Articles tagged "Ischemia"

2018 American Transplant Congress
CCAAT-Enhancer-Binding Protein Homologous Protein Promotes Liver Ischemia and Reperfusion Injury by Inhibiting Beclin-1-Mediated Autophagy in Hepatocytes
H. Zhou,¹ Z. Rao,¹ Y. Xia,¹ R. Liu,¹ S. Zhou,¹ X. Wang,¹ Y. Zhai,¹ L. Lu.¹
¹First Affiliated Hospital of Nanjing Medical University, Nanjing, China; ²David Geffen School of Medicine at University of California-Los Angeles, Los Angeles.
Background and Aims:Critical role of endoplasmic reticulum (ER) stress has been found in ischemia and reperfusion(IR) injury models. However, the role of CCAAT-Enhancer-Binding Protein Homologous…
2018 American Transplant Congress
The Aggressive Phenotype: Center-Level Characteristics in the Use of Suboptimal Lungs
M. Kosztowski, E. Bush, X. Luo, A. Thomas, M. Bowring, D. Segev, J. Garonzik Wang.
Johns Hopkins, Baltimore, MD.
The disparity between organ supply and demand has led some centers to expand their criteria for donor selection. We explored utilization of suboptimal lungs to…
2018 American Transplant Congress
Serelaxin-Notch1 Signaling Promotes Macrophage M2 Differentiation and Alleviates Hepatocellular Damage in Orthotopic Liver Transplantation: From Mouse-to-Human
S. Kageyama,¹ K. Nakamura,¹ B. Ke,¹ R. Sosa,² E. Reed,² F. Kaldas,¹ R. Busuttil,¹ J. Kupiec-Weglinski.¹
¹Surgery, Liver Transplant, UCLA, Los Angeles, CA; ²Pathology, UCLA, Los Angeles, CA.
Background/Aim: We have documented crucial role of macrophage Notch1 signaling in a mouse warm hepatic ischemia-reperfusion injury (IRI) model. However, its clinical relevance or therapeutic…
2018 American Transplant Congress
TGR5-Mediated AMPK/mTOR Signaling Regulates Macrophage Migration and Polarization in Liver Ischemia Reperfusion
S. Zhou, H. Zhou, R. Liu, F. Zhang, X. Wang, L. Lu.
Liver Transplantation Center, First Affiliated Hospital, Nanjing Medical University, Nanjing, Jiangsu, China.
Background: Although the plasma membrane-bound G protein–coupled bile acid receptor (TGR5) exerts protective roles in various inflammatory diseases, little is known about the effects and…
2018 American Transplant Congress
Assessing Necroptosis in Brain Dead Kidney Donors: Implications for Predicting Recipient Outcomes
A. Zmijewska, J. Murphy, J. Chen, J. Zmijewski, R. Mannon.
Medicine, University of Alabama at Birmingham, Birmingham, AL.
Introduction: Kidney graft transplant obtained from Brain Dead Donors (BDD) is more frequently associated with development of delayed graft function (DGF) and higher risk of…
2017 American Transplant Congress
Vendor to Center in 0-60: A Safe and Effective Blueprint for Creating an In-House On-Call System for Organ Offers.
K. Driggers, J. Davenport, D. Cassidy, L. Curry, A. Milling, A. Hauser, H. Crego, P. Baliga, N. Pilch, D. Dubay, J. Anderson.
Transplant, Medical University of South Carolina, Charleston, SC
Introduction: Our center returned to an in-house nurse coordinator on-call program 7/2016 after using a vendor from 11/2012 to 7/2016 for organ allocation. It was…
2017 American Transplant Congress
Succinate Accumulation During Warm and Cold Ischemia in Mouse, Pig and Man: Mechanistic and Therapeutic Implications for Transplant Ischemia-Reperfusion Injury.
J. Martin,^1,3 A. Costa,² A. Gruszczyk,^1,3 M. Hamed,¹ N. Georgakopoulos,¹ G. Pettigrew,¹ A. James,³ C. Frezza,² M. Murphy,³ K. Saeb-Parsy.¹
¹Department of Surgery, Cambridge, United Kingdom; ²MRC Cancer Unit, Cambridge, United Kingdom; ³MRC Mitochondrial Biology Unit, Cambridge, United Kingdom
Introduction: The burst of reactive oxygen species associated with ischemia-reperfusion (IR) injury is mediated through a specific metabolic pathway involving mitochondrial accumulation of the metabolite…
2017 American Transplant Congress
Novel Application of Localized Nanodelivery of Anti-IL6 Protects Organ Transplant from Ischemia Reperfusion Injuries.
M. Uehara,¹ Z. Solhjou,¹ B. Bahmani,¹ O. Maarouf,¹ T. Ichimura,² C. Brooks,² W. Xu,¹ V. Kasinath,¹ N. Banouni,¹ A. Elkhal,³ I. Guleria,² M. McGrath,¹ S. Tullius,³ R. Abdi.¹
¹Transplantation Research Center/Renal Devision, Brigham and Women's Hospital/ Harvard Medical School, Boston; ²Renal Division, Brigham and Women's Hospital/ Harvard Medical School, Boston; ³Division of Transplant Surgery and Transplantation Surgery Research Laboratory, Brigham and Women's Hospital/ Harvard Medical School, Boston
Ischemia reperfusion injury (IRI) evokes major intra-graft inflammatory responses that markedly augment alloimmune responses. Understanding mechanisms involved is critical for the development of novel therapeutic…
2017 American Transplant Congress
Objective Assessment of Graft Metabolism and Function During Ex Vivo Liver Perfusion.
J. Echeverri,¹ S. Cleland,² M. Kaths,¹ I. Linares,¹ R. Roizales,¹ N. Goldaracena,¹ D. Kollmann,¹ M. Hamar,¹ P. Urbanellis,¹ S. Ganesh,¹ O. Adeyi,³ D. Grant,¹ N. Selzner,⁴ M. Wasowicz,² M. Selzner.¹
¹Multi-Organ Transplant Program, Department of Surgery, University of Toronto - Toronto General Hospital, Toronto, ON, Canada; ²Multi-Organ Transplant Program, Department of Anesthesia, University of Toronto - Toronto General Hospital, Toronto, ON, Canada; ³Multi-Organ Transplant Program, Department of Pathology, University of Toronto - Toronto General Hospital, Toronto, ON, Canada; ⁴Multi-Organ Transplant Program, Department of Medicine, University of Toronto - Toronto General Hospital, Toronto, ON, Canada
During EVLP no objective perfusion parameters have been found to predict outcome after transplantation.Methods: Livers with 4grades of injury were perfused for 4 hours and…
2017 American Transplant Congress
CD47 Blockade Reduces Ischemia/Reperfusion Injury in Donation After Cardiac Death Rat Kidney Transplantation.
X. Wang,¹ M. Xu,¹ J. Jia,¹ Z. Zhang,¹ J. Gaut,² G. Upadhya,¹ P. Manning,³ Y. Lin,¹ W. Chapman.¹
¹Department of Surgery, Washington University School of Medicine, Saint Louis; ²Pathology and Immunology, Washington University School of Medicine, Saint Louis; ³Tioma Therapeutics, Saint Louis
Purpose: We evaluated the potential effects of antibody-mediated CD47 blockade to modulate vascular endothelial nitric oxide activity and reduce ischemia reperfusion injury in a rat…