2020 American Transplant Congress
Two Pilot Studies Exploring the Diagnostic and Predictive Potential of Serum LAG3 and FGL1 in Kidney Transplant Recipients
*Purpose: Lymphocyte activation gene 3 (LAG3), an immune checkpoint, plays an important role in the negative regulation of immune response and the induction of immune…2020 American Transplant Congress
Tyrosine Receptor Kinase Axl Regulates Intragraft Trafficking of Alloreactive T Cells Post Kidney Transplantation
1Nephrology/Medicine, Duke University, Durham, NC, 2Pathology, Northwestern University, Chicago, IL
*Purpose: Previous studies have shown that receptor tyrosine kinase Axl, primarily expressed on dendritic cells and some tissue-specific macrophage population, is required for T cells…2020 American Transplant Congress
To Wait or Not to Wait: The Survival Benefit of Preemptive Kidney Transplantation after Accounting for Lead Time Bias
1Johns Hopkins, Baltimore, MD, 2SRTR, Minneapolis, MN
*Purpose: Over 2,000 preemptive living donor kidney transplants (LDKT) per year are performed in the US. Preemptive LDKT allows recipients to avoid dialysis, but increases…2020 American Transplant Congress
UNOS Hard to Place Kidneys: Are We Working Too Hard?
Columbia University, New York, NY
*Purpose: Kidneys requiring more than 100 offers before acceptance are defined by UNOS as “hard to place," but many are suitable for transplantation. We sought…2020 American Transplant Congress
Transient Cd4+ T Cell and Cd20+ B Cell Depletion Leads to Prolonged Pig-To-Primate Kidney Xenograft Survival
1Emory University School of Medicine, Atlanta, GA, 2University of Miami, Miami, FL
*Purpose: “Delayed” antibody-mediated xenograft rejection is the one of the most important obstacle to clinical application of pig organ xenografts. The aim of this study…2020 American Transplant Congress
Parathyroidectomy Post Kidney Transplant: A Single Center Report of Short Term Outcomes
University of Alabama at Birmingham, Birmingham, AL
*Purpose: Whether parathyroidectomy in ESRD patients should be performed before or after kidney transplant remains controversial. There is concern that post-transplant parathyroidectomy can adversely affect…2020 American Transplant Congress
Peer Feedback Improves Nephrologists’ Transplant Referral Practices
Medicine, University Hospitals Cleveland Medical Center, Cleveland, OH
*Purpose: While preemptive kidney transplant is associated with superior outcomes, timely referral remains a significant barrier. Peer feedback may help improve practice. Our hypothesis is…2020 American Transplant Congress
Stability of T Reg with Combination of mTOR Inhibitors with Belatacept in Reducing Risk of Acute Rejection in Kidney Transplant
University of California San Francisco (UCSF), San Francisco, CA
*Purpose: Belatacept is a costimulatory blocker that is used as de novo maintenance immunosuppression in kidney transplantation to avoid toxic effects of calcineurin inhibitors and…2020 American Transplant Congress
Modelling Patient Outcomes after Listing for Deceased Donor Kidney Transplantation in the UK: A Novel Technique
*Purpose: Novel methods of data analysis and communication are needed to aid clinician and patient understanding of clinical outcomes. We aimed to demonstrate patient outcomes…2020 American Transplant Congress
Successful Tacrolimus Withdrawal in Kidney Transplant Recipients Unleashes a Peripheral Blood Transcriptional and Functional Signature Resembling Exhaustion
Icahn School of Medicine at Mount Sinai, New York, NY
*Purpose: Tacrolimus (Tac) is an effective anti-rejection drug in kidney transplant recipients (KTR), but its off-target effects make withdrawal desirable. Studies indicate that Tac can…
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