Articles tagged "Kidney transplantation"

2020 American Transplant Congress
Mitochondrial Metabolism is Enriched Following Normothermic Ex-Vivo Kidney Perfusion of Grafts Procured Following Cardiac Death
P. Urbanellis¹, C. McEvoy¹, L. Mazilescu¹, S. Ganesh¹, R. John¹, I. Mucsi¹, A. Ghanekar¹, D. Bagli², A. Konvalinka¹, L. Robinson², M. Selzner¹
¹University Health Network, Toronto, ON, Canada, ²The Hospital for Sick Children, Toronto, ON, Canada
*Purpose: Normothermic ex-vivo kidney perfusion (NEVKP) preservation has demonstrated superior graft outcomes for kidneys procured following donation-after-cardiac death (DCD) over static cold storage (SCS). To…
2020 American Transplant Congress
Thymoglobulin Induction in Kidney Transplant Recipients: A Single Center Experience Comparing 3 Mg/kg vs 5 Mg/kg Cumulative Dosing
K. Progar¹, S. January¹, N. Nesselhauf¹, J. Hagopian¹, A. Malone²
¹Transplant, Barnes-Jewish Hospital, St. Louis, MO, ²Transplant Nephrology, Washington University, St. Louis, MO
*Purpose: Beginning in 2016, our center implemented a protocol change to thymoglobulin (r-ATG) induction dosing in kidney transplant recipients at low rejection risk from 5…
2020 American Transplant Congress
Calcium Level-Dependence of the Adverse Effect of Tertiary Hyperparathyroidism on Graft Survival in Renal Transplant Recipients
M. Okada, T. Tomosugi, T. Hiramitsu, K. Futamura, A. Kanda, N. Goto, S. Narumi, T. Ichimori, Y. Watarai
Transplant and Endocrine Surgery, Nagoya Daini Red Cross Hospital, Nagoya, Japan
*Purpose: Tertiary hyperparathyroidism (THPT) is a condition in which hyperparathyroidism persists after renal transplantation (RTx), and is a frequent complication. The aim of this retrospective…
2020 American Transplant Congress
Treatment of Chronic Active Antibody Mediated Rejection in Kidney Transplant Recipients is Associated with Increased Risk of Urinary Tract Infections and Pneumonia
E. Joachim, S. Parajuli, K. Swanson, F. Aziz, N. Garg, M. Mohamed, D. Mandelbrot, A. Djamali
University of Wisconsin, Madison, WI
*Purpose: Infections are a common cause of morbidity and mortality after kidney transplantation. Chronic active antibody mediated rejection (cABMR) is a leading cause of kidney…
2020 American Transplant Congress
Clinical Implication of Tertially Lymphoid Tissue in the Renal Graft
M. Saito¹, Y. Lee², Y. Sato², S. Narita¹, S. Satoh¹, M. Yanagita², T. Habuchi¹
¹Urology, Akita University Hospital, Akita, Japan, ²Nephrology, Kyoto University Graduate School of Medicine, Kyoto, Japan
*Purpose: Tertialy lymphoid organs (TLTs) are defined as inducible lymphoid tissues that arise in non-lymphoid organs, and chronic sustained inflammation is one of the most…
2020 American Transplant Congress
Outcomes of De Novo Belatacept-Based Immunosuppression in Recipients of Kidneys at High Risk for Delayed Graft Function in the Setting of Lymphocyte Depleting Immune Modulation
T. L. Shertel¹, M. A. Wynd¹, M. A. Pereiras¹, J. T. McKeen¹, Y. Y. Yushkov², B. R. Schleich³, S. E. Geatrakas², A. Patel², M. J. Goldstein²
¹Pharmacy, Hackensack University Medical Center, Hackensack, NJ, ²Organ Transplant, Hackensack University Medical Center, Hackensack, NJ, ³Patient Safety and Quality, Hackensack University Medical Center, Hackensack, NJ
*Purpose: Our center created an immunosuppression protocol using de novo belatacept (DNB) in the setting of lymphocyte depletion to increase the utilization of deceased donor…
2020 American Transplant Congress
Impact of Organ Donor Infections on Kidney Transplant Recipient Outcomes
M. Santarossa¹, C. Muran², S. Sanchez², L. Heinrich², J. Yoo³, F. Albarillo¹, S. Akkina³, N. Clark¹, G. Reid¹
¹Department of Medicine, Division of Infectious Diseases, Loyola University Medical Center, Maywood, IL, ²Department of Pharmacy, Loyola University Medical Center, Maywood, IL, ³Department of Medicine, Division of Transplant Nephrology, Loyola University Medical Center, Maywood, IL
*Purpose: Donor-derived infections can lead to significant morbidity and mortality in organ transplant recipients. There is variability by center on treatment of positive donor cultures…
2020 American Transplant Congress
A Data-Driven Approach to Defining the Volume-Outcome Relationship in Renal Transplantation
E. L. Godfrey¹, M. D. Bailey¹, W. C. Frankel¹, A. Rana²
¹Baylor College of Medicine, Houston, TX, ²Division of Abdominal Transplantation, Department of Surgery, Baylor College of Medicine, Houston, TX
*Purpose: Advances in immunosuppression and management continually improve short- and long-term outcomes of renal transplantation. However, center volume and expertise, while commonly believed to affect…
2020 American Transplant Congress
Ion AmpliSeq RNA Expression Panel Evaluated by Next-Generation Sequencing (NGS) Can Detect Genes in Human Formalin-Fixed Paraffin-Embedded Kidney Biopsies to Predict T Cell and Antibody Mediated Rejection in Renal Allografts
P. Ruiz¹, E. Margolles-Clark¹, G. Guerra², A. Mattiazzi², M. Ortigosa-Goggins², G. Ciancio¹, L. Chen¹, G. Burke¹
¹Surgery, University of Miami, Miami, FL, ²University of Miami, Miami, FL
*Purpose: Optimization of effective anti-rejection therapies to prevent allograft rejection and to minimize drug toxicity may be aided by utilizing in situ biomarkers for detection…
2020 American Transplant Congress
Evaluation of the Ability of the Integrative Box (ibox) to Predict Kidney Allograft Survival in a Cohort of Brazilian Patients
K. Linhares¹, M. Raynaud², O. Aubert², C. Lefaucher², G. Gomes¹, C. Peixoto¹, L. Villanueva¹, C. Legendre³, A. Loupy², H. Tedesco-Silva¹
¹Nephrology Division, Hospital do Rim, Sao Paulo, Brazil, ²Research Centre for Organ Transplantation, Université de Paris, Paris, France, ³Research Centre for Organ Transplantation, Hospital do Rim, Sao Paulo, Brazil
*Purpose: Kidney transplantation lacks robust models to predict graft survival. The Paris Transplant Group recently developed the iBox system (NCT03474003), a prediction tool that accurately…