2018 American Transplant Congress
Evaluation of Culture/Preservation Conditions on Human Islet Survival and Function
BackgroundIslet transplantation is an effective treatment for type-1 diabetic patients suffering from severe hypoglycemic episodes. Islet culture or preservation post-isolation has been adopted by various…2018 American Transplant Congress
Islet Xenotransplantation: A Quest for Clinically Available Immunosuppression Regimens
Department of Surgery, Duke University Medical Center, Durham, NC.
IntroductionThe field of porcine islet xenotransplantation has made significant progress in non-human primate studies in recent years. However, one major barrier preventing clinical translation of…2018 American Transplant Congress
Extracellular Matrix from Pancreas Improves Human Islet Function In Vitro
Background:Islets which are clinically transplanted into the portal vein are subjected to inflammatory insults in the peri-transplant period followed by immune assault causing long-term islet…2018 American Transplant Congress
Ex Vivo Expanded Regulatory B Cells Promote Allograft Survival through IL-10-Dependent Pathway
Massachusetts General Hospital, Boston.
Immunomodulatory capacity of B cells make them a promising therapeutic tool for autoimmune and alloimmune response in patients. We found that transplant tolerance induced by…2018 American Transplant Congress
Analysis of Human Islet Damage during In Vitro Culture Using miRNA 375
BackgroundIslet culture prior to transplantation has been shown to facilitate recovery, reduce immunogenicity, suppress exocrine contamination and provides flexibility for evaluation of islets and preparation…2018 American Transplant Congress
CD4+ T Cells Are Key Barriers to Tolerance Resistance to Islet Allografts in Autoimmune NOD Mice
Pancreatic islet allografts are effective for restoring euglycemia in type 1 diabetics (T1D) but are vulnerable to rejection by autoreactive (islet-specific) and/or conventional alloreactive T…2018 American Transplant Congress
Ex-Vivo Pretreatment of Islets with Mitomycin-C Have a Potential to Induce Specific Immune Response for Peripheral Tolerance
Hepato-Biliary-Pancreatic and Transplant Sugery, Fukushima Medical University, Fukushima, Japan.
Background.Our previous study demonstrated that ex-vivo Mitomycin-C(MMC) pretreatment of islets reduced immunogenicity, enhancing graft survival without immunosuppression(IS). However, it is still unclear whether donor specific…2018 American Transplant Congress
A Novel Approach to Preserve Pancreatic Islet Grafts in Extrahepatic Space for Reversal of Diabetes Using Parathyroid Gland Co-Transplantation
Intro: Islet transplantation can cure type 1 diabetes; however, multiple donors are needed due to extensive perioperative loss of islets away from their native blood…2018 American Transplant Congress
Analysis of NIH Research Funding in Transplantation: The Important Impact of Physician-Scientists in Abdominal Transplant Research
Surgery, University of Virginia, Charlottesville, VA.
Introduction: Obtaining National Institutes of Health (NIH) funding for scientific research has become increasingly difficult. With increasing clinical demands and declining NIH funding, performing research…2017 American Transplant Congress
Assessment of Simple Indices Based on a Single Fasting Blood Sample in Search for an Optimal Tool to Estimate Beta Cell Function After Islet Transplantation.
Background:Precise yet logistically feasible evaluation of beta-cell function is extremely important after islet allotransplantation. We investigated the utility and possible limitations of indices using only…
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