2018 American Transplant Congress
A Novel Approach to Preserve Pancreatic Islet Grafts in Extrahepatic Space for Reversal of Diabetes Using Parathyroid Gland Co-Transplantation
Intro: Islet transplantation can cure type 1 diabetes; however, multiple donors are needed due to extensive perioperative loss of islets away from their native blood…2018 American Transplant Congress
Analysis of NIH Research Funding in Transplantation: The Important Impact of Physician-Scientists in Abdominal Transplant Research
Surgery, University of Virginia, Charlottesville, VA.
Introduction: Obtaining National Institutes of Health (NIH) funding for scientific research has become increasingly difficult. With increasing clinical demands and declining NIH funding, performing research…2018 American Transplant Congress
Ten Year Follow-Up of Islet Recipients on Anti-LFA1 Therapy: Over-Immunosuppression Leads to Operational Tolerance?
Introduction: Ten-year outcomes from a cohort of five pre-uremic islet transplant (txp) recipients treated with anti-leukocyte functional antigen-1 (LFA-1) antibody Efalizumab (EFA) revealed two patients…2018 American Transplant Congress
An Economic Analysis of the UK Pancreas Allocation Scheme
Introduction: Economics provides input to decisions concerning the best use of available resources. In transplantation, limitations include organ availability and competing organ demands. This is…2018 American Transplant Congress
Stress-Related Exosomal MicroRNA Biomarkers Released by Human Islets during Transplantation
1Baylor Scott & White Research Institute, Dallas; 2Baylor Simmons Transplant Institute, Dallas.
Purpose: Pancreatic islets release noncoding microRNAs (miRNAs) upon damage and stress during islet transplant procedures. In this study, we sought to identify miRNAs released by…2018 American Transplant Congress
Pancreas Transplant for Type 2 Diabetes is Associated with Preserved Function, but Impaired Glucose Tolerance: A Comparative Analysis
Multi-Organ Transplant Program, Toronto General Hospital, Toronto, ON, Canada.
Background: The indications and outcomes of pancreas transplantation for type 2 diabetes mellitus (T2DM) remains controversial. The aim of this study was to compare the…2018 American Transplant Congress
Estimation of Beta Cell Function after Total Pancreatectomy with Islet Autotransplantation Using Single Fasting Blood Sample Based Indices and Modified Igls Score.
Background: For precise yet logistically feasible evaluation of beta-cell function after total pancreatectomy with islet autotransplantation (TPIAT), we investigated the utility of indices using only…2018 American Transplant Congress
An Effective Tolerance Approach for Porcine Islet Xenotransplantation in Humanized Mice
Purpose: Tolerance for pig-to-human islet transplantation could render a feasible and sustainable cure for T1D. We have previously described a triple therapy (TT) approach consisting…2018 American Transplant Congress
Early Infectious Complications Post Total Pancreatectomy with Islet Autotransplantation
Introduction: We decided to assess infectious complications in patients after total pancreatectomy with islet autotransplantation (TPIAT) and check whether positive microbiological results of the islet…2018 American Transplant Congress
Early Blockade of Toll-Like Receptor 4 Reduces Ischemia-Reperfusion Injury and Improves Islet Transplantation Outcomes
Purpose: Inflammatory damage to islets during isolation is a major hurdle for success in transplantation. We investigated the safety and therapeutic potential of pharmacological blockade…
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