Articles tagged "Islets"

2018 American Transplant Congress
Ex Vivo Expanded Regulatory B Cells Promote Allograft Survival through IL-10-Dependent Pathway
K. Lee, K. Deng, L. Kojima, C. Dai, C. Rickert, H. Yeh, J. Markmann.
Massachusetts General Hospital, Boston.
Immunomodulatory capacity of B cells make them a promising therapeutic tool for autoimmune and alloimmune response in patients. We found that transplant tolerance induced by…
2018 American Transplant Congress
Analysis of Human Islet Damage during In Vitro Culture Using miRNA 375
Y. Shindo,¹ M. Levy,^1,2 M. Kanak.¹
¹Department of Surgery, School of Medicine, Virginia Commonwealth University, Richmond; ²Hume-Lee Transplant Center, VCU Health System, Richmond.
BackgroundIslet culture prior to transplantation has been shown to facilitate recovery, reduce immunogenicity, suppress exocrine contamination and provides flexibility for evaluation of islets and preparation…
2018 American Transplant Congress
CD4⁺ T Cells Are Key Barriers to Tolerance Resistance to Islet Allografts in Autoimmune NOD Mice
A. Burrack,¹ K. Beard,² M. Coulombe,² R. Gill.²
¹Microbiology, Immunology, and Cancer Biology, University of Minnesota, Minneapolis, MN; ²Surgery, University of Colorado Denver, Aurora, CO.
Pancreatic islet allografts are effective for restoring euglycemia in type 1 diabetics (T1D) but are vulnerable to rejection by autoreactive (islet-specific) and/or conventional alloreactive T…
2018 American Transplant Congress
Ex-Vivo Pretreatment of Islets with Mitomycin-C Have a Potential to Induce Specific Immune Response for Peripheral Tolerance
N. Sato, A. Kenjo, T. Kimura, R. Okada, T. Ishigame, Y. Kofunato, J. Watanabe, M. Muto, S. Suzushino, T. Shimura, S. Marubashi.
Hepato-Biliary-Pancreatic and Transplant Sugery, Fukushima Medical University, Fukushima, Japan.
Background.Our previous study demonstrated that ex-vivo Mitomycin-C(MMC) pretreatment of islets reduced immunogenicity, enhancing graft survival without immunosuppression(IS). However, it is still unclear whether donor specific…
2018 American Transplant Congress
A Novel Approach to Preserve Pancreatic Islet Grafts in Extrahepatic Space for Reversal of Diabetes Using Parathyroid Gland Co-Transplantation
C. Ward, G. Faleo, G. Nair, Q. Duh, M. Hebrok, W. Chang, P. Stock, Q. Tang.
UCSF, San Francisco, CA.
Intro: Islet transplantation can cure type 1 diabetes; however, multiple donors are needed due to extensive perioperative loss of islets away from their native blood…
2018 American Transplant Congress
Analysis of NIH Research Funding in Transplantation: The Important Impact of Physician-Scientists in Abdominal Transplant Research
A. Narahari, J. Mehaffey, A. Chandrabhatla, P. Baderdinni, L. Kron, K. Brayman.
Surgery, University of Virginia, Charlottesville, VA.
Introduction: Obtaining National Institutes of Health (NIH) funding for scientific research has become increasingly difficult. With increasing clinical demands and declining NIH funding, performing research…
2018 American Transplant Congress
Ten Year Follow-Up of Islet Recipients on Anti-LFA1 Therapy: Over-Immunosuppression Leads to Operational Tolerance?
J. Gardner,¹ A. Posselt,¹ S. Wisel,¹ U. Mashirani,² G. Szot,¹ V. Nguyen,¹ K. Johnson,¹ J. McElroy,¹ Q. Tang,¹ P. Stock.¹
¹Surgery, University of California, San Francisco, San Francisco, CA; ²Endocrinology, University of California, San Francisco, San Francisco, CA.
Introduction: Ten-year outcomes from a cohort of five pre-uremic islet transplant (txp) recipients treated with anti-leukocyte functional antigen-1 (LFA-1) antibody Efalizumab (EFA) revealed two patients…
2018 American Transplant Congress
An Economic Analysis of the UK Pancreas Allocation Scheme
K. Burke,¹ S. Birch,^2,3 T. Augustine.¹
¹The Renal and Pancreas Transplantation Unit, Manchester Royal Infirmary, Manchester, United Kingdom; ²Centre for Health Economics, University of Manchester, Manchester, United Kingdom; ³Department of Health Research Methods, Evidence and Impact, McMaster University, Hamilton, Canada.
Introduction: Economics provides input to decisions concerning the best use of available resources. In transplantation, limitations include organ availability and competing organ demands. This is…
2018 American Transplant Congress
Stress-Related Exosomal MicroRNA Biomarkers Released by Human Islets during Transplantation
P. Saravanan,¹ P. Nguyen,¹ G. Yoshimatsu,¹ C. Chang,¹ C. Darden,¹ R. Bhattacharjee,¹ X. Wang,¹ J. Gu,¹ M. Lawrence,¹ B. Naziruddin.²
¹Baylor Scott & White Research Institute, Dallas; ²Baylor Simmons Transplant Institute, Dallas.
Purpose: Pancreatic islets release noncoding microRNAs (miRNAs) upon damage and stress during islet transplant procedures. In this study, we sought to identify miRNAs released by…
2018 American Transplant Congress
Pancreas Transplant for Type 2 Diabetes is Associated with Preserved Function, but Impaired Glucose Tolerance: A Comparative Analysis
S. Doshi, C. Pulitano, D. Al-Adra, A. Norgate, G. Sapisochin, M. Selzner, I. McGilvray, J. Schiff, M. Cattral.
Multi-Organ Transplant Program, Toronto General Hospital, Toronto, ON, Canada.
Background: The indications and outcomes of pancreas transplantation for type 2 diabetes mellitus (T2DM) remains controversial. The aim of this study was to compare the…