2020 American Transplant Congress
Immunohistochemical and Molecular Detection of NK Cells in Kidney Allografts with Antibody Mediated Rejection
Pathology, University of Michigan, Ann Arbor, MI
*Purpose: Molecular signatures specific to Natural Killer (NK) cells are closely associated with antibody mediated rejection (AMR) in transplant biopsies. We have developed an immunohistochemical…2020 American Transplant Congress
Autoimmune Responses to DNA Topoisomerase I Exacerbate Renal Allograft Injury
Inflammation and Immunity, Cleveland Clinic, Cleveland, OH
*Purpose: Multiple clinical and pre-clinical studies describe correlations between de novo autoimmune responses and poor transplant outcome. We have previously reported that following renal transplantation,…2020 American Transplant Congress
Does Hope for a Better Future or Fear of Death Motivate Kidney Patients More? A Decisional Balance Exploration of Motivation to Pursue Living Donor Kidney Transplant
*Purpose: We assessed whether the importance attributed to “living a longer life with transplant” versus “fear of death during transplant surgery” by kidney transplant (KT)…2020 American Transplant Congress
Survival Benefit of Accepting Kidneys from Older Donation after Cardiac Death Donors
*Purpose: Kidneys from older donation after cardiac death (DCD) donors are less likely to be transplanted due to concerns about inferior post-transplant survival. But candidates…2020 American Transplant Congress
Donor Intervention and Recipient Treatment with Recombinant Human C1 Inhibitor Prevents Delayed Graft Function in a Non-Human Primate Model of Kidney Transplantation
*Purpose: There is currently no FDA-approved treatment to prevent delayed graft function (DGF) in kidney transplantation. We have shown that donor or recipient treatment with…2020 American Transplant Congress
Survival Benefit of Accepting Kidneys with Acute Kidney Injury
Department of Surgery, Johns Hopkins School of Medicine, Baltimore, MD
*Purpose: Accepting an acute kidney injury kidney (AKI) or remaining on the waitlist to receive a better offer is under discussed due to the worse…2020 American Transplant Congress
Opioid Utilization Post-Operatively in Kidney Transplantation
*Purpose: The Centers for Disease Control and Prevention has reported prescription opioid involved deaths increasing since the 1990s. National efforts are being made to fight…2020 American Transplant Congress
Prospective Donor-Specific CellUlar Alloresponse Assessment for Immunosuppression MinImization in De Novo Renal Transplantation: Results of a Randomized Controlled Biomarker-Guided Trial
*Purpose: Early immunosuppression minimization is associated with higher rates of BPAR. Preformed donor-specific T-cell alloreactivity (DST) assessed with an IFN-γ ELISPOT assay has shown to…2020 American Transplant Congress
High-Activity Classical and Alternative Complement Pathway Genotypes – Association with Donor-Specific Antibody-Triggered Injury and Renal Allograft Survival
*Purpose: Complement may contribute to donor-specific antibody (DSA)-triggered transplant injury. Here, we investigated whether the intrinsic strength of classical (CP) and alternative complement pathways (AP)…2020 American Transplant Congress
Kidney after Intestinal Transplantation: A Comparison with Combined Kidney with Intestinal Transplant. A UNOS Database Analysis
Indiana University School of Medicine, Indianapolis, IN
*Purpose: There is limited data on outcomes for patients receiving a isolated kidney transplant (KAIT) after any prior Multi-organ or Isolated Intestinal transplant (IT). We…
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