2022 American Transplant Congress
The Intracellular Tacrolimus Concentration in CD3+ T Lymphocytes and CD14+ Monocytes and Its Association with Kidney Transplant Rejection
Erasmus MC, Rotterdam, Netherlands
*Purpose: The intracellular tacrolimus concentration in peripheral blood mononuclear cells (PBMCs) (TAC[PBMC]) was proposed to better represent active concentration than pre-dose whole blood concentration (C0).…2022 American Transplant Congress
Absolute Quantification of Donor-Derived Cell-Free DNA Does Not Provide Additional Discriminating Power Over Donor-derived Cell-Free DNA Fraction for Detection of Allograft Rejection
*Purpose: High level of background cell-free DNA (cfDNA) has been hypothesized as a concern for false negative results in molecular diagnostics for allograft rejection that…2022 American Transplant Congress
Evaluation of Technical Bladder Complications in Kidney Transplantation Recipients with a Prolonged Dialysis History
University of Southern California, Los Angeles, CA
*Purpose: The kidney transplant (KT) waiting list continues to expand, resulting in prolonged dialysis times of >8 years prior to transplantation in some regions. The…2022 American Transplant Congress
Bystander Suppression: Enhancing the Power of Ex Vivo Expanded Antigen Specific Regulatory Cell Lines
*Purpose: The potential of T regulatory cell (Treg) based therapies in transplantation has been demonstrated in various preclinical models. Multiple clinical trials are currently undergoing…2022 American Transplant Congress
Circulating and Intragraft Donor (HLA)-Specific B Cells Drive Allograft Rejection After Kidney Transplantation
*Purpose: Besides donor-specific antibodies (DSA), circulating donor(HLA)-specific memory B cells (mBc) have also shown to play a deleterious role driving antibody-mediated rejection (ABMR) in kidney…2022 American Transplant Congress
Pre-Transplant Desensitization Utilizing Intravenous Immune-Globulin and Tocilizumab: A Single Center Experience
Virginia Commonwealth University Health System, Richmond, VA
*Purpose: Highly sensitized end stage kidney disease patients face a huge barrier to transplant due to lack of effective pre-transplant desensitization therapies. Various strategies have…2022 American Transplant Congress
Clinical Validation of Automated Urinary Chemokine Assays for Non-Invasive Detection of Kidney Transplant Rejection: A Large Prospective Cohort Study
*Purpose: Non-invasive diagnostic markers for kidney transplant rejection can provide useful information but often do not reach the clinical implementation stage. The chemokines CXCL9 and…2022 American Transplant Congress
Moving Beyond the Waitlist in Measurement of Access in Kidney Transplantation
University of British Columbia, Vancouver, BC, Canada
*Purpose: Studies limited to waitlist candidates have suggested better access to kidney transplantation and fewer disparities in acesss since the new kidney allocation system (KAS)…2022 American Transplant Congress
Longitudinal Characterization of the Microvirome in a Cohort of Renal Transplant Recipients
*Purpose: The selective targeting of T cells in transplant immunosuppression medications leads to a high rate of viral infections, with different immunosuppression regimens resulting in…2022 American Transplant Congress
Conversion to Everolimus-Based Immunosuppression Regimen with Calcineurin Inhibitor Reduction Ameliorates Histological Damage in Kidney Transplant Recipients with Calcineurin Inhibitor-Induced Nephrotoxicity
Hokkaido University Hospital, Sapporo, Japan
*Purpose: In the last two decades, the short-term results for kidney transplantation (KTX) have improved owing to the use of calcineurin inhibitors (CNIs). However, long-term…
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