Articles tagged "Ischemia"

2022 American Transplant Congress
Stabilization of Cell-Cell Junctions Improves Outcomes in an Ex-Vivo Porcine Renal Ischemia-Reperfusion Injury Culture Model
L. Plumblee¹, K. Patel², L. Langerude³, Z. Tu³, D. Nord⁴, T. Beduschi³, S. Nadig⁵, C. Atkinson⁶
¹MUSC College of Medicine, Gainesville, FL, ²University of Virgina, Charlottesville, VA, ³University of Florida, Gaineville, FL, ⁴Division of Pulmonary, Critical Care, and Sleep Medicine, University of Florida, Gainesville, FL, ⁵Northwestern University, Charleston, SC, ⁶Pulmonary Medicine, University of Florida, Gainesville, FL
*Purpose: Renal transplant is an accepted therapy for end-stage renal failure. Chronic transplant dysfunction remains the leading cause of long-term graft loss and is, in…
2022 American Transplant Congress
p40 Homodimers Stimulate Graft Dendritic Cells to Produce IL-15 Driving Endogenous Donor-Reactive Memory CD8 T Cell Activation within High-Risk Cardiac Allografts
H. Tsuda¹, A. Valujskikh², R. Fairchild³
¹Inflammation and Immunity, Cleveland Clinic, Cleveland, OH, ²The Cleveland Clinic Fdn, Cleveland, OH, ³Cleveland Clinic Foundation, Cleveland, OH
*Purpose: Acute allograft injury occurring during the first 1-2 days post-transplant is mediated by graft infiltrating endogenous donor-reactive memory CD8 T cells and requires their…
2022 American Transplant Congress
Estrogen Receptor Beta Deletion is Protective in Renal Ischemia Reperfusion Injury but Pharmacologic Inhibition of Estrogen Receptor Beta is Not
C. OBrien¹, P. Hernandez², S. Concors², Z. Wang¹, G. Ge¹, W. Hancock³, M. Levine²
¹Surgery, University of Pennsylvania, Philadelphia, PA, ²University of Pennsylvania, Philadelphia, PA, ³Childrens Hospital of Philadelphia, Philadelphia, PA
*Purpose: Renal Ischemia Reperfusion Injury (IRI) contributes substantially to delayed graft function (DGF) in kidney transplantation. Prior work by our group has shown lower rates…
2022 American Transplant Congress
Development of Ex-Situ Hypothermic and Normothermic Reperfusion as an Innovative Method to Preserve an Assess Uterus: A Preliminary Result
L. Dion¹, E. Loiseau², B. Mesnard³, G. Blancho⁴, T. Thubert⁵, J. Hervouet⁴, D. Minault⁴, S. Le Bas-Bernardet⁶, R. Josien⁶, V. Lavoué¹, J. Branchereau⁷
¹Gynécologie, CHU Rennes, Rennes, France, ²Gynécologie, CHU Nantes, Nantes, France, ³Department of Urology, Chu Nantes, Nantes Université, ITUN, Nantes, France, Nantes, France, ⁴CHU Nantes, Nantes, France, ⁵Gynécologie, CHU Nantes, nantes, France, ⁶Université de Nantes, Nantes, France, ⁷Urologie, CHU Nantes, Nantes, France
*Purpose: Uterine transplantation is a new surgical approach in transplantation community. It can be performed after living donation (LD) or Dead-Brain Donation (DBD). Static cold…
2022 American Transplant Congress
PACAP-Mediated Autophagy Prevents Liver Ischemia Reperfusion Injury in OLT
Z. Xue, B. Yang, R. Busuttil, J. Kupiec-Weglinski, H. Ji
UCLA Medical Center, Los Angeles, CA
*Purpose: Pituitary adenylate cyclase-activating polypeptide (PACAP) is from vasoactive intestinal peptide-glucagon-secretin family. Our group was the first to demonstrate that neuropeptide PACAP, which innervates the…
2022 American Transplant Congress
The Role Of Ferroptosis In Modulating Ischemia Reperfusion Injury(IRI) Gene Expression In Marginal Donor Livers(MDLS) Using The Novel Protect Normothermic Perfusion Pump
M. D. Nazzal¹, K. Kurashima², J. Bettag², A. Chen², S. Bruno², A. Nagarapu², J. Van Nispen¹, J. Krebs², J. Teckman², D. Carpenter³, D. Hermelin³, C. Varma¹, A. Jain²
¹Surgery, Saint Louis University, Saint Louis, MO, ²Pediatrics, Saint Louis University, Saint Louis, MO, ³Pathology, Saint Louis University, Saint Louis, MO
*Purpose: Severe IRI can impair liver allograft when using MDLs and accounts for high discard rates. We tested iron chelators to reduce ferroptosis and IRI.…
2022 American Transplant Congress
Final Report of the Use of α-Lipoic Acid in Liver Transplantation to Prevent Ischemia Reperfusion Injury
P. C. Casciato¹, N. Ambrosi², F. Caro², L. Oliveira¹, F. Zalazar¹, A. Garmendia¹, M. Bonifacio¹, M. Padilla¹, J. Paladini¹, J. Di Menno¹, J. Pekjol¹, E. de Santibañes¹, M. de Santibañes¹, G. Adrian¹, C. Incardona¹, E. Chuluyan²
¹Hospital Italiano, Buenos Aires, Argentina, ²CEFYBO, Buenos Aires, Argentina
*Purpose: The ischemia and reperfusion injury contributs to grafts deterioration and adverse post-transplant outcomes. The aim of the present study was to evaluate the safety…
2022 American Transplant Congress
Type 1 Natural Killer T-cells: Key Mediators of Ischemia- Reperfusion Injury in Hepatic Steatosis
J. R. Liggett¹, J. Kang¹, K. Loh¹, K. Oza¹, Y. Cui¹, D. Kwon², H. Li³, B. Kallakury², T. Fishbein¹, W. Cui¹, K. Khalid¹, A. H. Kroemer¹
¹MedStar Georgetown Transplant Institute, Washington, DC, ²Pathology, MedStar Georgetown University Hospital, Washington, DC, ³Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, DC
*Purpose: Hepatic ischemia-reperfusion injury (IRI) poses a significant risk in liver transplantation and hepatic resection and is further exacerbated by hepatic steatosis. Type 1 Natural…
2022 American Transplant Congress
Changes in Cold Ischemia Time and Transplantation Practices with the Concentric Model of Kidney Allocation
C. M. Puttarajappa¹, P. Sood¹, A. Tevar¹, V. Gunabushanam¹, S. Hariharan¹, S. Mohan²
¹University of Pittsburgh Medical Center, Pittsburgh, PA, ²Columbia University, New York, NY
*Purpose: Evaluate impact of the new concentric kidney allocation system (KAS250) on kidney utilization, allocation practices and cold ischemia time (CIT).*Methods: Using data from the…
2022 American Transplant Congress
CEACAM1 Splice Isoforms Are Regulated by Hypoxia Inducible Factors 1 alpha (HIF-1a) to Protect Against Ischemic Injury in Mouse and Human Liver Transplantation
K. J. Dery¹, H. Kojima¹, K. Kadono², H. Hirao¹, J. Kupiec-Weglinski³
¹UCLA, Los Angeles, CA, ²Liver Transplant Surgery, UCLA, Los Angeles, CA, ³UCLA Medical Center, Los Angeles, CA
*Purpose: CEACAM1 (CC1) is a transmembrane glycoprotein that undergoes extensive alternative splicing (AS) to generate CC1-S and CC1-L. It is currently unclear which of these…

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