Articles tagged "Kidney transplantation"

2020 American Transplant Congress
Osmotic Nephropathy from a Non-Sucrose Based IVIG
S. Reddy, L. Kodali
Nephrology, Mayo Clinic, Phoenix, AZ
*Purpose: We present a case of acute renal failure and hyperkalemia due to osmotic nephropathy from a non-sucrose based IVIG infusion therapy.*Methods: A 67-year-old man…
2020 American Transplant Congress
A Single Center Experience of Atypical Hemolytic Uremic Syndrome Post Solid Organ Transplantation – “Benign Genetic Variants: Perhaps No More”
M. Khan, M. Anand, T. Kaur, S. Bumb, S. Shah, A. Govil, B. G. Abu Jawdeh
University of Cincinnati, Cincinnati, OH
*Purpose: Atypical hemolytic uremic syndrome (aHUS) is a genetic-based thrombotic microangiopathy (TMA) that is mediated by the activation of the alternative complement pathway. Heterozygous deletion…
2020 American Transplant Congress
Renal Immunoproteasome Function: A Possible Cause for Macrophage Associated Organ Damage During Renal Transplantation?
N. Parajuli, A. Khakurel
University of Arkansas for Medical Sciences, Little Rock, AR
*Purpose: A major hurdle in the field of renal transplantation is the shortage of suitable donor kidneys. Renal transplantation using living-donor organs perform better when…
2020 American Transplant Congress
Anti-Thymocyte Globulins Induced Immunomodulatory Effect and Increased Regulatory T Cell in a In Vitro Model of Allogeneic Cell Coculture
M. Colladant¹, J. Lion², P. Saas³, S. Perruche³, D. Ducloux¹, N. Mooney², J. Bamoulid¹
¹Nephrologie, Dialyse et Transplantation, CHU de Besançon, Besancon, France, ²Equipe INSERM: Endothelium, Inflammation et Alloreactivity INSERM UMR-S 976, Paris, France, ³INSERM U1098 RIGHT, Université de Franche-Comté EFS Bourgogne Franche-Comté, Besancon, France
*Purpose: Two types of Anti-Thymocyte Globulins (ATG) are commonly used in renal transplantation (Thymoglobuline and Grafalon) and induce severe, dose-dependent and sometimes persistent CD4+ T…
2020 American Transplant Congress
Tissue Resident Memory T Cells in Mouse Renal Transplantation
K. Abou-Daya¹, D. Zhao¹, R. Tieu¹, R. Rammal², M. Oberbarnscheidt¹, F. Lakkis¹
¹Starzl Transplantation Institute, Pittsburgh, PA, ²American University of Beirut, Beirut, Lebanon
*Purpose: The newly identified tissue resident subset of memory T cells (TRM) provides immune surveillance in the tissue and first response against infections. They are…
2020 American Transplant Congress
Development of a New Kidney Paired Donation (KPD) Program: Starting a Domino Chain with a Deceased Donor
L. Furian¹, C. Di Bella², C. Silvestre², F. Neri², F. Tuci², M. Cardillo³, E. Cozzi⁴, P. Rigotti¹
¹Kidney and Pancreas Transplantation Unit, University of Padova, Padua, Italy, ²Kidney and Pancreas Transplantation Unit, University of Padova, Italy, Italy, ³Italian National Transplant Center, Rome, Rome, Italy, ⁴Transplant Immunology Unit, Padova University-Hospital, Padua, Padua, Italy
*Purpose: The option of initiating a domino chain of living donor kidney transplants with a deceased donor (DD) has been proposed but never enforced. The…
2020 American Transplant Congress
Three Year Post Co-Stimulation Blocking Agent (Belatacept) Switch Outcomes of Kidney Transplant Patients Diagnosed with Post-Transplant Thrombotic Microangiopathy
A. Gamilla-Crudo, S. Hussain, A. Rizvi, R. Ramirez, M. Kueht, H. Stevenson-Lerner, J. Fair, M. Mujtaba
UTMB, Galveston, TX
*Purpose: Thrombotic microangiopathy (TMA) can happen after kidney transplant. It may occur de novo or as a recurrent disease. De novo is usually associated with…
2020 American Transplant Congress
The Clinical Significance of C1q+ Antibodies in Pediatric Kidney Transplant Recipients
N. Hayde¹, S. Solomon², A. Colovai¹
¹Montefiore Medical Center, Bronx, NY, ²Westchester Medical Center, Valhalla, NY
*Purpose: To evaluate the impact of denovo DSA (C1q+ vs C1q-) on graft outcomes in pediatric kidney transplant recipients.*Methods: Children transplanted between 2009 and 2016…
2020 American Transplant Congress
Uromodulin to Osteopontin Ratio in Deceased Donor Urine is Associated with Kidney Graft Outcomes
S. G. Mansour¹, C. Liu², Y. Jia², P. Reese³, I. Hall⁴, T. El-Achkar⁵, K. LaFavers⁵, W. Obeid², M. Thangamani⁶, A. Rosenberg², M. Doshi⁷, E. Akalin⁸, J. Bromberg⁹, M. Harhay¹⁰, S. Mohan¹¹, B. Schröppel¹², P. Daneshpajouhnejad², P. Singh¹³, F. Weng¹⁴, H. Thiessen-Philbrook², C. Parikh²
¹Yale, New Haven, CT, ²Johns Hopkins, Baltimore, MD, ³UPenn, Philadelphia, PA, ⁴Univ of Utah, Salt Lake City, UT, ⁵Indiana Univ, Bloomington, IN, ⁶Cornell, New York, NY, ⁷Univ of Michigan, Ann Arbor, MI, ⁸Montefiore, Bronx, NY, ⁹Univ of Maryland, College Park, MD, ¹⁰Drexel, Philadelphia, PA, ¹¹Columbia, NY, NY, ¹²Univ Hosp, Ulm, Germany, ¹³Thomas Jefferson, Philadelphia, PA, ¹⁴St. Barnabas, Livingston, NJ
*Purpose: Deceased-donor kidneys often experience extensive injury, activating adaptive and maladaptive pathways. While these adaptive and maladaptive mechanisms are initiated in donor kidneys prior to…
2020 American Transplant Congress
Your Path to Transplant Tailored Education Increases Living Donation Transplant Actions and Wait-Listing Rates: Final Randomized Controlled Trial Findings
A. Waterman¹, Y. Cui², J. L. Beaumont², J. D. Peipert³, A. Paiva⁴, M. L. Robbins⁴
¹Transplant Research and Education Center, Los Angeles, CA, ²Terasaki Research Institute, Los Angeles, CA, ³Feinberg School of Medicine, Northwestern University, Chicago, IL, ⁴Department of Psychology, University of Rhode Island, Kingston, RI
*Purpose: Tailoring education and behavior change interventions to address gaps in individual patients’ knowledge, readiness, and socio-economic challenges may help more end-stage kidney disease patients…