Articles tagged "Kidney transplantation"

2019 American Transplant Congress
Four-Year Follow Up of Kidney Transplantation Using Alemtuzumab Induction and Belatacept/Sirolimus Maintenance Therapy
A. Kirk¹, H. Xu¹, A. Ghali², A. Mehta², A. Guasch²
¹Surgery, Duke University, Durham, NC, ²Transplant Center, Emory University, Atlanta, GA
*Purpose: Kidney transplantation remains limited by the chronic toxicities associated with calcineurin inhibitors (CNIs) and steroids. The objective of this clinical trial was to determine…
2019 American Transplant Congress
Tocilizumab for Refractory Antibody-Mediated Rejection in Pediatric Kidney Transplantation
A. Dokras, C. Butler, Q. Zhang, E. Reed, R. Ettenger, P. Weng, M. Pearl
University of California, Los Angeles, Los Angeles, CA
*Purpose: IL-6 blockade may play a role in reducing human leukocyte antigen donor specific antibodies (HLA DSA) production and stabilizing allograft function. We aimed to…
2019 American Transplant Congress
The Economic Burden of Graft Failure in the United States
J. A. Sussell¹, A. R. Silverstein¹, P. Goutam¹, D. Incerti¹, R. Kee¹, D. S. Batty, Jr.², C. X. Chen², J. Jansen¹, B. L. Kasiske³
¹Precision Health Economics, Oakland, CA, ²Medeor Therapeutics, South San Francisco, CA, ³Hennepin County Medical Center, Minneapolis, MN
*Purpose: Despite recent advances, graft failure imposes a substantial burden on kidney transplant recipients. This study is the first to quantify this burden in economic…
2019 American Transplant Congress
Access To The Kidney Transplant Waitlist For Patients With Hiv And End-stage Renal Disease
A. A. Shaffer¹, H. Ying², N. Chu¹, A. G. Thomas³, C. Haugen², S. Norman⁴, D. L. Segev¹, M. A. McAdams-DeMarco¹
¹Surgery & Epidemiology, Johns Hopkins University, Baltimore, MD, ²Surgery, Johns Hopkins University, Baltimore, MD, ³Epidemiology, University of North Carolina, Chapel Hill, NC, ⁴Surgery, University of Michigan, Ann Arbor, MI
*Purpose: Patients with HIV and end-stage renal disease (ESRD) experience higher mortality on dialysis than those without HIV. These HIV+ dialysis patients may face barriers…
2019 American Transplant Congress
Center-Level Probability of Kidney Transplant Varies Considerably for Waitlisted Patients
K. L. King¹, S. A. Husain¹, P. Reese², J. Schold³, S. Pastan⁴, S. Mohan¹
¹Columbia University, New York, NY, ²University of Pennsylvania, Philadelphia, PA, ³Cleveland Clinic, Cleveland, OH, ⁴Emory University, Atlanta, GA
*Purpose: Prior studies identify reducing time spent on the waitlist as a top priority for deceased donor kidney (DDK) transplant (Tx) candidates. Despite well-described geographic…
2019 American Transplant Congress
Epidemiology and Outcomes of BKV Nephropathy Management by Screening Policy in a Real-Life Setting
V. D. GARCIA¹, F. V. Raupp¹, G. MEINERZ¹, K. Piegas², E. KEITEL¹
¹Nephrology and Kidney and Pancreas Transplant Department, ISCMPA, Porto Alegre, Brazil, ²Pathology Department, ISCMPA, Porto Alegre, Brazil
*Purpose: To verify the frequency of BKVAN in a single center's clinical setting and evaluate the response to immunosuppressive adjustments through graft survival analysis.*Methods: Retrospective…
2019 American Transplant Congress
Monitoring Circulating T Follicular Helper Cells Polarization, Activation and Function Distinguishes Asymptomatic Donor-Specific Anti-HLA Antibody Positive Kidney Transplant Recipients from Those Undergoing Antibody-Mediated Rejection
C. Macedo¹, K. Louis¹, P. Fadakar², M. Yamada², B. Elinoff¹, K. Hadi¹, P. Randhawa¹, D. Metes¹
¹Starzl Transplantation Institute, Pittsburgh, PA, ²Children's Hospital of Pittsburgh, Pittsburgh, PA
*Purpose: Donor-specific anti-HLA antibodies (DSA) represent an important biomarker for acute rejection and are a major cause of long-term graft failure after kidney transplantation (KTx).…
2019 American Transplant Congress
Association between a Chronic Kidney Disease Treatment Education Class and Receipt of a Kidney Transplantation in the Southeastern U.S. Population
J. C. Gander¹, L. Cromwell¹, A. S. Wilk², R. E. Patzer², M. Sesay¹, D. Walker-Williams¹, T. Davis¹, J. P. Austin¹, N. Mukerji¹
¹Kaiser Permanente, Atlanta, GA, ²Emory University, Atlanta, GA
*Purpose: Predialysis education is associated with improved patient survival and improved access to kidney transplantation (KT), however many of the findings are based on a…
2019 American Transplant Congress
Gut Microbiome And Acute Rejection After Kidney Transplantation
H. Cho¹, Y. Yang¹, J. Kim², J. Moon², J. Jeong², J. Park³, M. Kwak⁴, B. Kim⁴, D. Kim², J. Lee⁵, B. Kim⁶, Y. Kim², H. Lee²
¹Internal Medicine, Chungbuk National University Hospital, Cheongju, Korea, Republic of, ²Internal Medicine, Seoul National University Hospital, Seoul, Korea, Republic of, ³Internal Medicine, Kangwon National University Hospital, Chuncheon, Korea, Republic of, ⁴ChunLab Inc., Seoul, Korea, Republic of, ⁵Internal Medicine, Seoul National University, Boramae Hospital, Seoul, Korea, Republic of, ⁶Hallym University, Chuncheon, Korea, Republic of
*Purpose: Acute rejection (AR) is a common complication in kidney transplantation (KT) and associated with reduced patient-graft survival. Recent studies have shown that the gut…
2019 American Transplant Congress
A Prognostic Biomarker to Estimate the Likelihood of Developing De Novo Donor Specific Antibody in Kidney Transplant Recipients
S. Kawakita¹, L. M. Rebellato², K. P. Briley², A. Q. Maldonado³, C. E. Haisch², P. Bolin², S. A. Kendrick⁴, H. Jones⁴, K. McLawhorn⁴, D. Leeser², V. Jucaud¹, V. Burnett¹, M. J. Everly¹
¹Terasaki Research Institute, Los Angeles, CA, ²East Carolina University, Greenville, NC, ³Vidant Medical Center, Greenville, NC, ⁴Eastern Nephrology Associates, Greenville, NC
*Purpose: Evaluation of human leukocyte antigen (HLA) mismatch at antibody epitope level rather than antigen level may explain better the impact of HLA mismatch on…