Articles tagged "Islets"

2017 American Transplant Congress
Improved Method to Obtain High Islet Mass from Severely Fibrotic Pancreatitis Pancreases Intended for Clinical Islet Auto-Transplantation.
A. Balamurugan, G. Loganathan, W. Tucker, M. Dhanasekaran, S. Narayanan, A. Patel, S. Mokshagundam, S. Williams, M. Hughes.
Clinical Islet Laboratory, Dept. of Surgery, Cardiovascular Innovation Institute, University of Louisville, KY
A total pancreatectomy and islet autotransplant (TPIAT) offers substantial pain relief and improved quality of life for pancreatitis patients. Isolating a large quantity of islet…
2017 American Transplant Congress
CXCL12 Modulation of Localized Immune Responses to Subcutaneous Islet Macrocapsulation.
M. Penson, M. Sremac, R. Sirbulescu, T. Brauns, F. Harrington, M. Poznansky.
Infectious Disease, Massachusetts General Hospital, Boston, MA
Purpose:To determine the impact of CXCL12 on vascularization and immune response to xeno islets transplanted into TheraCyte macroencapsulation device in diabetic C57BL/6 mice.Materials and Methods:Three…
2017 American Transplant Congress
Impact of Pancreatic Texture Assessment on Islet Isolation and Metabolic Outcome After TPIAT.
G. Yoshimatsu,¹ M. Khadka,¹ M. Lawrence,¹ B. Appakalai,² B. Naziruddin.³
¹Baylor Scott and White Research Institute, Dallas, TX; ²University of Louisville, Louisville, KY; ³Baylor Simmons Transplant Institute, Dallas, TX
Introduction: Total pancreatectomy with islet autotransplantation (TPIAT) is an effective treatment for refractory chronic pancreatitis (CP). Chronic inflammation leads to fibrosis formation in pancreas and…
2017 American Transplant Congress
Suppression of Inflammation by Withaferin A in Cerulein-Induced Pancreatitis Model Results in Improved Syngeneic Islet Engraftment.
G. Yoshimatsu,¹ M. Kanak,² C. Chang,¹ C. Darden,¹ M. Lawrence,¹ B. Naziruddin.³
¹Baylor Scott and White Research Institute, Dallas, TX; ²Virginia Commonwellth University, Richmond, VA; ³Baylor Simmons Transplant Institute, Dallas, TX
Introduction: Chronic pancreatitis (CP) is characterized by inflammatory damage to acinar cells followed by islets. In clinical islet autotransplantation, patients with advanced stages of CP…
2017 American Transplant Congress
Total Pancreatectomy with Islet Autotransplantation Improves Quality of Life Allowing for the Resolution of the Intractable Pain with Good Glucose Control in Properly Selected Patients with Chronic Pancreatitis.
A. Kotukhov,¹ J. Solomina,¹ E. Konsur,¹ K. Cieply,¹ L. Basto,¹ L.-J. Wang,¹ K. Golab,¹ M. Tibudan,¹ A. Gelrud,² C. Thomas,² J. Matthews,¹ P. Witkowski.¹
¹Surgery, University of Chicago, Chicago, IL; ²Medicine, University of Chicago, Chicago, IL
Background: There is a group of Total pancreatectomy (TP) is offered as a last option to patients with chronic pancreatitis (CP) who despite optimal treatment…
2017 American Transplant Congress
Human Islet-Derived Extracellular Vesicles Stimulate CD14+ Monocytes Resulting in Proinflammatory Cytokine Production.
A. Rutman, S. Negi, C. Hasilo, M. Gasparrini, J. Tchervenkov, S. Paraskevas.
Department of Surgery, McGill University Health Centre, Montreal, QC, Canada
Introduction: The cellular events involved in the generation of an auto and allo-reactive immune response in recipients of islet transplantation are not well understood. In…
2017 American Transplant Congress
Initial Experince with Total Pancreatectomy-Islet Auto-Transplantation (TP-IAT) for Chronic Pancreatitis at the University of Louisville.
M. Hughes,¹ E. Davis,¹ S. Mokshagundam,² W. Tucker,¹ G. Logananthan,¹ S. Williams,³ B. Appakalai.¹
¹Surgery, University of Louisville, Louisville, KY; ²Medicine, University of Louisville, Louisville, KY; ³Physiology, University of Louisville, Louisville, KY
Chronic pancreatitis (CP) represents a highly significant healthcare challenge in Kentucky. To address this need, we created a TP-IAT program to cure patients of this…
2017 American Transplant Congress
D-Dimer Level, in Association with Humoral Responses, Negatively Correlates with Survival of Porcine Islet Grafts in Nonhuman Primates with Immunosuppression.
H. Kang,¹ H. Lee,¹ E. Park,¹ J. Kim,² B. Min,² C.-G. Park.²
¹Laboratory Medicine, Hallym University College of Medicine, Anyang, Korea; ²Xenotransplantation Research Center, Seoul National University College of Medicine, Seoul, Korea
Background: Several immunosuppression (IS) regimens achieve long-term graft survival in nonhuman primates (NHPs) after porcine islet transplantation (PITx), but their success rates vary. To understand…
2017 American Transplant Congress
Serva NB1 versus Vitacyte Collagenase: Comparable Human Islet Isolation Outcomes Using DCD Donor Pancreas in China.
Y. Liu, P. Sun, J. Zou, G. Wang, T. Liu, L. Wang, S. Wang.
Transplant Center, Tianjin First Center Hospital, Tianjin, China
Objective This study was designed to retrospectively compare the effect of Serva NB1 collagenase between Vitacyte collagenase on islet isolation of DCD pancreas in China.…
2017 American Transplant Congress
Immunosuppressive Ability of NFkB Inhibitor: Withaferin A.
M. Kanak,¹ Y. Shindo,¹ M. Levy,^1,2 B. Naziruddin.³
¹Transplant Surgery, Virginia Commonwealth University, Richmond, VA; ²Hume-Lee Transplant Center, VCU Health System, Richmond, VA; ³Simmons Transplant Institute, Baylor Scott and White Health, Dallas, TX
BackgroundThe advent of steroid-free protocol by the Edmonton group encouraged islet transplant as a therapy for Type-1 Diabetes. However, long-term dysfunction in islet transplantation is…