2019 American Transplant Congress
Risk of Delayed Graft Function after Deceased Donor Kidney Transplantation in the Current Era
*Purpose: Delayed graft function (DGF) is associated with morbidity and cost after deceased donor kidney transplantation. Some data suggest that previously sensitized patients and kidneys…2019 American Transplant Congress
Inhibition of CXCR3 Expression through Blockade of STAT3 Alpha Signaling Down-Regulate Inflammation of Renal Ischemia-Reperfusion Injury
*Purpose: Signal transducer and activator of transcription 3 (STAT3) is the main mediator of interleukin 6 (IL-6)-type cytokine signaling. Although it exists in two isoforms:…2019 American Transplant Congress
FTY720 Regulates Mitochondria Biogenesis in Dendritic Cells to Prevent Kidney Ischemic Reperfusion Injury
*Purpose: FTY720, a S1PR agonist has been shown to protect kidneys from IRI. However, systemic use is limited due to adverse side effects. Dendritic cells…2019 American Transplant Congress
Impact of Time-of-Day of Declamping on Kidney Transplant Outcome
*Purpose: Despite improvements in organ preservation techniques and efforts to minimize the duration of cold ischemia, ischaemia- reperfusion injury remains associated with poor graft function…2019 American Transplant Congress
Erk-elk1-mir-711 Signalling In Cardiac Ischemia Reperfusion Injury In Heart Transplantation
Pathology, University of Western Ontario, London, ON, Canada
*Purpose: This study aims to discover new molecular mechanisms involved in and to develop new treatment for preventing ischemia reperfusion injury in heart transplantation.*Methods: The…2019 American Transplant Congress
Analysis of Lactic Acid Response in Renal Transplant Patients
*Purpose: Lactic acid (LA) serves as an important biomarker in the evaluation of ischemia, sepsis, metabolic acidosis, and trauma. During renal transplantation (RT), there is…2019 American Transplant Congress
CEACAM1 – p38 Signaling Axis Alleviates Peri-Transplant Liver Injury: From Mouse-to-Human
1UCLA, Los Angeles, CA, 2City of Hope, Duarte, CA
*Purpose: Although CEACAM1 (CM1; carcinoembryonic antigen-related cell adhesion molecule 1; CD66a) regulates hepatic metabolism, its role in orthotopic liver transplantation (OLT) is unknown. A recent…2019 American Transplant Congress
Aquaporins May Be Involved in Renal Ischemia-Reperfusion Injury by Affecting the Pyroptosis of Renal Tubular Epithelial Cells
*Purpose: To determine whether aquaporins (AQPs) are involved in renal ischemia-reperfusion injury (IRI) by affecting the pyroptosis of renal tubular epithelial cells.*Methods: Hypoxia reoxygenation (H/R)…2019 American Transplant Congress
Effects of Omega-3 Fatty Acids on Outcome after Living Donor Right Hepatectomy
Department of Surgery, Samsung Medical Center, Seoul, Korea, Republic of
*Purpose: Preclinical data suggest that supplementation of omega-3 fatty acids may be beneficial in liver resections, by ameliorating ischemic injury during the surgical procedure. In…2019 American Transplant Congress
Obesity Induced IL-18 Production Impairs FOXP3+ Treg Function and Increases Risk of Primary Graft Dysfunction in Lung Transplant Recipients
*Purpose: Lung transplantation is a life-saving treatment for terminal lung diseases but long-term outcomes are poor, beginning with possible development of primary graft disease (PGD)…
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