Articles tagged "Ischemia"

2020 American Transplant Congress
A NASHional Crisis: Liver Transplantation Outcomes in Female Hispanics
R. A. Sosa¹, A. Q. Terry¹, M. Rossetti¹, F. M. Kaldas², B. V. Naini¹, J. Nevarez-Mejia¹, V. M. Groysberg¹, S. Younan², R. W. Busuttil², D. W. Gjertson¹, J. W. Kupiec-Weglinski², E. F. Reed¹
¹Pathology and Lab Medicine, UCLA, Los Angeles, CA, ²Surgery, UCLA, Los Angeles, CA
*Purpose: Obesity and metabolic syndrome have recently become an epidemic with Hispanics bearing a disproportionate burden. Non-alcoholic steatohepatitis (NASH) is a severe immune-mediated stage of…
2020 American Transplant Congress
Therapeutic Inhibition of Spleen Tyrosine Kinase Decreases Hepatic Damage after Ischemia Reperfusion Injury
A. Zarrinpar, V. Boominathan, A. Kobayashi, S. Duarte
Surgery, University of Florida, Gainesville, FL
*Purpose: Hepatic ischemia/reperfusion injury (IRI) is a major challenge in transplantation. The complex array of interrelated signaling events in IRI have been studied individually, but…
2020 American Transplant Congress
New IGL-2 Perfusate in Liver HOPE Strategies
A. Panisello-Rosello¹, C. Castro-Benítez², E. Folch-Puy¹, J. Rosello-Catafau¹, R. Adam²
¹Experimental Pathology, Instituto de Investigaciones Biomedicas de Barcelona, Barcelona, Spain, ²Centre Hépato-Billiare, Hôpital Paul Brousse, Paris, France
*Purpose: HOPE has shown to optimize graft liver preservation. However, the most used perfusion solutions as such as Belzer-MPS and its generics were initially for…
2020 American Transplant Congress
Muscle-Liver Crosstalk via the Myokine MG53 Plays a Critical Role in Hepatocellular Repair
C. Akateh, J. Ko, B. F. Reader, J. Kim, Y. Lee, B. A. Whitson, J. Ma, S. M. Black
The Ohio State University Wexner Medical Center, Columbus, OH
*Purpose: Transplantation remains the only effective treatment for end-stage liver disease, but the number of organs deemed suitable for transplantation falls far short of the…
2020 American Transplant Congress
The Efficacy and Safety of Ischemia-Free Liver Transplantation (IFLT) in the Treatment of End-Stage Liver Disease in a Prospective, Randomized, Controlled Trial: A Report of the First 25 Cases
X. He, Z. Guo, Q. Zhao, C. Huang, W. Ju, D. Wang, M. Chen, L. Wu, Y. Ma, Y. Chen, A. Hu, X. Zhu
Organ Transplant Center, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China
*Purpose: We’ve established a novel procedure called ischemia-free liver transplantation (IFLT). The results from the pilot study suggest that IFLT might prevent ischemia-reperfusion injury (IRI)…
2020 American Transplant Congress
Donor Lung Travel Distance and Time
C. Lehr¹, M. Skeans², M. Valapour¹, E. Lease³
¹Cleveland Clinic, Cleveland, OH, ²SRTR, Minneapolis, MN, ³University of Washington, Seattle, WA
*Purpose: With the policy change from donation service area (DSA) to 250 nautical miles (NM) as the first unit of US lung allocation, distances between…
2020 American Transplant Congress
Perfusion Regulated Organ Therapeutics with Enhanced Controlled Testing (PROTECT): Novel Human Model to Mitigate Ischemia-Reperfusion Injury in Liver Transplant
M. Nazzal, E. Madsen, M. Nguyen, A. Welu, H. Madnawat, C. Manithody, C. Denton, D. Blackall, D. Carpenter, J. Teckman, C. Varma, A. Jain
Saint Louis University, Saint Louis, MO
*Purpose: Despite a global organ shortage, there is almost a 10% discard rate of ‘marginal donor livers’ (MDL), deemed unsuitable for transplantation due to the…
2020 American Transplant Congress
Multimodal Theranostic Nanocolloid Platform for Imaging, Targeted Drug Delivery and Organ Preservation in Transplantation
J. M. Janjic¹, E. Lambert¹, L. Liu¹, M. Herneisey¹, V. S. Gorantla²
¹School of Pharmacy, Chronic Pain Research Consortium, Duquesne University, Pittsburgh, PA, ²Wake Forest Institute for Regenerative Medicine, Winston- Salem, NC
*Purpose: The goal of this project design and development of multifunctional nanomedicines to address unique and complex therapeutic outcomes in transplantation and organ preservation. Presented…
2020 American Transplant Congress
Identification of Novel Gene Targets Inducing Resistance in Liver Ischemia Reperfusion Injury by CRISPR Screening
C. Kuscu, A. R. Wolen, C. Kuscu, C. Watkins, A. Bajwa, J. D. Eason, D. Maluf, V. Mas
Dept of Surgery, Transplant Research Institute, James D. Eason Transplant Institute, University of Tennessee Health Science Center, Memphis, TN
*Purpose: Liver transplantation (LT) is the best treatment option for patients with end-stage liver disease (ESLD). However, the gap between available donors and recipients in…
2020 American Transplant Congress
Therapeutic Targeting of Bile Acid Metabolism Ameliorates Liver Ischemia/Reperfusion Injury
M. Ni¹, D. Jin², T. Lu², J. Zhang¹, R. Busuttil¹, J. Kupiec-Weglinski¹, J. Zhang², Y. Zhai¹
¹Dumont-UCLA Transplant Center, Los Angeles, CA, ²Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China
*Purpose: Farnesoid X receptor (FXR) is the major nuclear receptor of bile acids, which is also involved in the regulation of innate immune responses. As…