Articles tagged "Ischemia"

2018 American Transplant Congress
Ischemic Preconditioning Ameliorates Renal Ischemia-Reperfusion Injury in Mice via Heme Oxygenase-1-Mediated Autophagy
J. Hwang,² H. Choi,¹ M. Kim,² K. Jun,² K. Kown,² S. Park,² J. Kim,² I. Moon.²
¹Clinical Research, Daejeon St. Mary's Hospital, Daejeon, Korea; ²Surgery, College of Medicine, The Catholic University of Korea, Seoul, Korea.
Recent data from animal experiments and clinical trials indicate that ischemic preconditioning (IPC) confers protection from renal ischemia-reperfusion (I/R) injury. Nevertheless, the underlying mechanisms for…
2018 American Transplant Congress
The Superiority of Plasma Enriched Perfusate for Assessment of Donor Kidneys in an Ex-Vivo Normothermic Perfusion (EVNP) Setting
J. Palma, I. Palma, Y. Smolin, A. Perry, J. Sageshima, R. Perez.
Surgery, Transplant Division, UC Davis Health System, Sacramento, CA.
EVNP has been used to assess and repair marginal organs prior to transplantation but the optimal perfusate composition is unknown. We hypothesize that EVNP with…
2018 American Transplant Congress
Glycogen Synthase Kinase 3 beta Regulates Liver Inflammation Activation and Resolution by Controlling AMPK Activities
H. Wang,^1,2 M. Ni,^1,2 H. Zhou,² L. Lu,² R. Busuttil,¹ J. Kupiec-Weglinski,¹ Y. Zhai.¹
¹Surgery, David Geffen School of Medicine-UCLA, Los Angeles, CA; ²Liver Surgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China.
Background & Aims: Glycogen synthase kinase 3β (Gsk3β) is ubiquitously expressed with distinctive functions in different types of cells. Although its roles in regulating innate…
2018 American Transplant Congress
Gene Silencing with p53 si-RNA Downregulates Inflammatory Markers in the Liver: Potential Utilization during Normothermic Machine Preservation
C. Moore,¹ M. Thijssen,^1,2 X. Wang,³ P. Mandrekar,³ E. Xiaofei,³ R. Abdi,⁴ R. Porte,² A. Bozorgzadeh,¹ H. Leuvenink,² T. Kowalik,³ P. Martins.¹
¹Dept of Surgery, University of Massachusetts, Worcester, MA; ²Dept of Surgery, Groningen University, Gronigen, Netherlands; ³Dept of Medicine, Univ. of Massachusetts, Worcester, MA; ⁴Transplant Research Institute, Harvard University, Boston, MA.
Background: RNA interference (RNAi) is a process through which RNA induces the activation of endogenous cellular pathways of RNA degradation, resulting in selective and potent…
2018 American Transplant Congress
Ischemia-Free Liver Transplantation in Pigs: Ischemia Reperfusion Injury is Avoidable?
Z. Guo, X. He, Y. Tang, F. Ji, Z. Zhang, Q. Zhao, S. Huang, Z. Zhu, W. Ju, G. Chen.
Organ Transplant Center, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China.
BACKGROUND&AIMS: In organ transplantation, ischemia and reperfusion injury (IRI) is considered as an inevitable event and the major contributor of graft failure. Great efforts have…
2017 American Transplant Congress
TRPV4 Channels Mediate Pulmonary Edema and Inflammation During Ischemia-Reperfusion Injury.
E. Charles, Y. Zhao, K. Hong, C. Marziano, J. Mehaffey, I. Kron, S. Sonkusare, V. Laubach, A. Sharma.
University of Virginia, Charlottesville, VA
Rationale: Lung ischemia-reperfusion (IR) injury remains a major challenge in post-transplant patients. Transient receptor potential vanilloid 4 (TRPV4) cation channels mediate cellular calcium influx, and…
2017 American Transplant Congress
Effect of Epigenetic Modifications in Ischemia-Reperfusion-Injury Post Liver Transplantation: An Integrative Approach.
D. Bagchi, S. Bontha, M. Dozmorov, A. Fernandez, V. Mas, D. Maluf.
Surgery, UVA, Charlottesville; VCU, Richmond
Background Free radicals generated during ischemia reperfusion injury (IRI) might result in epigenetic modifications and gene expression (GE) changes affecting graft outcomes. Integrative analyses of…
2017 American Transplant Congress
Toll-Like Receptor 4-Dependent CCAAT-Enhancer-Binding Protein Homologous Protein Activation Induces Hepatocellular Cell Death in Liver Ischemia and Reperfusion Injury.
H. Zhou,¹ Z. Rao,² H. Wang,¹ X. Wang,¹ L. Lu.¹
¹Department of Liver Surgery, First Affiliated Hospital with Nanjing Medical University, Nanjing, Jiangsu, China; ²Department of Anesthesiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China
Background: Critical role of Toll-like receptor 4(TLR4) and endoplasmic reticulum (ER) stress has been found in ischemia and reperfusion(IR) injury models. However, the relationship between…
2017 American Transplant Congress
The mTOR Signal Regulates Myeloid Derived Suppressor Cells Differentiation and Immunosuppressive Function in Acute Kidney Injury.
C. Yang, C. Zhang, R. Rong, T. Zhu.
Urology, Zhongshan Hospital, Fudan University, Shanghai, China
The mammalian target of rapamycin (mTOR) is a serine–threonine kinase that senses various environmental stimuli. The mTOR signal controls innate and adaptive immune response in…
2017 American Transplant Congress
Effect of Bone Marrow Derived Mesenchymal Stem Cells on Renal Ischemia-Reperfusion Injury in Rabbit.
J. Jang, H. Ri, I. Hong.
Agriculture & Life Science, Pyongyang University of Science & Technology, Pyongyang, Democratic Peoples Republic of Korea
Background: We succeeded to set up a rabbit model of Ischemia-Reperfusion (I/R) injury to test future candidate substance or plant extract that may have anti-oxidant…