2018 American Transplant Congress
Preoperative Antibiotics Treatment Decreases Endoplasmic Reticulum Stress and Protects Liver Transplant from Ischemia-Reperfusion Injury
Department of Surgery, The Dumont-UCLA Transplant Center, Los Angeles, CA.
Ischemia-reperfusion injury (IRI) represents a major risk factor of graft dysfunction in liver transplantation (LT). We have reported a critical role of endoplasmic reticulum (ER)…2018 American Transplant Congress
Senolytic Drug Treatment Attenuates mtDNA-Mediated Inflammatory Injury in Old Donors and Prolongs Cardiac Allograft Survival
Introduction: Solid organ transplantation has seen a increase in the utilization of older organs. Here, we investigate how aging-associated kinetics of damage associated molecular patterns…2018 American Transplant Congress
Tax1bp3 is Upregulated in the Ischemia/Reperfusion Injury of Kidney
Department of Urology, Beijing Friendship Hospital, Capital Medical University, Beijing, China.
Objective The ischemia/reperfusion (I/R) injury plays an important role in delayed graft function (DGF) after kidney transplantation, however, the mechanism is not fully understood. Therefore,…2018 American Transplant Congress
Histone Deacetylase-6 Inhibition Mitigates Liver Ischemia-Reperfusion Injury and Acetaminophen Toxicity in Mice
Introduction: Ischemia/reperfusion injury (IRI) leads to poor outcomes and early graft loss in liver transplantation. Understanding the mechanisms of liver IRI may aid in prevention…2018 American Transplant Congress
Protective Effect of Ceria-Nanoparticle on Renal Ischemia Reperfusion Injury in Rats
Introduction: Ischemia-reperfusion injury (IRI) is a commonly encountered problem in organ transplantation. IRI is associated with delayed graft function and acute rejection; therefore IRI adversely…2017 American Transplant Congress
Twelve Hour Ex Vivo Normothermic Perfusion for the Assessment of High-Risk Discarded Deceased Donor Kidneys.
Department of Surgery, UC Davis Medical Center, Sacramento, CA
Ex-Vivo Normothermic Perfusion (EVNP) has been shown to be useful to assess viability of high-risk deceased donor kidneys, with high renal blood flow and immediate…2017 American Transplant Congress
AAV8 Delivery of TIMP-1 Prevents Hepatocyte Apoptosis After Liver Ischemia/Reperfusion Injury.
Dumont-UCLA Transplant Center, Los Angeles
Matrix metalloproteinase-9 (MMP-9) is a key mediator of leukocyte migration across vascular barriers in hepatic ischemia/reperfusion injury (IRI). Tissue inhibitor of metalloproteinase-1 (TIMP-1) is the…2017 American Transplant Congress
Preservation Solution Affects the Immunological Milieu in Lung Transplantation and Alters the Inflammatory Balance.
Background: The pro-/ anti-inflammatory balance in lung transplantation is shaped by the pulmonary immune compartments, i.e. the T and NK cell repertoire. At present, it…2017 American Transplant Congress
Neutering Worsens Liver Ischemia/Reperfusion Injury in Both Male and Female Mice.
Introduction: Ischemia/reperfusion injury (IRI) causes significant morbidity in liver transplantation and other surgical scenarios. A better understanding of the molecular mechanisms of IRI is required…2017 American Transplant Congress
Impact of STEEN vs Gelofusine as Perfusate During Normothermic Ex Vivo liver Perfusion on Outcome of Pig Liver Transplantation.
Multiorgan Transplant Program, Toronto General Hospital, Toronto, ON, Canada
European and North American clinical trials have used two different perfusate solutions for normothermic ex vivo liver perfusion (NEVLP): Gelofusine (bovine derived gelatin-based solution) and…
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