ATC Abstracts

American Transplant Congress abstracts

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Articles tagged "Ischemia"

  • 2022 American Transplant Congress

    Circulating Galectin-3 Levels Increase in Syngeneic Rat Recipients of Vascularized Composite Allografts Subjected to Prolonged Ischemia

    Z. Wang1, B. Li1, Y. Wang1, D. Yoeli1, N. Nakra1, N. Limon De La Rosa1, A. A. Su1, A. Jani1, D. W. Mathes1, K. M. Washington1, E. Farkash2, C. A. Huang1

    1University of Colorado, Denver | Anschutz Medical Campus, Aurora, CO, 2University of Michigan, Ann Arbor, Ann Arbor, MI

    *Purpose: During the process of transplantation, organs and tissue are necessarily subjected to some degree of hypoxic and ischemic injury during procurement, preservation and following…
  • 2022 American Transplant Congress

    Cold Stress-Induced Ferroptosis in Liver Sinusoidal Endothelial Cells Deteriorates Liver Transplant Outcomes

    H. Kojima, H. Hirao, K. Kadono, T. Ito, K. J. Dery, F. Kaldas, J. Kupiec-Weglinski

    UCLA Medical Center, Los Angeles, CA

    *Purpose: While hepatocytes are affected by ischemia-reperfusion injury (IRI) especially under normothermic stress, liver sinusoidal endothelial cells (LSECs) are particularly vulnerable to cold storage-induced IR-insult.…
  • 2022 American Transplant Congress

    Significant Reduction of Troponin I Elaboration After Ischemia Minimization in the First Hour of Ex Vivo Xeno Heart Perfusion

    F. Pollok1, M. R. Connolly1, A. Calhoun1, Z. Habibabady1, S. Miura1, M. Ma1, S. Pratts1, L. Burdorf1, Y. Kan2, J. V. Layer2, J. V. Layer2, E. Tan2, R. Anand2, M. Li2, K. C. Hall2, M. E. Youd2, K. Stiede2, W. Qin2, M. Curtis2, A. Azimzadeh1, R. N. Pierson1

    1Center for Transplantation Sciences, Massachusetts General Hospital, Cambridge, MA, 2eGenesis Inc., Cambridge, MA

    *Purpose: Previous studies showed that ischemia minimization (IM), accomplished by perfusing the heart xenograft during storage, prevents ‘initial cardiac xenograft dysfunction’ (ICXD) and enables prolonged…
  • 2022 American Transplant Congress

    Clusterin Protects Kidney Transplants from Ischemia-Reperfusion Injury by Modulating Neutrophil Infiltration

    Y. Shim1, R. Fan2, N. Dvorina2, K. McCrae1, B. William2

    1Cardiovascular and Metabolic Sciences, Cleveland Clinic Lerner Research Institute, Cleveland, OH, 2Inflammation and Immunity, Cleveland Clinic Lerner Research Institute, Cleveland, OH

    *Purpose: Ischemia-reperfusion injury (IRI) is inevitable during organ transplantation. Clusterin (CLU) has shown to be protective in IRI. Supplementation of storage solution with recombinant CLU…
  • 2022 American Transplant Congress

    Dynamic Changes and Roles of Specialized Pro-resolving Lipid Meditators in the Initiation and Resolution Process of Lung Ischemia-Reperfusion Injury in Rats

    H. Oda1, S. Tanaka1, M. Shinohara2, Y. Morimura1, Y. Yokoyama1, H. Kayawake1, Y. Yamada1, A. Ohsumi1, D. Nakajima1, H. Date1

    1Department of Thoracic Surgery, Kyoto University Graduate School of Medicine, Kyoto City, Japan, 2The Integrated Center for Mass Spectrometry, Kobe University Graduate School of Medicine, Kobe City, Japan

    *Purpose: Lung ischemia-reperfusion injury (IRI) is one of the significant complications after lung transplantation, which is a form of acute lung injury by robust inflammation.…
  • 2022 American Transplant Congress

    Ultrasound Targeted Microbubble Cavitation During Ex Vivo Normothermic Machine Perfusion Reduces Peribiliary Vascular Plexus Thrombi and Graft Injury in a DCD Liver Transplant Model

    Y. Nigmet1, C. Hughes1, X. Chen2, A. Demetris3, D. Stolz4, J. Pacella2, A. Humar5, F. Villanueva2

    1Transplant Surgery, University of Pittsburgh, Pittsburgh, PA, 2Center for Ultrasound Molecular Imaging and Therapeutics, University of Pittsburgh, Pittsburgh, PA, 3Transplant Pathology, University of Pittsburgh, Pittsburgh, PA, 4Center for Biological Imaging, University of Pittsburgh, Pittsburgh, PA, 5Thomas E Starzl Transplant Inst, Pittsburgh, PA

    *Purpose: Thrombus formation in the peribiliary vascular plexus (PBP) is a proposed mechanism for ischemic cholangiopathy (IC) after liver transplantation from donors after circulatory death…
  • 2022 American Transplant Congress

    Post-Operative Day 1 Galectin-3 is Predictive of Early Allograft Dysfunction in Liver Transplantation

    D. Yoeli, T. Ferrell, I. Rodriguez, N. Limon De La Rosa, N. Nakra, Z. Wang, E. Cervantes-Alvarez, R. Choudhury, M. Adams, T. Nydam, E. Pomfret, C. Huang, N. Navarro Alvarez, H. Moore

    University of Colorado Anschutz Medical, Aurora, CO

    *Purpose: Early allograft dysfunction (EAD) is an important outcome measure in liver transplantation that is predictive of graft failure, but the mechanism behind it remains…
  • 2022 American Transplant Congress

    Cold Ischemia Time is More Critical for Older Donor Kidney Survival: A Machine Learning Approach

    J. Kim, J. Ahn, A. Massie, D. Segev, S. Bae

    Johns Hopkins, Baltimore, MD

    *Purpose: Increasing utilization of kidneys from older donors is a potential solution to mitigate the organ shortage. However, older donor age is a risk factor…
  • 2022 American Transplant Congress

    Impact of Total Parenteral Nutrition on Donor Kidneys During Oxygenated Preservation at 22ºC Ex Vivo

    P. Luke1, A. Jackson2, A. Ruthirakanthan2, S. Juriasingani2, M. Levine1, L. Jiang2, R. Patel2, M. Richard-Mohamed1, S. Forrest1, A. Sener1, R. N. Bhattacharjee1

    1London Health Sciences Centre, London, ON, Canada, 2Western University, London, ON, Canada

    *Purpose: Recent studies have shown that ex vivo preservation at 37 º C can reduce kidney injury compared to current clinical practice. However, to mitigate…
  • 2022 American Transplant Congress

    Pulsatile Kidney Perfusion Improves Survival and Graft Function in High Acuity Combined Liver Kidney Transplant (CLKT) Recipients

    T. Liu1, G. Panayotova2, F. Paterno3, A. Amin2, L. Brown4, J. Guarrera5, K. Lunsford6

    1Surgery, Rutgers New Jersey Medical School, Newark, NJ, 2Division of Transplant and Hepatobiliary Surgery, Rutgers New Jersey Medical School, Newark, NJ, 3Rutgers State University of New Jersey, Montclair, NJ, 4Rutgers New Jersey Medical School, Morris Plains, NJ, 5Surgery/ Transplant, Rutgers New Jersey Medical School, Newark, NJ, 6Rutgers New Jersey Medical School, Newark, NJ

    *Purpose: Due to underlying renal dysfunction, CLKT recipients tend to have higher medical acuity at baseline resulting in a higher likelihood of post-operative complications and…
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