Articles tagged "Kidney transplantation"

2020 American Transplant Congress
Enough Initial Tacrolimus Blood Concentration is Crucial Even with Additional Everolimus in Corticosteroid Early Withdrawal Regimen for Kidney Transplant Recipients
H. Sasaki¹, T. Tanabe¹, H. Higuchi¹, T. Tsujimoto², H. Harada¹
¹Kidney Transplant Surgery, Sapporo City General Hospital, Sapporo, Japan, ²Pharmacy, Sapporo City General Hospital, Sapporo, Japan
*Purpose: Everolimus (EVR) in combination with low-dose calcineurin inhibitor has been demonstrated in clinical trials to have comparable efficacy in low immunological risk kidney transplant…
2020 American Transplant Congress
Prevalence of Primary Aldosteronism in Kidney Transplant Recipients: A Cross-Sectional Study
N. Garg, C. D. Votruba, F. Aziz, S. Parajuli, M. Mohamed, A. Djamali, D. A. Mandelbrot
University of Wisconsin-Madison, Madison, WI
*Purpose: The prevalence of primary aldosteronism (PA) in the general hypertensive (HTN) population is more than 5%, and substantially higher at 20% in certain high-risk…
2020 American Transplant Congress
Use of Angiotensin Converting Enzyme Inhibitors and Angiotensin II Receptor Blockers Therapy Prior to Kidney Transplantation Does Not Impact Recovery of Function
G. R. Bohan¹, J. Trofe-Clark¹, T. Fallah¹, M. Norris¹, R. D. Bloom², D. Sawinski², G. Malat¹
¹Pharmacy, Hosp of Univ of Pennsylvania, Philadelphia, PA, ²Renal Div, Univ of Pennsylvania, Philadelphia, PA
*Purpose: The impact of chronically administered medications for renin-angiotensin-aldosterone blockade (e.g. ACE-I, ARB), taken prior to kidney transplant (KTx), on immediate allograft function is unknown.*Methods:…
2020 American Transplant Congress
Does Antibiotic Prophylaxis at Ureteral Stent Removal Reduce Urinary Tract Infections in Kidney Transplant Recipients?
M. Tarokh¹, B. Frainey², M. Fascelli³, D. Goldfarb¹, A. Wee³, M. Eltemamy³
¹Kidney Transplant Surgery, Cleveland Clinic, Cleveland, OH, ²Glickman Urological and Kidney Institute, Urology, Cleveland Clinic, Cleveland, OH, ³Department of Urology, Glickman Urological and Kidney Institute, Cleveland Clinic, Cleveland, OH
*Purpose: Ureteral stents are commonly placed during kidney transplantation (KT). Urinary tract infections (UTI) are a common risk factor after KT and can have detrimental…
2020 American Transplant Congress
Belatacept Based Early Steroid Withdrawal Regimens: Differential Responses in African Americans and Non-African Americans
N. Wilson¹, A. R. Shields², A. L. Christianson¹, S. Tremblay¹, D. Kaufman³, A. Wiseman⁴, J. P. Leone⁵, P. West-Thielke⁶, A. J. Matas⁷, R. R. Alloway¹, E. S. Woodle¹
¹U Cincinnati, Cincinnati, OH, ²The Christ Hospital, Cincinnati, OH, ³U Wisconsin, Madison, WI, ⁴U Colorado, Denver, CO, ⁵Tampa General, Tampa, FL, ⁶U Illinois Chicago, Chicago, IL, ⁷U Minnesota, Minneapolis, MN
*Purpose: Racial disparities in outcomes of kidney transplant recipients (KTxR) are well-described for early steroid withdrawal (ESW) under calcineurin inhibitor (CNI)-based regimens, however little data…
2020 American Transplant Congress
Src Induces Endothelial-to-Mesenchymal Transition and Renal Allograft Fibrosis via Promoting WNT/β-catenin Pathway
W. Zijie, Z. Gui, M. Zheng, Z. Han, J. Tao, H. Chen, L. Sun, X. Ju, R. Tan, M. Gu
Jiangsu Province Hospital, Nanjing, China
*Purpose: Endothelial-to-mesenchymal(EndMT)is recognized as an important source of myofibroblasts contributing to the pathogenesis of allograft interstitial fibrosis in our previous studies. Increased proto-oncogene tyrosine-protein kinase…
2020 American Transplant Congress
Effects of Kidney Transplantation on Cystogenesis in Kidneys Procured from a Deceased Donor with Autosomal Dominant Polycystic Kidney Disease
M. C. Chumley¹, H. Kim², D. M. Williams³, V. Kumar³, M. Mrug³
¹University of Alabama at Birmingham, Birmingham, AL, ²Radiology, University of Alabama at Birmingham, Birmingham, AL, ³Nephrology, University of Alabama at Birmingham, Birmingham, AL
*Purpose: Autosomal Dominant Polycystic Kidney Disease (ADPKD) patients are not routinely considered as kidney donors for renal transplantation. This is partially due to a concern…
2020 American Transplant Congress
Low Mycophenolic Acid Levels are Associated with More Inflammation on 1 Year Protocol Biopsies and Lower Graft Survival in Kidney Transplant Recipients
J. Huskey, G. Mour, M. Ryan, S. Nair, M. Smith, R. Heilman
Mayo Clinic Arizona, Phoenix, AZ
*Purpose: Data is limited on the association of Mycophenolic Acid (MPA) concentration on protocol kidney transplant biopsies. Our aim is to compare clinical outcomes and…
2020 American Transplant Congress
Validation of PROMIS Computer Adaptive Testing (CAT) Sleep Disturbance Item Bank in Kidney Transplant Recipients
J. Hussain¹, G. Chawla¹, N. Ullah¹, H. Rafiqzad¹, S. J. Bartlett², M. Li³, D. Howell⁴, J. D. Peipert⁵, M. Novak⁶, I. Mucsi¹
¹Multi-Organ Transplant Program, University Health Network, Toronto, ON, Canada, ²Centre for Health Outcomes Research, McGill University, Montreal, QC, Canada, ³Department of Supportive Care, Princess Margaret Hospital, Toronto, ON, Canada, ⁴Princess Margaret Cancer Centre, Faculty of Nursing, University of Toronto, Toronto, ON, Canada, ⁵Department of Medical Social Sciences, Feinberg School of Medicine, Northwestern University, Chicago, IL, ⁶Centre for Mental Health, University Health Network, Toronto, ON, Canada
*Purpose: To assess the reliability and validity of the PROMIS Sleep Disturbance Item Bank using the Insomnia Severity Index as the primary legacy instrument in…
2020 American Transplant Congress
Bone Marrow Plasma Cell Heterogeneity Drives Resistance of Proteasome Inhibitor Therapy
C. M. Castro-Rojas¹, S. Tremblay², J. Driscoll³, K. Roskin⁴, R. R. Alloway³, E. Woodle², D. A. Hildeman¹
¹Immunobiology, Cincinnati Children's Hospital, Cincinnati, OH, ²Surgery, University of Cincinnati College of Medicine, Cincinnati, OH, ³Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, OH, ⁴Biomedical Informatics, Cincinnati Children's Hospital, Cincinnati, OH
*Purpose: Patients sensitized to HLA antigens by prior transplantation, pregnancy or blood transfusion may have markedly prolonged waiting times for transplant. Moreover, once transplanted, the…