Articles tagged "Ischemia"

2022 American Transplant Congress
Final Flow and Resistance with Cold Pulsatile Perfusion Preservation Are Independent Risk Factors for Dialysis in the First Week Post-Transplant, Analysis of SRTR Data
D. S. Keith, E. Lessmann
Kidney Transplant, Ascension Sacred Heart Hospital, Pensacola, FL
*Purpose: To determine if final flow or resistance on cold pulsatile perfusion preservation (CPPP) have independent predictive value for dialysis in the first week post-transplant.*Methods:…
2022 American Transplant Congress
Superoxide in Cardiac Allografts from Donors After Circulatory Death
M. Urban¹, T. Bruett², K. F. Duncan¹, N. W. Markin³, M. M. Chacon³, M. C. Zimmerman⁴
¹Department of Surgery. Division of Cardiothoracic Surgery, University of Nebraska Medical Center, Omaha, NE, ²College of Medicine. Department of Cellular and Integtrative Physiology., University of Nebraska Medical Center, Omaha, NE, ³Department of Anesthesiology, University of Nebraska Medical Center, Omaha, NE, ⁴Department of Cellular and Integrative Physiology, University of Nebraska Medical Center, Omaha, NE
*Purpose: Quality of cardiac allografts from donors after circulatory death (DCD) is adversely impacted by warm ischemia and subsequent reperfusion during organ resuscitation. Post-transplant myocardial…
2022 American Transplant Congress
Natural Killer Cell NKG2D Receptor Mediates Airway Cell Hypoxic Injury Through Recognition of Stress Molecules
T. Tsao¹, E. Aminian¹, A. Shemesh¹, L. Tran¹, P. Wang¹, F. Deiter¹, J. R. Greenland², D. R. Calabrese¹
¹University of California, San Francisco, San Francisco, CA, ²Medicine, University of California, San Francisco, CA
*Purpose: Primary graft dysfunction (PGD), the clinical syndrome of pulmonary hypoxia and reperfusion, occurs afer 1/3 of all lung transplants, and accounts for excess mortality.…
2022 American Transplant Congress
Exploration of the Optimal pH in Hypothermic Machine Perfusion for Rat Liver Grafts Retrieved from Circulatory Death
S. Sakamoto¹, M. Fukai¹, K. Shibata¹, H. Bochimoto², N. Mohd Zin², N. Kawamura¹, T. Ishikawa¹, M. Fujiyoshi¹, T. Shimamura³, A. Taketomi¹
¹Department of Gastroenterological Surgery 1, Hokkaido University Graduate School, Sapporo, Japan, ²Department of Cell Physiology, The Jikei University School of Medicine, Tokyo, Japan, ³Division of Organ Transplantation, Hokkaido University Hospital, Sapporo, Japan
*Purpose: Although some investigators have reported favorable results of hypothermic machine perfusion (HMP) in liver transplantation, the efficacy to the hepatic graft retrieved from circulatory…
2022 American Transplant Congress
Crosstalk Between micro-RNAs, mRNAs, and Long Non-Coding RNAs in Human Hepatic Ischemia Reperfusion Injury
C. Kuscu¹, S. Naik¹, C. Eymard², A. Bajwa¹, D. Maluf³, V. Mas³, J. Eason⁴, C. Kuscu¹
¹Transplant Research Institute, James D. Eason Transplant Institute, Department of Surgery, The University of Tennessee Health Science Center, Memphis, TN, ²James D. Eason Transplant Institute, Department of Surgery, The University of Tennessee Health Science Center, Memphis, TN, ³Surgery, University of Maryland, Baltimore, MD, ⁴University of Tennessee/Methodist Transplant Institute, Memphis, TN
*Purpose: Present study utilizes multiple omics tools and clinical samples with a system biology approach characterizing mRNAs, long non-coding RNAs (lncRNAs) and small non-coding RNAs…
2022 American Transplant Congress
Cold Ischemic Time and Kidney Graft Failure; Mediation Through Delayed Graft Function
J. Miller¹, W. Irish², D. Sawinski³, A. Massie⁴, J. Snyder¹
¹Scientific Registry of Transplant Recipients, Minneapolis, MN, ²Department of Surgery, East Carolina University, Greenville, NC, ³Division of Nephrology and Hypertension, Weill Cornell Medical College, New York, NY, ⁴Division of Surgery, Johns Hopkins School of Medicine, Baltimore, MD
*Purpose: Delayed graft function (DGF) has been associated with decreased graft survival and prolonged cold ischemia time (CIT) has been proposed as a modifiable DGF…
2022 American Transplant Congress
CD38 Knockout Mice Demonstrate Decreased Neutrophil Infiltration Following Renal Ischemia Reperfusion Injury
I. Woelfel¹, A. Ruffing¹, I. El-Ayachi¹, K. Washburn², S. Black¹, A. Schenk¹
¹Ohio State University, Columbus, OH, ²The Ohio State University, Columbus, OH
*Purpose: Ischemia reperfusion injury (IRI) perpetuates inflammation and causes significant organ injury in solid organ transplantation. CD38 is a ectoenzyme widely expressed on lymphocytes with…
2022 American Transplant Congress
Estimating the Effect of Increased Donor Heart Ischemic Time on Post-Transplant Survival Using Instrumental Variables
G. Ran¹, K. Lazenby¹, N. Narang², W. F. Parker³
¹Pritzker School of Medicine, University of Chicago, Chicago, IL, ²Department of Medicine, University of Illinois-Chicago, Chicago, IL, ³Department of Medicine, University of Chicago, Chicago, IL
*Purpose: Isolate the impact of organ ischemic time on post-transplant survival using the recent change in heart allocation policy as a natural experiment.*Methods: We examined…
2022 American Transplant Congress
Cost-Effectiveness of an Intra-Operative Renal Allograft Cooling Device
K. Hansen¹, C. Yock², J. Pietzsch²
¹University of California, San Francisco, San Francisco, CA, ²Stanford, Palo Alto, CA
*Purpose: Existing literature shows intra-operative cooling of a renal allograft during anastomosis reduces the incidence of delayed graft function in deceased donor kidney transplant recipients…
2022 American Transplant Congress
Timing of Hypotension Post Kidney Transplant Impacts the Risk of Subsequent Delayed Graft Function
S. A. Morrison¹, A. Thanamayooran², K. Tennankore¹, A. J. Vinson¹
¹Dalhousie University, Halifax, NS, Canada, ²Nova Scotia Health Authority, Halifax, NS, Canada
*Purpose: Hypotension is common post-kidney transplant and is associated with delayed graft function (DGF; a need for dialysis in the first week post-transplant) and prolonged…