Articles tagged "Ischemia"

2022 American Transplant Congress
Natural Killer Cell NKG2D Receptor Mediates Airway Cell Hypoxic Injury Through Recognition of Stress Molecules
T. Tsao¹, E. Aminian¹, A. Shemesh¹, L. Tran¹, P. Wang¹, F. Deiter¹, J. R. Greenland², D. R. Calabrese¹
¹University of California, San Francisco, San Francisco, CA, ²Medicine, University of California, San Francisco, CA
*Purpose: Primary graft dysfunction (PGD), the clinical syndrome of pulmonary hypoxia and reperfusion, occurs afer 1/3 of all lung transplants, and accounts for excess mortality.…
2022 American Transplant Congress
Exploration of the Optimal pH in Hypothermic Machine Perfusion for Rat Liver Grafts Retrieved from Circulatory Death
S. Sakamoto¹, M. Fukai¹, K. Shibata¹, H. Bochimoto², N. Mohd Zin², N. Kawamura¹, T. Ishikawa¹, M. Fujiyoshi¹, T. Shimamura³, A. Taketomi¹
¹Department of Gastroenterological Surgery 1, Hokkaido University Graduate School, Sapporo, Japan, ²Department of Cell Physiology, The Jikei University School of Medicine, Tokyo, Japan, ³Division of Organ Transplantation, Hokkaido University Hospital, Sapporo, Japan
*Purpose: Although some investigators have reported favorable results of hypothermic machine perfusion (HMP) in liver transplantation, the efficacy to the hepatic graft retrieved from circulatory…
2022 American Transplant Congress
Crosstalk Between micro-RNAs, mRNAs, and Long Non-Coding RNAs in Human Hepatic Ischemia Reperfusion Injury
C. Kuscu¹, S. Naik¹, C. Eymard², A. Bajwa¹, D. Maluf³, V. Mas³, J. Eason⁴, C. Kuscu¹
¹Transplant Research Institute, James D. Eason Transplant Institute, Department of Surgery, The University of Tennessee Health Science Center, Memphis, TN, ²James D. Eason Transplant Institute, Department of Surgery, The University of Tennessee Health Science Center, Memphis, TN, ³Surgery, University of Maryland, Baltimore, MD, ⁴University of Tennessee/Methodist Transplant Institute, Memphis, TN
*Purpose: Present study utilizes multiple omics tools and clinical samples with a system biology approach characterizing mRNAs, long non-coding RNAs (lncRNAs) and small non-coding RNAs…
2022 American Transplant Congress
Cold Ischemic Time and Kidney Graft Failure; Mediation Through Delayed Graft Function
J. Miller¹, W. Irish², D. Sawinski³, A. Massie⁴, J. Snyder¹
¹Scientific Registry of Transplant Recipients, Minneapolis, MN, ²Department of Surgery, East Carolina University, Greenville, NC, ³Division of Nephrology and Hypertension, Weill Cornell Medical College, New York, NY, ⁴Division of Surgery, Johns Hopkins School of Medicine, Baltimore, MD
*Purpose: Delayed graft function (DGF) has been associated with decreased graft survival and prolonged cold ischemia time (CIT) has been proposed as a modifiable DGF…
2022 American Transplant Congress
CD38 Knockout Mice Demonstrate Decreased Neutrophil Infiltration Following Renal Ischemia Reperfusion Injury
I. Woelfel¹, A. Ruffing¹, I. El-Ayachi¹, K. Washburn², S. Black¹, A. Schenk¹
¹Ohio State University, Columbus, OH, ²The Ohio State University, Columbus, OH
*Purpose: Ischemia reperfusion injury (IRI) perpetuates inflammation and causes significant organ injury in solid organ transplantation. CD38 is a ectoenzyme widely expressed on lymphocytes with…
2022 American Transplant Congress
Estimating the Effect of Increased Donor Heart Ischemic Time on Post-Transplant Survival Using Instrumental Variables
G. Ran¹, K. Lazenby¹, N. Narang², W. F. Parker³
¹Pritzker School of Medicine, University of Chicago, Chicago, IL, ²Department of Medicine, University of Illinois-Chicago, Chicago, IL, ³Department of Medicine, University of Chicago, Chicago, IL
*Purpose: Isolate the impact of organ ischemic time on post-transplant survival using the recent change in heart allocation policy as a natural experiment.*Methods: We examined…
2022 American Transplant Congress
Cost-Effectiveness of an Intra-Operative Renal Allograft Cooling Device
K. Hansen¹, C. Yock², J. Pietzsch²
¹University of California, San Francisco, San Francisco, CA, ²Stanford, Palo Alto, CA
*Purpose: Existing literature shows intra-operative cooling of a renal allograft during anastomosis reduces the incidence of delayed graft function in deceased donor kidney transplant recipients…
2022 American Transplant Congress
Timing of Hypotension Post Kidney Transplant Impacts the Risk of Subsequent Delayed Graft Function
S. A. Morrison¹, A. Thanamayooran², K. Tennankore¹, A. J. Vinson¹
¹Dalhousie University, Halifax, NS, Canada, ²Nova Scotia Health Authority, Halifax, NS, Canada
*Purpose: Hypotension is common post-kidney transplant and is associated with delayed graft function (DGF; a need for dialysis in the first week post-transplant) and prolonged…
2022 American Transplant Congress
Circulating Galectin-3 Levels Increase in Syngeneic Rat Recipients of Vascularized Composite Allografts Subjected to Prolonged Ischemia
Z. Wang¹, B. Li¹, Y. Wang¹, D. Yoeli¹, N. Nakra¹, N. Limon De La Rosa¹, A. A. Su¹, A. Jani¹, D. W. Mathes¹, K. M. Washington¹, E. Farkash², C. A. Huang¹
¹University of Colorado, Denver | Anschutz Medical Campus, Aurora, CO, ²University of Michigan, Ann Arbor, Ann Arbor, MI
*Purpose: During the process of transplantation, organs and tissue are necessarily subjected to some degree of hypoxic and ischemic injury during procurement, preservation and following…
2022 American Transplant Congress
Cold Stress-Induced Ferroptosis in Liver Sinusoidal Endothelial Cells Deteriorates Liver Transplant Outcomes
H. Kojima, H. Hirao, K. Kadono, T. Ito, K. J. Dery, F. Kaldas, J. Kupiec-Weglinski
UCLA Medical Center, Los Angeles, CA
*Purpose: While hepatocytes are affected by ischemia-reperfusion injury (IRI) especially under normothermic stress, liver sinusoidal endothelial cells (LSECs) are particularly vulnerable to cold storage-induced IR-insult.…