Articles tagged "Ischemia"

2016 American Transplant Congress
Ex-Vivo Normothermic Perfusion (EVNP) Attenuation of Kidney Ischemia-Reperfusion Injury (IRI): A Proposed Mechanism.
I. Palma,¹ S. Kabagambe,¹ Y. Smolin,¹ T. Boyer,¹ I. Palma,¹ O. Fiehn,² Y.-J. Chen,¹ J. Sageshima,¹ C. Santhanakrishnan,¹ C. Troppmann,¹ R. Perez.¹
¹Department of Surgery, University of California, Davis Medical Center, Sacramento, CA; ²Department of Molecular and Cellular Biology & Genome Center, University of California-Davis, Davis, CA.
Introduction: EVNP has the potential to repair deceased donor renal IRI. We hypothesize that EVNP may attenuate renal IRI via alteration of lipid metabolism.Methods: Eight…
2016 American Transplant Congress
The Impact of Total Ischaemic Time, Donor Age and the Pathway of Donor Death on Graft Outcomes After Deceased Donor Kidney Transplantation.
G. Wong,¹ A. Teixeira-Pinto,¹ C. Jeremy,¹ C. Jonathan,¹ M. Stephen,² L. Wai.³
¹University of Sydney, Sydney, Australia; ²University of Adelaide, Adelaide, Australia; ³University of Western Sydney, Perth, Australia.
Prolonged ischaemia is a known risk factor for delayed graft function and its interaction with donor characteristics, the pathways of donor death and graft outcomes…
2016 American Transplant Congress
DNA Methylation Patterns and Association with Graft Injury Severity Post Liver Transplantation.
R. Gehrau, S. Bontha, V. Mas, D. Maluf.
UVA, Charlottesville.
Background: Epigenetics modifications in the graft may influence injury severity and function post liver transplantation (LT). This study aimed to interrogate the effect of different…
2016 American Transplant Congress
The mTORC2 Activation Is Critical for Hepato-Cytoprotection Against Ischemia and Reperfusion Injury.
H. Zhou,^1,2 J. Zhu,^1,3 S. Yue,¹ R. Busuttil,¹ J. Kupiec-Weglinski,¹ X. Wang,² Y. Zhai.¹
¹Surgery, David Geffen School of Medicine-University of California-Los Angeles, LA, CA; ²Liver Surgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu Province, China; ³Liver Surgery, Renji Hospital, Shanghai, China.
Background & AimsRapamycin and Everolimus have been used in liver transplant patients, particularly those with calcineurin inhibitor-related nephrotoxicity and hepatocellular carcinoma. Although designed as mTORC1…
2016 American Transplant Congress
Activating Transcription Factor 5 (ATF5) Regulates Liver Ischemia/Reperfusion Injury.
G.-Q. Shen,² M. Morita,¹ J. Fung,² L. Lu,^1,2 S. Qian.^1,2
¹Immunology, LernerResearch Institute, Cleveland Clinic, Cleveland, OH; ²General Surgery, Transplant Center, Digestive Disease Institute, Cleveland Clinic, Cleveland, OH.
Activating transcription factor 5 (ATF5), a member of the ATF/cAMP response element-binding proteins, is extremely highly expressed in the liver, the significance of which is…
2016 American Transplant Congress
Fractional Excretion of NGAL Instead of ^99mTcMAG₃Renography to Monitor Resolution of Delayed Graft Function.
J. Bank, M. Reinders, L. Noordermeer, M. Mallat, S. van der Kooij, C. van Kooten, J. de Fijter.
Nephrology, Leiden University Medical Center, Leiden, Netherlands.
Introduction: Kidneys transplanted from extended criteria donors have a higher prevalence of delayed graft function (DGF). Early identification of factors that prolong duration of DGF…
2016 American Transplant Congress
Gsk3β Regulates Macrophage Pro-Inflammatory Immune Activation via AMPK-Mediated Induction of Small Heterodimer Partner (SHP).
H. Zhou,^1,2 J. Zhu,^1,3 S. Yue,¹ R. Busuttil,¹ J. Kupiec-Weglinski,¹ X. Wang,² Y. Zhai.¹
¹Surgery, David Geffen School of Medicine-University of California-Los Angeles, LA, CA; ²Liver Surgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu Province, China; ³Liver Surgery, Renji Hospital, Shanghai, China.
Background & AimsAlthough glycogen synthase kinase 3 β (Gsk3β) has been found to play key roles in ischemia and reperfusion injuries (IRI) of different organs,…
2016 American Transplant Congress
Heparanase: A New Factor Involved in the Pro-Fibrotic Renal Biological Machinery Activated by the Ischemia/Reperfusion (I/R) Injury.
G. Zaza,¹ V. Masola,¹ G. Gambaro,² M. Onisto,³ G. Bellin,¹ I. Vlodavsky,⁴ Z. Abassi,⁵ A. Lupo.¹
¹Renal Unit, Department of Medicine, University of Verona, Verona, Italy; ²Division of Nephrology and Dialysis, Columbus-Gemelli Hospital Catholic University, Rome, Italy; ³Department of Biomedical Sciences, University of Padova, Padova, Italy; ⁴Cancer and Vascular Biology Research Center, Rappapor Faculty of Medicine, Technion, Haifa, Israel, Italy; ⁵Department of Physiology and Biophysics, Rappaport Faculty of Medicine, Technion, Haifa, Israel, Italy.
Ischemia/reperfusion (I/R) is an important cause of acute renal failure and delayed graft function, and it may induce chronic renal damage by activating epithelial to…
2016 American Transplant Congress
Bioinformatic Analysis of Pathways Mediating Clusterin Functions in Kidney Cells Under Normoxia and Hypoxia.
G. Dairi, Q. Guan, C. Collins, C. Ong, M. Gleave, C. Nguan, C. Du.
Department of Urologic Sciences, University of British Columbia, Vancouver, BC, Canada.
Background: Clusterin (CLU) is a chaperone-like protein and contributes to the resistance of the kidney to ischemia-reperfusion injury (IRI), however its pathways are not fully…
2016 American Transplant Congress
Factors Associated with Prolonged Warm Ischemia Time Among Deceased Donor Kidney Transplant Recipients.
A. Miller,¹ B. Kiberd,¹ I. Alwayn,² S. Kim,³ K. Tennankore.¹
¹Medicine, Division of Nephrology, Dalhousie University, Halifax, NS, Canada; ²Surgery, Multi Organ Transplant Program, Dalhousie University, Halifax, NS, Canada; ³Medicine, Division of Nephrology, University of Toronto, Toronto, ON, Canada.
Prolonged warm ischemia time (the time from organ removal from cold storage to reperfusion with warm blood) is associated with graft failure and mortality among…