Articles tagged "Ischemia"

2022 American Transplant Congress
Donor-Derived IL-33 Plays a Critical Role in Lung Allograft Acceptance
Y. Guo¹, Z. Mei¹, M. Khalil¹, D. Li¹, A. Banerjee¹, A. Gelman², D. Kreisel², A. Krupnick¹
¹Department of Surgery, University of Maryland, Baltimore, Baltimore, MD, ²Washington University School of Medicine in St Louis, Saint Louis, MO
*Purpose: IL-33 is considered an alarmin secreted in response to tissue damage. While it is elaborated by the lung allograft as part of ischemia-reperfusion injury…
2022 American Transplant Congress
Analysis of Tissue and Effluent Damage Associated Molecular Patterns Following Hypothermic Oxygenated Machine Perfusion vs Static Cold Storage in Liver Transplantation
G. G. Panayotova, Y. Qin, S. Simonishvili, T. Ayorinde, F. Paterno, L. Brown, A. Amin, K. E. Lunsford, J. V. Guarrera
Transplant Surgery, Rutgers New Jersey Medical School, Newark, NJ
*Purpose: Hypothermic Oxygenated Machine Perfusion (HMP-O2) results in decreased ischemia/reperfusion injury (IRI) after liver transplantation; however, the molecular pathways of protection are largely unexplored. In…
2022 American Transplant Congress
Nebulized Mitochondria Localize to Transplanted Allografts and Improve Outcomes Following Lung Transplantation
D. Nord¹, Z. Tu², L. Langerude¹, A. McQuiston¹, J. Kwon³, S. Nadig⁴, T. Machuca⁵, C. Atkinson¹
¹Pulmonary Medicine, University of Florida, Gainesville, FL, ²University of Florida, Gaineville, FL, ³MUSC College of Medicine, Charleston, SC, ⁴Northwestern University, Charleston, SC, ⁵Department of Surgery, University of Florida, Gainesville, FL
*Purpose: Mitochondrial transplantation therapy is an innovative strategy for the treatment of mitochondrial dysfunction. The approach has shown efficacy in the treatment of cardiac ischemic…
2022 American Transplant Congress
Allograft TLR9 is Required for Endogenous Donor-Reactive Memory CD8 T Cell Activation in High-Risk Cardiac Allografts to Mediate CTLA-4Ig Resistant Graft Rejection
E. H. Koritzinsky, D. Ueda, H. Tsuda, S. Miyari, R. L. Fairchild
Inflammation and Immunity, Cleveland Clinic, Cleveland, OH
*Purpose: Prolonged allograft cold ischemic storage (CIS) and subsequent increased ischemia-reperfusion injury (IRI) following solid organ transplant act through innate immune pathways that promote early…
2022 American Transplant Congress
Delivery of Plasmin During Machine Perfusion or Cold Storage Flush Improves Early Transplant Outcomes in aRat Dcd Liver Transplant Model
N. Abraham¹, M. Zhang¹, P. Cray², R. Neill¹, G. Cywinska¹, J. Migaly¹, R. Kahan¹, A. Pontula¹, J. Penaflor¹, Q. Gao¹, K. P. Samy¹, J. J. Pollara², V. Novokhatny³, M. G. Hartwig¹, A. S. Barbas¹
¹Duke Division of Abdominal Transplant Surgery, Duke Ex-Vivo Organ Lab (DEVOL), Durham, NC, ²Duke Division of Surgical Sciences, Pollara lab, Durham, NC, ³Bioscience Industrial Group, Grifols R&D, Durham, NC
*Purpose: Ischemic injury of the peribiliary glands and vascular plexus has been described in DCD livers and correlates with the development of cholangiopathy. Investigators have…
2022 American Transplant Congress
Investigating RNA Interference-Mediated Inhibition of Liver Ischemia Reperfusion Injury During Liver Preservation
J. E. Buchwald¹, D. Echeverria², J. Sousa², N. McHugh², A. Khvorova², P. N. Martins³
¹RNA Therapeutics Institute, Department of Surgery, University of Massachusetts Chan Medical School, Worcester, MA, ²RNA Therapeutics Institute, University of Massachusetts Chan Medical School, Worcester, MA, ³Department of Surgery, University of Massachusetts Chan Medical School, Worcester, MA
*Purpose: Liver transplantation cures acute end-stage and chronic liver diseases, yet current strategies of organ preservation including static cold storage (SCS) and machine perfusion (MP)…
2022 American Transplant Congress
Type 1 Innate Lymphoid Cells Alleviate Acute Liver Injury Following Transplantation via Interferon-γ Mediated Pathway
H. Kojima, K. Kadono, H. Hirao, K. J. Dery, J. Kupiec-Weglinski, Y. Zhai
Dumont-UCLA Transplant Center, Los Angeles, CA
*Purpose: Innate lymphoid cells (ILCs), a heterogeneous population of non-B non-T lymphocytes, have been found in recent years to plays key regulatory roles in tissue…
2022 American Transplant Congress
Identification of Akkermansia Muciniphila and Bacteroides Thetaiotaomicron Associated with the Alleviation of Peritransplant Liver Damage in Mouse Recipients
K. Dery¹, H. Kojima², H. Hirao², K. Kadono³, T. Dong², J. Kupiec-Weglinski⁴
¹Surgery, UCLA, Los Angeles, CA, ²UCLA, Los Angeles, CA, ³Liver Transplant Surgery, UCLA, Los Angeles, CA, ⁴UCLA Medical Center, Los Angeles, CA
*Purpose: Although recent evidence shows that modifications of gut microbiota by antibiotics (Abx) influences liver allograft function, its compositional role in orthotopic liver transplantation (OLT)…
2022 American Transplant Congress
HDAC6 Inhibition Mediated Protection from Hepatic Ischemia Reperfusion is Associated with Preserved Glutathione Levels
C. OBrien¹, P. Hernandez¹, S. Concors², Z. Wang¹, G. Ge³, A. Kozikowski⁴, W. Hancock⁵, M. Levine²
¹Surgery, University of Pennsylvania, Philadelphia, PA, ²University of Pennsylvania, Philadelphia, PA, ³Surgery, University of Pensylvania, Philadelphia, PA, ⁴College of Pharmacy, University of Illinois at Chicago, Chicago, IL, ⁵Childrens Hospital of Philadelphia, Philadelphia, PA
*Purpose: Liver Ischemia reperfusion injury (IRI) and Acetaminophen (APAP) toxicity are important causes of acute liver failure in the United States, that lack effective therapy.…
2022 American Transplant Congress
Role of Mitochondrial Transplantation in Enhancing Liver Regeneration Following Partial Hepatectomy
G. Lamanilao¹, C. Watkins¹, C. Kuscu¹, C. Kuscu¹, J. Eason², A. Bajwa¹
¹Transplant Research Institute, James D. Eason Transplant Institute, Department of Surgery, The University of Tennessee Health Science Center, Memphis, TN, ²University of Tennessee/Methodist Transplant Institute, Memphis, TN
*Purpose: Therapeutic strategies that accelerate the rate of liver regeneration following partial hepatectomy (PH) should be developed to reduce occurrences of small for size syndrome…