Articles tagged "Islets"

2015 American Transplant Congress
Kidney Versus Islet Allograft Survival After Induction of Mixed Chimerism in Nonhuman Primates
T. Oura, D. Ko, J. O'Neil, S. Boskovic, O. Nadazdin, K. Hotta, K. Kawai, B. Cosimi, T. Kawai.
Transplant Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA.
Background: We have previously reported a successful induction of mixed chimerism and the long-term acceptance of renal allografts in MHC-mismatched nonhuman primates. In this study,…
2015 American Transplant Congress
Hypothermic Machine Perfusion Improves the Quality of Marginal Donor Pancreata
M. Leemkuil,¹ M. Engelse,² R. Ploeg,³ E. de Koning,² C. Krikke,¹ H. Leuvenink.¹
¹Surgery, University Medical Center Groningen, Groningen, Netherlands; ²Nephrology, Leiden University Medical Center, Leiden, Netherlands; ³Transplant Biology, Oxford Transplant Center, Oxford, United Kingdom.
Introduction. Pancreas or islet transplantation is considered the most effective treatment for patients with type 1 diabetes mellitus. Due to the persistent organ shortage, pancreata…
2015 American Transplant Congress
Proteasome Inhibition by Bortezomib Prevents Early Graft Failure After Pancreatic Islet Transplantation
H. Ono,¹ Y. Asahi,¹ T. Yoshida,¹ Y. Koshizuka,¹ M. Watanabe,¹ U. Tomaru,² S. Emoto,¹ M. Fukai,³ A. Taketomi,¹ S. Todo,⁴ K. Yamashita.³
¹Gastroenterological Surgery1, Hokkaido University Graduate School of Medicine, Sapporo, Japan; ²Department of Pathology, Hokkaido University Graduate School of Medicine, Sapporo, Japan; ³Department of Transplant Surgery, Hokkaido University Graduate School of Medicine, Sapporo, Japan; ⁴St Mary's Hospital, Kurume, Japan.
Background: Islet graft loss caused by injurious inflammatory and innate immune responses, is a major obstacle in pancreatic islet transplantation (PIT). In this pathophysiology, the…
2015 American Transplant Congress
Identifying Barriers Specific to Xenoislets by Direct Comparison to Alloislets in a Dual Transplant Model
K. Samy,¹ B. Martin,² P. Thompson,² A. Farris,² M. Song,² V. Leopardi,¹ B. Collins,¹ A. Kirk.¹
¹Department of Surgery, Duke University Medical Center, Durham, NC; ²Emory Transplant Center, Emory University, Atlanta, GA.
Purpose:The xenotransplantation of neonatal porcine islets (NPIs) may alleviate the shortage of islets currently limiting islet allotransplantation. However, successful implementation requires understanding of the immune…
2015 American Transplant Congress
Liver Versus Kidney. A Functional Study on Pancreatic Islet Implantation Sites
T. Corsello,¹ G. Curcuru,² D. Zorzi,³ M. Montalbano,¹ B. Carr,¹ L. Cicalese,¹ C. Rastellini.¹
¹Surgery, UTMB, Galveston, TX; ²Bioingegneria, Univ. of Palermo, Palermo, Sicilia, Italy; ³Surgical Oncology, MD Anderson, Houston, TX.
Background: In the clinical setting, liver is the site currently used for pancreatic islet transplantation (ITX). However, it has been shown that over 50% of…
2015 American Transplant Congress
Human Mesenchymal Stromal Cells Improve Survival and Function of Pancreatic Islets by Cell-to-Cell Contact
E. Montanari,¹ R. Mahou,^1,2 S. Passemard,² F. Noverraz,² P. Morel,¹ R. Meier,¹ D. Bosco,¹ J. Seebach,³ C. Wandrey,² S. Gerber,² C. Gonelle-Gispert,¹ L. Buhler.¹
¹Department of Surgery, Cell Isolation and Transplantation Center, Geneva University Hospitals and Medical Faculty, Geneva, Switzerland; ²Institut d'Ingénierie Biologique et Institut des Sciences et Ingénierie Chimiques, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland; ³Division of Immunology and Allergy, Geneva University Hospitals and Medical Faculty, Geneva, Switzerland.
Background and Aim:The aim of this study was to evaluate the survival and function of human pancreatic islets co-encapsulated with human Mesenchymal Stromal Cells (MSC)…
2015 American Transplant Congress
TGFβ Production By B Cells Is Critical for Transplant Tolerance Induction
J. Kim,¹ W. Liu,^1,2 L. Liu,^1,2 K. Lee,¹ R. Stott,¹ H. Yeh,¹ J. Markmann.¹
¹Surgery, Massachusetts General Hospital / Harvard Medical School, Boston, MA; ²Surgery, Chengdu Military General Hospital, Chengdu, Sichuan, China.
Regulatory B cells (Bregs) have been shown to play a critical role in immune homeostasis and in autoimmunity models. We have recently demonstrated that combined…
2015 American Transplant Congress
Association of IP-10 With Poor Islet Graft Function After Total Pancreatectomy With Islet Autotransplantation
M. Kanak,¹ M. Lawrence,² F. Kunnathodi,² G. Yoshimatsu,² R. Shahbazov,² M. Takita,² M. Levy,³ B. Naziruddin.³
¹Institute for Biomedical Studies, Baylor University, Waco, Tx; ²Islet Cell Laboratory, Baylor Research Institute, Dallas, TX; ³Baylor Annette C. and Harold C. Simmons Transplant Institute, Dallas, TX.
Introduction: Total pancreatectomy with islet autotransplantation (TPIAT) is an effective treatment for refractory chronic pancreatitis. The mechanisms underlying islet graft loss, however, remain unclear. Interferon…
2015 American Transplant Congress
Vaccine-Induced 'Incognito' CD8+ T Cell Memory Can Disrupt Transplantation Tolerance
M. Nelsen,¹ K. Beard,² R. Kedl,¹ R. Gill.²
¹Dept of Immunology & Microbiology, Univ of Colorado, Aurora, CO; ²Dept of Surgery, Univ of Colorado, Aurora, CO.
Transplant recipients harbor immunity to vaccines and pathogens (e.g. CMV, EBV). Pre-existing immunity can have significant antigen-specific ramifications, usually attributed to heterologous immunity, as pathogen-reactive…
2015 American Transplant Congress
Durability of Pancreatic Islets Transplantation in Brittle Type 1 Diabetics- 10 Year Follow Up
Z. Tekin,¹ L. Schenck,¹ M. Garfinkel,⁵ L. Philipson,² J. Thistlethwaite,¹ W. Chon,² K. Golab,¹ O. Savari,¹ S. Ramachandran,¹ K. Rezania,³ S. Hariprasad,⁴ J. Millis,¹ P. Witkowski.¹
¹Surgery, University of Chicago, Chicago, IL; ²Medicine, University of Chicago, Chicago, IL; ³Neurology, University of Chicago, Chicago, IL; ⁴Ophtalmology, University of Chicago, Chicago, IL; ⁵Surgery, Southern Illinois University, Springfield, IL.
The aim of the study was to assess long-term results of the pancreatic islet transplantation in our center.Methods: Human pancreatic islets were administered sequentially in…