Articles tagged "Kidney transplantation"

2020 American Transplant Congress
Gene Expression Signatures Associated with Antibody-Mediated Rejection (ABMR) in Renal Allograft Biopsies (Bx) Are Beneficial to Clarifying ABMR Activity in Ambivalent Cases
H. Zhang¹, C. C. Nast², N. Ammerman³, A. A. Vo³, I. Gallegos³, M. Arevalo³, S. C. Jordan³, M. Toyoda¹
¹Transplant Immunology Laboratory, Cedars-Sinai Medical Center, Los Angeles, CA, ²Pathology and Laboratory Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, ³Comprehensive Transplant Center, Cedars-Sinai Medical Center, Los Angeles, CA
*Purpose: “Thoroughly validated gene transcripts” in renal Bx was adopted as one of the criteria for ABMR diagnosis in the latest Banff classification. Here, we…
2020 American Transplant Congress
Pre-Renal Transplant Education and Psychosocial Evaluation Positively Impacts Post-Transplant Medication Adherence
M. Jesse¹, D. Kim¹, A. Patel¹, R. Patil¹, S. Bhavsar¹, S. Desai¹, K. Gartrelle¹, A. Eshelman¹, E. Fleagle¹, D. Nicholson¹, E. Clifton²
¹Henry Ford Health System, Detroit, MI, ²University of Michigan, Ann Arbor, MI
*Purpose: An essential element of the organ transplant evaluation process is the preparation of transplant candidates and their social supports. However, approaches to this process…
2020 American Transplant Congress
ATHENA – Patient and Allograft Outcome Differences after Kidney Transplantation – Germany vs. France
F. Thaiss¹, C. Sommerer¹, B. Suwelack¹, D. Dragun¹, I. A. Hauser¹, O. Witzke¹, C. Hugo¹, P. Schenker¹, N. Kamar², P. Merville², I. Kroeger³, M. Junge³, B. Nashan¹
¹Athena, Study Group, Germany, ²Athena, Study Group, France, ³Novartis Pharma GmbH, Nürnberg, Germany
*Purpose: In the ATHENA trial [NCT01843348], efficacy and safety of everolimus in combination with tacrolimus [EVR+TAC] or cyclosporine A [EVR+CyA] vs. TAC and mycophenolic acid…
2020 American Transplant Congress
The Impact of Cold Ischaemia Time on Living Donor Kidney Transplantation Outcomes
S. C. van de Laar¹, M. Robb², R. Hogg², V. Papalois¹, F. J. Dor¹
¹Department of Surgery & Cancer, Imperial College London, Imperial College Renal and Transplant Centre, Hammersmith Hospital, Imperial College Healthcare NHS Trust, White City, London, United Kingdom, ²NHS Blood and Transplant, Bristol, United Kingdom
*Purpose: Living donor KTx (LDKT) provides the best option for patients with end-stage kidney disease (ESKD). ESKD patients who have an incompatible living donor still…
2020 American Transplant Congress
Analysis of 1000 Protocol Kidney Biopsies: Complications, Benefits, and Predictive Potential of Prior Sensitization
M. Eslami¹, J. Patel², S. Karzai¹, D. T. Collins¹, C. Liu¹, J. Jonsson¹, R. Wali¹, J. B. Piper¹
¹Surgery, Inova Fairfax Hospital, Falls Church, VA, ²General Surgery, Pennsylvania State University, State College, PA
*Purpose: Protocol biopsy of kidney transplants can allow for early recognition of treatable findings, both immunologic and non-immunologic. This comes with the risk of biopsy…
2020 American Transplant Congress
Renal Allograft Surveillance with Allospecific T-cytotoxic Memory Cells Which Express CD154
V. Rohan, A. Alqassieh, N. Patel, K. Soliman, V. Rao
Surgery, Medical University of South Carolina, Charleston, SC
*Purpose: Allo-antigen-specific T-cytotoxic memory cells (TcM) which express CD40 ligand (CD154) in overnight lymphocyte co-culture are strongly associated with acute cellular rejection (ACR) seen in…
2020 American Transplant Congress
Optimal Recipient Selection and Surgical Complications in Dual Kidney Transplantation
S. Patel¹, S. Chang², R. Sussman³, R. Plews¹, R. Lopez-Soler⁴, D. Conti¹
¹Kidney and Pancreas Transplantation, Albany Medical Center, Albany, NY, ²Nephrology and Transplantation, University at Buffalo, Buffalo, NY, ³Center for Donation and Transplantation, Albany Medical Center, Albany, NY, ⁴Renal Transplant Program, Hines VA Medical Center, Chicago, IL
*Purpose: Kidney allocation has recently been modified to allow enhanced utilization of dual kidney transplants (DKT) to reduce organ discards. This study evaluates surgical complications…
2020 American Transplant Congress
Dual Donor-Recipient Intervention with Recombinant Human C1 Inhibitor Prevents Delayed Graft Function and Reduces Antibody-Mediated Rejection after Kidney Transplantation in Non-Human Primates
C. Blanton¹, J. Reyes¹, M. Eerhart¹, P. Chlebeck¹, M. Springer¹, Y. Ponstein², E. vanAmersfoort², J. Torrealba³, Y. Yankol¹, A. D’Alessandro¹, L. Fernandez¹
¹University of Wisconsin, Madison, WI, ²Pharming Technologies BV, Leiden, Netherlands, ³Pathology, UTSouthwestern, Dallas, TX
*Purpose: Patients with delayed graft function (DGF) are at increased risk for rejection and inferior graft survival. Complement activation during brain death and ischemia reperfusion…
2020 American Transplant Congress
Large Academic Center Experience with Treatment of Suspected/Confirmed Kidney Transplant Active Antibody Mediated Rejection
J. T. Reece¹, B. A. Steiner², V. Bhoj¹, N. Aqui¹, R. D. Bloom³, J. Trofe-Clark⁴
¹Transfusion Medicine Div, Univ of Pennsylvania, Philadelphia, PA, ²Pharmacy, Hosp of Univ of Pennsylvania, Philadelphia, PA, ³Renal Div, Univ of Pennsylvania, Philadelphia, PA, ⁴Pharmacy, Hospital of University of Pennsylvania, Philadelphia, PA
*Purpose: Therapeutic plasma exchange (TPE) and intravenous immunoglobulin (IVIG) are common active antibody mediated rejection (ABMR) treatments in kidney transplant recipients (KTRs), but with unclear…
2020 American Transplant Congress
Kidney Transplantation from Hepatitis C Infected Donors to Hepatitis C Negative Recipients: Does Organs Selection Matter?
B. Rawashdeh¹, L. Luu¹, Z. Sahli¹, E. McCracken¹, A. Doyle², K. Brayman¹, A. Agarwal¹
¹Transplant Surgery, University of Virginia, Charlottesville, VA, ²Division of Transplant Nephrology, University of Virginia, Charlottesville, VA
*Purpose: Recently, there has been a marked increase in the availability and use of kidneys from hepatitis C virus (HCV) positive deceased donors for transplantation.…