Articles tagged "Kidney transplantation"

2020 American Transplant Congress
Effects of Kidney Transplantation on Cystogenesis in Kidneys Procured from a Deceased Donor with Autosomal Dominant Polycystic Kidney Disease
M. C. Chumley¹, H. Kim², D. M. Williams³, V. Kumar³, M. Mrug³
¹University of Alabama at Birmingham, Birmingham, AL, ²Radiology, University of Alabama at Birmingham, Birmingham, AL, ³Nephrology, University of Alabama at Birmingham, Birmingham, AL
*Purpose: Autosomal Dominant Polycystic Kidney Disease (ADPKD) patients are not routinely considered as kidney donors for renal transplantation. This is partially due to a concern…
2020 American Transplant Congress
Low Mycophenolic Acid Levels are Associated with More Inflammation on 1 Year Protocol Biopsies and Lower Graft Survival in Kidney Transplant Recipients
J. Huskey, G. Mour, M. Ryan, S. Nair, M. Smith, R. Heilman
Mayo Clinic Arizona, Phoenix, AZ
*Purpose: Data is limited on the association of Mycophenolic Acid (MPA) concentration on protocol kidney transplant biopsies. Our aim is to compare clinical outcomes and…
2020 American Transplant Congress
Validation of PROMIS Computer Adaptive Testing (CAT) Sleep Disturbance Item Bank in Kidney Transplant Recipients
J. Hussain¹, G. Chawla¹, N. Ullah¹, H. Rafiqzad¹, S. J. Bartlett², M. Li³, D. Howell⁴, J. D. Peipert⁵, M. Novak⁶, I. Mucsi¹
¹Multi-Organ Transplant Program, University Health Network, Toronto, ON, Canada, ²Centre for Health Outcomes Research, McGill University, Montreal, QC, Canada, ³Department of Supportive Care, Princess Margaret Hospital, Toronto, ON, Canada, ⁴Princess Margaret Cancer Centre, Faculty of Nursing, University of Toronto, Toronto, ON, Canada, ⁵Department of Medical Social Sciences, Feinberg School of Medicine, Northwestern University, Chicago, IL, ⁶Centre for Mental Health, University Health Network, Toronto, ON, Canada
*Purpose: To assess the reliability and validity of the PROMIS Sleep Disturbance Item Bank using the Insomnia Severity Index as the primary legacy instrument in…
2020 American Transplant Congress
Bone Marrow Plasma Cell Heterogeneity Drives Resistance of Proteasome Inhibitor Therapy
C. M. Castro-Rojas¹, S. Tremblay², J. Driscoll³, K. Roskin⁴, R. R. Alloway³, E. Woodle², D. A. Hildeman¹
¹Immunobiology, Cincinnati Children's Hospital, Cincinnati, OH, ²Surgery, University of Cincinnati College of Medicine, Cincinnati, OH, ³Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, OH, ⁴Biomedical Informatics, Cincinnati Children's Hospital, Cincinnati, OH
*Purpose: Patients sensitized to HLA antigens by prior transplantation, pregnancy or blood transfusion may have markedly prolonged waiting times for transplant. Moreover, once transplanted, the…
2020 American Transplant Congress
Characteristics of Early BK Viremia after Renal Transplantation at an Urban Academic Medical Center
K. Kurzweil, K. Lamartina, K. Svaflarska, D. Kutrzuba, N. Fayyaz, O. Piatek, P. West-Thielke, Z. Hajjiri, I. Tzvetanov, E. Benedetti, A. Lichvar
University of Illinois at Chicago, Chicago, IL
*Purpose: BK viremia (BKV) is a deleterious complication after renal transplantation that can compromise allograft function. Centers face the challenge of identifying at-risk patients and…
2020 American Transplant Congress
Zoledronate Induced AKI with Nephrotic Range Proteinuria in a Transplant Kidney
S. Reddy, H. Khamash
Nephrology, Mayo Clinic, Phoenix, AZ
*Purpose: An unusual presentation of acute kidney injury with nephrotic range proteinuria following zoledronate in a normal functioning transplant kidney.*Methods: 61-year-old lady with history of…
2020 American Transplant Congress
Caspase-1 Knockout Mice Have Increased Survival after Cold Ischemia in a Murine Kidney Transplant Model
S. Jain¹, R. Plenter², T. Nydam², A. Jani¹
¹Renal, University of Colorado, Aurora, CO, ²Transplant Microsurgery Program, University of Colorado, Aurora, CO
*Purpose: Prolonged cold ischemia (CI) is a known risk factor for acute kidney injury (AKI) after kidney transplantation. However, the mechanism by which CI leads…
2020 American Transplant Congress
A Novel Polymer Product, APP-103, Reduces IRI-Induced Damage and Promotes Functional Improvement in Syngeneic Models of Renal Transplantation
K. Minami¹, S. Bae², H. Uehara¹, J. Iske¹, J. Reder³, H. Azuma⁴, A. Weins¹, E. Van Keuren⁵, B. Houser³, A. El-Khal¹, P. Kang², S. Tullius¹
¹Brigham and Women's Hospital, Boston, MA, ²Beth Israel Deaconess Medical Center, Boston, MA, ³Celdara Medical, Lebanon, NH, ⁴Osaka Medical College, Osaka, Japan, ⁵Georgetown University, Washington DC, DC
*Purpose: Our data introduce APP-103 as a novel, non-toxic and site-activating therapeutic approach that effectively ameliorates the consequences of ischemia/reperfusion injury in solid organ transplantation.*Methods:…
2020 American Transplant Congress
Patient-Reported Outcomes in a Prospective Multicenter Trial of Belatacept-Based CNI- and Corticosteroid-Free Immunosuppression Regimens in Kidney Transplantation: A Prospective Analysis Across Two Years
J. M. Rohan¹, J. Leone², E. Woodle³, D. Kaufman⁴, A. Shields⁵, A. Wiseman⁶, A. Matas⁷, P. West-Thielke⁸, E. King⁵, R. Alloway³
¹Pediatrics, Children's Hospital of Richmond at Virginia Commonwealth University, Richmond, VA, ²Tampa General, Tampa, FL, ³University of Cincinnati, Cincinnati, OH, ⁴U Wisconsin, Madison, WI, ⁵U Cincinnati, Cincinnati, OH, ⁶U Colorado, Denver, CO, ⁷U Minnesota, Minneapolis, MN, ⁸UIC, Chicago, IL
*Purpose: Previous trials have not examined 2-year longitudinal differences in patient-reported outcomes (PRO) between belatacept (BELA)- and tacrolimus (TAC)-based therapies in adult kidney transplant (KTx)…
2020 American Transplant Congress
Kidney Paired Donation Outcomes among High PRA Recipients
A. Thomas¹, A. Shaffer², M. Henderson², D. Segev²
¹University of North Carolina, Chapel Hill, NC, ²Johns Hopkins, Baltimore, MD
*Purpose: Kidney paired donation (KPD) accounts for an increasing amount of living donor transplants in the US. Previous studies have shown equivalent outcomes between transplants…