2017 American Transplant Congress
Patterns and Associated Risk Factors for Early Readmissions Post Total Pancreatectomy and Islet Auto-Transplantation(TP-IAT).
University of Minnesota, Minneapolis
Introduction: For four decades, TP-IAT has been performed to provide pain relief and preserve insulin function in patients(pts) with chronic/acute relapsing pancreatitis. Despite advances in…2017 American Transplant Congress
Antioxidant Thermoresponsive Hydrogel as a Versatile Islets Scaffolds for Treating Type I Diabetes.
Introduction: Hepatic islets transplantation procedure to treat type I diabetes often results in limited islets survival presumably due to uneven islet distribution, acute inflammatory response…2017 American Transplant Congress
Intraomental Non-Purified Islet Transplantation Isolated from DCD Donor Pancreas.
Transplant Center, Tianjin First Center Hospital, Tianjin, China
Objective: We have proved that omentum was a more efficient site to perform non-purified islet transplantation with more safety in Beagle dog islet auto-transplantation model.…2017 American Transplant Congress
Cibinetide (ARA 290), the Innate Repair Receptor Ligand, Improves Engraftment in Pancreatic Islet Transplantation by Protecting Islets and Reducing Inflammatory Reactions.
Purpose. Cibinetide, an innate repair receptor ligand, exerts anti-inflammatory, anti-apoptotic, and cytoprotective effects. We have shown that cibinetide protected mouse pancreatic islets from cytokine-induced damage…2017 American Transplant Congress
Improved Method to Obtain High Islet Mass from Severely Fibrotic Pancreatitis Pancreases Intended for Clinical Islet Auto-Transplantation.
A total pancreatectomy and islet autotransplant (TPIAT) offers substantial pain relief and improved quality of life for pancreatitis patients. Isolating a large quantity of islet…2017 American Transplant Congress
CXCL12 Modulation of Localized Immune Responses to Subcutaneous Islet Macrocapsulation.
Infectious Disease, Massachusetts General Hospital, Boston, MA
Purpose:To determine the impact of CXCL12 on vascularization and immune response to xeno islets transplanted into TheraCyte macroencapsulation device in diabetic C57BL/6 mice.Materials and Methods:Three…2017 American Transplant Congress
Impact of Pancreatic Texture Assessment on Islet Isolation and Metabolic Outcome After TPIAT.
Introduction: Total pancreatectomy with islet autotransplantation (TPIAT) is an effective treatment for refractory chronic pancreatitis (CP). Chronic inflammation leads to fibrosis formation in pancreas and…2017 American Transplant Congress
Suppression of Inflammation by Withaferin A in Cerulein-Induced Pancreatitis Model Results in Improved Syngeneic Islet Engraftment.
Introduction: Chronic pancreatitis (CP) is characterized by inflammatory damage to acinar cells followed by islets. In clinical islet autotransplantation, patients with advanced stages of CP…2017 American Transplant Congress
Total Pancreatectomy with Islet Autotransplantation Improves Quality of Life Allowing for the Resolution of the Intractable Pain with Good Glucose Control in Properly Selected Patients with Chronic Pancreatitis.
1Surgery, University of Chicago, Chicago, IL; 2Medicine, University of Chicago, Chicago, IL
Background: There is a group of Total pancreatectomy (TP) is offered as a last option to patients with chronic pancreatitis (CP) who despite optimal treatment…2017 American Transplant Congress
Human Islet-Derived Extracellular Vesicles Stimulate CD14+ Monocytes Resulting in Proinflammatory Cytokine Production.
Department of Surgery, McGill University Health Centre, Montreal, QC, Canada
Introduction: The cellular events involved in the generation of an auto and allo-reactive immune response in recipients of islet transplantation are not well understood. In…
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