, Republic of, ⁵Internal Medicine, Seoul National University, Boramae Hospital, Seoul, Korea, Republic of, ⁶Hallym University, Chuncheon, Korea, Republic of
*Purpose: Acute rejection (AR) is a common complication in kidney transplantation (KT) and associated with reduced patient-graft survival. Recent studies have shown that the gut…
2019 American Transplant Congress
A Prognostic Biomarker to Estimate the Likelihood of Developing De Novo Donor Specific Antibody in Kidney Transplant Recipients
S. Kawakita¹, L. M. Rebellato², K. P. Briley², A. Q. Maldonado³, C. E. Haisch², P. Bolin², S. A. Kendrick⁴, H. Jones⁴, K. McLawhorn⁴, D. Leeser², V. Jucaud¹, V. Burnett¹, M. J. Everly¹
¹Terasaki Research Institute, Los Angeles, CA, ²East Carolina University, Greenville, NC, ³Vidant Medical Center, Greenville, NC, ⁴Eastern Nephrology Associates, Greenville, NC
*Purpose: Evaluation of human leukocyte antigen (HLA) mismatch at antibody epitope level rather than antigen level may explain better the impact of HLA mismatch on…
2019 American Transplant Congress
Urine Uromodulin Associates with Deceased Donor Acute Kidney Injury and Allograft Failure
S. G. Mansour¹, I. Hall², P. Reese³, T. Ashkar⁴, Y. Jia⁴, H. Thiessen-Philbrook⁴, M. Doshi⁵, C. R. Parikh⁴
¹Yale, New Haven, CT, ²University of Utah, Salt Lake City, UT, ³Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, ⁴Johns Hopkins University, Baltimore, MD, ⁵University of Michigan, Ann Arbor, MI
*Purpose: Produced exclusively by renal epithelial cells of the thick ascending limb, Uromodulin (UMOD, also known as Tamm-Horsfall protein) is the major component of hyaline…
2019 American Transplant Congress
Natural Killer Cells Express Significantly More CD16 during Chronic Active Antibody Mediated Rejection Which is Not Caused by a Single Nucleotide Polymorphism within the CD16 Gene
K. Sablik, N. Litjens, A. Peeters, M. Clahsen-van Groningen, M. Klepper, M. Betjes
Erasmus MC, Rotterdam, Netherlands
*Purpose: Chronic-active antibody mediated rejection (c-aABMR) is the leading cause of long-term renal allograft loss. Fc-receptor CD16 bearing natural killer (NK) cells may be involved…
2019 American Transplant Congress
Renal Transplantation in Patients Older Than 60 Years with High Comorbidity. Is There a Survival Benefit? A Multicenter Study in Argentina
G. D. Fragale¹, G. A. Laham², L. Bisignano³, A. Antik³, P. M. Raffaele⁴, M. Fortunato⁴, H. Trimarchi⁵, V. Pomeranz⁵, R. Maldonado⁶, N. Matamala⁶, N. C. Imperiali⁷, M. C. Giordani⁷, M. F. Taylor⁸, J. M. Ciappa⁸, J. L. De La Fuente⁹, S. Naser¹⁰, G. Soler Pujol²
¹Nephrology, Hospital Universitario Austral, Derqui, Argentina, ²Nephrology, CEMIC, Buenos Aires, Argentina, ³INCUCAI, Buenos Aires, Argentina, ⁴Fundacion Favaloro, Buenos Aires, Argentina, ⁵Hospital Britanico de Buenos Aires, Buenos Aires, Argentina, ⁶Clinica Velez Sarsfield, Cordoba, Argentina, ⁷Hospital Italiano de Buenos Aires, Buenos Aires, Argentina, ⁸Crai Sur, Buenos Aires, Argentina, ⁹Hospital Privado Universitario de Cordoba, Cordoba, Argentina, ¹⁰Hospital Privado Universitario de Cordoba, Buenos Aires, Argentina
*Purpose: The impact of renal transplantation (RT) in the elderly with comorbid conditions is a matter of concern. Our aim was to assess the impact…
2019 American Transplant Congress
Early Tacrolimus Trough Attainment in De Novo Kidney Transplant Recipients Treated with LCP-Tacrolimus (LCPT) vs. Immediate-Release Tacrolimus (IR-Tac)
K. Budde¹, S. Bunnapradist², S. J. Patel³, D. R. Stevens³, U. Meier-Kriesche³, B. Suwelack⁴
¹Charité University Medicine Berlin, Berlin, Germany, ²UCLA Medical Center, Los Angeles, CA, ³Veloxis Pharmaceuticals Inc., Cary, NC, ⁴University Hospital of Münster, Münster, Germany
*Purpose: Early achievement of therapeutic tacrolimus concentrations has been associated with reduced rates of acute rejection. A prospective, randomized, controlled study demonstrated safe and efficacious…
2019 American Transplant Congress
Impacts of Mycophenolate Mofetile Addition to Very Low Exposure Everolimus and Calcineurine Inhibitor Based Immunosuppression in De Novo Kidney Transplantation 5 Years Results
Y. Watarai¹, S. Narumi¹, T. Tomosugi¹, M. Okada¹, K. Futamura², M. Tsujita², T. Hiramitsu¹, T. Kobayashi³, N. Goto²
¹Transplant Surgery, Nagoya Daini Red Cross Hospital, Nagoya, Japan, ²Transplant Nephrology, Nagoya Daini Red Cross Hospital, Nagoya, Japan, ³Kidney Transplant Surgery, Aichi Medical University, Nagoya, Japan
*Purpose: Prospective randomized study of MMF addition to everolimus (EVR) based immunosuppression was evaluated in clinical outcomes as well as protocol biopsies findings and donor…