Articles tagged "Kidney transplantation"

2020 American Transplant Congress
Modelling Patient Outcomes after Listing for Deceased Donor Kidney Transplantation in the UK: A Novel Technique
M. Ibrahim¹, L. Mumford¹, R. Hogg¹, R. Johnson¹, M. Pearson², J. Forsythe³, C. Callaghan⁴
¹Statistics and Clinical Studies, NHS Blood and Transplant, Bristol, United Kingdom, ²Winton Centre for Risk Evidence and Communication, Cambridge, United Kingdom, ³NHS Blood and Transplant, Bristol, United Kingdom, ⁴Renal, Guy's and St Thomas' NHS Trust, London, United Kingdom
*Purpose: Novel methods of data analysis and communication are needed to aid clinician and patient understanding of clinical outcomes. We aimed to demonstrate patient outcomes…
2020 American Transplant Congress
Successful Tacrolimus Withdrawal in Kidney Transplant Recipients Unleashes a Peripheral Blood Transcriptional and Functional Signature Resembling Exhaustion
P. Cravedi, M. Fribourg, S. Harztell, L. Anderson, P. Heeger
Icahn School of Medicine at Mount Sinai, New York, NY
*Purpose: Tacrolimus (Tac) is an effective anti-rejection drug in kidney transplant recipients (KTR), but its off-target effects make withdrawal desirable. Studies indicate that Tac can…
2020 American Transplant Congress
Benefits of Normothermia Regional Perfusion (NRP), Hypothermic Machine Perfusion (HMP) and Short Cold Ischemia Time (CIT) for Kidney Transplants with Controlled Donation after Circulatory Death (cDCD)
E. Savoye¹, C. Legeai¹, J. Branchereau², S. Gay³, S. Drouin⁴, F. Gaudez⁵, B. Veber⁶, J. Venhard⁷, G. Cheisson⁸, T. Kerforne⁹, O. Bastien¹, C. Antoine¹
¹Agence de la Biomedecine, La Plaine Saint Denis, France, ²CHU Nantes, Nantes, France, ³CH Annecy, Annecy, France, ⁴CHU Pitié Salpetriere, Paris, France, ⁵CHU Saint Louis, Paris, France, ⁶CHU Rouen, Rouen, France, ⁷CHU Tours, Tours, France, ⁸CHU Kremlin-Bicetre, Kremlin-Bicetre, France, ⁹CHU Poitiers, Poitiers, France
*Purpose: cDCD are considered as extended criteria donors with poorer kidney transplant outcomes and high delayed graft function (DGF) rate. We built a French national…
2020 American Transplant Congress
Reduced Dose Valganciclovir is Effective for CMV Prevention without Excess Breakthrough or Resistance in Kidney Transplantation
M. Luu¹, P. Klem¹, B. Crowther¹, M. Abidi², M. Miller¹, K. Schoeppler¹, S. Davis²
¹Pharmacy, University of Colorado Hospital, Aurora, CO, ²Medicine, University of Colorado, Aurora, CO
*Purpose: Reduced dose valganciclovir (VGC) (450 mg daily) may be a useful alternative to full dose VGC for cytomegalovirus (CMV) prophylaxis due to drug cost…
2020 American Transplant Congress
Migration of Passenger Leukocytes During Ex Vivo Warm Perfusion
L. Brasile¹, B. Stubenitsky²
¹Research and Development, BREONICS Inc., Watervliet, NY, ²Plastic, Reconstructive & Aesthetic Surgery, St. Antonius Hospital, Utrecht, Netherlands
*Purpose: Organ transplantation is a unique immunologic situation in which donor and recipient antigen presenting cells (APCs) are present upon reperfusion. Passenger leukocytes (PL) are…
2020 American Transplant Congress
Prolonged In Vivo Perfusion of a Re-Endothelialized Human-Scale Tissue Engineered Kidney Graft
J. S. Uzarski¹, E. E. Russell¹, E. C. Beck¹, M. Holzner², V. Wadhera², D. Adamson², T. Gilbert¹, S. Florman², D. S. Davidow¹, R. Shapiro², J. Ross¹
¹Research & Development, Miromatrix Medical Inc., Eden Prairie, MN, ²Recanati/Miller Institute, Mount Sinai, New York, NY
*Purpose: Advances are desperately needed to increase the supply of transplantable kidneys for the 100,000 patients on the waiting list. Whole organ engineering is one…
2020 American Transplant Congress
Peak DSA Levels Pre-Transplant but Not at Transplant Predict Graft Survival
A. Y. Choi¹, D. Olaso¹, T. Risoli Jr², M. Kuchibhatla², Z. Fitch³, R. Schmitz³, P. M. Schroder³, A. Jackson³, M. Manook³, J. Yoon³, A. B. Farris⁴, J. Kwun³, S. J. Knechtle³
¹Duke University School of Medicine, Durham, NC, ²Duke Biostatistics, Epidemiology, and Research Design Core, Duke University, Durham, NC, ³Department of Surgery, Duke University Medical Center, Durham, NC, ⁴Department of Pathology, Emory University Hospital, Atlanta, GA
*Purpose: Immunization to major histocompatibility complex (MHC) antigens is a barrier in kidney transplantation (KTx) due to higher risk of antibody-mediated rejection (AMR) and graft…
2020 American Transplant Congress
Low-Dose Rabbit Antithymocyte Globulin Induction in Elderly Kidney Transplant Recipients at High Immunologic Risk is Safe and May Prevent Excess Rejection
E. Sartain¹, B. Nettles¹, B. Crowther¹, P. Klem¹, K. Schwarz¹, S. Davis²
¹University of Colorado Hospital, Aurora, CO, ²University of Colorado School of Medicine, Aurora, CO
*Purpose: Patients aged ≥65 years are a growing segment of kidney transplant recipients (KTRs). Consensus on induction immunosuppression in this population is unclear given higher…
2020 American Transplant Congress
Kidney Paired Donation in Brazil
J. Bastos¹, M. Mankowski², S. Gentry³, A. Massie⁴, C. Bisi¹, C. Duarte¹, V. Colares¹, D. Segev⁴, G. Ferreira¹
¹Transplant, Santa Casa de Misericordia de Juiz de Fora, Juiz de Fora, Brazil, ²King Abdullah University of Science and Technology, Thuwal, Saudi Arabia, ³US Naval Academy, Annapolis, MD, ⁴JHU, Baltimore, MD
*Purpose: It is estimated that up to 30% of potential living donor/recipient pairs are unable to proceed to living donor kidney transplantation (LDKT) for immunological…
2020 American Transplant Congress
Would You Rather Receive a High KDPI SCD Kidney or a Lower KDPI ECD Kidney?
V. Gurram, D. Harriman, A. Farney, J. Rogers, G. Orlando, A. Reeves-Daniel, A. Mena-Gutierrez, C. Jay, R. Stratta
Abdominal Transplant Surgery, Wake Forest Baptist Health, Winston Salem, NC
*Purpose: The study purpose was to review our kidney transplant (KT) experience with emphasis placed on outcomes in patients receiving kidneys that were “discordant” within…