Articles tagged "Kidney transplantation"

2019 American Transplant Congress
RNA Sequencing Identifies a Differential Role of Coding and Non-Coding Genes by Types of Rejection
S. Pineda¹, O. Bestard², T. K. Sigdel¹, M. Sirota³, M. Sarwal¹
¹Department of Surgery, UCSF, San Francisco, CA, ²Department of Surgery, Bellvitge University Hospital, Barcelona, Spain, ³BCHSI, UCSF, San Francisco, CA
*Purpose: The differentiation of histological phenotypes of T cell mediated cellular rejection (TCMR) and humoral or antibody mediated rejection (AMR) of kidney allografts, bears relevance…
2019 American Transplant Congress
The Impact of Eplet Mismatches on Kidney Transplant Outcome: A Single-Center Cohort Study
A. Senev¹, M. Coemans¹, V. Van Sandt², B. Sprangers³, D. Kuypers³, M. Emonds², M. Naesens³
¹Department of Microbiology and Immunology, KU Leuven, Leuven, Belgium, ²Histocompatibility and Immunogenetics Laboratory, Belgian Red Cross-Flanders, Mechelen, Belgium, ³University Hospitals Leuven, Leuven, Belgium
*Purpose: It has been shown that HLA-matching at classic antigen-level for HLA-A, -B and -DRB1 loci, provides benefits in matching and outcome after solid organ…
2019 American Transplant Congress
CYP3A5 Genotype Had No Influence on Renal Function after Renal Transplantation
J. E. Kimpton, A. J. Hughes, I. MacPhee
Renal Medicine and Transplantation, St George’s University Hospitals NHS Foundation Trust, London, United Kingdom
*Purpose: Tacrolimus metabolism rate has been reported to be associated with renal function after renal transplantation (Thölking et al., 2014); this study aimed to determine…
2019 American Transplant Congress
Outcomes of ABO Incompatible Transplant on Steroid Free Immunosuppression
A. Wang, D. Mishler, T. Taber, M. Yaqub, A. Sharfuddin, W. Goggins, O. Adebiyi
Department of Medicine, Division of Nephrology, Indiana University School of Medicine, Indianapolis, IN
*Purpose: ABO incompatible (ABOi) kidney transplant (KTx) was introduced to expand donor organ pool. However it is also an immunologically high-risk procedure requiring pre-transplant antibody…
2019 American Transplant Congress
Comparison of Initial Sirolimus (SRL) and Everolimus (EVR) Exposure Patterns in Kidney Transplant Recipients
C. Rosso Felipe, L. Viana, M. Pontello Cristelli, M. Nakamura, L. Ramagnoli, S. Braga, V. Lima, A. Carnevalle, D. Casarini, J. Medina Pestana, H. Tedesco Silva Junior
Hospital do Rim, Nephrology Division, EPM - UNIFESP, São Paulo, Brazil
*Purpose: Despite distinct pharmacokinetic properties, SRL and EVR bind to the same intracellular target protein, suggesting that equivalent blood concentrations may exert similar pharmacodynamic effect.*Methods:…
2019 American Transplant Congress
Histone Deacetylase-8 (HDAC8) Inhibition is Protective in a Murine Model of Renal Ischemia Reperfusion Injury (IRI)
P. T. Hernandez¹, S. J. Concors¹, D. D. Aufhauser¹, L. Krumeich¹, Z. Wang¹, G. Ge¹, A. Beeler², M. Levine¹, W. Hancock³
¹Hospital of the University of Pennsylvania, Philadelphia, PA, ²Chemistry, Boston University, Boston, MA, ³Children's Hospital of Philadelphia, Philadelphia, PA
*Purpose: IRI is a major source of morbidity after renal transplantation, contributing to poor transplant outcomes and decreased graft survival. Histone deacetylases (HDACs) are enzymes…
2019 American Transplant Congress
Need of a New Formula to Estimate Creatinine Clearance in Immediate Post Kidney Transplant Period with Functioning Allograft
A. B. Jain¹, U. Farooq², A. Brooks¹, T. Dohi¹, F. Butt¹, Z. Kadry¹
¹Surgery ( Transplant), Penn State Milton Hershey Medical Center, Hershey 17033, PA, ²Medicine( Neprhology), Penn State Milton Hershey Medical Center, Hershey, PA
*Purpose: Introduction: Post kidney transplant (KTx), with functioning renal allograft, serum creatinine continues to decrease at a variable rate until it stabilizes after a few…
2019 American Transplant Congress
Temporal Trends Following Uncontrolled Donation after Cardiac Death Kidney Transplantation: Implications for Normothermic Regional Perfusion?
R. A. Choudhury, K. Prins, D. Yoeli, H. B. Moore, T. L. Nydam
Transplant Surgery, University of Colorado, Aurora, CO
*Purpose: Kidney transplantation following uncontrolled donation after cardiac (uDCD) remains an underutilized resource in the United States when compared to controlled DCD (cDCD) which has…
2019 American Transplant Congress
Detection and Desensitization of Donor-Specific Antibody Reduces Risk of Early but Not Late Renal Transplant Failure in a Cohort of 1000 Cases
M. Tsai, C. Lee, C. Yang, C. Chen
Department of Surgery, National Taiwan University Hospital, Taipei, Taiwan
*Purpose: The Human Organ Transplant Act in Taiwan was promulgated in 1987 and, thereafter, organ transplantation from brain-dead donors legalized. To review the results of…
2019 American Transplant Congress
Basiliximab vs. Low-Dose Thymoglobulin Induction Therapy in Low Risk Kidney Transplant Patients: Prospective Randomized Study in Southeastern Mexico
G. Martinez-Mier, P. I. Moreno-Ley, L. F. Budar-Fernandez, M. T. Mendez-Lopez, D. A. Barrera-Amoros, M. De la Paz-Roman, L. A. Jimenez-López, E. G. Aguilar-Sandoval, C. A. Allende-Castellanos
Organ Transplantation & Research, IMSS UMAE HE 14, Veracruz, Mexico
*Purpose: Demonstrate that low dose Thymoglobulin (3 mg/kg total ) has similar efficacy (DGF, SGF, BPAR, hospitalizations, adverse events, graft loss and death) than Basiliximab…