Articles tagged "Kidney transplantation"

2020 American Transplant Congress
Outcomes of De Novo Belatacept-Based Immunosuppression in Recipients of Kidneys at High Risk for Delayed Graft Function in the Setting of Lymphocyte Depleting Immune Modulation
T. L. Shertel¹, M. A. Wynd¹, M. A. Pereiras¹, J. T. McKeen¹, Y. Y. Yushkov², B. R. Schleich³, S. E. Geatrakas², A. Patel², M. J. Goldstein²
¹Pharmacy, Hackensack University Medical Center, Hackensack, NJ, ²Organ Transplant, Hackensack University Medical Center, Hackensack, NJ, ³Patient Safety and Quality, Hackensack University Medical Center, Hackensack, NJ
*Purpose: Our center created an immunosuppression protocol using de novo belatacept (DNB) in the setting of lymphocyte depletion to increase the utilization of deceased donor…
2020 American Transplant Congress
Impact of Organ Donor Infections on Kidney Transplant Recipient Outcomes
M. Santarossa¹, C. Muran², S. Sanchez², L. Heinrich², J. Yoo³, F. Albarillo¹, S. Akkina³, N. Clark¹, G. Reid¹
¹Department of Medicine, Division of Infectious Diseases, Loyola University Medical Center, Maywood, IL, ²Department of Pharmacy, Loyola University Medical Center, Maywood, IL, ³Department of Medicine, Division of Transplant Nephrology, Loyola University Medical Center, Maywood, IL
*Purpose: Donor-derived infections can lead to significant morbidity and mortality in organ transplant recipients. There is variability by center on treatment of positive donor cultures…
2020 American Transplant Congress
A Data-Driven Approach to Defining the Volume-Outcome Relationship in Renal Transplantation
E. L. Godfrey¹, M. D. Bailey¹, W. C. Frankel¹, A. Rana²
¹Baylor College of Medicine, Houston, TX, ²Division of Abdominal Transplantation, Department of Surgery, Baylor College of Medicine, Houston, TX
*Purpose: Advances in immunosuppression and management continually improve short- and long-term outcomes of renal transplantation. However, center volume and expertise, while commonly believed to affect…
2020 American Transplant Congress
Ion AmpliSeq RNA Expression Panel Evaluated by Next-Generation Sequencing (NGS) Can Detect Genes in Human Formalin-Fixed Paraffin-Embedded Kidney Biopsies to Predict T Cell and Antibody Mediated Rejection in Renal Allografts
P. Ruiz¹, E. Margolles-Clark¹, G. Guerra², A. Mattiazzi², M. Ortigosa-Goggins², G. Ciancio¹, L. Chen¹, G. Burke¹
¹Surgery, University of Miami, Miami, FL, ²University of Miami, Miami, FL
*Purpose: Optimization of effective anti-rejection therapies to prevent allograft rejection and to minimize drug toxicity may be aided by utilizing in situ biomarkers for detection…
2020 American Transplant Congress
Evaluation of the Ability of the Integrative Box (ibox) to Predict Kidney Allograft Survival in a Cohort of Brazilian Patients
K. Linhares¹, M. Raynaud², O. Aubert², C. Lefaucher², G. Gomes¹, C. Peixoto¹, L. Villanueva¹, C. Legendre³, A. Loupy², H. Tedesco-Silva¹
¹Nephrology Division, Hospital do Rim, Sao Paulo, Brazil, ²Research Centre for Organ Transplantation, Université de Paris, Paris, France, ³Research Centre for Organ Transplantation, Hospital do Rim, Sao Paulo, Brazil
*Purpose: Kidney transplantation lacks robust models to predict graft survival. The Paris Transplant Group recently developed the iBox system (NCT03474003), a prediction tool that accurately…
2020 American Transplant Congress
Bariatric Surgery to Improve Candidacy for Kidney Transplantation: A Systematic Review and Meta-Analysis
J. Purvis¹, S. Mehta¹, R. Stahl¹, J. Grams¹, M. Hanaway¹, D. Anderson¹, C. Young¹, R. Cannon¹, C. Lewis¹, N. Terrault², J. Locke¹, B. Orandi¹
¹University of Alabama at Birmingham, Birmingham, AL, ²University of Southern California, Los Angeles, CA
*Purpose: There is a growing epidemic of obesity in patients with end stage kidney disease in need of kidney transplant, paralleling the general population. Most…
2020 American Transplant Congress
Calcium Phosphate Crystals: An Under Recognized Cause of Kidney Allograft Injury?
R. H. Naik, E. Ramos, B. Paueksakon, M. Anand, A. Fogo, B. P. Concepcion, M. Lusco
Vanderbilt University Medical Center, Nashville, TN
*Purpose: Calcium phosphate (CaPhos) crystals are a known cause of dysfunction in native kidneys. Our objectives were to describe the incidence of CaPhos crystal deposition…
2020 American Transplant Congress
Evaluation Of Typical Renal Transplant Infections In Simultaneous Heart-kidney Transplant Recipients
E. J. Henricksen¹, U. Wang¹, R. Lee¹, R. Imai¹, A. Puing², A. Couture², A. Multani³, Y. Moayedi⁴, C. Lenihan⁵, K. K. Khush⁶, J. J. Teuteberg⁵
¹Pharmacy, Stanford Healthcare, Stanford, CA, ²Infectious Diseases and Geographic Medicine, Stanford University, Stanford, CA, ³Infectious Diseases, UCLA, Los Angeles, CA, ⁴Cardiology, University Health Network, Toronto, ON, Canada, ⁵Department of Medicine, Stanford University, Stanford, CA, ⁶Medicine, Stanford University, Stanford, CA
*Purpose: Simultaneous heart-kidney transplant (SHKT) is an increasingly utilized treatment for patients with end stage heart failure and advanced kidney disease. Data regarding infectious complications…
2020 American Transplant Congress
Outreach as a Way to Improve Access to Kidney Transplants: A Model to Align with Future of Kidney Disease Care
A. Govil¹, P. Gudsoorkar¹, C. Siemer², C. King², T. Diwan¹, E. Woodle¹, S. Shah¹, C. V. Thakar¹
¹Univ of Cincinnati, Cincinnati, OH, ²UC Health, Cincinnati, OH
*Purpose: In 2018, there were more than 100,000 patients wait-listed for kidney transplant whereas only around 21,000 patients received a kidney transplant. Increasing access to…
2020 American Transplant Congress
Inflammatory Cytokines Have a Different Effect from One HLA-II Subclass to Another on Human Endothelium
S. Beland, F. Bouchard-Boivin, A. Gama, O. Desy, S. A. De Serres
Universite Laval, Quebec, QC, Canada
*Purpose: Development of de novo donor-specific antibodies (DSAs) is associated with antibody-mediated rejection and allograft failure. More particularly, HLA-II DSAs, especially those against DQ are…