Articles tagged "Ischemia"

2022 American Transplant Congress
Type 1 Natural Killer T-cells: Key Mediators of Ischemia- Reperfusion Injury in Hepatic Steatosis
J. R. Liggett¹, J. Kang¹, K. Loh¹, K. Oza¹, Y. Cui¹, D. Kwon², H. Li³, B. Kallakury², T. Fishbein¹, W. Cui¹, K. Khalid¹, A. H. Kroemer¹
¹MedStar Georgetown Transplant Institute, Washington, DC, ²Pathology, MedStar Georgetown University Hospital, Washington, DC, ³Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, DC
*Purpose: Hepatic ischemia-reperfusion injury (IRI) poses a significant risk in liver transplantation and hepatic resection and is further exacerbated by hepatic steatosis. Type 1 Natural…
2022 American Transplant Congress
Changes in Cold Ischemia Time and Transplantation Practices with the Concentric Model of Kidney Allocation
C. M. Puttarajappa¹, P. Sood¹, A. Tevar¹, V. Gunabushanam¹, S. Hariharan¹, S. Mohan²
¹University of Pittsburgh Medical Center, Pittsburgh, PA, ²Columbia University, New York, NY
*Purpose: Evaluate impact of the new concentric kidney allocation system (KAS250) on kidney utilization, allocation practices and cold ischemia time (CIT).*Methods: Using data from the…
2022 American Transplant Congress
CEACAM1 Splice Isoforms Are Regulated by Hypoxia Inducible Factors 1 alpha (HIF-1a) to Protect Against Ischemic Injury in Mouse and Human Liver Transplantation
K. J. Dery¹, H. Kojima¹, K. Kadono², H. Hirao¹, J. Kupiec-Weglinski³
¹UCLA, Los Angeles, CA, ²Liver Transplant Surgery, UCLA, Los Angeles, CA, ³UCLA Medical Center, Los Angeles, CA
*Purpose: CEACAM1 (CC1) is a transmembrane glycoprotein that undergoes extensive alternative splicing (AS) to generate CC1-S and CC1-L. It is currently unclear which of these…
2022 American Transplant Congress
Donor Exercise Preconditioning Protects Murine Orthotopic Liver Grafts During Ischemia Reperfusion Injury
H. O. Yazdani, C. Kaltenmeier, R. Nakano, R. L. Simmons, D. A. Geller, S. Tohme
Surgery, University of Pittsburgh Medical Center, Pissburgh, PA
*Purpose: Orthotopic liver transplantation (LTx) serves as the gold standard of care in patients with end-stage liver disease. However, a major obstacle to the immediate…
2022 American Transplant Congress
Donor Organ Utilization And Transplantation Outcomes In Donation After Circulatory Death Using Thoracoabdominal Normothermic Regional Perfusion
M. Urban, S. Merani, N. W. Markin, A. Castleberry, J. Um
University of Nebraska Medical Center, Omaha, NE
*Purpose: Evidence suggests that in-situ reperfusion of abdominal organs with normothermic oxygenated blood in donation after circulatory death (DCD) provides superior post-transplantation outcomes in comparison…
2022 American Transplant Congress
Evolution of Donor-Derived Cell-Free DNA During the First Week After Surgery Predicts Renal Function Recovery After Kidney Transplantation
D. Cucchiari¹, E. Cuadrado¹, E. Gonzalez¹, J. Puig¹, M. Ramirez-Bajo¹, P. Ventura-Aguiar¹, I. Revuelta², B. Bayès¹, F. Diekmann¹
¹Hospital Clínic de Barcelona, Barcelona, Spain, ²Hospital Clinic de Barcelona, Barcelona, Spain
*Purpose: Donor-derived cell-free DNA (ddcfDNA) is usually employed starting from the second week after kidney transplantation (KT), as its earlier increase can be due to…
2022 American Transplant Congress
Gene Expression Changes Including Long Non-Coding RNAs in Human Hepatic Ischemia Reperfusion Injury
C. Kuscu¹, S. Naik¹, C. Eymard², H. Ingram¹, A. Bajwa¹, D. Maluf³, V. Mas⁴, J. Eason⁵, C. Kuscu¹
¹Transplant Research Institute, James D. Eason Transplant Institute, Department of Surgery, The University of Tennessee Health Science Center, Memphis, TN, ²James D. Eason Transplant Institute, Department of Surgery, The University of Tennessee Health Science Center, Memphis, TN, ³Surgery, University of Maryland, Baltimore, MD, ⁴University of Maryland, Baltimore, MD, ⁵University of Tennessee/Methodist Transplant Institute, Memphis, TN
*Purpose: Ischemia reperfusion injury (IRI) is still one of the major problems in liver transplantation affecting long term outcomes. This study is sought out to…
2022 American Transplant Congress
The Post-operative Clinical Outcomes Of 59 Tanrp Cases In An International Cohort
J. Louca¹, N. Patel¹, S. Messer², J. Chindu², S. Large²
¹Cambridge University, Cambridge, United Kingdom, ²Royal Papworth Hospital, Cambridge, United Kingdom
*Purpose: Heart transplantation is an immensely effective service and is currently the only definitive treatment for heart failure. However, transplantation is limited by donor availability.…
2022 American Transplant Congress
Sigma-1 Receptor Agonists Are Protective in a Rat Model of Kidney Transplantation
A. Hosszu¹, T. Lakat¹, A. Toth¹, J. Hodrea¹, L. Wagner², A. J. Szabo¹, A. Fekete¹
¹1st Department of Pediatrics, Semmelweis University, Budapest, Hungary, ²Department of Transplantation and Surgery, Semmelweis University, Budapest, Hungary
*Purpose: Kidney transplantation (Tx) is associated with better long-term outcomes and quality of life compared to dialysis, but the shortage in donor organs is serious…
2022 American Transplant Congress
Inhibition of ITGB5 Protects Hepatocytes from Ischemia Reperfusion Injury
M. Dogan¹, S. Naik¹, C. Watkins¹, A. Bajwa¹, V. Mas², J. Eason³, C. Kuscu¹, C. Kuscu¹
¹Transplant Research Institute, James D. Eason Transplant Institute, Department of Surgery, The University of Tennessee Health Science Center, Memphis, TN, ²Surgery, University of Maryland, Baltimore, MD, ³University of Tennessee/Methodist Transplant Institute, Memphis, TN
*Purpose: Liver transplantation is the best treatment option for patients with end-stage liver disease (ESLD). Despite the increasing interest to the machine reperfusion, cold preservation…