Articles tagged "Kidney transplantation"

2020 American Transplant Congress
A Prospective Randomized Multicenter Trial (BEST Trial) of Belatacept-Based CNI- and Corticosteroid-Free Immunosuppression: Infectious Complications
P. West-Thielke¹, A. Shields², D. Kaufman³, J. Leone⁴, A. Wiseman⁵, A. Matas⁶, T. Sa⁷, E. King⁷, R. Alloway², S. Woodle²
¹University of Illinois, Chicago, IL, ²University of Cincinnati, Cincinnati, OH, ³University of Wisconsin, Madison, IL, ⁴Tampa General Hospital, Tampa, FL, ⁵University of Colorado, Aurora, CO, ⁶University of Minnesota, Minneapolis, MN, ⁷Cincinnati Children's Hospital Medical Center, Cincinnati, OH
*Purpose: The BEST Trial (Belatacept-based Early Steroid Withdrawal Trial) is a prospective, randomized, multi-center trial designed to compare two belatacept (BELA)-based calcineurin inhibitor-free (CNI), early…
2020 American Transplant Congress
Donor-Derived DCREG Infusion Prolongs Kidney Allograft Survival in Rhesus Monkeys Treated with Co-Stimulation Blockade and Calcineurin Inhibition
Y. Wang, S. Kazuki, L. Lu, A. Zahorchak, H. Dai, A. Ganoza, M. Wijkstrom, A. Humar, M. Ezzelarab, A. Thomson
Thomas E. Starzl Transplantation Institute, Pittsburgh, PA
*Purpose: We have shown previously that pre-transplantation (Tx) infusion of donor-derived regulatory dendritic cells (DCreg) safely prolongs MHC-mismatched renal allograft survival and regulates donor-reactive T…
2020 American Transplant Congress
Pulmonary Hypertension is Associated with Inferior Graft and Patient Survival after Kidney Transplantation
M. C. Nguyen, P. Chiang, J. Motter, D. Brennan, A. Massie, J. Garonzik-Wang, D. Segev, D. Segev
Johns Hopkins Hospital, Baltimore, MD
*Purpose: Pulmonary hypertension (PH) is increasingly recognized among patients with chronic kidney disease largely driven by left heart failure, high cardiac output, hypoxic lung diseases…
2020 American Transplant Congress
Role of Cross-Dressing in Kidney Transplantation
D. Zhao, R. Tieu, K. Abou-Daya, A. Williams, M. Oberbarnscheidt, F. Lakkis
Thomas E. Starzl Transplantation Institute, Pittsburgh, PA
*Purpose: Activation of host T cells that mediate allograft rejection is relied on dendritic cells (DCs) presenting alloantigens to T cells. Our recent study revealed…
2020 American Transplant Congress
Maintenance Belatacept Therapy is Associated with Increased Rates of Polyoma Viremia
D. Conti, E. Maciera, D. Pluckrose, M. Garner, D. Schuster, S. Patel
Albany Medical Center, Albany, NY
*Purpose: The introduction of belatacept costimulatory blockade therapy has added a novel and powerful agent to the immunosuppressive armamentarium utilized after renal transplantation. However, limited…
2020 American Transplant Congress
Opioid-Free Pain Control? Surgical Opioid Avoidance Protocol (SOAP) Following Kidney Transplant
J. Benken¹, M. Campara¹, E. Votta Velis², I. Tzvetanov³, E. Benedetti³
¹Pharmacy Practice, University of Illinois at Chicago, Chicago, IL, ²Anesthesiology, University of Illinois at Chicago, Chicago, IL, ³Surgery, University of Illinois at Chicago, Chicago, IL
*Purpose: The opioid epidemic within the United States has devastated patients and their families in addition to triggering a national public health crisis. Unnecessary prescribing…
2020 American Transplant Congress
Utilization and Outcomes of Simultaneous Liver-Kidney Transplants after Change in Allocation Policy
M. L. Samoylova¹, B. I. Shaw¹, S. J. Kesseli¹, S. Sanoff², Y. Patel², A. S. Barbas¹, L. McElroy¹
¹Surgery, Duke University Hospital, Durham, NC, ²Medicine, Duke University Hospital, Durham, NC
*Purpose: The July 10, 2017 change in simultaneous liver-kidney (SLK) listing policy imposed more stringent criteria on recipient renal function. Recipient outcomes following this change…
2020 American Transplant Congress
Characterization of Histological Phenotypes of Acute Rejection Episodes in Kidney Transplant Recipient Receiving a Single 3mg/kg Dose of Rabbit Antithymocyte Globulin
R. S. Campos¹, M. Cristelli¹, H. Proença², R. D. Foresto¹, L. Viana¹, S. Stopa Martins¹, M. Nakamura¹, L. Takara¹, J. Taddeo¹, C. Felipe¹, H. T. Tedesco Jr.¹, J. Pestana¹
¹Nephrology Division, Hospital Do Rim, Sao Paulo, Brazil, ²Pathology Division, Hospital Do Rim, Sao Paulo, Brazil
*Purpose: Late acute rejections appear to exert a more negative effect on graft kidney allograft survival than earlier events. Literature lacks studies that detail the…
2020 American Transplant Congress
Challenges to National Kidney Paired Donation Education and Opportunities for Improvement
A. Waterman¹, E. H. Wood¹, O. N. Ranasinghe¹, J. L. Beaumont², S. McGuire³, K. Miller⁴, V. Chipman⁵, J. Sinacore⁶, M. Cooper⁷
¹Division of Nephrology, David Geffen School of Medicine, Los Angeles, CA, ²Terasaki Research Institute, Los Angeles, CA, ³UCLA Kidney and Pancreas Transplant Programs, Los Angeles, CA, ⁴UW Health, Madison, WI, ⁵UCSF Medical Center, San Francisco, CA, ⁶National Kidney Registry, Babylon, NY, ⁷Medstar Georgetown Transplant Institute, Washington, DC
*Purpose: To increase kidney paired donation (KPD) rates nationally, we need to overcome systematic barriers to educating potential donors and recipients consistently about the option…
2020 American Transplant Congress
Outcomes of High KDPI Kidneys in Selected Recipients at a Large Center
J. Pagan, L. Preczewski, M. Muldoon, L. Mendez, A. Harshman, E. Shipman, G. Guerra
Miami Transplant Institute, Miami, FL
*Purpose: Kidneys from donors with high KDPI’s are frequently discarded due to concerns about short- and long-term outcomes. Despite the decreased graft survival of these…