Articles tagged "Ischemia"

2019 American Transplant Congress
Pgc1α Protects against Graft Ischemic Injury and Reduces Alloimmunity
T. J. Borges¹, M. T. Tran², S. Cai¹, N. Murakami¹, A. Uffing¹, M. Uehara¹, E. P. Rhee³, S. M. Parikh⁴, L. V. Riella¹
¹Schuster Transplantation Research Center, Brigham & Women's Hospital, Harvard Medical School, Boston, MA, ²Division of Nephrology and Center for Vascular Biology Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, ³Nephrology Division, Massachusetts General Hospital, Boston, MA, ⁴Division of Nephrology and Center for Vascular Biology Research, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA
*Purpose: Prolonged ischemia reperfusion injury (IRI) during organ transplantation activates innate immunity and potentiates adaptive immunity, leading to worse transplant outcomes. The mitochondria are particularly…
2019 American Transplant Congress
Predicting Graft Function And Long-term Outcomes Following Kidney Transplantation Using An Intraoperative Tissue Oximetry Sensor
H. Lau, A. Shimomura, E. Tantisattamo, U. G. Reddy, D. Dafoe, H. Ichii
University of California Irvine, Orange, CA
*Purpose: Marginal kidneys have been increasingly used due to the severe shortage of organs. Deceased-donor kidney transplantation is associated with a higher incidence of delayed…
2019 American Transplant Congress
Anti CD45RB Antibody Therapy Attenuates Renal Ischemia Reperfusion Injury by Inducing Regulatory B Cells
S. Lee¹, S. Park¹, J. Hwang¹, J. Ryu², T. Koo², C. Ahn², J. Yang³
¹Biomedical Research Institute, Transplantation Center, Seoul National University Hospital, Seoul, Korea, Republic of, ²Department of Internal Medicine, Seoul National University Hospital, Seoul, Korea, Republic of, ³Department of surgery, Seoul National University Hospital, Seoul, Korea, Republic of
*Purpose: Regulatory B cells (Bregs) are a new B cell subset that suppresses immune responses. Recently, both anti-CD45RB and anti-Tim-1 treatments have been found to…
2019 American Transplant Congress
miR-20a Inhibits Autophagy by Targeting AKT and BIM in Renal Reperfusion Injury
T. Lin, T. Song, Y. Jiang, J. Liu, Z. Wang, L. Li, Z. Huang, Y. Fan, X. Wang
Organ Transplantation Center, Urology Department, Urology Research Institute, WestChina Hospital, Sichuan University, Chengdu, China
*Purpose: Previously, we found up-regulation of miR-20a after kidney ischemia reperfusion (I/R) injury and may serves as a protector; however, its specific mechanism remains unclear.Autophagy…
2019 American Transplant Congress
Tubastatin-A, an HDAC6 Inhibitor, is Protective in Liver Ischemia Reperfusion Injury and Acetaminophen-Mediated Liver Injury
S. Concors¹, D. Murken¹, P. Hernandez¹, D. Aufhauser¹, Z. Wang¹, G. Ge¹, L. Krumeich¹, T. Bhatti², A. Kozikowski³, W. Hancock², M. H. Levine¹
¹Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, ²Children's Hospital of Philadelphia, Philadelphia, PA, ³Starwise Therapeutics, Madison, WI
*Purpose: Ischemia reperfusion injury (IRI) causes morbidity and contributes to early graft loss in liver transplantation and no current therapy exists. Liver injury complicates other…
2019 American Transplant Congress
CD47 Blockade Promotes Hepatic Macrophage Polarization toward M1 during Normothermic Machine Perfusion of Discarded Human Livers
M. Xu¹, F. Zhou¹, S. Garcia-Aroz¹, B. Banan¹, W. Yang², G. Upadhya¹, K. Byrnes³, B. Wong¹, P. Manning⁴, Y. Lin¹, W. Chapman¹
¹Department of Surgery, Washington University School of Medicine, St. Louis, MO, ²Department of Genetics, Washington University School of Medicine, St. Louis, MO, ³Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, ⁴Arch Oncology, St. Louis, MO, USA, St. Louis, MO
*Purpose: M1 macrophages have been shown to be able to phagocytize dead cells after ischemia-reperfusion injury (IRI). This study investigated the therapeutic effect of CD47…
2019 American Transplant Congress
Comprehensive and Combined Transcriptomic and Proteomic Analysis Reveals Key Factors Underlying Ischemia-Reperfusion Injury in Human Liver Transplantation
S. Huang, X. He, C. Sun, Z. Guo, W. Ju, Z. Zhu, Q. Zhao, G. Chen
Organ Transplant Center, the First Affiliated Hospital of SYSU, Guangzhou, China
*Purpose: Ischemia-reperfusion injury (IRI) is a major challenge in liver resection and liver transplantation surgery. Hepatic IRI can seriously impair liver function and even cause…
2019 American Transplant Congress
PD-1+CD3+CD4-CD8- (Double Negative T-cells) Are Early Responders during Kidney Ischemia Reperfusion Injury and Regulated by Non-Classical MHC Molecules
M. Sadasivam, S. Noel, S. Lee, J. Gong, A. Hamad, H. Rabb
Johns Hopkins University and School of Medicine, Baltimore, MD
*Purpose: Unconventional T-cells (e.g. Tregs and γδT-cells) are increasingly recognized for their roles in maintaining homeostasis and protecting non-lymphoid tissues against injury/stress. Double negative (DN)…
2019 American Transplant Congress
Organ Resilience Contributes to Different Impact of Delayed Graft Function (DGF) on Graft Survival in Kidneys Donated by Brain Death (DBD) and Circulatory Death Donors (DCD)
M. J. de Kok, A. F. Schaapherder, L. G. Wijermars, D. K. de Vries, J. L. Lindeman
Transplantation Center, LUMC, Leiden, Netherlands
*Purpose: Despite a tripled higher incidence of DGF in DCD kidney grafts compared to DBD kidney grafts, large studies show equivalent long-term graft survival with…
2019 American Transplant Congress
Distinct Delayed Classical Complement Pathway Activation Highlights Transition of Ischemic Acute Kidney Injury to Chronic Kidney Disease with Interstitial Fibrosis/Tubular Atrophy
S. Kumar, S. Jordan
Comprehensive Transplant Center, Cedars Sinai Medical Ctr, Los Angeles, CA
*Purpose: Ischemia reperfusion Injury (IRI)-induced AKI of the renal allograft frequently leads to delayed graft function (DGF). Patients with DGF suffer from prolonged hospitalization with…