Articles tagged "Islets"

2018 American Transplant Congress
Ten Year Follow-Up of Islet Recipients on Anti-LFA1 Therapy: Over-Immunosuppression Leads to Operational Tolerance?
J. Gardner,¹ A. Posselt,¹ S. Wisel,¹ U. Mashirani,² G. Szot,¹ V. Nguyen,¹ K. Johnson,¹ J. McElroy,¹ Q. Tang,¹ P. Stock.¹
¹Surgery, University of California, San Francisco, San Francisco, CA; ²Endocrinology, University of California, San Francisco, San Francisco, CA.
Introduction: Ten-year outcomes from a cohort of five pre-uremic islet transplant (txp) recipients treated with anti-leukocyte functional antigen-1 (LFA-1) antibody Efalizumab (EFA) revealed two patients…
2018 American Transplant Congress
An Economic Analysis of the UK Pancreas Allocation Scheme
K. Burke,¹ S. Birch,^2,3 T. Augustine.¹
¹The Renal and Pancreas Transplantation Unit, Manchester Royal Infirmary, Manchester, United Kingdom; ²Centre for Health Economics, University of Manchester, Manchester, United Kingdom; ³Department of Health Research Methods, Evidence and Impact, McMaster University, Hamilton, Canada.
Introduction: Economics provides input to decisions concerning the best use of available resources. In transplantation, limitations include organ availability and competing organ demands. This is…
2018 American Transplant Congress
Stress-Related Exosomal MicroRNA Biomarkers Released by Human Islets during Transplantation
P. Saravanan,¹ P. Nguyen,¹ G. Yoshimatsu,¹ C. Chang,¹ C. Darden,¹ R. Bhattacharjee,¹ X. Wang,¹ J. Gu,¹ M. Lawrence,¹ B. Naziruddin.²
¹Baylor Scott & White Research Institute, Dallas; ²Baylor Simmons Transplant Institute, Dallas.
Purpose: Pancreatic islets release noncoding microRNAs (miRNAs) upon damage and stress during islet transplant procedures. In this study, we sought to identify miRNAs released by…
2018 American Transplant Congress
Pancreas Transplant for Type 2 Diabetes is Associated with Preserved Function, but Impaired Glucose Tolerance: A Comparative Analysis
S. Doshi, C. Pulitano, D. Al-Adra, A. Norgate, G. Sapisochin, M. Selzner, I. McGilvray, J. Schiff, M. Cattral.
Multi-Organ Transplant Program, Toronto General Hospital, Toronto, ON, Canada.
Background: The indications and outcomes of pancreas transplantation for type 2 diabetes mellitus (T2DM) remains controversial. The aim of this study was to compare the…
2018 American Transplant Congress
Estimation of Beta Cell Function after Total Pancreatectomy with Islet Autotransplantation Using Single Fasting Blood Sample Based Indices and Modified Igls Score.
J. Gołębiewska,¹ P. Bachul,² L. Basto,² M. Kijek,² N. Fillman,² K. Cieply,² K. Golab,² L. Wang,² M. Tibudan,² C. Thomas,³ A. Dębska-Ślizień,¹ J. Fung,² P. Witkowski.²
¹Nephrology, Transplantology and Internal Medicine, Medical University of Gdańsk, Gdańsk, Poland; ²Surgery, University of Chicago, Chicago; ³Medicine, University of Chicago, Chicago.
Background: For precise yet logistically feasible evaluation of beta-cell function after total pancreatectomy with islet autotransplantation (TPIAT), we investigated the utility of indices using only…
2018 American Transplant Congress
An Effective Tolerance Approach for Porcine Islet Xenotransplantation in Humanized Mice
F. Lee,¹ A. Dangi,¹ M. Burnette,¹ X. Zhang,¹ B. Hering,² X. Luo.¹
¹Comprehensive Transplant Center, Northwestern University, Chicago, IL; ²Diabetes/Endocrinology, Diabetes Institute, Minneapolis, MN.
Purpose: Tolerance for pig-to-human islet transplantation could render a feasible and sustainable cure for T1D. We have previously described a triple therapy (TT) approach consisting…
2018 American Transplant Congress
Early Infectious Complications Post Total Pancreatectomy with Islet Autotransplantation
J. Gołębiewska,¹ P. Bachul,² L. Basto,² M. Kijek,² N. Fillman,² K. Cieply,² K. Golab,² L. Wang,² M. Tibudan,² C. Thomas,³ A. Dębska-Ślizień,¹ J. Fung,² P. Witkowski.²
¹Nephrology, Transplantology and Internal Medicine, Medical University of Gdańsk, Gdańsk, Poland; ²Surgery, University of Chicago, Chicago; ³Medicine, University of Chicago, Chicago.
Introduction: We decided to assess infectious complications in patients after total pancreatectomy with islet autotransplantation (TPIAT) and check whether positive microbiological results of the islet…
2018 American Transplant Congress
Early Blockade of Toll-Like Receptor 4 Reduces Ischemia-Reperfusion Injury and Improves Islet Transplantation Outcomes
C. Chang,¹ M. Lawrence,² R. Kane,¹ B. Naziruddin.³
¹Institute of Biomedical Studies, Baylor University, Waco; ²Baylor Scott & White Research Institute, Dallas; ³Baylor Simmons Transplant Institute, Dallas.
Purpose: Inflammatory damage to islets during isolation is a major hurdle for success in transplantation. We investigated the safety and therapeutic potential of pharmacological blockade…
2018 American Transplant Congress
Early Predictors of Metabolic Outcomes in TPIAT
M. Kanak,¹ Y. Shindo,¹ M. Levy.^1,2
¹Surgery, Virginia Commonwealth University, Richmond, VA; ²Hume-Lee Transplant Center, VCU Health System, Richmond, VA.
BackgroundTotal Pancreatectomy with Islet Auto-transplantation (TPIAT) has been actively performed on patients with severe, debilitating pain of chronic pancreatitis or recurrent acute pancreatitis. It is…
2018 American Transplant Congress
Ultra Low Dose of IL-2 Produces Long-Term Drug-Free Survival of Cynomolgus Islets Allografts
M. Koulmanda,¹ V. Chipashivili,¹ L. Li,¹ M. Duggan,² T. Strom.¹
¹Medicine and Surgery, Beth Israel Deaconess Medical Center, Boston, MA; ²Surgery, MGH, Boston, MA.
Therapeutic principles established in non-human transplant models have value for clinical application despite cost related limitations on sample size. We have tested new therapies in…