2022 American Transplant Congress
Natural Antibodies Are Associated With Rejection And Long-term Renal Allograft Loss In A Multi-center International Cohort
*Purpose: Potentially harmful non-donor-specific human leukocyte antigen antibodies have been identified in renal transplantation, including natural IgG antibodies (Nabs) reactive to varied antigenic structures.*Methods: In…2022 American Transplant Congress
Regulatory T Cell PopulationsMay be Associated with Transplant Outcomes
*Purpose: The development of immunosuppressants has enabled remarkable progress in kidney transplantation (KT). However, current immunosuppressants cannot achieve induction of immune tolerance and their nonspecific…2022 American Transplant Congress
Five-Year Follow-Up from a Prospective, Randomized Trial of Belatacept-Based, CNI Free/Early Steroid Withdrawal Regimens
1University of Cincinnati, Cincinnati, OH, 2Christ Hospital, Cincinnati, OH
*Purpose: A prospective, randomized, multi-center trial designed to compare two belatacept (BELA)-based, calcineurin inhibitor-free (CNI), early corticosteroid withdrawal (ESW) regimens with a tacrolimus (TAC)-based ESW…2022 American Transplant Congress
Local Cognate Antigen in Kidney Allografts Promotes Tissue Resident Memory T Cell Maintenance
*Purpose: Our lab has demonstrated that tissue resident memory T cells (TRM cells) sustain chronic kidney allograft rejection in mice. It remains unknown how TRM…2022 American Transplant Congress
No Grapefruit Juice Interaction with Tacrolimus LCP in Kidney Transplant Recipients
*Purpose: It is well known that grapefruit juice (GFJ) interacts with many medications through an intestinal CYP3A-mediated interaction that does not involve hepatic CYP3A and…2022 American Transplant Congress
Enhanced Histological Yield and Actionable Findings When Biopsy is Guided by Donor-Derived Cell-Free DNA (dd-cfDNA)
*Purpose: Implementation of molecular biomarkers in kidney transplantation has expanded the amount of information available to clinicians before deciding to pursue biopsy. We evaluated how…2022 American Transplant Congress
A Pilot Study Using Registry-Based External Controls for the Cyclosporine Arm of the BENEFIT Study
1Transplant Therapeutics Consortium, Critical Path Institute, Tucson, AZ, 2UNOS, Richmond, VA
*Purpose: The Transplant Therapeutics Consortium established a real-world evidence workgroup evaluating the potential of supplementing internal control arms with external controls to understand the impact…2022 American Transplant Congress
Impact of Sub-therapeutic Tacrolimus Troughs at Discharge from Index Admission on Short-Term Outcomes in Kidney Transplant Recipients Receiving Rabbit Anti-Thymocyte Globulin Induction
*Purpose: Kidney transplant (KTx) recipients are often discharged with subtherapeutic tacrolimus (TAC) troughs due to short hospital lengths of stay (LOS) for index KTx admissions.…2022 American Transplant Congress
The Performance of the Kidney Donor Profile Index in Predicting Outcomes for Kidney Transplant Recipients of Standard Criteria Donors: Results from a Brazilian Single-Center Cohort Study
Nephrology Division - Hospital do Rim, Universidade Federal de São Paulo, São Paulo, Brazil
*Purpose: To evaluate the performance of the Kidney Donor Profile Index (KDPI) in predicting outcomes for kidney transplant recipients (KTR) of standard criteria donors (SCD)…2022 American Transplant Congress
Evaluation of Renal Function After Donation in Living Marginal Kidney Donor
*Purpose: Chronic kidney-donor shortage is major concern in Japan where more than 90% of recipients received kidneys from living donor as kidney transplantation from deceased…
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