Articles tagged "Kidney transplantation"

2020 American Transplant Congress
Building Kidneys from Stem Cells for Transplantation
I. M. Rogers¹, J. Whiteley², T. Chow², T. Bongolan², L. Mazilescu³, P. Urbanellis³, S. Ganesh³, M. Selzner³
¹Physiology, University of Toronto, Toronto, ON, Canada, ²LTRI-Sinai Health System, Toronto, ON, Canada, ³MOTU, University Health Network, Toronto, ON, Canada
*Purpose: Our vision is to build a human kidney by combining human stem cells with porcine kidney extracellular matrix.*Methods: Kidneys were decellularized followed by repopulation…
2020 American Transplant Congress
Clinical Outcomes Associated with Long-Term Exposure to Airborne Particulate Pollution in Kidney Transplant Recipients
Y. Kim¹, J. Lee²
¹Internal Medicine, Seoul National University Hospital, Seoul, Korea, Republic of, ²Internal Medicine, Seoul National University Boramae Hospital, Seoul, Korea, Republic of
*Purpose: We aimed to evaluate the relationship of 10-μm particulate matter (PM10) with the risk of graft failure, mortality, and decline of graft function in…
2020 American Transplant Congress
Single Cell RNA Sequencing of Normal Kidney Allograft Surveillance Biopsies Show Evidence of Dynamic Glomerular Endothelial Cell Activation
A. S. Naik, R. Menon, E. Otto, C. C. Berthier, E. Farkash, S. P. Norman, M. Kretzler
University of Michigan, Ann Arbor, MI
*Purpose: Indication and surveillance biopsy studies show a high prevalence of post kidney transplant (KT) glomerular disease (ElZoghby 2009,Stegall 2017) that cannot be explained by…
2020 American Transplant Congress
Belatacept-Based Regimens: Induction and Recipient Gender Influence Outcomes
N. Wilson¹, A. R. Shields², A. Wiseman³, A. L. Christianson¹, S. Tremblay¹, D. Kaufman⁴, J. P. Leone⁵, A. J. Matas⁶, P. West-Thielke⁷, R. R. Alloway¹, E. S. Woodle¹
¹U Cincinnati, Cincinnati, OH, ²The Christ Hospital, Cincinnati, OH, ³U Colorado, Denver, CO, ⁴U Wisconsin, Madison, WI, ⁵Tampa General, Tampa, FL, ⁶U Minnesota, Minneapolis, MN, ⁷U Illinois Chicago, Chicago, IL
*Purpose: Renal function and adverse event profiles in kidney transplant (KTx) patients under belatacept (BELA) based immunosuppression are significantly improved over calcineurin inhibitors, however BELA…
2020 American Transplant Congress
Variability in Educational Content about Kidney Paired Donation at 68 National Kidney Registry-Affiliated Centers
A. D. Waterman¹, O. N. Ranasinghe¹, E. H. Wood¹, J. L. Beaumont², S. McGuire³, K. Miller⁴, V. Chipman⁵, J. Sinacore⁶, M. Cooper⁷
¹Division of Nephrology, David Geffen School of Medicine, Los Angeles, CA, ²Terasaki Research Institute, Los Angeles, CA, ³UCLA Kidney and Pancreas Transplant Programs, Los Angeles, CA, ⁴UW Health, Madison, WI, ⁵UCSF Medical Center, San Francisco, CA, ⁶National Kidney Registry, Babylon, NY, ⁷Medstar Georgetown Transplant Institute, Washington, DC
*Purpose: Equipping patients and donors with in-depth information about kidney paired donation (KPD) processes, risks, benefits, and protections is necessary for informed decision-making and comfort.…
2020 American Transplant Congress
Predicting Kidney Allograft Discard: The Kidney Discard Risk Index
M. B. Price, M. Joshi, T. Zhang, J. Vierling, T. Galvan, R. Cotton, C. O'Mahony, J. Goss, A. Rana
Michael E. DeBakey Department of Surgery, Division of Abdominal Transplantation, Baylor College of Medicine, Houston, TX
*Purpose: The disparity between the supply and demand for kidney allografts is exacerbated by an 18.9% discard rate. It is our aim to determine predictors…
2020 American Transplant Congress
Comparative Review of Adult Kidney Transplant Medicare Cost Report Reimbursement in U. S. Transplant Hospitals
E. Zavala¹, J. Rogers², S. Karp¹
¹Vanderbilt University Medical Center, Nashville, TN, ²Transplant Management Group, San Diego, CA
*Purpose: Medicare organ acquisition reimbursement (MOAR) from the Medicare Cost Report (MCR) includes but is not limited to costs associated with candidate evaluation, maintenance on…
2020 American Transplant Congress
Single Cell Profiling of PBMC Identifies Immune Populations Associated with High Risk of Early Acute Rejection
W. Zhang, S. Farouk, Z. Sun, W. Huang, Z. Yi, J. Fu, C. Wei, M. Fribourg-Casajuana, C. He, P. Cravedi, B. Murphy
Icahn School of Medicine at Mount Sinai, New York, NY
*Purpose: Our previous transcriptomic analysis of pre-transplant peripheral blood revealed a 23-gene set predictive of early acute rejection (EAR) post kidney transplant (JCI Insight, 2019).…
2020 American Transplant Congress
Activation of the ICOS/ICOS-Ligand Pathway in Antibody-Mediated Kidney Graft Rejection
V. Cantaluppi¹, G. Merlotti¹, M. Quaglia¹, G. Rosso¹, N. Clemente¹, G. Cappellano¹, A. Chiocchetti¹, G. Castellano², U. Dianzani¹, G. Camussi³
¹Nephrology and Kidney Transplantation Unit, University of Piemonte Orientale (UPO), Novara, Italy, ²Nephrology, Dialysis and Kidney Transplantation Unit, University of Foggia, Foggia, Italy, ³Department of Medical Sciences, University of Torino, Torino, Italy
*Purpose: The costimulatory pathway ICOS/ICOS-Ligand may represent a new therapeutic target in antibody-mediated rejection (ABMR), the major cause of long term kidney graft failure. The…
2020 American Transplant Congress
Impact of Non-Active Hepatitis B after Renal Transplantation
M. G. Naik, W. Duettmann, M. Mayrdorfer, F. Halleck, K. Budde, M. Duerr
Medical Department, Division of Nephrology and Internal Intensive Care Medicine, Charité, Berlin, Germany
*Purpose: Hepatitis B (HB) is more frequent in dialysis patients (pts) than in the general population. Patient and graft survival in pts with chronic HB…