2020 American Transplant Congress
Outcomes of Kidney Transplantation in Patients with Sickle Cell Disease and Trait
Department of Medicine, Thomas Jefferson University Hospital, Philadelphia, PA
*Purpose: Sickle cell disease (SCD) is an autosomal recessive hematological disorder caused by point mutation (substitution of valine for glutamine). There are about 100,000 patients…2020 American Transplant Congress
Synergistic Impact of Obesity and Pre-sensitization in Kidney Transplant Recipients on the Long Term Allograft Survival
*Purpose: Obesity is emerging as important health problems worldwide. In recent years, with the development of desensitization therapy, successful kidney transplantation has been performed even…2020 American Transplant Congress
Anatomy of a Conversation: Assessing ESRD Patients’ Transplant-Related Communication
Social and Behavioral Sciences, Temple University, Philadelphia, PA
*Purpose: Live Donor and Deceased Donor Kidney Transplantation (LDKT and DDKT) confer meaningful survival, and quality of life benefits to patients with End Stage Renal…2020 American Transplant Congress
Estimating Alloantibody Levels in Highly-Sensitized Renal Allograft Candidates Using Serial Dilutions
1Northwestern University, Chicago, IL, 2Mayo Clinic, Rochester, MN
*Purpose: Despite the new Kidney Allocation System and Kidney Paired Donation, renal allograft candidates with a >99.9% cPRA still have extremely low rates of transplantation…2020 American Transplant Congress
The Clinical Impact of HCV D+/r- Kidney Transplantation
1Lahey Clinic, Burlington, MA, 2Transplantation, Lahey Clinic, Burlington, MA
*Purpose: Transplantation of hepatitis C (HCV) positive organs into HCV negative recipients raises concerns regarding potential for infections unresponsive to DAAs. In September 2018, we…2020 American Transplant Congress
The Histological Picture of Indication Biopsies in the First Days after Renal Transplantation
Microbiology, Immunology and Transplantation, KU Leuven, Leuven, Belgium
*Purpose: In preclinical studies, ischemia reperfusion injury and older donor age are associated with renal inflammation in the early phase after transplantation. In human kidney…2020 American Transplant Congress
Noninvasive Detection of Subclinical Rejection in Urine RNA
*Purpose: Subclinical rejection may lead to long-term graft injury and can currently only be detected by repeated biopsies. A noninvasive method is needed to monitor…2020 American Transplant Congress
HLA Molecular Mismatch Analysis in Recipients of Kidney Plus Hematopoietic Stem/Facilitating Cell Transplant Tolerance Induction Protocol
1NU, Chicago, IL, 2Cambridge, Cambridge, United Kingdom, 3U of Louisville, Lousville, KY
*Purpose: To evaluate the potential role of HLA molecular mismatch (MM) analysis in predicting outcomes in a cohort of HLA-mismatched, related and unrelated recipients of…2020 American Transplant Congress
The Association between Alloimmunity and De Novo Glomerulonephritis Post Kidney Transplantation
Columbia University Medical Center, New York, NY
*Purpose: In contrast to recurrent immune complex-mediated glomerulonephritis (ICGN), de novo ICGN of the allograft is poorly characterized. We hypothesize that alloimmunity results in immune-complex…2020 American Transplant Congress
Missing Self Increases the Incidence of Microvascular Inflammation after Kidney Transplantation
*Purpose: Anti-HLA donor-specific antibodies (HLA-DSA) are often absent in serum of kidney allograft recipients with biopsies demonstrating microvascular inflammation (MVI), the histological hallmark of antibody-mediated…
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