Articles tagged "Ischemia"

2020 American Transplant Congress
Risk Factors for Adverse Clinical Outcomes amongst Renal Transplant Candidates Undergoing Screening Angiography for Coronary Artery Disease
M. Shah¹, A. Yung¹, J. Ebinger¹, J. Mirocha², E. Huang³, D. Geft¹, A. Peng³, B. Azarbal¹
¹Heart Institute, Cedars-Sinai Medical Center, Los Angeles, CA, ²Cedars-Sinai Medical Center, Los Angeles, CA, ³Department of Nephrology, Cedars-Sinai Medical Center, Los Angeles, CA
*Purpose: Patient’s with ESRD undergoing evaluation for kidney transplantation routinely undergo screening for coronary artery disease (CAD). Screening recommendations in this population differ between ACC/AHA…
2020 American Transplant Congress
Effect of Hepatic Steatosis on Hepatic Ischemia-Reperfusion Induced Acute Kidney Injury in Mice
T. Nikumbh¹, N. Biswas², A. Das², C. K. Sen², S. Kubal¹
¹Transplant Surgery, Indiana University School of Medicine, Indianapolis, IN, ²ICRME, Indiana University School of Medicine, Indianapolis, IN
*Purpose: Livers with mild to moderate steatosis have been used to expand the donor pool for transplantation. However, livers with steatosis have a propensity for…
2020 American Transplant Congress
In-Depth Assessment of Ischemia/Reperfusion Injury in a Murine Model of Hindlimb Transplantation
F. Messner¹, K. Kadono², Y. Guo¹, B. Oh¹, J. Kupiec-Weglinski², G. Brandacher¹
¹Department of Plastic Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, ²Department of Surgery, Division of Liver and Pancreas Transplantation, University of California, Los Angeles, Los Angeles, CA
*Purpose: Static cold storage (SCS) still represents the gold standard for organ and tissue preservation in transplantation. Ischemia/reperfusion injury (IRI) that occurs due to the…
2019 American Transplant Congress
FTY720 Regulates Mitochondria Biogenesis in Dendritic Cells to Prevent Kidney Ischemic Reperfusion Injury
A. Bajwa¹, V. Bontha¹, C. Kuscu¹, L. Gallon², C. Kuscu¹, J. Eason³, D. Maluf¹, V. Mas⁴
¹UTHSC, Memphis, TN, ²Northwestern University, Chicago, IL, ³Director Transplant Institute, Memphis, TN, ⁴Director Transplant Reserach Institute, Memphis, TN
*Purpose: FTY720, a S1PR agonist has been shown to protect kidneys from IRI. However, systemic use is limited due to adverse side effects. Dendritic cells…
2019 American Transplant Congress
Impact of Time-of-Day of Declamping on Kidney Transplant Outcome
D. Montaigne¹, N. Al Hawajri², M. Jacquelinet¹, A. Coppin¹, M. Frimat³, S. Bouyé³, G. Lebuffe³, F. Bayer², M. Lassalle², B. Staels¹, M. Hazzan³, C. Jacquelinet⁴
¹University Hospital CHU Lille, Lille University and Inserm U1011, University Lille - EGID, Institut Pasteur de Lille, 59000, Lille, France, ²Agence de la Biomedecine, 93212, Saint-Denis la Plaine, France, ³University Hospital CHU Lille, University of Lille, 59000, Lille, France, ⁴REIN Registry, Agence de la Biomedecine and Inserm U1018, 93212, Saint-Denis la Plaine, France
*Purpose: Despite improvements in organ preservation techniques and efforts to minimize the duration of cold ischemia, ischaemia- reperfusion injury remains associated with poor graft function…
2019 American Transplant Congress
Erk-elk1-mir-711 Signalling In Cardiac Ischemia Reperfusion Injury In Heart Transplantation
H. Zheng, Y. Su, C. Zhu, V. Veramkovich, X. Zheng
Pathology, University of Western Ontario, London, ON, Canada
*Purpose: This study aims to discover new molecular mechanisms involved in and to develop new treatment for preventing ischemia reperfusion injury in heart transplantation.*Methods: The…
2019 American Transplant Congress
Analysis of Lactic Acid Response in Renal Transplant Patients
A. A. Henderson¹, H. Ahmed², M. R. Wakefield¹
¹Surgery/Urology, University of Missouri School of Medicine, Columbia, MO, ²University of Missouri School of Medicine, Columbia, MO
*Purpose: Lactic acid (LA) serves as an important biomarker in the evaluation of ischemia, sepsis, metabolic acidosis, and trauma. During renal transplantation (RT), there is…
2019 American Transplant Congress
CEACAM1 – p38 Signaling Axis Alleviates Peri-Transplant Liver Injury: From Mouse-to-Human
H. Hirao¹, K. Nakamura¹, S. Kageyama¹, T. Ito¹, K. Kadono¹, M. Kujawski², K. J. Dery¹, R. A. Sosa¹, E. F. Reed¹, F. M. Kaldas¹, R. W. Busuttil¹, J. W. Kupiec‐Weglinski¹
¹UCLA, Los Angeles, CA, ²City of Hope, Duarte, CA
*Purpose: Although CEACAM1 (CM1; carcinoembryonic antigen-related cell adhesion molecule 1; CD66a) regulates hepatic metabolism, its role in orthotopic liver transplantation (OLT) is unknown. A recent…
2019 American Transplant Congress
Aquaporins May Be Involved in Renal Ischemia-Reperfusion Injury by Affecting the Pyroptosis of Renal Tubular Epithelial Cells
T. Lin, Y. Fan, Y. Jiang, J. Liu, Z. Wang, L. Li, T. Song, Z. Huang, X. Wang
Organ Transplantation Center, Urology Department, Urology Research Institute, WestChina Hospital, Sichuan University, Chengdu, China
*Purpose: To determine whether aquaporins (AQPs) are involved in renal ischemia-reperfusion injury (IRI) by affecting the pyroptosis of renal tubular epithelial cells.*Methods: Hypoxia reoxygenation (H/R)…
2019 American Transplant Congress
Effects of Omega-3 Fatty Acids on Outcome after Living Donor Right Hepatectomy
S. Lee, J. Kim, G. Choi, J. Joh, S. Lee
Department of Surgery, Samsung Medical Center, Seoul, Korea, Republic of
*Purpose: Preclinical data suggest that supplementation of omega-3 fatty acids may be beneficial in liver resections, by ameliorating ischemic injury during the surgical procedure. In…