Articles tagged "Islets"

2015 American Transplant Congress
Liver Versus Kidney. A Functional Study on Pancreatic Islet Implantation Sites
T. Corsello,¹ G. Curcuru,² D. Zorzi,³ M. Montalbano,¹ B. Carr,¹ L. Cicalese,¹ C. Rastellini.¹
¹Surgery, UTMB, Galveston, TX; ²Bioingegneria, Univ. of Palermo, Palermo, Sicilia, Italy; ³Surgical Oncology, MD Anderson, Houston, TX.
Background: In the clinical setting, liver is the site currently used for pancreatic islet transplantation (ITX). However, it has been shown that over 50% of…
2015 American Transplant Congress
Human Mesenchymal Stromal Cells Improve Survival and Function of Pancreatic Islets by Cell-to-Cell Contact
E. Montanari,¹ R. Mahou,^1,2 S. Passemard,² F. Noverraz,² P. Morel,¹ R. Meier,¹ D. Bosco,¹ J. Seebach,³ C. Wandrey,² S. Gerber,² C. Gonelle-Gispert,¹ L. Buhler.¹
¹Department of Surgery, Cell Isolation and Transplantation Center, Geneva University Hospitals and Medical Faculty, Geneva, Switzerland; ²Institut d'Ingénierie Biologique et Institut des Sciences et Ingénierie Chimiques, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland; ³Division of Immunology and Allergy, Geneva University Hospitals and Medical Faculty, Geneva, Switzerland.
Background and Aim:The aim of this study was to evaluate the survival and function of human pancreatic islets co-encapsulated with human Mesenchymal Stromal Cells (MSC)…
2015 American Transplant Congress
TGFβ Production By B Cells Is Critical for Transplant Tolerance Induction
J. Kim,¹ W. Liu,^1,2 L. Liu,^1,2 K. Lee,¹ R. Stott,¹ H. Yeh,¹ J. Markmann.¹
¹Surgery, Massachusetts General Hospital / Harvard Medical School, Boston, MA; ²Surgery, Chengdu Military General Hospital, Chengdu, Sichuan, China.
Regulatory B cells (Bregs) have been shown to play a critical role in immune homeostasis and in autoimmunity models. We have recently demonstrated that combined…
2015 American Transplant Congress
Association of IP-10 With Poor Islet Graft Function After Total Pancreatectomy With Islet Autotransplantation
M. Kanak,¹ M. Lawrence,² F. Kunnathodi,² G. Yoshimatsu,² R. Shahbazov,² M. Takita,² M. Levy,³ B. Naziruddin.³
¹Institute for Biomedical Studies, Baylor University, Waco, Tx; ²Islet Cell Laboratory, Baylor Research Institute, Dallas, TX; ³Baylor Annette C. and Harold C. Simmons Transplant Institute, Dallas, TX.
Introduction: Total pancreatectomy with islet autotransplantation (TPIAT) is an effective treatment for refractory chronic pancreatitis. The mechanisms underlying islet graft loss, however, remain unclear. Interferon…
2015 American Transplant Congress
Vaccine-Induced 'Incognito' CD8+ T Cell Memory Can Disrupt Transplantation Tolerance
M. Nelsen,¹ K. Beard,² R. Kedl,¹ R. Gill.²
¹Dept of Immunology & Microbiology, Univ of Colorado, Aurora, CO; ²Dept of Surgery, Univ of Colorado, Aurora, CO.
Transplant recipients harbor immunity to vaccines and pathogens (e.g. CMV, EBV). Pre-existing immunity can have significant antigen-specific ramifications, usually attributed to heterologous immunity, as pathogen-reactive…
2015 American Transplant Congress
Durability of Pancreatic Islets Transplantation in Brittle Type 1 Diabetics- 10 Year Follow Up
Z. Tekin,¹ L. Schenck,¹ M. Garfinkel,⁵ L. Philipson,² J. Thistlethwaite,¹ W. Chon,² K. Golab,¹ O. Savari,¹ S. Ramachandran,¹ K. Rezania,³ S. Hariprasad,⁴ J. Millis,¹ P. Witkowski.¹
¹Surgery, University of Chicago, Chicago, IL; ²Medicine, University of Chicago, Chicago, IL; ³Neurology, University of Chicago, Chicago, IL; ⁴Ophtalmology, University of Chicago, Chicago, IL; ⁵Surgery, Southern Illinois University, Springfield, IL.
The aim of the study was to assess long-term results of the pancreatic islet transplantation in our center.Methods: Human pancreatic islets were administered sequentially in…
2015 American Transplant Congress
CD3+CD4+ROR gamma t+ TH17 Cells Do Not Play a Critical Role in Islet Allograft Rejection
M. Koulmanda, Z. Fan.
Medicine, The Transplant Institute, Beth Israel Deaconess Medical Center, Boston, MA.
We have developed a “color-coded” adoptive transfer model for T cell subset identification that enables serial analysis of islet allograft infiltrating yellow induced regulatory T…
2015 American Transplant Congress
Beneficial Effects of Controlling Peritransplant Inflammation in Total Pancreatectomy With Islet Autotransplantation: A Single Center Experience With Large Cohort of Patients
M. Takita,¹ M. Kanak,² R. Shahbazov,¹ G. Yoshimatsu,¹ M. Lawrence,¹ A. Dabous,³ P. Kim,³ N. Onaca,³ B. Naziruddin,³ M. Levy.³
¹Islet Cell Laboratory, Baylor Research Institute, Dallas, TX; ²Institute for Biomedical Studies, Baylor University, Waco, TX; ³Baylor Annette C. and Harold C. Simmons Transplant Institute, Dallas, TX.
Background: Total pancreatectomy with islet autotransplantation (TPIAT) is an effective surgical treatment for patients with intractable chronic pancreatitis (CP). We recently reported that significant mass…
2015 American Transplant Congress
Effective Control of Anti-Xenogeneic IL-17 Response for Tolerance Induction in Xenogeneic Islet Cell Transplantation
H. Kang,¹ S. Wang,^1,2 X. Zhang,³ L. Zhang,¹ S. Miller,⁴ B. Hering,⁵ X. Luo.^1,3,4
¹Medicine, Northwestern University Feinberg school of Medicine, Chicago, IL; ²Tianjin Union Medical Center, Nankai University Affiliated Hospital, Tianjin, China; ³Comprehensive Transplant Center, Northwestern University Feinberg School of Medicine, Chicago, IL; ⁴Microbiology and Immunology, Northwestern University Feinberg School of Medicine, Chicago, IL; ⁵Schulze Diabetes Institute, University of Minnesota, Minneapolis, MN.
We have previously shown that peri-transplant infusion of donor cells treated with 1-ethyl-3-(3'-dimethylaminopropyl)-carbodiimide (ECDI) in combination with peri-transplant anti-CD20 and rapamycin induce permanent porcine islet…
2015 American Transplant Congress
Pancreas-Derived Mesenchymal Stem Cells from Chronic Pancreatitis Patients Enhance Islet Graft Function
M. Lawrence,¹ F. Kunnathodi,¹ N. Borenstein-Auerbach,¹ G. Yoshimatsu,¹ M. Kanak,² R. Shahbazov,¹ M. Takita,¹ M. Levy,³ B. Naziruddin.³
¹Baylor Research Institute, Dallas, TX; ²Baylor University, Waco, TX; ³Baylor Annette C. and Harold C. Simmons Transplant Institute, Dallas, TX.
PURPOSE: Islet transplantation represents a promising procedure to reverse or prevent diabetes. However, significant mass of islet graft is lost within hours of transplantation due…