Articles tagged "Ischemia"

2016 American Transplant Congress
Anti-LG3 Antibodies Enhance Renal Microvascular Rarefaction, Fibrosis and Dysfunction Associated with Ischemia-Reperfusion Injury.
B. Yang,^1,3 K. Hamelin,^1,3 M. HÉnault-Rondeau,^1,3 N. Patey,^1,2,3 J. Turgeon,^1,3 S. Lan,^1,3 L. Pomerleau,¹ J. Peng,¹ J. Tremblay,¹ M. DieudÉ,^1,3 M.-J. HÉbert,^1,3 H. Cardinal.^1,3
¹Research Centre, Centre Hospitalier de l'Université de Montréal (CRCHUM), Montreal, QC, Canada; ²Department of Pathology, CHU Ste-Justine, Montreal, QC, Canada; ³Canadian National Transplant Research Program, CNTRP, Canada.
Delayed graft function (DGF) is associated with decreased kidney graft survival. We have shown that pre-transplant anti-LG3 autoantibodies were associated with increased risk of DGF…
2016 American Transplant Congress
Probability, Risk Factors, and Long-Term Outcomes of Biliary Complications After Hepatic Artery Thrombosis in Adult Liver Transplant Recipients: 20 Years Experience from a Single Center.
M. Fujiki, K. Hashimoto, T. Diago, C. Quintini, F. Aucejo, D. Kelly, B. Eghtesad, J. Fung, C. Miller.
General Surgery, Cleveland Clinic, Cleveland, OH.
Hepatic artery thrombosis (HAT) after liver transplantation (LT) is a devastating complication associated with ischemic biliary cholangiopathy (IBC) that can occur even after successful revascularization.…
2016 American Transplant Congress
Metabolic Dysregulation and Mitochondrial Dysfunction Are Key Features of Injury Profiles of Donor Kidneys After Brain Death.
M. Lo Faro,¹ M. Akhtar,¹ H. Huang,¹ M. Kaisar,¹ R. Robolledo,² K. Morten,¹ L. Heather,¹ A. Dona,³ H. Leuvenink,² S. Fuggle,¹ B. Kessler,¹ C. Pugh,¹ R. Ploeg.¹
¹University of Oxford, Oxford, United Kingdom; ²University of Groningen, Groningen, Netherlands; ³University of Sydney, Sydney, Australia.
Donation after brain death (DBD) organ donors remain an important source for kidney transplantation. However, brain death affects donor organs rendering them susceptible to ischemia…
2016 American Transplant Congress
Attenuation of Warm Hepatic Ischemia-Reperfusion Injury by Bruton's Tyrosine Kinase Inhibition.
A. Zarrinpar,¹ T. Palumbo,¹ K. Nakamura,¹ C. Lassman,² R. Busuttil,¹ J. Kupiec-Weglinski.¹
¹Surgery, Dumont-UCLA Translant Center, Los Angeles, CA; ²Pathology, UCLA, Los Angeles, CA.
Bruton's tyrosine kinase (Btk) is a central player in multiple signaling pathways in lymphoid and myeloid cells, including neutrophils. Neutrophils are crucial effectors in the…
2016 American Transplant Congress
Hypothermic Machine Perfusion Is Also Beneficial for Deceased Donor Kidneys When Cold Ischemic Time Is Short and a Short Cold Ischemic Time Is Also Beneficial When Kidneys Are Machine Perfused.
J. Kox,¹ C. Moers,² D. Monbaliu,³ A. Strelniece,⁴ J.-W. Treckmann,⁵ I. Jochmans,³ H. Leuvenink,² L. van Heurn,¹ J. Pirenne,³ A. Paul,⁵ R. Ploeg.^2,6
¹Dept. of Surgery, Maastricht University Medical Center, Maastricht, Netherlands; ²Dept. of Surgery, University Medical Center Groningen, Groningen, Netherlands; ³Abdominal Transplant Surgery, University Hospital Leuven, Leuven, Belgium; ⁴Eurotransplant, Leiden, Netherlands; ⁵General, Visceral and Transplantation Surgery, University Hospital Essen, Essen, Germany; ⁶Oxford Transplant Centre, Oxford, United Kingdom.
IntroductionHypothermic machine perfusion (HMP) of deceased donor kidneys is associated with better outcome compared to static cold storage (SCS). It is generally assumed that HMP…
2016 American Transplant Congress
Liver Ischemia Induces Kupffer Cell Necroptosis to Facilitate Liver Inflammatory Immune Activation.
S. Yue,¹ H. Zhou,^1,2 R. Busuttil,¹ J. Kupiec-Weglinski,¹ X. Wang,² Y. Zhai.¹
¹Surgery, David Geffen School of Medicine-University of California-Los Angeles, Los Angeles, CA; ²Liver Surgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu Province, China.
Background & AimsAlthough mechanisms of liver immune activation against ischemia reperfusion injury (IRI) have been studied extensively, cellular bases have yet to be fully defined…
2016 American Transplant Congress
Hydrogen Sulfide Supplementation Helps Mitigate Effects of Ischemia Reperfusion Injury in a Murine Model of Donation After Cardiac Death Renal Transplantation.
J. Grewal,¹ I. Lobb,¹ M. Saha,² J. Jiang,² A. Haig,¹ A. Sener.^1,2
¹Microbiology & Immunology, University of Western Ontario, London, Canada; ²Matthew Mailing Centre for Translational Transplant Studies, London Health Sciences Centre, London, Canada.
Donation after cardiac death(DCD) renal grafts experience a combination of prolonged warm and cold ischemia leading to greater ischemia reperfusion injury(IRI) that results in higher…
2016 American Transplant Congress
SLPI in the Perfusion Liquid: A Predictor Marker of Short and Long Term Clinical Outcomes.
A. Dotta,¹ F. Caro,² K. Peña Ponce,¹ N. Ambrosi,² J. Salaberry,² X. García,¹ E. Minué,¹ L. León,¹ F. Sánchez,² F. Togniolo,¹ C. Incardona,³ E. Chuluyan,² D. Casadei.¹
¹Instituto de Nefrología, Caba, Argentina; ²CEFYBO-UBA, Caba, Argentina; ³Fundación GADOR, Caba, Argentina.
A lot of efforts have been done to identify the risk factors that tend to diminish the incidence of delayed graft function (DGF). Recently, the…
2016 American Transplant Congress
Recombinant TSGL-Ig Protects Liver Endothelial Cells Against Prolonged Cold Preservation Injury in Mouse Liver Transplantation.
C. Zhang,^1,2 H. Ji,¹ Y. Liu,^1,2 Y. Zhang,^1,2 X.-D. Shen,¹ F. Gao,¹ R. Busuttil, G. Shaw, J. Kupiec-Weglinski.
¹Dumont-UCLA Transplant Center, Division of Liver and Pancreas Transplantation, Department of Surgery, David Geffen School of Medicine at University of California-Los Angeles, Los Angeles, CA; ²Department of Surgery, Division of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China.
Background: Liver endothelial cells (LEC) suffer from ROS-mediated stress in the pathogenesis of liver ischemia-reperfusion injury (IRI). We used a novel recombinant form of soluble…
2016 American Transplant Congress
Markers of Activation of Microvascular Endothelial Cells Predict a Poor Long-Term Graft Outcome in Early Renal Graft Biopsies Displaying Acute Tubular Necrosis.
Y.-C. Dubois-Xu,¹ P. Ahmadpoor,¹ A. Corchia,¹ D. Buob,² P. Galichon,¹ I. Brochériou,¹ C. Suberbielle,³ A. Hertig,¹ E. Rondeau.¹
¹INSERM UMR_S1155, INSERM, Paris, France; ²Pathology, APHP, Hoptal Tenon, Paris, France; ³HLA Institute, INSERM_S940, Paris, France.
Acute tubular necrosis (ATN), is a histopathological feature frequently seen in the early post renal transplant biopsies taken from patients with delayed graft function (DGF).…