Articles tagged "Islets"

2018 American Transplant Congress
An Effective Tolerance Approach for Porcine Islet Xenotransplantation in Humanized Mice
F. Lee,¹ A. Dangi,¹ M. Burnette,¹ X. Zhang,¹ B. Hering,² X. Luo.¹
¹Comprehensive Transplant Center, Northwestern University, Chicago, IL; ²Diabetes/Endocrinology, Diabetes Institute, Minneapolis, MN.
Purpose: Tolerance for pig-to-human islet transplantation could render a feasible and sustainable cure for T1D. We have previously described a triple therapy (TT) approach consisting…
2018 American Transplant Congress
Early Infectious Complications Post Total Pancreatectomy with Islet Autotransplantation
J. Gołębiewska,¹ P. Bachul,² L. Basto,² M. Kijek,² N. Fillman,² K. Cieply,² K. Golab,² L. Wang,² M. Tibudan,² C. Thomas,³ A. Dębska-Ślizień,¹ J. Fung,² P. Witkowski.²
¹Nephrology, Transplantology and Internal Medicine, Medical University of Gdańsk, Gdańsk, Poland; ²Surgery, University of Chicago, Chicago; ³Medicine, University of Chicago, Chicago.
Introduction: We decided to assess infectious complications in patients after total pancreatectomy with islet autotransplantation (TPIAT) and check whether positive microbiological results of the islet…
2018 American Transplant Congress
Early Blockade of Toll-Like Receptor 4 Reduces Ischemia-Reperfusion Injury and Improves Islet Transplantation Outcomes
C. Chang,¹ M. Lawrence,² R. Kane,¹ B. Naziruddin.³
¹Institute of Biomedical Studies, Baylor University, Waco; ²Baylor Scott & White Research Institute, Dallas; ³Baylor Simmons Transplant Institute, Dallas.
Purpose: Inflammatory damage to islets during isolation is a major hurdle for success in transplantation. We investigated the safety and therapeutic potential of pharmacological blockade…
2018 American Transplant Congress
Early Predictors of Metabolic Outcomes in TPIAT
M. Kanak,¹ Y. Shindo,¹ M. Levy.^1,2
¹Surgery, Virginia Commonwealth University, Richmond, VA; ²Hume-Lee Transplant Center, VCU Health System, Richmond, VA.
BackgroundTotal Pancreatectomy with Islet Auto-transplantation (TPIAT) has been actively performed on patients with severe, debilitating pain of chronic pancreatitis or recurrent acute pancreatitis. It is…
2018 American Transplant Congress
Ultra Low Dose of IL-2 Produces Long-Term Drug-Free Survival of Cynomolgus Islets Allografts
M. Koulmanda,¹ V. Chipashivili,¹ L. Li,¹ M. Duggan,² T. Strom.¹
¹Medicine and Surgery, Beth Israel Deaconess Medical Center, Boston, MA; ²Surgery, MGH, Boston, MA.
Therapeutic principles established in non-human transplant models have value for clinical application despite cost related limitations on sample size. We have tested new therapies in…
2018 American Transplant Congress
Obese Patients Show Resistance to Narcotics Reduction after TPIAT for Chronic Pancreatitis
G. Yoshimatsu,¹ B. Naziruddin,³ K. Kumano,² H. Fernandez,³ E. Beecherl,³ N. Onaca.³
¹Fukuoka University, Fukuoka, Japan; ²Baylor Scott and White Research Institute, Dallas; ³Baylor Simmons Transplant Institute, Dallas.
Total pancreatectomy with islet autotransplantation (TPIAT) is an effective treatment option for chronic pancreatitis patients with refractory pain. Patients with high BMI (>30) are known…
2018 American Transplant Congress
NFkB Inhibitor Improves Glycemic Control after Syngeneic Islet Transplantation by Suppression of Proinflammatory and Apoptotic Gene Expression in a Cerulein-Induced Pancreatitis Model
G. Yoshimatsu,¹ C. Darden,² K. Kumano,² C. Chang,² P. Saravanan,² M. Lawrence,² B. Naziruddin.³
¹Fukuoka University, Fukuoka, Japan; ²Baylor Scott and White Research Institute, Dallas; ³Baylor Simmons Transplant Institute, Dallas.
Total pancreatectomy with islet autotransplantation (TPIAT) is an effective treatment for refractory chronic pancreatitis. Repeated or continuous pancreatitis attack leads islet damage beyond inflamed exocrine…
2018 American Transplant Congress
Hypoxia Results in Endoplasmic Reticulum Stress and Activation of the Unfolded Protein Response in Isolated Human Islets and Human Donor Pancreases
B. Sandhu, M. Prendecki, N. Vallant, G. Rutter, C. Pusey, V. Papalois.
Imperial College London, London, United Kingdom.
Background: The Unfolded Protein Response (UPR) is activated as an adaptive response to endoplasmic reticulum (ER) stress, however if ER stress is not resolved, UPR…
2018 American Transplant Congress
Human Pancreatic ECM Scaffolds for Islet Culture and Transplantation
D. Tremmel, S. Sackett, A. Feeney, R. Maguire, J. Odorico.
Univ of Wisconsin, Madison.
Extracellular matrix (ECM) plays an important role through structural and biochemical interaction with cells. Tissue-specific ECM, attained through decellularization (decel), has been proposed in many…
2018 American Transplant Congress
IL-10 Requirement in In Vitro Expanded Breg-Mediated Allograft Tolerance is Tissue Specific
C. Dai, K. Lee, L. Kojima, K. Deng, S. Kimura, C. Rickert, H. Yeh, J. Markmann.
Center for Transplantation Sciences, Massachusetts General Hospital, Boston, MA.
Introduction:Regulatory B cells (Bregs) have shown several multiple mechanisms of suppression, including Treg induction and IL-10 production. Consistent with work of other groups on Breg…