ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Islets"

  • 2017 American Transplant Congress

    Impact of Pancreatic Texture Assessment on Islet Isolation and Metabolic Outcome After TPIAT.

    G. Yoshimatsu,1 M. Khadka,1 M. Lawrence,1 B. Appakalai,2 B. Naziruddin.3

    1Baylor Scott and White Research Institute, Dallas, TX; 2University of Louisville, Louisville, KY; 3Baylor Simmons Transplant Institute, Dallas, TX

    Introduction: Total pancreatectomy with islet autotransplantation (TPIAT) is an effective treatment for refractory chronic pancreatitis (CP). Chronic inflammation leads to fibrosis formation in pancreas and…
  • 2017 American Transplant Congress

    Suppression of Inflammation by Withaferin A in Cerulein-Induced Pancreatitis Model Results in Improved Syngeneic Islet Engraftment.

    G. Yoshimatsu,1 M. Kanak,2 C. Chang,1 C. Darden,1 M. Lawrence,1 B. Naziruddin.3

    1Baylor Scott and White Research Institute, Dallas, TX; 2Virginia Commonwellth University, Richmond, VA; 3Baylor Simmons Transplant Institute, Dallas, TX

    Introduction: Chronic pancreatitis (CP) is characterized by inflammatory damage to acinar cells followed by islets. In clinical islet autotransplantation, patients with advanced stages of CP…
  • 2017 American Transplant Congress

    Total Pancreatectomy with Islet Autotransplantation Improves Quality of Life Allowing for the Resolution of the Intractable Pain with Good Glucose Control in Properly Selected Patients with Chronic Pancreatitis.

    A. Kotukhov,1 J. Solomina,1 E. Konsur,1 K. Cieply,1 L. Basto,1 L.-J. Wang,1 K. Golab,1 M. Tibudan,1 A. Gelrud,2 C. Thomas,2 J. Matthews,1 P. Witkowski.1

    1Surgery, University of Chicago, Chicago, IL; 2Medicine, University of Chicago, Chicago, IL

    Background: There is a group of Total pancreatectomy (TP) is offered as a last option to patients with chronic pancreatitis (CP) who despite optimal treatment…
  • 2017 American Transplant Congress

    Human Islet-Derived Extracellular Vesicles Stimulate CD14+ Monocytes Resulting in Proinflammatory Cytokine Production.

    A. Rutman, S. Negi, C. Hasilo, M. Gasparrini, J. Tchervenkov, S. Paraskevas.

    Department of Surgery, McGill University Health Centre, Montreal, QC, Canada

    Introduction: The cellular events involved in the generation of an auto and allo-reactive immune response in recipients of islet transplantation are not well understood. In…
  • 2017 American Transplant Congress

    Initial Experince with Total Pancreatectomy-Islet Auto-Transplantation (TP-IAT) for Chronic Pancreatitis at the University of Louisville.

    M. Hughes,1 E. Davis,1 S. Mokshagundam,2 W. Tucker,1 G. Logananthan,1 S. Williams,3 B. Appakalai.1

    1Surgery, University of Louisville, Louisville, KY; 2Medicine, University of Louisville, Louisville, KY; 3Physiology, University of Louisville, Louisville, KY

    Chronic pancreatitis (CP) represents a highly significant healthcare challenge in Kentucky. To address this need, we created a TP-IAT program to cure patients of this…
  • 2017 American Transplant Congress

    D-Dimer Level, in Association with Humoral Responses, Negatively Correlates with Survival of Porcine Islet Grafts in Nonhuman Primates with Immunosuppression.

    H. Kang,1 H. Lee,1 E. Park,1 J. Kim,2 B. Min,2 C.-G. Park.2

    1Laboratory Medicine, Hallym University College of Medicine, Anyang, Korea; 2Xenotransplantation Research Center, Seoul National University College of Medicine, Seoul, Korea

    Background: Several immunosuppression (IS) regimens achieve long-term graft survival in nonhuman primates (NHPs) after porcine islet transplantation (PITx), but their success rates vary. To understand…
  • 2017 American Transplant Congress

    Serva NB1 versus Vitacyte Collagenase: Comparable Human Islet Isolation Outcomes Using DCD Donor Pancreas in China.

    Y. Liu, P. Sun, J. Zou, G. Wang, T. Liu, L. Wang, S. Wang.

    Transplant Center, Tianjin First Center Hospital, Tianjin, China

    Objective This study was designed to retrospectively compare the effect of Serva NB1 collagenase between Vitacyte collagenase on islet isolation of DCD pancreas in China.…
  • 2017 American Transplant Congress

    Immunosuppressive Ability of NFkB Inhibitor: Withaferin A.

    M. Kanak,1 Y. Shindo,1 M. Levy,1,2 B. Naziruddin.3

    1Transplant Surgery, Virginia Commonwealth University, Richmond, VA; 2Hume-Lee Transplant Center, VCU Health System, Richmond, VA; 3Simmons Transplant Institute, Baylor Scott and White Health, Dallas, TX

    BackgroundThe advent of steroid-free protocol by the Edmonton group encouraged islet transplant as a therapy for Type-1 Diabetes. However, long-term dysfunction in islet transplantation is…
  • 2017 American Transplant Congress

    Total Pancreatectomy and Islet Autotransplantation into the Liver of a Patient with Previous Hepatitis C Infection.

    A. Rajab,1 J. Buss,1 P. Hart,2 D. Conwell,2 S. Black,1 K. Washburn.1

    1Transplant Surgery, The Ohio State Wexner Medical Center, Columbus, OH; 2Internal Medicine, The Ohio State Wexner Medical Center, Columbus, OH

    Hepatic parenchymal disease such as hepatitis has been considered a relative contraindication to islet transplantation as the islets are infused into the liver. Islet transplantation…
  • 2017 American Transplant Congress

    Maintenance of the Phenotype and Abundance of Islet-Resident Macrophages Promotes Islet Graft Survival and Appears to Prevent Type 1 Diabetes.

    P. Kyriazis, T. Thornley, K. Agarwal, L. Ma, T. Strom, M. Koulmanda.

    Department of Medicine, Beth Israel Deaconess Medical Center, Boston, MA

    Immunoregulatory tissue resident macrophage subsets have been reported in skin, heart, lung and adipose tissue.We now demonstrate the existence of a functionally immunoregulatory population of…
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