Articles tagged "Ischemia"

2022 American Transplant Congress
Normothermic Machine Perfusion of the Liver Supports Protein Translation and Mitochondrial Function While Reducing Protein Degradation and Metabolic Imbalance: A Proteomics Study
L. Lo Faro¹, A. Thorne², H. Huang³, P. Charles³, M. Kaisar¹, S. Davis³, F. Dengu¹, S. Shaheed¹, J. Mulvey¹, R. Fischer³, D. Nasralla⁴, B. Kessler³, H. Leuvenink², P. Friend¹, R. Ploeg¹
¹Nuffield Department of Surgical Sciences, University of Oxford, Oxford, United Kingdom, ²University Medical Center Groningen, Groningen, Netherlands, ³Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom, ⁴Royal Free London NHS Foundation Trust, London, United Kingdom
*Purpose: Liver preservation by normothermic machine perfusion (NMP) involves perfusion of the graft with oxygenated blood and nutrients. The NMP Liver trial by the Consortium…
2022 American Transplant Congress
Impact of Cold Ischemia Times on 1 Year Kidney Transplant Outcomes
T. Fletchinger, L. Burdine
Department of Surgery, University of Arkansas for Medical Sciences, Little Rock, AR
*Purpose: Recent organ allocation changes have increased travel and subsequent cold ischemia times (CIT) of kidney allografts. We sought to investigate the impact of prolonged…
2022 American Transplant Congress
An Immune-Modulatory Strategy to Mitigate Hepatic Ischemia Reperfusion Injury in a Murine Model
S. Duarte, A. Kobayashi, V. Boominathan, A. Kwiatkowski, J. Simonovich, A. Wanchoo, G. Hudalla, B. Keselowsky, A. Zarrinpar
University of Florida, Gainesville, FL
*Purpose: Hepatic ischemia/reperfusion injury (IRI) is the leading cause of early graft dysfunction and contributes to the shortage of donor liver grafts. However, despite its…
2022 American Transplant Congress
Normothermic Ex Vivo Pancreas Perfusion for the Preservation of Porcine Pancreas Grafts
C. Parmentier, S. Ray, L. Mazilescu, M. Kawamura, T. Goto, Y. Noguchi, B. Arulratnam, S. Ganesh, M. Selzner, T. Reichman
Multi-Organ Transplant Department, University Health Network - Toronto General Hospital, Toronto, ON, Canada
*Purpose: The purpose of this study was to develop a stable porcine model for normothermic ex-vivo pancreas perfusion (NEVPP) for the preservation of grafts with…
2022 American Transplant Congress
Final Flow and Resistance with Cold Pulsatile Perfusion Preservation Are Independent Risk Factors for Dialysis in the First Week Post-Transplant, Analysis of SRTR Data
D. S. Keith, E. Lessmann
Kidney Transplant, Ascension Sacred Heart Hospital, Pensacola, FL
*Purpose: To determine if final flow or resistance on cold pulsatile perfusion preservation (CPPP) have independent predictive value for dialysis in the first week post-transplant.*Methods:…
2022 American Transplant Congress
Superoxide in Cardiac Allografts from Donors After Circulatory Death
M. Urban¹, T. Bruett², K. F. Duncan¹, N. W. Markin³, M. M. Chacon³, M. C. Zimmerman⁴
¹Department of Surgery. Division of Cardiothoracic Surgery, University of Nebraska Medical Center, Omaha, NE, ²College of Medicine. Department of Cellular and Integtrative Physiology., University of Nebraska Medical Center, Omaha, NE, ³Department of Anesthesiology, University of Nebraska Medical Center, Omaha, NE, ⁴Department of Cellular and Integrative Physiology, University of Nebraska Medical Center, Omaha, NE
*Purpose: Quality of cardiac allografts from donors after circulatory death (DCD) is adversely impacted by warm ischemia and subsequent reperfusion during organ resuscitation. Post-transplant myocardial…
2022 American Transplant Congress
Natural Killer Cell NKG2D Receptor Mediates Airway Cell Hypoxic Injury Through Recognition of Stress Molecules
T. Tsao¹, E. Aminian¹, A. Shemesh¹, L. Tran¹, P. Wang¹, F. Deiter¹, J. R. Greenland², D. R. Calabrese¹
¹University of California, San Francisco, San Francisco, CA, ²Medicine, University of California, San Francisco, CA
*Purpose: Primary graft dysfunction (PGD), the clinical syndrome of pulmonary hypoxia and reperfusion, occurs afer 1/3 of all lung transplants, and accounts for excess mortality.…
2022 American Transplant Congress
Exploration of the Optimal pH in Hypothermic Machine Perfusion for Rat Liver Grafts Retrieved from Circulatory Death
S. Sakamoto¹, M. Fukai¹, K. Shibata¹, H. Bochimoto², N. Mohd Zin², N. Kawamura¹, T. Ishikawa¹, M. Fujiyoshi¹, T. Shimamura³, A. Taketomi¹
¹Department of Gastroenterological Surgery 1, Hokkaido University Graduate School, Sapporo, Japan, ²Department of Cell Physiology, The Jikei University School of Medicine, Tokyo, Japan, ³Division of Organ Transplantation, Hokkaido University Hospital, Sapporo, Japan
*Purpose: Although some investigators have reported favorable results of hypothermic machine perfusion (HMP) in liver transplantation, the efficacy to the hepatic graft retrieved from circulatory…
2022 American Transplant Congress
Crosstalk Between micro-RNAs, mRNAs, and Long Non-Coding RNAs in Human Hepatic Ischemia Reperfusion Injury
C. Kuscu¹, S. Naik¹, C. Eymard², A. Bajwa¹, D. Maluf³, V. Mas³, J. Eason⁴, C. Kuscu¹
¹Transplant Research Institute, James D. Eason Transplant Institute, Department of Surgery, The University of Tennessee Health Science Center, Memphis, TN, ²James D. Eason Transplant Institute, Department of Surgery, The University of Tennessee Health Science Center, Memphis, TN, ³Surgery, University of Maryland, Baltimore, MD, ⁴University of Tennessee/Methodist Transplant Institute, Memphis, TN
*Purpose: Present study utilizes multiple omics tools and clinical samples with a system biology approach characterizing mRNAs, long non-coding RNAs (lncRNAs) and small non-coding RNAs…
2022 American Transplant Congress
Cold Ischemic Time and Kidney Graft Failure; Mediation Through Delayed Graft Function
J. Miller¹, W. Irish², D. Sawinski³, A. Massie⁴, J. Snyder¹
¹Scientific Registry of Transplant Recipients, Minneapolis, MN, ²Department of Surgery, East Carolina University, Greenville, NC, ³Division of Nephrology and Hypertension, Weill Cornell Medical College, New York, NY, ⁴Division of Surgery, Johns Hopkins School of Medicine, Baltimore, MD
*Purpose: Delayed graft function (DGF) has been associated with decreased graft survival and prolonged cold ischemia time (CIT) has been proposed as a modifiable DGF…

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