2020 American Transplant Congress
An Immune-Modulatory Strategy to Mitigate Hepatic Ischemia Reperfusion/Injury in a Murine Model
*Purpose: Hepatic ischemia/reperfusion injury (IRI) is the leading cause of early graft dysfunction and contributes to the shortage of donor organs. However, despite its obvious…2020 American Transplant Congress
ANG-3777 Treatment Attenuates Ischemia-Reperfusion-Induced Renal Injury in Rat and Dog Models
1Angion Biomedica, Uniondale, NY, 2Virginia Commonwealth University, Richmond, VA
*Purpose: The effect of ANG-3777, a small-molecule mimetic of hepatocyte growth factor, was evaluated on reducing ischemia-reperfusion-induced renal injury and mortality in rats and dogs…2020 American Transplant Congress
DAMPs and NLRP3 Inflammasome Response in Fatty Liver Grafts Preservation in Different Preservation Solutions
*Purpose: Preservation solutions (UW, HTK and IGL-1) are widely used in clinical liver transplantation. It is well known that the composition of the preservation solution…2020 American Transplant Congress
Kidney Alkalization Increases Macula Densa NOS1β Expression and Improves Transplanted Renal Graft Function
*Purpose: Ischemia-reperfusion injury (IRI) is a major survival hurdle with kidney transplantation (KTX). Currently, no effective strategies for the prevention and treatment of IRI during…2020 American Transplant Congress
Allograft Parenchymal Cell Expression of Tlr9 is Required for Endogenous Donor-Reactive Memory Cd8 T Cell Activation within High-Risk Cardiac Allografts to Mediate Ctla-4 Ig Resistant Graft Rejection
Lerner Reserch Institute, Cleveland Clinic, Cleveland, OH
*Purpose: Increased ischemia-reperfusion graft inflammation provokes activation of endogenous donor-reactive memory CD8 T cells within complete MHC-mismatched cardiac allografts at 24 hrs after graft reperfusion…2020 American Transplant Congress
TGR5/Cathepsin E Signaling Regulates Macrophage Innate Immune Activation in the Sterile Inflammatory Liver Injury
The First Affiliated Hospital of Nanjing Medical University, Nanjing, China
*Purpose: The hepatic proinflammatory response represents a major cause of liver ischemia and reperfusion (IR) injury. Although the role of plasma membrane-bound G protein-coupled bile…2020 American Transplant Congress
In Vivo Phosphorylation of C-MET by ANG-3777, A Hepatocyte Growth Factor Mimetic
Angion Biomedica, Uniondale, NY
*Purpose: : The biological effects of hepatocyte growth factor/scatter factor (HGF) and its mimetics are mediated by a signal cascade initiated by binding of HGF…2020 American Transplant Congress
Hepatic Microenvironment: Molecular and Chemical Changes Associated with Preconditioning Maneuvers
*Purpose: Liver preconditioning has been described to protect liver from ischemia injury and trigger liver regeneration. Hereby, we aimed to assess the effect of preconditioning…2020 American Transplant Congress
Gasdermin-D Mutation is Protective against Renal Ischemia Reperfusion Injury
*Purpose: Pyroptosis, a pro-inflammatory form of cell death, is dependent on membrane pore formation through the assembly of cleaved Gasdermin-D molecules. We hypothesized that this…2020 American Transplant Congress
The Inflammatory Response in the Context of Tissue Injury: Roles of Tyro3, Axl, and Mer (TAM) Receptors in Liver Ischemia/Reperfusion Injury
Dumont-UCLA Transplant Center, Los Angeles, CA
*Purpose: Although the inflammatory response in liver ischemia reperfusion injury has been studied extensively, how the context of tissue injury (presence of necrotic/apoptotic cells) regulates…
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