Articles tagged "Kidney transplantation"

2022 American Transplant Congress
Digital Spatial Profiling of Kidney Allograft Biopsies with Chronic Allograft Dysfunction in African American Transplant Recipients
C. R. Dorr¹, S. A. Elmer¹, B. Wu², B. Guo², J. Czyzyk², G. Crary³, G. Onyeaghala¹, W. Oetting², P. Jacobson², R. B. Mannon⁴, G. Agarwal⁵, J. Maltzman⁶, A. Matas², A. Israni³
¹Hennepin Healthcare Research Institute, Minneapolis, MN, ²University of Minnesota, Minneapolis, MN, ³Hennepin County Medical Center, Minneapolis, MN, ⁴Medicine, University of Nebraska Medical Center, Omaha, NE, ⁵University of Alabama at Birmingham, Birmingham, AL, ⁶Stanford University, Palo Alto, CA
*Purpose: Understanding tissue heterogeneity is important to identify the molecular and cellular mechanisms of kidney allograft loss in African American (AA) transplant recipients. Our aim…
2022 American Transplant Congress
Belatacept-Based Maintenance Immunosuppression Promoted Long-Term Antibody-Mediated Rejection Free Graft Survival After Desensitization in Sensitized Multiparous Female Recipients
M. Manook, I. Anwar, R. Schmitz, Z. Fitch, J. Yoon, A. Jackson, J. Kwun, S. Knechtle
Duke Transplant Center, Durham, NC
*Purpose: Amongst sensitized patients awaiting a transplant, females are disproportionately represented. To date, nonhuman primate (NHP) models of transplantation have relied on male animals, sensitized…
2022 American Transplant Congress
Association of Change in Kidney Volume with Proteinuria After Donation
M. Tsujita¹, K. Uchida¹, K. Morozumi¹, K. Futamura², T. Hiramitsu², M. Okada², S. Narumi², N. Goto², Y. Watarai²
¹Masuko Memorial Hospital, Nagoya, Japan, ²Japanese Red Cross Aichi Medical Center Nagoya Daini Hospital, Nagoya, Japan
*Purpose: In living kidney transplantation, the risk of end-stage kidney disease in kidney donors is crucial, however, it still remains to be resolved. Any useful…
2022 American Transplant Congress
Clinical Relevance of Class II HLA Mismatches in Living Donor Kidney Transplantation
J. Lan¹, M. Kadatz¹, D. Chang¹, R. Liwski², E. Wagner², P. Campbell², J. Gill¹, J. Gill¹
¹University of British Columbia, Vancouver, BC, Canada, ²On behalf of Canadian HLA Advisory Committee, Ottawa, ON, Canada
*Purpose: The benefit of class II HLA matching is primarily shown in deceased donor kidney transplantation. The objective of this study was to determine the…
2022 American Transplant Congress
Incidence of Urinary Tract Infection or Asymptomatic Bacteriuria in Kidney Transplant Recipients with Sulfamethoxazole-Trimethoprim vs. Pentamidine for Pneumocystis Jiroveci Pneumonia Prophylaxis
L. Selznick, H. Sweiss, C. Long, S. Bhayana, R. Hall
University Health, San Antonio, TX
*Purpose: To compare the incidence of urinary tract infection (UTI) or asymptomatic bacteriuria (ASB) post-kidney transplant (KT) with multiple Pneumocystis jiroveci pneumonia (PJP) prophylaxis regimens*Methods:…
2022 American Transplant Congress
Heterologous Vaccine Schedule Against Sars-CoV-2 with 2 Doses of Inactivated Virus and a Booster of mRNA BNT162b2 in Kidney Transplant Recipients
M. Seija¹, F. Rammauro², J. Santiago¹, N. Orihuela³, C. Zulberti³, D. Machado⁴, C. Recalde⁴, J. Noboa¹, R. Astesiano¹, F. Yandian¹, A. Guerisoli¹, A. Morra³, D. Cassinelli¹, A. Pippolo¹, B. De Aramburu¹, C. Coelho¹, P. González¹, R. Romero¹, R. Rodriguez-Teja⁴, G. Acuña⁴, V. Rabaza⁴, N. Perg⁴, R. Cordero⁴, S. Orihuela³, L. Curi³, E. Burgstaller⁴, O. Noboa¹, O. Pritsch², M. Nin¹, S. Bianchi⁵
¹Centro de Nefrología, Hospital de Clínicas. Facultad de Medicina UdeLaR, Montevideo, Uruguay, ²Departamento de Inmunobiología, Facultad de Medicina, UdeLaR, Montevideo, Uruguay, ³Hospital Italiano, Montevideo, Uruguay, ⁴Hospital Evangélico, Montevideo, Uruguay, ⁵Departamento de Fisiopatología, Facultad de Medicina UdeLar, Montevideo, Uruguay
*Purpose: Emerging evidence suggests that 3 doses of SARS-CoV-2 mRNA vaccine enhance immunity in kidney transplant (KT) patients. However, few studies have focused on humoral…
2022 American Transplant Congress
Early versus Delayed Cytomegalovirus Prophylaxis in High-Risk Kidney Transplant Recipients
A. Hutchins¹, M. Leick², M. Keck², J. S. McMullen²
¹Pharmacy, Houston Methodist Hospital, Houston, TX, ²Pharmacy, Nebraska Medicine, Omaha, NE
*Purpose: The purpose of this study is to determine the effect of delaying cytomegalovirus (CMV) prophylaxis to day of discharge or post-operative day (POD) 7…
2022 American Transplant Congress
The Relative Association of Clinical Variables and Histologic Lesions with Molecular Rejection in Kidney Transplant Biopsies
M. L. Sikosana¹, J. Reeve², P. F. Halloran², INTERCOMEX Investigators³
¹University of Alberta, Edmonton, AB, Canada, ²Alberta Transplant Applied Genomics Centre, Edmonton, AB, Canada, ³INTERCOMEX, Edmonton, AB, Canada
*Purpose: Availability of molecular assessment (MMDx) independent of conventional variables (time, clinical, histologic, and HLA antibody) presents an opportunity to re-assess the relative strength of…
2022 American Transplant Congress
Concordance of POLQ and PARP-1 Expression and MMEJ Type Viral Integration in the Progression of BKPyV-Associated Diseases
Y. Wang¹, Z. Yan¹, Y. Liu², J. Geng³, W. Deng¹, R. Xia¹, W. Zeng¹, J. Xu¹, C. Wu⁴, Y. Miao¹
¹Department of Transplantation, Nanfang Hospital, Southern Medical University, Guangzhou, China, ²Department of Microbiology and Infectious Disease Center, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, China, ³Department of Pathology, Nanfang Hospital, Southern Medical University, Guangzhou, China, ⁴Departments of Urology & Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, MA
*Purpose: To reveal the mechanism of the increasing dominant position of integration, especially the microhomology-mediated end joint (MMEJ) form in the development of BK Polyomavirus…
2022 American Transplant Congress
Utility of Porcine Kidneys in Transplantation Model for Training General Surgery Residents
O. Eletta, V. Putatunda, D. Walls, C. Antwi-Buosiako, B. Perry, N. Maloney Patel, R. Pelletier, A. Bongu
Rutgers Robert Wood Johnson Medical School, New Brunswick, NJ
*Purpose: We sought to increase the opportunities for general surgery residents to hone their vascular anastomosis skills. Accordingly, we created a kidney transplant model using…