2017 American Transplant Congress
PPAR-γ Agonist Attenuates Hepatic Ischemia-Reperfusion Injury in a Mouse Model by Regulating Kupffer Cell Polarization.
PPAR-γ agonists have shown protective effect on ischemia-reperfusion injury (IRI) in cerebral and renal tissue. The effects of PPAR-γ on hepatic IRI is unclear. We…2017 American Transplant Congress
Risk of Ischemic Biliary Injury Is Not Associated with Prolonged Hepatic Artery Ischemic Times During Liver Transplantation.
1Univ. Colorado, Aurora, CO; 2Univ. Washington, Seattle, WA
Biliary strictures after liver transplant (LT) are associated with increased patient morbidity and graft failure. AIM: To assess the association of duration of hepatic artery…2017 American Transplant Congress
A Promising MyD88 Inhibitor TJ-M2010-2 Protects Heart from Myocardial Ischemia Reperfusion Injury.
BACKGROUND: The activation of innate immunity via myeloid differentiation factor 88 (MyD88) contributes to myocardial ischemia reperfusion injury (IRI). This study is to investigate the…2017 American Transplant Congress
TIMP-3 Plays a Key Regulatory Role in the Cleavage of E-Cadherin and Has an Essential Protective Function in Hepatic IRI.
Surgery, David Geffen School of Medicine at UCLA, Los Angeles, CA
Liver ischemia-reperfusion injury (IRI) remains a challenging problem in clinical orthotopic liver transplantation. Tissue inhibitor of metalloproteinases-3 (TIMP-3), an extracellular matrix-associated protein, has been linked…2017 American Transplant Congress
Mitochondrial Dysfunction Is a Common Feature of Injury in Donor Kidneys After Brain and Circulatory Death.
The pro-coagulatory and pro-inflammatory environment in donors after brain death (DBD) and warm ischemia in donors after circulatory death (DCD) can cause injury to target…2017 American Transplant Congress
Clinical Evaluation of the Safety and Preliminary Efficacy of Continuous Infusion of Treprostinil to Prevent Ischemia and Reperfusion Injury in Adult Orthotopic Liver Transplant Recipients.
Introduction:Liver transplantation is currently the only therapeutic option for patients with end stage liver diseases. Liver allografts undergo cold ischemic injury and warm reperfusion injury…2017 American Transplant Congress
Role of Protease Activated Receptor 1 and Sphingosine-1-Phospate Receptor 1 in Mice Hepatic Ischemia-Reperfusion Injury for Targeting Cell Signal Pathways of Activated Protein C.
Introduction: Hepatic ischemia-reperfusion injury (IRI) is a serious comlication during liver surgery. As for therapeutic strategies on hepatic IRI, we previously demonstrated that activated protein…2017 American Transplant Congress
Histone Deacetylase Inhibition Mitigates Liver Ischemia/Reperfusion Injury in Mice.
Introduction: Ischemia/reperfusion injury (IRI) causes significant morbidity in liver transplantation and other surgical scenarios. A better understanding of the molecular mechanisms of IRI is required…2017 American Transplant Congress
Autotransplantation of the Left Lung for the Treatment of Recurrent Life Threatening Pulmonary Hemorrhage Related to Pulmonary Vascular Malformation: A Unique Chance to Study Ischemia/Reperfusion Injury.
Background: Ischemia reperfusion injury (IRI) remains a major clinical problem in lung transplantation. Here, we report the investigation of IRI in a 17-year-old patient who…2017 American Transplant Congress
Increased Ischemic Inflammation Induces Recipient Endogenous Memory CD4 Cell-Graft Dendritic Cell Interactions to Provide Help for Activation of Endogenous Memory CD8 T Cells.
Immunology, Cleveland Clinic, Cleveland, OH
Memory T cells provide protection against recurrent pathogens, but memory T cells with donor-reactivity pose a major barrier to successful allograft transplant and tolerance induction.…
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