ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Ischemia"

  • 2021 American Transplant Congress

    Ex Situ Heart Perfusion and Standard of Care Cold Storage Differentially Affect the Ischemic Secretome of Donor Hearts in Perfusates but Not the Reperfusion Response in Recipient Plasma

    E. Chichelnitskiy1, B. Wiegmann2, N. Ledwoch1, F. Ius2, F. Wandrer1, J. Kühne1, K. Beushausen1, J. Keil1, S. V. Rojas2, W. Sommer2, C. Kühn2, I. Tudorache2, M. Avsar2, A. Haverich2, G. Warnecke2, C. S. Falk1

    1MHH, Institute of Transplant Immunology, Hannover, Germany, 2MHH, Department for Cardiothoracic, Transplantation and Vascular Surgery, Hannover, Germany

    *Purpose: Various allograft preservation procedures influence the donor organ status that may be reflected by the cytokine/chemokine microenvironment in heart transplant (HTx) recipients. In addition,…
  • 2021 American Transplant Congress

    Recovery After Extended Static Cold Storage Preservation Using Subnormothermic Machine Perfusion in VCA

    M. Goutard1, R. J. de Vries1, A. G. Lellouch1, E. Lupon1, C. Pendexter1, S. N. Tessier1, M. A. Randolph1, L. Lantieri2, C. L. Cetrulo1, K. Uygun1

    1Massachusetts General Hospital, Harvard Medical School, Shriners Hospitals for Children, Boston, MA, 2Hôpital Européen Georges Pompidou, Paris, France

    *Purpose: Vascularized composite allografts (VCA) are more sensitive to cold ischemia than solid organ transplants due to the remaining metabolism in skeletal muscle cells. In…
  • 2021 American Transplant Congress

    Cold Perfusion for Ischemia Minimization Reduces Cardiac Injury in an Ex Vivo Xenoperfusion Model

    M. R. Connolly1, A. Calhoun1, F. Pollok1, L. Burdorf1, Z. Habibabady1, M. Ma1, S. Miura1, W. Eyestone2, C. Phelps2, D. Ayares2

    1Massachusetts General Hospital, Boston, MA, 2Revivicor, Blacksburg, VA

    *Purpose: Prior studies using Steen’s cold perfusion storage technique for heart ischemia minimization (IM) prevented initial xenograft dysfunction (IXD). Our pilot data evaluates the effect…
  • 2021 American Transplant Congress

    Intravenous Immunoglobulin Protects Liver Allograft from Ischemia Reperfusion Injury in Human Liver Transplantation

    S. Yokota, J. C. Alonso-Escalante, R. P. Tindall, K. R. Tabar, L. Machado, T. Uemura, N. L. Thai

    Department of Surgery, Allegheny General Hospital, Pittsburgh, PA

    *Purpose: Ischemia/reperfusion (I/R) injury following prolonged cold storage has a significant impact on early and late human liver transplantation (LTx) outcomes. Prevention of I/R injury…
  • 2021 American Transplant Congress

    Hypothermic Oxygenated Machine Perfusion Protects Against Cholangiocyte and Hepatocyte Injury and Mitigates Inflammation vs Static Cold Storage: Preliminary Results from a Single Center

    G. Panayotova, F. Paterno, M. McCarty, G. Dikdan, S. Simonishvili, Y. Qin, L. Brown, A. Amin, K. E. Lunsford, J. V. Guarrera

    Transplant Surgery, Rutgers NJMS, Newark, NJ

    *Purpose: Hypothermic-oxygenated machine perfusion (HMP-O2) is a promising preservation technique with potential to mitigate ischemia/reperfusion injury and improve graft and patient outcomes. Here we present…
  • 2021 American Transplant Congress

    MiRNA as Regulator of Cell Death and Inflammatory Response in Hepatic Iri

    E. Bardhi1, T. Rousselle1, J. McDaniels1, S. Bontha1, J. Eason2, D. Maluf1, V. Mas3

    1Surgery, University of Maryland, Baltimore, MD, 2Surgery, James D Eason Transplant Institute, Memphis, TN, 3Surgery, University of Maryland - Division of Surgical Science, Baltimore, MD

    *Purpose: Hepatic IRI represents a barrier to the use of available organs. Early graft dysfunction of donor livers is directly related to the severity of…
  • 2021 American Transplant Congress

    Classification of Distinct Patterns of Ischemic Cholangiopathy Following DCD Liver Transplantation: Distinct Clinical Courses and Long-Term Outcomes from a Multicenter Cohort

    K. P. Croome1, A. K. Mathur2, B. Aqel2, L. Yang1, J. K. Heimbach3, T. Taner3, C. B. Rosen3, R. Paz-Fumagalli1, C. Taner1

    1Mayo Clinic Jacksonville, Jacksonville, FL, 2Mayo Clinic Arizona, Scottsdale, AZ, 3Mayo Clinic Rochester, Rochester, MN

    *Purpose: As the number of donation after circulatory death (DCD) liver transplants (LTs) performed in the United States continues to increase annually, there has been…
  • 2021 American Transplant Congress

    Spleen Tyrosine Kinase (syk): A Novel Regulator of Neutrophil Infiltration in Hepatic Iri

    V. Boominathan, A. Kobayashi, S. Duarte, A. Zarrinpar

    Surgery, University of Florida, Gainesville, FL

    *Purpose: Hepatic ischemia-reperfusion injury (IRI) plays a governing role in orthotopic liver transplantation, significantly impairing early graft function and increasing organ susceptibility to rejection. Neutrophil…
  • 2021 American Transplant Congress

    The Impact of Combined Warm and Cold Ischemia Times on Post Transplant Outcomes

    M. E. Foley1, A. J. Vinson2, K. K. Tennankore2

    1Faculty of Medicine, Dalhousie University, Halifax, NS, Canada, 2Division of Nephrology, Medicine, Dalhousie University/ Nova Scotia Health, Halifax, NS, Canada

    *Purpose: Both prolonged warm ischemia time (WIT) and cold ischemia time (CIT) have been associated with an increased risk of graft failure following kidney transplantation,…
  • 2021 American Transplant Congress

    Hepatic Ferroptosis in Cold Stress and Warm Ischemia-reperfusion: A Novel Therapeutic Target in Liver Transplantation

    H. Kojima1, H. Hirao1, K. Kadono1, T. Ito1, K. J. Dery1, S. Kageyama2, K. Nakamura3, F. M. Kaldas1, D. G. Farmer1, J. W. Kupiec-Weglinski1

    1UCLA Medical Center, Los Angeles, CA, 2Kyoto University, Kyoto, Japan, 3Nishi-Kobe Medical Center, Kyoto, Japan

    *Purpose: Ferroptosis, a newly discovered programmed cell death platform, due to iron-dependent accumulation of lipid peroxides, has been reported to aggravate ischemia-reperfusion (IR) injury in…
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