Articles tagged "Kidney transplantation"

2022 American Transplant Congress
Transplant Centers That Assess Frailty as Part of Clinical Practice Have Better Outcomes
X. Chen¹, Y. Liu¹, V. Thompson¹, N. M. Chu¹, E. A. King¹, J. D. Walston², J. A. Kobashigawa³, D. M. Dadhania⁴, D. L. Segev¹, M. A. McAdams-DeMarco¹
¹Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, ²Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, ³Comprehensive Transplant Center, Cedars-Sinai Medical Center, Los Angeles, CA, ⁴Division of Nephrology and Hypertension, Weill Cornell Medicine, New York, NY
*Purpose: Frailty predicts adverse post-kidney transplant (KT) outcomes, yet impacts of frailty assessments on center-level outcomes remain unclear. We tested whether transplant centers assessing frailty…
2022 American Transplant Congress
Cold Ischemia Time is More Critical for Older Donor Kidney Survival: A Machine Learning Approach
J. Kim, J. Ahn, A. Massie, D. Segev, S. Bae
Johns Hopkins, Baltimore, MD
*Purpose: Increasing utilization of kidneys from older donors is a potential solution to mitigate the organ shortage. However, older donor age is a risk factor…
2022 American Transplant Congress
Immunogenicity of a 3rd Dose of Mrna Covid-19 Vaccine in Kidney Transplant Recipients Who Failed to Respond to 2 Prior Doses
W. Werbel¹, A. Karaba¹, T. Chiang¹, T. Liang¹, A. Massie¹, M. Bettinotti¹, W. Clarke¹, N. Watson², A. Tobian¹, C. Durand¹, N. Bridges², D. Rostrosen², C. Larsen³, P. Heeger⁴, D. Segev¹
¹Johns Hopkins, Baltimore, MD, ²NIAID, Bethesda, MD, ³Emory University, Atlanta, GA, ⁴Mt. Sinai School of Medicine, New York, NY
*Purpose: Kidney transplant recipients (KTRs) have diminished immune response and protection after 2-dose mRNA COVID-19 vaccination. It is unknown if additional doses improve neutralization of…
2022 American Transplant Congress
Improving Efficiency in Kidney Distribution: A Comparison of UNet Deceased Donor Criteria to Actual Kidney Acceptance Practices
L. B. Zeiser, J. Ruck, D. Segev, A. Massie
Johns Hopkins University, Baltimore, MD
*Purpose: Efficient utilization of UNet deceased-donor criteria could help streamline kidney allocation by reducing the number of unwanted offers made to transplant centers. We compared…
2022 American Transplant Congress
Post-Kidney Transplant Body Mass Index Trajectories Are Associated with Graft Loss and Mortality
Y. Liu¹, V. Bendersky¹, X. Chen¹, M. Harhay², D. Segev¹, M. McAdams-DeMarco¹
¹Johns Hopkins University, Baltimore, MD, ²Drexel University, Philadelphia, PA
*Purpose: Early post-kidney transplantation (KT) changes in physiology, medications, and health stressors likely impact body mass index (BMI). Hence, we sought to estimate trajectories of…
2022 American Transplant Congress
Early Outcomes of Kidney Transplant Recipients from Donors with Severe Sars-cov-2 Pneumonia
M. Rosenzweig, M. Finotti, A. Gupta, S. Lee, N. Onaca, G. J. McKenna, J. Bayer, H. Fernandez, R. Ruiz, E. Martinez, A. Yango, T. Sam, C. Spak, B. Fischbach, G. Testa, A. Wall
Baylor University Medical Center, Dallas, TX
*Purpose: Transplantation of kidneys from donors with active SARS-CoV-2 infection is uncommon due to concerns about the risk of viral transmission and kidney quality. To…
2022 American Transplant Congress
Defining the Characteristics and Graft Outcomes of Kidney Transplant Recipients with Pre-Transplant Elevated Plasma Oxalate Levels
D. Khan, N. Zhang, M. Keddis
Mayo Clinic, Scottsdale, AZ
*Purpose: The objective of this study is to compare graft outcomes for patients with pre-transplant elevated plasma oxalate (Pox) compared to a matched cohort.*Methods: Kidney…
2022 American Transplant Congress
Low-Dose Aspirin is More Critical Than Statins in Preventing Transplant Renal Artery Stenosis
B. Ji, X. Tian, G. Jing, T. Yan, X. Wu, G. Cao, C. Zhang
Urology, Henan Provincial People's Hospital, Zhengzhou, China
*Purpose: To explore the clinical value of low-dose aspirin (100mg) and statins (10 ~ 20mg) in the prevention of transplant renal artery stenosis (TRAS).*Methods: A…
2022 American Transplant Congress
Reproductive Counseling in Kidney Transplant: Patient Needs and Current Practices
S. Rajagopal¹, J. Ritchie², D. Seidman³, Y. Srisengfa⁴, E. R. Perito⁵, D. Adey⁶, M. Sarkar⁷
¹Internal Medicine, Brookdale University Hospital, Brooklyn, NY, ²Obstetrics and Gynecology, St Luke's University Health Network, Bethlehem, PA, ³Obstetrics and Gynecology, University of California San Francisco, San Francisco, CA, ⁴University of California San Francisco, San Francisco, CA, ⁵Pediatric GI/Hepatology, University of California San Francisco, San Francisco, CA, ⁶Nephrology, University of California San Francisco, San Francisco, CA, ⁷GI/Hepatology, University of California San Francisco, San Francisco, CA
*Purpose: Nearly 20% of female kidney transplant (KT) recipients are reproductive-aged. Early/unplanned pregnancies post-KT increase maternal and fetal risks, though data on reproductive counseling in…
2022 American Transplant Congress
Prolonged Xeno-Kidney Graft Survival in Highly Allo-Sensitized Nonhuman Primate Using Triple-Knockout Donor Pigs with 7 Human Transgenes
M. Manook¹, D. Olaso¹, I. Anwar¹, J. Yoon¹, M. Song¹, A. B. Farris², K. Stiede³, K. Hall³, M. Youd³, S. Knechtle¹, J. Kwun¹
¹Surgery, Duke Transplant Center, Durham, NC, ²Pathology, Emory University, Atlanta, GA, ³eGenesis Inc, Cambridge, MA
*Purpose: We have previously shown using porcine kidneys from genetically modified knockout alpha 1,3-galactosyltransferase (GGTA1KO) and human decay accelerating factor transgenic (CD55Tg) pigs that compared…