Articles tagged "Kidney transplantation"

2022 American Transplant Congress
Post Transplant Virologic Outcomes in DCD Kidney Transplant Recipients Treated with Thymoglobulin Induction Immunosuppression and Maintenance Belatacept vs Calcineurin Inhibitor Therapy
T. Engebretsen¹, M. Kueht¹, A. Lea², M. Mujtaba³
¹Abdominal Transplant Surgery, University of Texas Medical Branch, Galveston, TX, ²Infectious Disease, University of Texas Medical Branch, Galveston, TX, ³Nephrology, University of Texas Medical Branch, Galveston, TX
*Purpose: Belatacept is an inhibitor of the T-Cell costimulatory pathway that can be used in recipients of Donation after Circulatory Death (DCD) where the intended…
2022 American Transplant Congress
Monitoring Efficacy of Tocilizumab Treatment for Chronic Antibody Mediated Rejection (cAMR) in Kidney Transplants Using Donor-Derived Cell-Free DNA (dd-cf-DNA)
J. Tang¹, A. Vo¹, E. Huang¹, X. Zhang², N. Ammerman¹, A. Peng¹, R. Najjar¹, S. Sethi¹, K. Lim¹, M. Gillespie¹, N. Badash¹, S. Jordan¹
¹Comprehensive Transplant Center, Cedars Sinai Medical Ctr, Los Angeles, CA, ²HLA Laboratory, Cedars Sinai Medical Ctr, Los Angeles, CA
*Purpose: IL-6/IL-6R have emerged as important targets for treating cAMR. Recent data show that long-term treatment can stabilize eGFR, reduce DSAs and result in a…
2022 American Transplant Congress
Utility of Genetic Testing in Kidney Transplant Evaluation
N. Singh¹, A. Palermini², A. Qamar¹, M. S. Naseer¹, H. Shokouh-Amiri¹, G. Zibari¹, D. Aultman¹, L. Beretich³, D. Luksic³, J. Gibson³, S. McCormick³, H. Tabriziani³, P. Billings³
¹Willis Knighton Physician's Network, John C. McDonald Regional Transplant Center, Shreveport, LA, ²Arkansas College of Osteopathic Medicine, Fort Smith, AR, ³Natera, Inc., Austin, TX
*Purpose: Genetic testing is an emerging tool in pre-kidney transplant (KT) evaluations for individuals with end-stage renal disease (ESRD). A known genetic etiology can inform…
2022 American Transplant Congress
PD-1 Expression on CD8+ T Cells Contributes to the Establishment of Mixed Chimerism-Based Operational Tolerance
C. J. Little, S. C. Kim, J. Fechner, J. Post, M. Winslow, D. B. Kaufman
Surgery, University of Wisconsin, Madison, WI
*Purpose: PD-1 is a T cell co-inhibitory molecule involved in T cell exhaustion and antigen specific hypo-reactivity. Given the role of PD-1 signaling in the…
2022 American Transplant Congress
Impact of the Weekend Effect on Adult and Pediatric Liver or Kidney Offer Acceptance
T. Yamamoto, M. Fruscione, A. Shah, L. Dageforde, S. Kimura, H. Yeh, N. Elias, T. Kawai, J. F. Markmann
Transplant Surgery, Massachusetts General Hospital/Harvard Medical School, Boston, MA
*Purpose: Weekends may impose resource and manpower constraints on hospitals. Studies using data from prior allocation schemas showed increased adult organ discards on weekends. We…
2022 American Transplant Congress
Dynamic Changes of Serum Soluble B Cell Activating Factor in Kidney Transplant with De Novo Donor Specific Antibody
S. Wu¹, X. Su¹, Y. Gao¹, Y. Wei¹, Q. Ye¹, M. Huang², Y. Chen¹, J. Wang¹, Q. Zhang³, Q. Fu¹, J. Li², H. Huang², B. Xu², H. Zhang¹, L. Liu², C. Wang²
¹Organ Transplant Center, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China, ²The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China, ³Charité - Universitätsmedizin Berlin, Berlin, Germany
*Purpose: De novo donor specific antibody (dnDSA) plays a crucial role in the development of antibody mediated rejection (ABMR) and is correlated to the worse…
2022 American Transplant Congress
Pretransplant Recipient TNFR2⁺T Regulatory Cell Frequency Predicts Long-Term Outcomes After Kidney Transplantation
A. Kouyoumdjian, N. Saberi, S. Negi, J. Tchervenkov, S. Paraskevas
McGill University Health Centre, Montreal, QC, Canada
*Purpose: Pre-transplant indices capable of predicting long-term renal allograft function could improve graft allocation strategies. We previously associated pretransplant frequency of Tumor Necrosis Factor Receptor…
2022 American Transplant Congress
Racial Barriers to Kidney Transplant After Listing, 2015 – 2020
W. T. McKinney¹, D. Schladt², J. Miller², T. Weaver², J. Pyke², T. Madhusoodanan³, A. K. Israni¹
¹Nephrology, Hennepin Healthcare Research Institute, Minneapolis, MN, ²Scientific Registry of Transplant Recipients, Minneapolis, MN, ³Nephrology, Hennepin Healthcare, Minneapolis, MN
*Purpose: We sought to evaluate racial disparities in access to deceased donor kidney transplant (DDKT) following changes to kidney allocation system (KAS) implemented in 2014.…
2022 American Transplant Congress
Metagenomic Next-Generation Sequencing Reveals the Profile of Viral Infections in Kidney Transplant Recipients During the Covid-19 Pandemic
X. Tian, W. Duan, C. Zhang, X. Wu, T. Yan
Henan Province People's Hospital, Zhengzhou, Henan Province, China
*Purpose: To study the clinical application of metagenomic next-generation sequencing (mNGS) in the detection of viral infections in kidney transplant recipients (KTRs) during the COVID-19…
2022 American Transplant Congress
Long-Term Follow Up of Solid Organ Transplantation Using Hepatitis C Virus Positive Donor for Hepatitis C Virus Negative Recipients
H. Sogawa¹, I. Lee², K. Okumura³, R. Bodin⁴, D. C. Wolf⁴, B. Partiula⁴, A. Dhand⁴, M. Kai⁵, S. Ohira⁵, R. Misawa¹, G. Veillette⁶, D. John¹, S. Nishida⁷, T. Diflo⁶
¹Division of Intra-abdominal Organ Transplant, Department of Surgery, Westchester Medical Center/ New York Medical College, Valhalla, NY, ²Department of Surgery, Westchester Medical Center/ New York Medical College, Valhalla, NY, ³Surgery, Westchester Medical Center/New York Medical College, Valhalla, NY, ⁴Department of Medicine, Westchester Medical Center/ New York Medical College, Valhalla, NY, ⁵Cardiothoracic Surgery, Westchester Medical Center/ New York Medical College, Valhalla, NY, ⁶Westchester Medical Center, Valhalla, NY, ⁷Westchester Medical Center/ New York Medical College, Valhalla, NY
*Purpose: To determine the effects of transplanting an HCV + solid organ to an uninfected patient who is on the transplant waiting list. Outcomes include…