Articles tagged "Ischemia"

2019 American Transplant Congress
Graft TIM4 Deficiency Protects Liver from Ischemia Reperfusion Injury: From Mouse to Human
S. Kageyama¹, K. Kadono¹, H. Hirao¹, K. Nakamura¹, T. Ito², K. J. Dery¹, D. Oncel¹, B. Ke¹, F. M. Kaldas², R. W. Busuttil², J. W. Kupiec-Weglinski¹
¹Surgery, Dumont-UCLA Transplant Center, Los Angeles, CA, ²Surgery, Ronald Reagan UCLA Medical Center, Los Angeles, CA
*Purpose: Liver ischemia-reperfusion injury (IRI) is a major risk factor for early graft dysfunction and rejection in orthotopic liver transplantation (OLT). We and others have…
2019 American Transplant Congress
Ceria-Zirconia Nanoparticles as an Enhanced Antioxidant Attenuates Apoptosis of Human Kidney Proximal Tubular Epithelial Cells in Hypoxia
S. Yoon¹, K. Yoon², S. Hong³, S. Yun¹, W. Hwang¹, J. Moon⁴, J. Lee¹, H. Jeon¹
¹Nephrology, Konyang University Hospital, Daejeon, Korea, Republic of, ²Hannam University, Daejeon, Korea, Republic of, ³Chemistry, Hannam University, Daejeon, Korea, Republic of, ⁴General Surgery, Konyang University Hospital, Daejeon, Korea, Republic of
*Purpose: Ischemia/reperfusion injury, resulting from hypoxic damage within a graft, is the leading cause of delayed graft function and graft rejection. Various mechanisms have been…
2019 American Transplant Congress
Supercooling Preservation Prolonged Mouse Cardiac Graft Cold Ischemia Time
W. Que¹, X. Hu¹, M. Fujino¹, Y. Yamada², L. Zhong³, X. Li¹
¹Division of Transplantation Immunology, National Research Institute for Child Health and Development, Tokyo, Japan, ²Technican Co., Ltd., Kanagawa, Japan, ³Department of Surgery, Shanghai General Hospital, shanghai Jiao Tong University School of Medicine, Shanghai, China
*Purpose: Supercooling preservation techniques store a donor organ below 0°C without freezing. This has great advantages in inhibiting metabolism and preserving the organ in comparison…
2019 American Transplant Congress
Histologic Ischemia Reperfusion Injury in Liver Transplantation: A Large Single Center Experience
F. M. Kaldas, T. Ito, S. Younan, J. Aziz, M. Lu, V. G. Agopian, J. DiNorcia III, H. Yersiz, D. G. Farmer, R. W. Busuttil
Department of Surgery, The Dumont-UCLA Transplant Center, Los Angeles, CA
*Purpose: Ischemia Reperfusion Injury (IRI) is known to adversely affect graft outcomes in Liver Transplantation (LT). Large series examining the significance of IRI found on…
2019 American Transplant Congress
Heart-Associated Cytokine and Endothelial Patterns Dominate the Ischemia/Reperfusion Response in Recipients of Combined Heart/Lung Transplantation in Comparison to Lung Transplantation
F. Wandrer¹, B. Wiegmann², N. Ledwoch¹, R. Bellmas Sanz¹, F. Ius², W. Sommer², S. Rojas², C. Kühn², I. Tudorache², M. Avsar², A. Haverich², G. Warnecke², C. S. Falk¹
¹Institute of Transplant Immunology, Hannover Medical School, Hannover, Germany, ²Department for Cardiothoracic, Transplantation and Vascular Surgery, Hannover Medical School, Hannover, Germany
*Purpose: Organ-specific differences are discussed for ischemia/reperfusion injury (IRI) in cardiothoracic transplantation (Tx) but rarely compared directly in a clinical setting. Therefore, we compared a…
2019 American Transplant Congress
Evaluation of New Baskent University Preservation Solution for Liver, Kidney and Intestine Graft during Cold Ischemia: Preliminary Experimental Animal Study
M. Haberal¹, M. Kirnap¹, R. Erdem², H. Ozdemir³, M. Lux², D. Bacanli⁴
¹Transplantation, Baskent University, Ankara, Turkey, ²Pharmacology, Baskent University, Ankara, Turkey, ³Pathology, Baskent University, Ankara, Turkey, ⁴Experimental Laboratory, Baskent University, Ankara, Turkey
*Purpose: Despite significant advances in organ transplantation, damage caused to organs due to long cold ischemia time and perfusion solutions remains a serious hurdle. The…
2019 American Transplant Congress
Ischemia-Free Liver Transplantation Protects Bile Duct from Ischemia/Reperfusion Injury
J. Yang, S. Huang, Z. Zhang, Q. Zhao, W. Ju, Z. Zhu, Y. Tang, L. Wang, Y. Zhang, C. Sun, L. Wu, Z. Guo, X. He
Organ Transplant Center, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China
*Purpose: Ischemia-free liver transplantation (IFLT), based on normothermic machine perfusion and innovations in surgical technique, can provide continue blood supply from procurement to implantation that…
2019 American Transplant Congress
Complete Robotic-Assisted Kidney Transplantation: Our Initial Experience
A. Khan, C. Bhati, T. Reichman, A. Cotterell, D. Kumar, G. Gupta, L. Kamal, A. King, A. Sharma, M. Levy
VCU Medical Center, Richmond, VA
*Purpose: Kidney transplantation is the standard treatment for patients with ESRD. Very limited advancement has been made in its surgical aspects. Minimal invasive approach for…
2019 American Transplant Congress
Normothermic Regional Perfusion of Kidneys: A Single Non-Retrieval Centre Experience
R. Pearson, C. Geddes, M. Clancy, J. Asher
Renal Transplant, Queen Elizabeth University Hospital, Glasgow, Glasgow, United Kingdom
*Purpose: With the aim of safely expanding the pool of usable donors from circulatory death (DCD) there is increasing interest in normothermic regional (NRP) perfusion…
2019 American Transplant Congress
Sigma-1 Receptor Agonists Are Renoprotective in a Rat Model of Kidney Transplantation
A. Hosszu¹, Z. Antal², L. Illesy², L. Lenart¹, D. B. Balogh¹, L. Wagner³, A. Vannay⁴, A. J. Szabo², A. Fekete¹
¹"Lendulet" Diabetes Research Group, MTA-SE, Budapest, Hungary, ²1st Department of Pediatrics, Semmelweis University, Budapest, Hungary, ³Department of Transplantation and Surgery, Semmelweis University, Budapest, Hungary, ⁴Pediatrics and Nephrology Research Group, MTA-SE, Budapest, Hungary
*Purpose: Kidney transplantation is associated with better quality of life and reduced costs compared to dialysis, but the shortage in donor organs is a limiting…