2015 American Transplant Congress
Mesenchymal Stem Cells Enhance Rejection Free and Overall Islet Allograft Survival
The purpose of this study was 1) to assess the effect of mesenchymal stem cells (MSC) on intrahepatic, allogeneic islet survival in a cynomolgus monkey…2015 American Transplant Congress
Immunosuppression With Anti-CD40 mAb and Rapamycin for Islet and Kidney Co-Transplantation in Nonhuman Primates
Transplant Center, Massachusetts General Hospital, Boston, MA.
Background: For patients with end-stage renal disease secondary to type 1 diabetes mellitus, islet and kidney co-transplantation can be an ideal transplant option. However, a…2015 American Transplant Congress
Persistent Expansion of DX5- Memory NK Cells in the Liver After Intraportal Islet Transplantation
Gastroenterological and Transplant Surgery, Hiroshima University, Hiroshima, Japan.
Introduction: We have previously demonstrated that liver NK cells play a pivotal role in islet graft loss during the early phase after intraportal islet transplantation…2015 American Transplant Congress
Mesenchymal Stem Cells Suppress Cytotoxicity of Activated Natural Killer Cells in Liver Via the TRAIL-TRAIL Receptor Pathway in Islet Transplantation
Department of Gastroenterological and Transplant Surgery, Hiroshima University, Hiroshima, Japan.
Introduction: Innate immune reactions against islet grafts are considered a major obstacle for intraportal islet transplantation. We have previously reported that liver natural killer (NK)…2015 American Transplant Congress
Kidney Versus Islet Allograft Survival After Induction of Mixed Chimerism in Nonhuman Primates
Transplant Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA.
Background: We have previously reported a successful induction of mixed chimerism and the long-term acceptance of renal allografts in MHC-mismatched nonhuman primates. In this study,…2015 American Transplant Congress
Hypothermic Machine Perfusion Improves the Quality of Marginal Donor Pancreata
Introduction. Pancreas or islet transplantation is considered the most effective treatment for patients with type 1 diabetes mellitus. Due to the persistent organ shortage, pancreata…2015 American Transplant Congress
Proteasome Inhibition by Bortezomib Prevents Early Graft Failure After Pancreatic Islet Transplantation
Background: Islet graft loss caused by injurious inflammatory and innate immune responses, is a major obstacle in pancreatic islet transplantation (PIT). In this pathophysiology, the…2015 American Transplant Congress
Identifying Barriers Specific to Xenoislets by Direct Comparison to Alloislets in a Dual Transplant Model
Purpose:The xenotransplantation of neonatal porcine islets (NPIs) may alleviate the shortage of islets currently limiting islet allotransplantation. However, successful implementation requires understanding of the immune…2015 American Transplant Congress
Liver Versus Kidney. A Functional Study on Pancreatic Islet Implantation Sites
Background: In the clinical setting, liver is the site currently used for pancreatic islet transplantation (ITX). However, it has been shown that over 50% of…2015 American Transplant Congress
Human Mesenchymal Stromal Cells Improve Survival and Function of Pancreatic Islets by Cell-to-Cell Contact
Background and Aim:The aim of this study was to evaluate the survival and function of human pancreatic islets co-encapsulated with human Mesenchymal Stromal Cells (MSC)…
American Transplant Congress abstracts