2021 American Transplant Congress
The Inflammatory Response in the Context of Tissue Injury: Roles of Tyro3, Axl, and Mer (TAM) Receptor Tyrosine Kinases in Liver Ischemia/reperfusion Injury
*Purpose: Although the inflammatory response in liver ischemia reperfusion injury has been studied extensively, how the context of tissue injury (presence of necrotic/apoptotic cells) regulates…2021 American Transplant Congress
Proxies of Ischemia Time Do Not Predict 1-Year Posttransplant Survival
*Purpose: A barrier to broader distribution of donor organs is a concern that increased donor-to-recipient (DtR) distances could increase ischemia times and compromise posttransplant (PT)…2021 American Transplant Congress
Glycogen Synthase Kinase 3 Beta Regulates Distinctive Macrophage Subsets in the Activation and Resolution of Liver Ischemia Reperfusion Injury
*Purpose: Glycogen synthase kinase 3β (Gsk3β) differentially regulates pro- and anti-inflammatory programs in macrophages upon TLR stimulations. We have documented in a murine liver partial…2021 American Transplant Congress
Autoimmune Responses to DNA Topoisomerase I Exacerbate Renal Allograft Injury
Inflammation and Immunity, Cleveland Clinic, Cleveland, OH
*Purpose: Multiple clinical and pre-clinical studies describe correlations between pre-existing or de novo autoimmune responses and poor transplant outcome. We have previously reported that following…2021 American Transplant Congress
Identification and Comprehensive Validation of Prognostic Genes After Ischemic and Reperfusion Injury Across Different Donor Types in Renal Transplantation
Department of Urology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China
*Purpose: Ischemic and reperfusion injury (IRI) remains an inevitable and major challenge for renal transplant patients. The current study aims to obtain overall insights into…2021 American Transplant Congress
Pathways and Factors That Confer Therapeutic Properties of Adipose Derived Regenerative Cells in Reducing Ischaemia Reperfusion Injury in Kidney Transplantation
Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, United Kingdom
*Purpose: Studies in our rat model of ischemic reperfusion injury (IRI) demonstrate improved kidney function post injection of non-cultured autologous adipose-derived regenerative cells (ADRC). The…2021 American Transplant Congress
Early Hypertransaminasemia in Kidney Transplant Recipient: Influence of Donor Type and Clinical Significance
Nephrology, Hospital del Mar, Barcelona, Spain
*Purpose: The increase in transaminases after kidney transplant (KT) is frequent. Although the cause is unknown, it has been associated with factors such as immunosuppression,…2021 American Transplant Congress
Microbial Signatures Promote Antibiotic-Mediated Alleviation of Peritransplant Liver Damage in Mouse Recipients
*Purpose: Although recent evidence shows that modifications of gut microbiota by antibiotics (Abx) influences liver allograft function, its compositional role in orthotopic liver transplantation (OLT)…2021 American Transplant Congress
Ex Situ Heart Perfusion and Standard of Care Cold Storage Differentially Affect the Ischemic Secretome of Donor Hearts in Perfusates but Not the Reperfusion Response in Recipient Plasma
*Purpose: Various allograft preservation procedures influence the donor organ status that may be reflected by the cytokine/chemokine microenvironment in heart transplant (HTx) recipients. In addition,…2021 American Transplant Congress
Recovery After Extended Static Cold Storage Preservation Using Subnormothermic Machine Perfusion in VCA
*Purpose: Vascularized composite allografts (VCA) are more sensitive to cold ischemia than solid organ transplants due to the remaining metabolism in skeletal muscle cells. In…
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