Articles tagged "Islets"

2017 American Transplant Congress
Total Pancreatectomy and Islet Autotransplantation into the Liver of a Patient with Previous Hepatitis C Infection.
A. Rajab,¹ J. Buss,¹ P. Hart,² D. Conwell,² S. Black,¹ K. Washburn.¹
¹Transplant Surgery, The Ohio State Wexner Medical Center, Columbus, OH; ²Internal Medicine, The Ohio State Wexner Medical Center, Columbus, OH
Hepatic parenchymal disease such as hepatitis has been considered a relative contraindication to islet transplantation as the islets are infused into the liver. Islet transplantation…
2017 American Transplant Congress
Maintenance of the Phenotype and Abundance of Islet-Resident Macrophages Promotes Islet Graft Survival and Appears to Prevent Type 1 Diabetes.
P. Kyriazis, T. Thornley, K. Agarwal, L. Ma, T. Strom, M. Koulmanda.
Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA
Immunoregulatory tissue resident macrophage subsets have been reported in skin, heart, lung and adipose tissue.We now demonstrate the existence of a functionally immunoregulatory population of…
2017 American Transplant Congress
Hypoxia Induces Tissue Factor Upregulation in Isolated Human Islets.
B. Sandhu,¹ M. Prendecki,¹ G. Rutter,¹ A. Martinez-Sanchez,¹ N. Kanda,¹ N. Galloway-Phillips,¹ R. Smith,² C. Pusey,¹ V. Papalois.¹
¹Imperial College, London, United Kingdom; ²King's College, London, United Kingdom
Purpose: Early islet loss post-infusion remains a significant problem in islet transplantation, despite the use of heparinised media to abrogate the effects of Tissue Factor…
2017 American Transplant Congress
Safety and Decreased Inflammation of Early Double Cytokine Blockade (IL-1β and TNF-α) Facilitates Engraftment in Islet Allotransplantation.
N. Onaca,¹ M. Takita,² M. Levy,³ B. Naziruddin.¹
¹Simmons Transplant Institute, Baylor University Medical Center, Dallas; ²Baylor Scott and White Research Institute, Dallas; ³Hume Lee Transplant Center, Virginia Commonwealth University, Richmond
Enhanced early islet engraftment offers the potential for improved graft function after islet allotransplantation (IT). Nine patients underwent IT under a fully completed prospective research…
2017 American Transplant Congress
Assessment of Islet Damage During Isolation Utilizing miRNAs and Its Significance with Post-Transplant Outcome in TPIAT.
P. Saravanan,¹ M. Kanak,² G. Yoshimatsu,¹ M. Lawrence,¹ B. Naziruddin.³
¹Baylor Scott and White Research Institute, Dallas, TX; ²Virginia Commonwealth University, Richmond, VA; ³Baylor Simmons Transplant Institute, Dallas, TX
Background: Pancreatic islets with high quality are essential for better endocrine function and post-transplant outcome in total pancreatectomy with islet autotransplantation (TPIAT). The islets are…
2017 American Transplant Congress
Ex-Vivo Mitomycin-C Exposure Reduced Immunogenicity and Prolonged Survival of Islets by Suppressing the Secretion of Multiple Chemotaxis Factors.
N. Sato,¹ T. Anazawa,² A. Kenjyo,¹ T. Kimura,¹ R. Okada,¹ T. Ishigame,¹ Y. Kofunato,¹ J. Watanabe,¹ M. Muto,¹ A. Nishimagi,¹ M. Gotoh,¹ S. Marubashi.¹
¹Department of Surgery, Division of Hepato-Biliary-Pancreatic and Transplant, Fukushima Medical University, Fukushima, Japan; ²Department of Surgery, Graduate School of Midicine, Kyoto University, Kyoto, Japan
Background. Strategies to reduce immunogenicity of islets, and to prevent activation of pro-inflammatory events are essential to successful islet engraftment. We previously demonstrated that ex-vivo…
2017 American Transplant Congress
Combination Therapy of iNKT Cell Ligand and CD40-CD154 Signal Blockade Establishes Islet Allograft Tolerance in Non-Myeloablative Bone Marrow Transplant Recipients.
T. Kanzawa,¹ T. Hirai,¹ R. Ishii,¹ M. Okumi,¹ H. Ishida,¹ Y. Ishii,² K. Tanabe.¹
¹Department of Urology, Tokyo Women's Medical University, Tokyo, Japan; ²Cluster for Industry Partnerships (CIP), RIKEN, Tokyo, Japan
Background: Allogeneic islet transplantation is an effective therapeutic option for type 1 diabetes. Toxicity associated with chronic use of immunosuppressants still remains an obstacle for…
2017 American Transplant Congress
Assessment of Simple Indices Based on a Single Fasting Blood Sample in Search for an Optimal Tool to Estimate Beta Cell Function After Islet Transplantation.
J. Golebiewska,¹ J. Solomina,² E. Konsur,² K. Cieply,² L. Basto,² A. Kotukhov,² K. Golab,² C. Thomas,³ A. Debska-Slizien,¹ P. Witkowski.²
¹Department of Nephrology, Medical University of Gdansk, Gdansk, Poland; ²Departemt of Surgery, University of Chicago, Chicago; ³Department of Medicine, University of Chicago, Chicago
Background:Precise yet logistically feasible evaluation of beta-cell function is extremely important after islet allotransplantation. We investigated the utility and possible limitations of indices using only…
2017 American Transplant Congress
Measurement of Dissolved Oxygen by ¹⁹F MRI of Microcapsules Implanted IP in Non-Human Primates.
S. Safley,¹ M. Graham,² M. Garwood,³ K. Papas,⁵ B. Weegman,^3,4 G. Barber,¹ E. Lin,¹ J. Leisen,⁷ A. Sambanis,⁶ B. Hering,² C. Weber.¹
¹Surgery, Emory University, Atlanta, GA; ²Surgery, University of Minnesota, Minneapolis, MN; ³Radiology, University of Minnesota, Minneapolis, MN; ⁴Sylvatica Biotech, Inc., Charleston, SC; ⁵Surgery, University of Arizona, Tucson, AZ; ⁶School of Chemical and Biomedical Engineering, Georgia Institute of Technology, Atlanta, GA; ⁷School of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, GA
Since our encapsulated NHP islet allografts and porcine islet xenografts fail after i.p. transplantation in immunosuppressed NHPs without a cellular or humoral immune response, we…
2017 American Transplant Congress
Dendritic Cells That Highly Express SOCS1 Induce T-Cell Hypo-Responsiveness and Prolong Islet Allograft Survival.
R. Deng, X. Lu, M. Chen, Z. Xue, X. Zhang, J. Xu, L. Wu, Y. Ma.
Organ Transplant Center, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China
The capability of dendritic cells (DCs) to induce an immune response or immune tolerance is dependent on their status. Suppressor of cytokine signaling 1 (SOCS1)…