Articles tagged "Ischemia"

2020 American Transplant Congress
Aging Aggravated Liver Ischemia and Reperfusion Injury by Promoting Sting-Mediated NLRP3 Activation in Macrophages
Z. Rao, W. Zhong, H. Zhou, P. Wang, X. Wang, L. Lu
The First Affiliated Hospital of Nanjing Medical University, Nanjing, China
*Purpose: Aggravated liver injury and enhanced intrahepatic inflammation was found in old livers post ischemia and reperfusion (IR). However, the function and underlying mechanism of…
2020 American Transplant Congress
The Impact of Cold Ischaemia Time on Living Donor Kidney Transplantation Outcomes
S. C. van de Laar¹, M. Robb², R. Hogg², V. Papalois¹, F. J. Dor¹
¹Department of Surgery & Cancer, Imperial College London, Imperial College Renal and Transplant Centre, Hammersmith Hospital, Imperial College Healthcare NHS Trust, White City, London, United Kingdom, ²NHS Blood and Transplant, Bristol, United Kingdom
*Purpose: Living donor KTx (LDKT) provides the best option for patients with end-stage kidney disease (ESKD). ESKD patients who have an incompatible living donor still…
2020 American Transplant Congress
Consistent Prevention of Perioperative Cardiac Xenograft Dysfunction with Non-Ischemic Cardiac Preservation in Life-Supporting Cardiac Xenotransplantation Model
C. E. Goerlich¹, A. Singh¹, D. Kaczorowski¹, M. Abdullah¹, B. Lewis¹, I. Tatarov¹, A. Hershfeld¹, T. Zhang¹, P. Odonkor¹, A. Tabatabai¹, A. Bhutta¹, E. Strauss¹, B. Williams¹, D. Ayares², M. Mohiuddin¹
¹Surgery, University of Maryland School of Medicine, Baltimore, MD, ²Revivicor, Blacksburg, VA
*Purpose: Transplantation of organs from animals to humans (xenotransplantation) has been proposed to address the critical shortage of organs for transplantation. The use of genetically…
2020 American Transplant Congress
Prophylactic Treatment with Antioxidant Nanoparticles Attenuate Ischemia/Reperfusion Injury in BALB/c Mice
S. Yoon¹, K. Lee¹, W. Hwang¹, S. Yun¹, K. Yoon²
¹Nephrology, Konyang University Hospital, Daejeon, Korea, Republic of, ²Chemistry, Hannam University, Daejeon, Korea, Republic of
*Purpose: Kidney is more susceptible to hypoxic damage than other organ because kidney tissue consumes most of oxygen to move various solute across membrane. Ischemia/reperfusion…
2020 American Transplant Congress
Use of ICG Fluorescent Imaging in the Assessment of Kidney Transplant Perfusion after a Vascular Complication Requiring Complex Vascular Reconstruction
A. Cracco, D. Reino, S. Joshua, S. Ebaid, J. Vanatta
Cleveland Clinic Florida, Weston, FL
*Purpose: Demonstrate the utility of fluorescent imaging to assess the perfusion of a kidney transplant, after a vascular complication, requiring complex reconstruction.*Methods: Case report.*Results: We…
2020 American Transplant Congress
The Role of CXCL16/CXCR6 in Mediating Macrophage Chemotaxis and M1 Macrophage Polarization in Murine Renal Ischemia Reperfusion Injury
W. Zhang¹, X. Zhang², G. Tu², C. Yang¹, G. Qi¹, M. Xu¹, T. Zhu¹
¹Department of Urology, Zhongshan Hospital, Fudan University, Shanghai, China, ²Department of Critical Care Medicine, Zhongshan Hospital, Fudan University, Shanghai, China
*Purpose: The objective of this study is to investigate the role of Chemokine (C-X-C motif) ligand 16 (CXCL16) and its unique receptor C-X-C chemokine receptor…
2020 American Transplant Congress
Gingival Mesenchymal Stem Cells (GMSCs) Mitigate Liver Ischemia-Reperfusion Injury by Regulating Macrophage Polarization Through miR-199a-3p
Y. Zhang, M. Chen, W. Ju, T. Wang, Z. Chen, C. Huang, R. Xie, Q. Zhao, Z. Guo, X. He
Organ Transplant Center, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China
*Purpose: Mesenchymal stromal cells (MSCs) have been increasingly studied in organ ischemia-reperfusion injury, but the mechanism is still unclear. This study explored the immunoregulatory effects…
2020 American Transplant Congress
Comparing Two Methods of Minimally-Ischemic Cardiac Preservation in Life-Supporting Cardiac Xenotransplantation Model
C. E. Goerlich¹, A. Singh¹, D. Kaczorowski¹, M. Abdullah¹, B. Lewis¹, I. Tatarov¹, A. Hershfeld¹, T. Zhang¹, E. Strauss¹, P. Odonkor¹, B. Williams¹, D. Ayares², B. Griffith¹, M. Mohiuddin¹
¹Surgery, University of Maryland School of Medicine, Baltimore, MD, ²Surgery, Revivicor, Blacksburg, VA
*Purpose: Transplantation of organs from animals to humans (xenotransplantation) has been proposed to address the critical shortage of organs for transplantation. The use of genetically…
2020 American Transplant Congress
Anti-CD321 Antibody (90G4) Protects Liver against Ischemia Reperfusion Injury in a Murine Model
E. Yin¹, T. Fukuhara², H. Bashuda¹, K. Uchida³
¹Atopy Research Center, Juntendo University School of Medicine, Tokyo, Japan, ²Department of Neurology, Juntendo University School of Medicine, Tokyo, Japan, ³Juntendo Advanced Research Institute for Health Science, Juntendo University School of Medicine, Tokyo, Japan
*Purpose: Ischemia reperfusion results in increased transmigration of leukocytes into tissue. This eventually leads to post transplant graft damage after organ transplantation. CD321 (also known…
2020 American Transplant Congress
Sex-Dependent Resistance to Ischemia-Reperfusion Injury in Mouse and Human Liver Transplantation
S. Kageyama, H. Kojima, K. Kadono, H. Hirao, K. J. Dery, S. Younan, T. Ito, F. M. Kaldas, R. W. Busuttil, J. W. Kupiec-Weglinski
Surgery, Dumont-UCLA Transplant Center, Los Angeles, CA
*Purpose: Ischemia-reperfusion injury (IRI) is a major risk factor for early allograft dysfunction and rejection in orthotopic liver transplantation (OLT). The influence of sex on…