Articles tagged "Kidney transplantation"

2020 American Transplant Congress
Two-Year Post-Transplant eGFR as a Surrogate Outcome of Allograft Survival in Kidney Transplant Recipients
S. Yu, E. Lee, W. Zhang, D. Segev, J. Garonzik-Wang, A. Massie
Johns Hopkins, Baltimore, MD
*Purpose: Graft failure is a major cause of morbidity and mortality in kidney transplant recipients. However, trials aimed to assess the effect of interventions on…
2020 American Transplant Congress
Missing Self Increases the Incidence of Microvascular Inflammation after Kidney Transplantation
J. Callemeyn¹, A. Senev², M. Coemans¹, E. Lerut³, B. Sprangers¹, D. Kuypers¹, A. Koenig⁴, O. Thaunat⁴, M. Emonds², M. Naesens¹
¹Microbiology, Immunology and Transplantation, KU Leuven, Leuven, Belgium, ²Histocompatibility and Immunogenetics Laboratory, Red Cross-Flanders, Mechelen, Belgium, ³Imaging and Pathology, KU Leuven, Leuven, Belgium, ⁴INSERM U1111, Université Claude Bernard Lyon I, Lyon, France
*Purpose: Anti-HLA donor-specific antibodies (HLA-DSA) are often absent in serum of kidney allograft recipients with biopsies demonstrating microvascular inflammation (MVI), the histological hallmark of antibody-mediated…
2020 American Transplant Congress
T and B Lymphocyte Dynamics after Genetically-Modified Pig-To-Baboon Kidney Xenotransplantation with an Anti-CD40mAb-Based Immunosuppressive Regimen
A. Jagdale¹, H. Iwase¹, H. Nguyen¹, T. Yamamoto¹, D. Ayares², D. Anderson¹, D. Eckhoff¹, D. Cooper¹, H. Hara¹
¹Surgery, University of Alabama at birmingham, Birmingham, AL, ²Revivicor, Blacksburg, VA, VA
*Purpose: We have evaluated recovery of T and B lymphocytes and their subsets after depletion by anti-thymocyte globulin (ATG) and an anti-CD20mAb (Rituximab), followed by…
2020 American Transplant Congress
Timing of Bariatric Surgery for Obese Kidney Transplant Candidates
R. A. Choudhury¹, D. Yoeli¹, G. Hoeltzel², H. B. Moore¹, H. Yaffe¹, K. R. Dumon³, N. N. Williams³, P. L. Abt⁴, K. D. Conzen¹, T. Pshak¹, P. T. Kennealey¹, T. L. Nydam¹
¹Department of Surgery- Division of Transplantation Surgery, University of Colorado Hospital, Aurora, CO, ²Thomas Jefferson University Hospital, Philadelphia, PA, ³Department of Surgery, University of Pennsylvania Hospital, Philadelphia, PA, ⁴Department of Surgery- Division of Transplantation Surgery, University of Pennsylvania Hospital, Philadelphia, PA
*Purpose: The high risk profile of bariatric surgery in obese end-stage-renal disease (ESRD) patients has caused many to suggest that surgery should be reserved for…
2020 American Transplant Congress
Outcomes and Health Care Utilization after Early Hospital Dismissal in Kidney Transplantation: An Analysis of 1001 Consecutive Cases
E. Calderon¹, Y. Chang², J. M. Chang¹, C. Velazco¹, E. Giorgakis¹, A. A. Moss¹, H. Khamash³, R. Heilman³, K. S. Reddy¹, A. K. Mathur¹
¹Transplant Surgery, Mayo Clinic, Phoenix, AZ, ²Kern Center for the Science of Health Care Delivery, Mayo Clinic, Phoenix, AZ, ³Department of Nephrology, Mayo Clinic, Phoenix, AZ
*Purpose: Perioperative care after kidney transplantation has improved with reduction in length of operative stay to as low as two days, but this has an…
2020 American Transplant Congress
Outcomes Analysis of Transplant Centers Performing High Volumes of Hard to Place Kidneys: An Update
D. Bahl¹, N. Mehta², Y. A. Qazi³
¹School of Medicine, St. George's University, West Indies, Grenada, ²University of California, Berkeley, Torrance, CA, ³School of Medicine, Keck Medicine of USC, Los Angeles, CA
*Purpose: Despite a growing number of patients awaiting a kidney transplant, the discard rate remains significantly high. The UNOS SRTR data now provides information on…
2020 American Transplant Congress
A Prospective Randomized Multicenter Trial (BEST Trial) of Belatacept-Based CNI- and Corticosteroid-Free Immunosuppression: Infectious Complications
P. West-Thielke¹, A. Shields², D. Kaufman³, J. Leone⁴, A. Wiseman⁵, A. Matas⁶, T. Sa⁷, E. King⁷, R. Alloway², S. Woodle²
¹University of Illinois, Chicago, IL, ²University of Cincinnati, Cincinnati, OH, ³University of Wisconsin, Madison, IL, ⁴Tampa General Hospital, Tampa, FL, ⁵University of Colorado, Aurora, CO, ⁶University of Minnesota, Minneapolis, MN, ⁷Cincinnati Children's Hospital Medical Center, Cincinnati, OH
*Purpose: The BEST Trial (Belatacept-based Early Steroid Withdrawal Trial) is a prospective, randomized, multi-center trial designed to compare two belatacept (BELA)-based calcineurin inhibitor-free (CNI), early…
2020 American Transplant Congress
Donor-Derived DCREG Infusion Prolongs Kidney Allograft Survival in Rhesus Monkeys Treated with Co-Stimulation Blockade and Calcineurin Inhibition
Y. Wang, S. Kazuki, L. Lu, A. Zahorchak, H. Dai, A. Ganoza, M. Wijkstrom, A. Humar, M. Ezzelarab, A. Thomson
Thomas E. Starzl Transplantation Institute, Pittsburgh, PA
*Purpose: We have shown previously that pre-transplantation (Tx) infusion of donor-derived regulatory dendritic cells (DCreg) safely prolongs MHC-mismatched renal allograft survival and regulates donor-reactive T…
2020 American Transplant Congress
Pulmonary Hypertension is Associated with Inferior Graft and Patient Survival after Kidney Transplantation
M. C. Nguyen, P. Chiang, J. Motter, D. Brennan, A. Massie, J. Garonzik-Wang, D. Segev, D. Segev
Johns Hopkins Hospital, Baltimore, MD
*Purpose: Pulmonary hypertension (PH) is increasingly recognized among patients with chronic kidney disease largely driven by left heart failure, high cardiac output, hypoxic lung diseases…
2020 American Transplant Congress
Role of Cross-Dressing in Kidney Transplantation
D. Zhao, R. Tieu, K. Abou-Daya, A. Williams, M. Oberbarnscheidt, F. Lakkis
Thomas E. Starzl Transplantation Institute, Pittsburgh, PA
*Purpose: Activation of host T cells that mediate allograft rejection is relied on dendritic cells (DCs) presenting alloantigens to T cells. Our recent study revealed…