Articles tagged "Ischemia"

2018 American Transplant Congress
Cardiac Grafts from Insulin Resistant Donors Trigger a Heightened Immune Response via Excessive Induction of Autophagy
S. Cai,¹ J. Miao,² A. Chandraker.¹
¹Transplantation Research Center, Renal Division, Brigham and Women's Hospital, Boston, MA; ²Division of Endocrinology, Boston Children's Hospital, Boston, MA.
Background Heart transplantation remains the treatment of choice for many patients with medically refractory heart failure. The use of organs from patients with insulin resistant…
2018 American Transplant Congress
Exenatide Reduces Ischemia/Reperfusion Injury in Donation after Cardiac Death Rat Kidney Transplantation
H. Yang,¹ Y. Shi,² X. Li,¹ C. Long,¹ Z. Xu,¹ L. Luo,¹ W. Luo,¹ Y. Zhang,¹ T. Zeng,³ M. Chen,⁴ H. Li,⁵ Z. Wang.⁵
¹Department of Organ Transplantation, People's Hospital of Jiangxi Province, Nanchang, Jiangxi Province, China; ²Department of Pathology, Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei Province, China; ³Department of Urologic Surgery, People's Hospital of Jiangxi Province, Nanchang, Jiangxi Province, China; ⁴Department of Vascular Surgery, People's Hospital of Jiangxi Province, Nanchang, Jiangxi Province, China; ⁵Department of Urologic Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei Province, China.
Background: Exenatide provide protection against warm Ischemia/Reperfusion Injury (IRI) in the rat heart and kidney. We hypothesized that Exenatide reduces IRI in a rat donation…
2018 American Transplant Congress
Linking Donor Ischemia Reperfusion Injury (IRI) to Costimulatory Blockade Resistant Murine Heart Graft Rejection through Complement-Initiated Necroptosis
R. Ang, N. Chun, A. Ting, P. Heeger.
Immunology Institute, Translational Transplant Research, Icahn School of Medicine at Mount Sinai, New York, NY.
We previously showed that prolonged cold ischemic storage (CIS) of donor B6 hearts results in complement dependent, CTLA4Ig-resistant rejection in BALB/c recipients. In this system,…
2018 American Transplant Congress
Ischemic Preconditioning Ameliorates Renal Ischemia-Reperfusion Injury in Mice via Heme Oxygenase-1-Mediated Autophagy
J. Hwang,² H. Choi,¹ M. Kim,² K. Jun,² K. Kown,² S. Park,² J. Kim,² I. Moon.²
¹Clinical Research, Daejeon St. Mary's Hospital, Daejeon, Korea; ²Surgery, College of Medicine, The Catholic University of Korea, Seoul, Korea.
Recent data from animal experiments and clinical trials indicate that ischemic preconditioning (IPC) confers protection from renal ischemia-reperfusion (I/R) injury. Nevertheless, the underlying mechanisms for…
2018 American Transplant Congress
The Superiority of Plasma Enriched Perfusate for Assessment of Donor Kidneys in an Ex-Vivo Normothermic Perfusion (EVNP) Setting
J. Palma, I. Palma, Y. Smolin, A. Perry, J. Sageshima, R. Perez.
Surgery, Transplant Division, UC Davis Health System, Sacramento, CA.
EVNP has been used to assess and repair marginal organs prior to transplantation but the optimal perfusate composition is unknown. We hypothesize that EVNP with…
2018 American Transplant Congress
Glycogen Synthase Kinase 3 beta Regulates Liver Inflammation Activation and Resolution by Controlling AMPK Activities
H. Wang,^1,2 M. Ni,^1,2 H. Zhou,² L. Lu,² R. Busuttil,¹ J. Kupiec-Weglinski,¹ Y. Zhai.¹
¹Surgery, David Geffen School of Medicine-UCLA, Los Angeles, CA; ²Liver Surgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China.
Background & Aims: Glycogen synthase kinase 3β (Gsk3β) is ubiquitously expressed with distinctive functions in different types of cells. Although its roles in regulating innate…
2018 American Transplant Congress
Gene Silencing with p53 si-RNA Downregulates Inflammatory Markers in the Liver: Potential Utilization during Normothermic Machine Preservation
C. Moore,¹ M. Thijssen,^1,2 X. Wang,³ P. Mandrekar,³ E. Xiaofei,³ R. Abdi,⁴ R. Porte,² A. Bozorgzadeh,¹ H. Leuvenink,² T. Kowalik,³ P. Martins.¹
¹Dept of Surgery, University of Massachusetts, Worcester, MA; ²Dept of Surgery, Groningen University, Gronigen, Netherlands; ³Dept of Medicine, Univ. of Massachusetts, Worcester, MA; ⁴Transplant Research Institute, Harvard University, Boston, MA.
Background: RNA interference (RNAi) is a process through which RNA induces the activation of endogenous cellular pathways of RNA degradation, resulting in selective and potent…
2018 American Transplant Congress
Ischemia-Free Liver Transplantation in Pigs: Ischemia Reperfusion Injury is Avoidable?
Z. Guo, X. He, Y. Tang, F. Ji, Z. Zhang, Q. Zhao, S. Huang, Z. Zhu, W. Ju, G. Chen.
Organ Transplant Center, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China.
BACKGROUND&AIMS: In organ transplantation, ischemia and reperfusion injury (IRI) is considered as an inevitable event and the major contributor of graft failure. Great efforts have…
2018 American Transplant Congress
DAP12 and Its Triggering Co-Receptor TREM2 Play Key Roles in Regulation of Mouse and Human Liver DC Function and Control of Liver Ischemia-Reperfusion Injury
T. Nakao,¹ Y. Ono,¹ H. Dai,¹ A. Perez-Gutierrez,¹ G. Camirand,¹ H. Huang,¹ D. Geller,^1,2 A. Thomson.^1,3
¹Thomas E. Starzl Transplantation Institute, University of Pittsburgh School of Medicine, Pittsburgh, PA; ²Liver Cancer Center, University of Pittsburgh Medical Center, Pittsburgh, PA; ³Department of Immunology, University of Pittsburgh School of Medicine, Pittsburgh, PA.
Background: Liver interstitial dendritic cells (DCs) have been implicated in the control of liver ischemia/reperfusion injury (IRI) and in the induction of liver transplant tolerance.…
2018 American Transplant Congress
HO-1 Regulates SIRT1– Autophagy Pathway in Liver Transplantation: From Mouse-to-Human
K. Nakamura,¹ S. Kageyama,¹ S. Yue,¹ A. Aziz,¹ T. Ito,¹ D. Oncel,¹ B. Ke,¹ R. Sosa,² E. Reed,² F. Kaldas,¹ R. Busuttil,¹ J. Kupiec-Weglinski.¹
¹Surgery, Division of Liver Transplantation, UCLA, Los Angeles, CA; ²Pathology and Laboratory Medicine, UCLA, Los Angeles, CA.
Liver ischemia-reperfusion injury (IRI) represents a major risk factor for early graft dysfunction and a key obstacle to expanding the donor pool in orthotopic liver…