2018 American Transplant Congress
Evaluation of a Marine OXYgen Carrier (Hemo2Life®) for Organ Preservation: First Use in Kidney Transplantation in Humans
Preventing ischemia/reperfusion injuries (IRIs) is a major issue in organ transplantation. At present, grafts are preserved at 4[deg]C in preservation solution in order to reduce…2018 American Transplant Congress
Ischemia Reperfusion Injury & Risk for Antibody Mediated Rejection (ABMR) in HLA Sensitized Patients Treated with C1 Esterase Inhibitor (C1INH)
Introduction: Ischemia reperfusion injury (IRI) contributes to delayed graft function (DGF). IRI/DGF in HLA-sensitized (HS) patients likely activates innate and memory injury pathways that may…2018 American Transplant Congress
Cold Pulsatile Machine Perfusion versus Static Cold Storage in Kidneys from Donation after Circulatory Death: A Multi-Centre Randomised Controlled Trial
Introduction:Delayed graft function affects around half of all recipients of donation after circulatory death (DCD) kidneys in the UK and has a significant impact on…2018 American Transplant Congress
Significant Difference between Proteasome and Immunoproteasome Inhibition in Acute Kidney Injury
The proteasome inhibitor bortezomib has successful administrated in kidney transplant recipients with acute or chronic antibody-mediated rejection, but there were some unfavorable cases which arised…2018 American Transplant Congress
Preoperative Antibiotics Treatment Decreases Endoplasmic Reticulum Stress and Protects Liver Transplant from Ischemia-Reperfusion Injury
Department of Surgery, The Dumont-UCLA Transplant Center, Los Angeles, CA.
Ischemia-reperfusion injury (IRI) represents a major risk factor of graft dysfunction in liver transplantation (LT). We have reported a critical role of endoplasmic reticulum (ER)…2018 American Transplant Congress
Senolytic Drug Treatment Attenuates mtDNA-Mediated Inflammatory Injury in Old Donors and Prolongs Cardiac Allograft Survival
Introduction: Solid organ transplantation has seen a increase in the utilization of older organs. Here, we investigate how aging-associated kinetics of damage associated molecular patterns…2018 American Transplant Congress
Tax1bp3 is Upregulated in the Ischemia/Reperfusion Injury of Kidney
Department of Urology, Beijing Friendship Hospital, Capital Medical University, Beijing, China.
Objective The ischemia/reperfusion (I/R) injury plays an important role in delayed graft function (DGF) after kidney transplantation, however, the mechanism is not fully understood. Therefore,…2018 American Transplant Congress
Histone Deacetylase-6 Inhibition Mitigates Liver Ischemia-Reperfusion Injury and Acetaminophen Toxicity in Mice
Introduction: Ischemia/reperfusion injury (IRI) leads to poor outcomes and early graft loss in liver transplantation. Understanding the mechanisms of liver IRI may aid in prevention…2018 American Transplant Congress
Protective Effect of Ceria-Nanoparticle on Renal Ischemia Reperfusion Injury in Rats
Introduction: Ischemia-reperfusion injury (IRI) is a commonly encountered problem in organ transplantation. IRI is associated with delayed graft function and acute rejection; therefore IRI adversely…2018 American Transplant Congress
Graft Dendritic Cell p40 Homodimers Activate Donor-Reactive Endogenous Memory CD8 T Cells within Higher Risk Allografts
Immunology, Cleveland Clinic, Cleveland, OH.
Memory T cells with donor-reactivity pose a major barrier to successful allograft transplantation and tolerance induction. Longer cold ischemic storage (CIS) prior to transplantation promotes…
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