2022 American Transplant Congress
Dynamic Changes and Roles of Specialized Pro-resolving Lipid Meditators in the Initiation and Resolution Process of Lung Ischemia-Reperfusion Injury in Rats
*Purpose: Lung ischemia-reperfusion injury (IRI) is one of the significant complications after lung transplantation, which is a form of acute lung injury by robust inflammation.…2022 American Transplant Congress
Ultrasound Targeted Microbubble Cavitation During Ex Vivo Normothermic Machine Perfusion Reduces Peribiliary Vascular Plexus Thrombi and Graft Injury in a DCD Liver Transplant Model
*Purpose: Thrombus formation in the peribiliary vascular plexus (PBP) is a proposed mechanism for ischemic cholangiopathy (IC) after liver transplantation from donors after circulatory death…2022 American Transplant Congress
Post-Operative Day 1 Galectin-3 is Predictive of Early Allograft Dysfunction in Liver Transplantation
University of Colorado Anschutz Medical, Aurora, CO
*Purpose: Early allograft dysfunction (EAD) is an important outcome measure in liver transplantation that is predictive of graft failure, but the mechanism behind it remains…2022 American Transplant Congress
Cold Ischemia Time is More Critical for Older Donor Kidney Survival: A Machine Learning Approach
*Purpose: Increasing utilization of kidneys from older donors is a potential solution to mitigate the organ shortage. However, older donor age is a risk factor…2022 American Transplant Congress
Impact of Total Parenteral Nutrition on Donor Kidneys During Oxygenated Preservation at 22ºC Ex Vivo
1London Health Sciences Centre, London, ON, Canada, 2Western University, London, ON, Canada
*Purpose: Recent studies have shown that ex vivo preservation at 37 º C can reduce kidney injury compared to current clinical practice. However, to mitigate…2022 American Transplant Congress
Pulsatile Kidney Perfusion Improves Survival and Graft Function in High Acuity Combined Liver Kidney Transplant (CLKT) Recipients
*Purpose: Due to underlying renal dysfunction, CLKT recipients tend to have higher medical acuity at baseline resulting in a higher likelihood of post-operative complications and…2022 American Transplant Congress
Characterization of Acute Kidney Injury in Fatty Liver Ischemia Reperfusion Injury
Department of Surgery, Indiana University School of Medicine, Indianapolis, IN
*Purpose: The association between hepatic ischemia reperfusion injury (hIRI) and acute kidney injury (AKI) has been well established. AKI is commonly observed following transplantation of…2022 American Transplant Congress
Understanding the Response of Human Lung Microvascular Endothelial Cells During Lung Transplantation via an In Vitro Model of Ischemia Reperfusion Injury
*Purpose: Lung Transplantation (LTx) is a therapeutic option for patients with end-stage lung disease. One of the major complications is primary graft dysfunction largely attributed…2022 American Transplant Congress
Stabilization of Cell-Cell Junctions Improves Outcomes in an Ex-Vivo Porcine Renal Ischemia-Reperfusion Injury Culture Model
*Purpose: Renal transplant is an accepted therapy for end-stage renal failure. Chronic transplant dysfunction remains the leading cause of long-term graft loss and is, in…2022 American Transplant Congress
p40 Homodimers Stimulate Graft Dendritic Cells to Produce IL-15 Driving Endogenous Donor-Reactive Memory CD8 T Cell Activation within High-Risk Cardiac Allografts
*Purpose: Acute allograft injury occurring during the first 1-2 days post-transplant is mediated by graft infiltrating endogenous donor-reactive memory CD8 T cells and requires their…
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