2021 American Transplant Congress
Autoimmune Responses to DNA Topoisomerase I Exacerbate Renal Allograft Injury
Inflammation and Immunity, Cleveland Clinic, Cleveland, OH
*Purpose: Multiple clinical and pre-clinical studies describe correlations between pre-existing or de novo autoimmune responses and poor transplant outcome. We have previously reported that following…2021 American Transplant Congress
Identification and Comprehensive Validation of Prognostic Genes After Ischemic and Reperfusion Injury Across Different Donor Types in Renal Transplantation
Department of Urology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China
*Purpose: Ischemic and reperfusion injury (IRI) remains an inevitable and major challenge for renal transplant patients. The current study aims to obtain overall insights into…2021 American Transplant Congress
Pathways and Factors That Confer Therapeutic Properties of Adipose Derived Regenerative Cells in Reducing Ischaemia Reperfusion Injury in Kidney Transplantation
Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, United Kingdom
*Purpose: Studies in our rat model of ischemic reperfusion injury (IRI) demonstrate improved kidney function post injection of non-cultured autologous adipose-derived regenerative cells (ADRC). The…2021 American Transplant Congress
Early Hypertransaminasemia in Kidney Transplant Recipient: Influence of Donor Type and Clinical Significance
Nephrology, Hospital del Mar, Barcelona, Spain
*Purpose: The increase in transaminases after kidney transplant (KT) is frequent. Although the cause is unknown, it has been associated with factors such as immunosuppression,…2021 American Transplant Congress
Microbial Signatures Promote Antibiotic-Mediated Alleviation of Peritransplant Liver Damage in Mouse Recipients
*Purpose: Although recent evidence shows that modifications of gut microbiota by antibiotics (Abx) influences liver allograft function, its compositional role in orthotopic liver transplantation (OLT)…2021 American Transplant Congress
Ex Situ Heart Perfusion and Standard of Care Cold Storage Differentially Affect the Ischemic Secretome of Donor Hearts in Perfusates but Not the Reperfusion Response in Recipient Plasma
*Purpose: Various allograft preservation procedures influence the donor organ status that may be reflected by the cytokine/chemokine microenvironment in heart transplant (HTx) recipients. In addition,…2020 American Transplant Congress
Tissue Specificity and the Role of Lymphocytes in Estrogen-Mediated Protection from Renal Ischemia Reperfusion Injury
Hospital of the University of Pennsylvania, Philadelphia, PA
*Purpose: Renal ischemia reperfusion injury (IRI) is a major contributor to delayed graft function (DGF) in kidney transplantation. We previously demonstrated lower rates of DGF…2020 American Transplant Congress
Impact of Liver Graft Preservation Methods on the Gut Microbiome and Metabolome
*Purpose: Normothermic ex-vivo liver perfusion (NEVLP) is a powerful platform for organ preservation and assessment. It induces metabolic reactivation that potentially helps clear accumulated toxic…2020 American Transplant Congress
Effect of Cold Ischemia Time on Long-Term Graft Survival of Post-One Year Survivor Deceased Donor Kidney Transplant Recipients
*Purpose: Prolonged cold ischemia time (CIT) is known to adversely affect short-term graft survival among renal allografts. However, its effect on long-term graft survival is…2020 American Transplant Congress
The Pro-Inflammatory Profile of Alcoholic Patients Increases Risk for Ischemia-Reperfusion Injury During Orthotopic Liver Transplantation
*Purpose: Ischemia-reperfusion injury (IRI) elicits cellular damage which triggers a pro-inflammatory immune response that can lower allograft survival in orthotopic liver transplant (OLT) patients. In…
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