Articles tagged "Kidney transplantation"

2019 American Transplant Congress
Comparison of Pregnancy Outcomes by Conception Age in Female Kidney Transplant Recipients
S. Rao¹, L. A. Coscia², D. Kliniewski², S. Constantinescu³, M. J. Moritz⁴
¹Medicine, University of Virginia Health System, Charlottesville, VA, ²Gift of Life Institute, Transplant Pregnancy Registry International, Philadelphia, PA, ³Medicine, Lewis Katz School of Medicine, Temple University, Philadelphia, PA, ⁴Surgery, Lehigh Valley Health Network, Allentown, PA
*Purpose: The purpose of this study is to compare pregnancy outcomes in 1066 female kidney transplant recipients by different conception ages.*Methods: Data were collected by…
2019 American Transplant Congress
Characterizing the Dominant Phenotype in Kidney Transplant Biopsies: Improving the Prediction of Risk by a Global View of Rejection, Injury, and Atrophy-Fibrosis
P. F. Halloran and The INTERCOMEX Investigators¹, J. Reeve²
¹University of Alberta, Edmonton, AB, Canada, ²Alberta Transplant Applied Genomics Centre, Edmonton, AB, Canada
*Purpose: Interpreting kidney transplant biopsies by histology or molecules involves assigning scores for separate pathologic categories: rejection, acute injury (molecules only), and chronic parenchymal loss…
2019 American Transplant Congress
The Changing Face of T Cell-Mediated Rejection
A. Perkowska-Ptasinska and INTERCOMEX investigators¹, P. F. Halloran²
¹Medical University of Warsaw, Warsaw, Poland, ²Alberta Transplant Applied Genomics Centre, Edmonton, AB, Canada
*Purpose: We studied how the problem of TCMR in indication biopsies was changing with time by exploring features of 138 biopsies with molecular TCMR in…
2019 American Transplant Congress
Complement Blockade in Kidney Recipients Prevents Delayed Graft Function and Antibody-Mediated Rejection in Non-Human Primates
M. Eerhart¹, J. Reyes¹, C. Blanton¹, J. Danobeitia¹, P. Chlebeck¹, L. Zitur¹, J. Coonen¹, S. Capuano¹, A. D’Alessandro¹, J. Torrealba², W. Zhong¹, Y. Yankol¹, L. Fernandez¹
¹University of Wisconsin, Madison, WI, ²UT Southwestern, Dallas, TX
*Purpose: Ischemia-reperfusion injury (IRI) leading to inflammation, complement activation, cytokine release and acute kidney injury has been implicated in the mechanism for delayed graft function…
2019 American Transplant Congress
Social Loafing: Distribution of Kidneys with Multiple Renal Arteries in a National Paired Kidney Exchange Program
G. R. Roll¹, W. Irish², M. Cooper³, M. Ronin⁴, G. Hil⁴, A. D. Waterman⁵, D. B. Leeser²
¹UCSF, San Francisco, CA, ²ECU, Greenville, NC, ³Georgetown Univ, Washington, DC, ⁴NKR, Babylon, NY, ⁵UCLA and Terasaki Research Institute, Los Angeles, CA
*Purpose: To describe the distribution and outcomes after kidney transplantation of multiple renal artery kidneys (MRAK) in a national exchange program.*Methods: We retrospectively reviewed donor…
2019 American Transplant Congress
Estimated Glomerular Filtration Rate at Donor Screening to Predict Measured Glomerular Filtration Rate after Living Kidney Donation
J. van der Weijden, M. van Londen, M. Y. Said, S. J. Bakker, S. P. Berger, G. Navis, M. H. de Borst
Nephrology, University Medical Center Groningen, Groningen, Netherlands
*Purpose: Accurate post-donation renal function prediction is important to minimize the risk of future severe renal function impairment in living kidney donors. Recent studies focused…
2019 American Transplant Congress
Effects of Static Subnormothermic Preservation of Extended Warm Ischemic Porcine Kidneys Assessed by Ex-Vivo Machine Perfusion and Renal Transplant Model
H. Sahara, Y. Ariyoshi, M. Sekijima, T. Iwanaga, A. Shimizu, K. Yamada
Center for Advanced Biomedical Science and Swine Research, Kagoshima University, Kagoshima, Japan
*Purpose: The donation after circulatory death (DCD) donors has the potential to match the increasing need for transplantable organs, however, DCD kidneys have a higher…
2019 American Transplant Congress
Analysis of Immune Cell Proportions in Kidney Transplant Biopsies of Acute Cellular Rejection and Antibody Mediated Rejection Compared with Non-Rejecters
C. R. Dorr¹, A. Muthusamy¹, D. P. Schladt¹, W. Guan², B. Wu², J. S. Maltzman³, W. S. Oetting², P. A. Jacobson², A. K. Israni¹
¹Hennepin Healthcare Research Institute, Minneapolis, MN, ²University of Minnesota, Minneapolis, MN, ³Stanford University, Palo Alto, CA
*Purpose: Understanding the immune cell types that are associated with acute rejection (AR) in kidney transplant biopsies may lead to new therapeutic targets for AR.…
2019 American Transplant Congress
Randomized Controlled Trial Of Spironolactone Effect In Kidney Transplant Recipients Of Living Donors
N. A. Bobadilla¹, L. E. Morales-Buenrostro¹, J. A. Ortega-Trejo¹, R. Perez-Villalva¹, L. Marino¹, Y. González-Bobadilla¹, H. Juarez¹, F. Zamora-Mejía¹, N. Gonzalez¹, R. Espinoza², J. Barrera-Chimal³
¹Nephrology, INCMNSZ, Mexico City, Mexico, ²Nephrology, Centro Médico Nacional Siglo XXI, Mexico City, Mexico, ³Molecular Physiology Unit, Instituto de Investigaciones Biomédicas, UNAM, Mexico City, Mexico
*Purpose: Mineralocorticoid receptor antagonism prevents acute kidney injury induced by ischemia/reperfusion in rodent and pig preclinical models. In a pilot study, we showed that spironolactone…
2019 American Transplant Congress
Pre-Transplant Donor-Specific IFN-γ ELISPOT as a Predictor of Allograft Rejection: A Diagnostic Test Accuracy Meta-Analysis
S. Farouk¹, I. Gandolfini², N. Montero³, E. Crespo⁴, M. Jarque⁴, M. Meneghini⁴, U. Maggiore², O. Bestard³, P. Cravedi¹
¹Medicine, Division of Nephrology, Icahn School of Medicine at Mt. Sinai, New York, NY, ²Centro Trapianti Rene-Pancreas, Azienda Ospedaliera-Universitaria di Parma, Parma, Italy, ³Nephrology, Bellvitge University Hospital, Barcelona, Spain, ⁴Experimental Nephrology Laboratory. IDIBELL, Barcelona, Spain
*Purpose: Pre-transplant interferon-γ (IFN-γ) enzyme-linked immunospot (IFN- γ ELISPOT) has been proposed as a tool to quantify alloreactivity of memory T cells and estimate the…